Immune system transcriptome in gingival tissues of young nonhuman primates
Background and Objective Young/adolescent humans harbor many microorganisms associated with periodontal disease in adults and show substantial gingival inflammatory responses. However, younger individuals do not demonstrate the soft‐ and hard‐tissue destruction that hallmark periodontitis. Material...
Saved in:
| Published in: | Journal of periodontal research Vol. 51; no. 2; pp. 152 - 163 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Blackwell Publishing Ltd
01-04-2016
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Background and Objective
Young/adolescent humans harbor many microorganisms associated with periodontal disease in adults and show substantial gingival inflammatory responses. However, younger individuals do not demonstrate the soft‐ and hard‐tissue destruction that hallmark periodontitis.
Material and Methods
This study evaluated responses to the oral microbial ecology in gingival tissues from clinically healthy young Macaca mulatta (< 3 years of age) compared with older animals (5–23 years of age). RNA was isolated from the tissues and analyzed for the transcriptome using the Rhesus Macaque GeneChip (Affymetrix).
Results
Global transcriptional profiling of four age groups revealed a subset of 159 genes that were differentially expressed across at least one of the age comparisons. Correlation metrics generated a relevance network ion of these genes. Partitioning of the relevance network revealed seven distinct communities comprising functionally related genes associated with host inflammatory and immune responses. A group of genes was identified that were selectively increased/decreased or positively/negatively correlated with gingival profiles in the animals. A principal components analysis created metagenes of expression profiles for classifying the 23 animals.
Conclusion
The results provide novel system‐level insights into gene‐expression differences in gingival tissues from healthy young animals, weighted toward host responses associated with anti‐inflammatory biomolecules or those linked with T‐cell regulation of responses. The combination of the regulated microenvironment may help to explain the apparent ‘resistance’ of younger individuals to developing periodontal disease. |
|---|---|
| AbstractList | Background and Objective
Young/adolescent humans harbor many microorganisms associated with periodontal disease in adults and show substantial gingival inflammatory responses. However, younger individuals do not demonstrate the soft‐ and hard‐tissue destruction that hallmark periodontitis.
Material and Methods
This study evaluated responses to the oral microbial ecology in gingival tissues from clinically healthy young Macaca mulatta (< 3 years of age) compared with older animals (5–23 years of age). RNA was isolated from the tissues and analyzed for the transcriptome using the Rhesus Macaque GeneChip (Affymetrix).
Results
Global transcriptional profiling of four age groups revealed a subset of 159 genes that were differentially expressed across at least one of the age comparisons. Correlation metrics generated a relevance network ion of these genes. Partitioning of the relevance network revealed seven distinct communities comprising functionally related genes associated with host inflammatory and immune responses. A group of genes was identified that were selectively increased/decreased or positively/negatively correlated with gingival profiles in the animals. A principal components analysis created metagenes of expression profiles for classifying the 23 animals.
Conclusion
The results provide novel system‐level insights into gene‐expression differences in gingival tissues from healthy young animals, weighted toward host responses associated with anti‐inflammatory biomolecules or those linked with T‐cell regulation of responses. The combination of the regulated microenvironment may help to explain the apparent ‘resistance’ of younger individuals to developing periodontal disease. BACKGROUND AND OBJECTIVEYoung/adolescent humans harbor many microorganisms associated with periodontal disease in adults and show substantial gingival inflammatory responses. However, younger individuals do not demonstrate the soft- and hard-tissue destruction that hallmark periodontitis.MATERIAL AND METHODSThis study evaluated responses to the oral microbial ecology in gingival tissues from clinically healthy young Macaca mulatta (< 3 years of age) compared with older animals (5-23 years of age). RNA was isolated from the tissues and analyzed for the transcriptome using the Rhesus Macaque GeneChip (Affymetrix).RESULTSGlobal transcriptional profiling of four age groups revealed a subset of 159 genes that were differentially expressed across at least one of the age comparisons. Correlation metrics generated a relevance network abstraction of these genes. Partitioning of the relevance network revealed seven distinct communities comprising functionally related genes associated with host inflammatory and immune responses. A group of genes was identified that were selectively increased/decreased or positively/negatively correlated with gingival profiles in the animals. A principal components analysis created metagenes of expression profiles for classifying the 23 animals.CONCLUSIONThe results provide novel