TAL2, A Helix-Loop-Helix Gene Activated by the (7;9)(q34;q32) Translocation in Human T-Cell Leukemia

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 88; no. 24; pp. 11416 - 11420
• Main Authors: YING XIA, BROWN, L, YING-CHUAN YANG, C, TSOU TSAN, J, SICILIANO, M. J, ESPINOSA, R. III, LE BEAU, M. M, BAER, R. J
• Format: Journal Article
• Language: English
• Published: Washington, DC National Academy of Sciences of the United States of America 15-12-1991; National Acad Sciences
• Subjects: Acute T cell leukemia; Amino Acid Sequence; ANIMAL CELLS; Animals; Base Sequence; BASIC BIOLOGICAL SCIENCES; Basic Helix-Loop-Helix Transcription Factors; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; Biological and medical sciences; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; Cell lines; CHEMICAL REACTIONS; CHROMOSOMAL ABERRATIONS; CHROMOSOMES; Chromosomes, Human, Pair 7; Chromosomes, Human, Pair 9; CONNECTIVE TISSUE CELLS; DAYS LIVING RADIOISOTOPES; DIMERIZATION; DISEASES; DNA; DNA HYBRIDIZATION; DNA probes; DNA SEQUENCING; DNA, Neoplasm - genetics; DNA, Neoplasm - isolation & purification; DNA-Binding Proteins - genetics; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation, Neoplastic; GENES; Genetic Linkage; Genomics; HETEROCHROMOSOMES; Humans; HYBRIDIZATION; Hypoplastic left heart syndrome; IMMUNE SYSTEM DISEASES; ISOTOPES; LEUKEMIA; Leukemia, T-Cell - genetics; Leukemia-Lymphoma, Adult T-Cell - genetics; LEUKOCYTES; LIGHT NUCLEI; LYMPHOCYTES; MATERIALS; Mice; Molecular and cellular biology; MOLECULAR BIOLOGY; Molecular genetics; Molecular Sequence Data; MUTATIONS; Neoplasm Proteins - genetics; NEOPLASMS; NUCLEI; ODD-ODD NUCLEI; Oligodeoxyribonucleotides; Open Reading Frames; ORGANIC COMPOUNDS; PHOSPHORUS 32; PHOSPHORUS ISOTOPES; Polymerase Chain Reaction - methods; POLYMERIZATION; PROTEINS; Proto-Oncogenes; RADIOISOTOPES; Restriction Mapping; RNA; Sequence Homology, Nucleic Acid; SOMATIC CELLS; STRUCTURAL CHEMICAL ANALYSIS 550200 > Biochemistry; T lymphocytes; Translocation, Genetic; Human; Translocation; Gene; Transcription; Leukemia; T-Lymphocyte; Helix; Chromosome; Activation; Gastropoda; Invertebrata; Mollusca
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.88.24.11416

Tumor-specific alteration of the TAL1 gene occurs in almost 25% of patients with T-cell acute lymphoblastic leukemia (T-ALL). We now report the identification of TAL2, a distinct gene that was isolated on the basis of its sequence homology with TAL1. The TAL2 gene is located 33 kilobase pairs from the chromosome 9 breakpoint of t(7;9)(q34;q32), a recurring translocation specifically associated with T-ALL. As a consequence of t(7;9)(q34;q32), TAL2 is juxtaposed with sequences from the T-cell receptor β-chain gene on chromosome 7. TAL2 sequences are actively transcribed in SUP-T3, a T-ALL cell line that harbors the t(7;9)(q34;q32). The TAL2 gene product includes a helix-loop-helix protein dimerization and DNA binding domain that is especially homologous to those encoded by the TAL1 and LYL1 protooncogenes. Hence, TAL2, TAL1, and LYL1 constitute a discrete subgroup of helix-loop-helix proteins, each of which can potentially contribute to the development of T-ALL.