Odour-plume dynamics influence the brain's olfactory code

• Published in: Nature (London) Vol. 410; no. 6827; pp. 466 - 470
• Main Authors: Vickers, Neil J, Baker, Thomas C, Christensen, Thomas A, Hildebrand, John G
• Format: Journal Article
• Language: English
• Published: London Nature Publishing 22-03-2001; Nature Publishing Group
• Subjects: Action Potentials; Animals; Biochemistry. Physiology. Immunology; Biological and medical sciences; Brain; Brain - physiology; Female; Flight, Animal; Fundamental and applied biological sciences. Psychology; Heliothis virescens; Insecta; Insects; Invertebrates; Male; Models, Neurological; Moths; Neurology; Neurons - drug effects; Neurons - physiology; Noctuidae; Odorants; Odors; Physiology. Development; Sense Organs - physiology; Sex Attractants - pharmacology; Smell; Smell - physiology; Stimulants; Heliothis virescens; Insecta; Electrophysiology; Nervous system; Pheromone; Stimulus intensity; Olfactory receptor; Sensory receptor; Olfactory system; Arthropoda; Lepidoptera; Olfaction; Feather; Noctuidae; Invertebrata; Odor; Antenna
• ISSN: 0028-0836; 1476-4687
• DOI: 10.1038/35068559

The neural computations used to represent olfactory information in the brain have long been investigated. Recent studies in the insect antennal lobe suggest that precise temporal and/or spatial patterns of activity underlie the recognition and discrimination of different odours, and that these patterns may be strengthened by associative learning. It remains unknown, however, whether these activity patterns persist when odour intensity varies rapidly and unpredictably, as often occurs in nature. Here we show that with naturally intermittent odour stimulation, spike patterns recorded from moth antennal-lobe output neurons varied predictably with the fine-scale temporal dynamics and intensity of the odour. These data support the hypothesis that olfactory circuits compensate for contextual variations in the stimulus pattern with high temporal precision. The timing of output neuron activity is constantly modulated to reflect ongoing changes in stimulus intensity and dynamics that occur on a millisecond timescale.