Inhibition of Poly(Adenosine Diphosphate-Ribose) Polymerase Attenuates Ventilator-induced Lung Injury

Mechanical ventilation can induce organ injury associated with overwhelming inflammatory responses. Excessive activation of poly(adenosine diphosphate-ribose) polymerase enzyme after massive DNA damage may aggravate inflammatory responses. Therefore, the authors hypothesized that the pharmacologic i...

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Bibliographic Details
Published in:	Anesthesiology (Philadelphia) Vol. 108; no. 2; pp. 261 - 268
Main Authors:	VASCHETTO, Rosanna, KUIPER, Jan W, CHIANG, Shyh Ren, HAITSMA, Jack J, JUCO, Jonathan W, UHLIG, Stefan, PLÖTZ, Frans B, CORTE, Francesco Della, HAIBO ZHANG, SLUTSKY, Arthur S
Format:	Journal Article
Language:	English
Published:	Hagerstown, MD Lippincott 01-02-2008
Subjects:	Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Bronchoalveolar Lavage Fluid Cytokines - metabolism Lung - physiopathology Male Medical sciences Poly(ADP-ribose) Polymerase Inhibitors Positive-Pressure Respiration Rats Rats, Sprague-Dawley Respiration, Artificial Thromboplastin - metabolism Tidal Volume Wounds and Injuries - prevention & control Lung disease Purine nucleoside Adenosine Ventilator Respiratory disease Ribose Anesthesia
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