Pseudomonas aeruginosa responds to exogenous polyunsaturated fatty acids (PUFAs) by modifying phospholipid composition, membrane permeability, and phenotypes associated with virulence

Pseudomonas aeruginosa, a common opportunistic pathogen, is known to cause infections in a variety of compromised human tissues. An emerging mechanism for microbial survival is the incorporation of exogenous fatty acids to alter the cell's membrane phospholipid profile. With these findings, we...

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Bibliographic Details
Published in:	BMC microbiology Vol. 18; no. 1; p. 117
Main Authors:	Baker, Lyssa Y, Hobby, Chelsea R, Siv, Andrew W, Bible, William C, Glennon, Michael S, Anderson, Derek M, Symes, Steven J, Giles, David K
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 14-09-2018 BioMed Central BMC
Subjects:	Amides Antibiotics Antimicrobial peptides Bacteria Bacterial cell walls Biofilm Biofilms Chromatography Colistin Cystic fibrosis Drug resistance Ethidium bromide Fatty acids Gene expression Gram-positive bacteria Health aspects Human tissues Imipenem Lipids Liquid chromatography Mass spectrometry Mass spectroscopy Membrane permeability Metabolism Microorganisms Motility Nosocomial infections Opportunist infection Pathogens Peptide antibiotics Peptides Permeability Phenotypes Phosphatidylethanolamine Phosphatidylglycerol Phospholipid composition Phospholipids Physiological aspects Physiology Polymyxin B Polyunsaturated fatty acids Proteins Pseudomonas aeruginosa Studies Survival Swimming Thin layer chromatography Unsaturated fatty acids Virulence Virulence (Microbiology) Biofilm Pseudomonas aeruginosa Phospholipids Motility Fatty acids Antimicrobial peptides
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