Activation of the SDF1/CXCR4 pathway retards muscle atrophy during cancer cachexia

Cancer cachexia is a life-threatening syndrome that affects most patients with advanced cancers and causes severe body weight loss, with rapid depletion of skeletal muscle. No treatment is available. We analyzed microarray data sets to identify a subset of genes whose expression is specifically alte...

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Bibliographic Details
Published in:	Oncogene Vol. 35; no. 48; pp. 6212 - 6222
Main Authors:	Martinelli, G B, Olivari, D, Re Cecconi, A D, Talamini, L, Ottoboni, L, Lecker, S H, Stretch, C, Baracos, V E, Bathe, O F, Resovi, A, Giavazzi, R, Cervo, L, Piccirillo, R
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-12-2016 Nature Publishing Group
Subjects:	13/105 13/106 13/95 14/35 14/63 38/61 42/109 631/67/2327 64/60 96/1 Adenocarcinoma Adenylate cyclase Animals Apoptosis Atrophy Biomarkers Body weight Body weight loss Cachexia Cachexia - etiology Cachexia - pathology Cancer Cell Biology Cellular signal transduction Chemokine CXCL12 - metabolism Chemokine receptors Complications and side effects CXCR4 protein Cytokines Cytokines - metabolism Development and progression Diabetes mellitus Disease Models, Animal Female Gene Expression Gene Expression Profiling Gene Expression Regulation, Neoplastic - drug effects Genetic aspects GTP-binding protein Health aspects Hepatoma Heterocyclic Compounds - pharmacology Homeostasis Human Genetics Humans Indoles - pharmacology Internal Medicine Isoforms Kidney cancer Male Medicine Medicine & Public Health Mice Muscle fatigue Muscle Fibers, Skeletal - metabolism Muscle Fibers, Skeletal - pathology Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscular Atrophy Myotubes Neoplasms - complications Neoplasms - genetics Neoplasms - metabolism Oncology original-article Patients Properties Proteins Pyrroles - pharmacology Rats Receptors, CXCR4 - metabolism SDF-1 protein Signal Transduction - drug effects Skeletal muscle Skeletal system Sunitinib Tibialis anterior muscle Ubiquitin Uremia
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