Ribonucleoside Hydrolases–Structure, Functions, Physiological Role and Practical Uses

Ribonucleoside Hydrolases–Structure, Functions, Physiological Role and Practical Uses

Ribonucleoside hydrolases are enzymes that catalyze the cleavage of ribonucleosides to nitrogenous bases and ribose. These enzymes are found in many organisms: bacteria, archaea, protozoa, metazoans, yeasts, fungi and plants. Despite the simple reaction catalyzed by these enzymes, their physiologica...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Vol. 13; no. 9; p. 1375
Main Authors: Shaposhnikov, Leonid A, Savin, Svyatoslav S, Tishkov, Vladimir I, Pometun, Anastasia A
Format: Journal Article
Language:English
Published: Basel MDPI AG 01-09-2023
MDPI
Subjects:
Adenosine
Bacteria
Bases (nucleic acids)
cancer drug design
Catalysis
catalysis mechanism
crystal structure
Dengue fever
enzyme kinetics
Enzymes
Fungi
Genomes
Hydrolases
Metabolism
nucleoside hydrolases
Organisms
Phosphorylation
Physiological aspects
Physiology
Protozoa
Review
Structure
Yeast
Russia
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Summary:Ribonucleoside hydrolases are enzymes that catalyze the cleavage of ribonucleosides to nitrogenous bases and ribose. These enzymes are found in many organisms: bacteria, archaea, protozoa, metazoans, yeasts, fungi and plants. Despite the simple reaction catalyzed by these enzymes, their physiological role in most organisms remains unclear. In this review, we compare the structure, kinetic parameters, physiological role, and potential applications of different types of ribonucleoside hydrolases discovered and isolated from different organisms.
Bibliography:ObjectType-Article-2
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ISSN:2218-273X
2218-273X
DOI:10.3390/biom13091375