system-level insights into gene-expression differences in gingival tissues from healthy young animals, weighted toward host responses associated with anti-inflammatory biomolecules or those linked with T-cell regulation of responses. The combination of the regulated microenvironment may help to explain the apparent 'resistance' of younger individuals to developing periodontal disease. Young/adolescent humans demonstrate many microorganisms associated with periodontal disease in adults and substantial gingival inflammatory responses. However, younger individuals do not demonstrate the soft and hard tissue destruction that hallmark periodontitis. This study evaluated responses to the oral microbial ecology in gingival tissues from clinically healthy young Macaca mulatta (<3 years old) compared to older animals (5-23 years old). Global transcriptional profiling of four age groups revealed a subset of 159 genes that were differentially expressed at least across one of the age comparisons. Correlation metrics generated a relevance network abstraction of these genes. Partitioning of the relevance network revealed seven distinct communities comprising functionally related genes associated with host inflammatory and immune responses. A group of genes were identified that were selectively increased/decreased or positively/negatively correlated with gingival profiles in the animals. A Principal Components Analysis created metagenes of expression profiles for classifying the 23 animals. The results provide novel system-level insights into gene expression differences in healthy young tissues weighted towards host responses that were associated with anti-inflammatory biomolecules or those linked with T cell regulation of responses. The combination of the regulated microenvironment may help to explain the apparent “resistance” of younger individuals to developing periodontal disease. Young/adolescent humans harbor many microorganisms associated with periodontal disease in adults and show substantial gingival inflammatory responses. However, younger individuals do not demonstrate the soft- and hard-tissue destruction that hallmark periodontitis. This study evaluated responses to the oral microbial ecology in gingival tissues from clinically healthy young Macaca mulatta (< 3 years of age) compared with older animals (5-23 years of age). RNA was isolated from the tissues and analyzed for the transcriptome using the Rhesus Macaque GeneChip (Affymetrix). Global transcriptional profiling of four age groups revealed a subset of 159 genes that were differentially expressed across at least one of the age comparisons. Correlation metrics generated a relevance network abstraction of these genes. Partitioning of the relevance network revealed seven distinct communities comprising functionally related genes associated with host inflammatory and immune responses. A group of genes was identified that were selectively increased/decreased or positively/negatively correlated with gingival profiles in the animals. A principal components analysis created metagenes of expression profiles for classifying the 23 animals. The results provide novel system-level insights into gene-expression differences in gingival tissues from healthy young animals, weighted toward host responses associated with anti-inflammatory biomolecules or those linked with T-cell regulation of responses. The combination of the regulated microenvironment may help to explain the apparent 'resistance' of younger individuals to developing periodontal disease. |
| Author | Orraca, L. Nagarajan, R. Gonzalez-Martinez, J. A. Kirakodu, S. S. Ebersole, J. L. Gonzalez, O. A. Novak, M. J. |
| AuthorAffiliation | 1 Center for Oral Health Research, College of Dentistry, University of Kentucky 4 Caribbean Primate Research Center, Sabana Seca, PR 3 School of Dentistry, University of Puerto Rico, San Juan, PR 2 Division of Biomedical Informatics, Department of Biostatistics, College of Public Health, University of Kentucky |
| AuthorAffiliation_xml | – name: 3 School of Dentistry, University of Puerto Rico, San Juan, PR – name: 4 Caribbean Primate Research Center, Sabana Seca, PR – name: 1 Center for Oral Health Research, College of Dentistry, University of Kentucky – name: 2 Division of Biomedical Informatics, Department of Biostatistics, College of Public Health, University of Kentucky |
| Author_xml | – sequence: 1 givenname: O. A. surname: Gonzalez fullname: Gonzalez, O. A. organization: Center for Oral Health Research, College of Dentistry, University of Kentucky, KY, Lexington, USA – sequence: 2 givenname: R. surname: Nagarajan fullname: Nagarajan, R. organization: Division of Biomedical Informatics, College of Public Health, University of Kentucky, Lexington, KY, USA – sequence: 3 givenname: M. J. surname: Novak fullname: Novak, M. J. organization: Center for Oral Health Research, College of Dentistry, University of Kentucky, KY, Lexington, USA – sequence: 4 givenname: L. surname: Orraca fullname: Orraca, L. organization: School of Dentistry, University of Puerto Rico, San Juan, Puerto Rico – sequence: 5 givenname: J. A. surname: Gonzalez-Martinez fullname: Gonzalez-Martinez, J. A. organization: Caribbean Primate Research Center, Sabana Seca, Puerto Rico – sequence: 6 givenname: S. S. surname: Kirakodu fullname: Kirakodu, S. S. organization: Center for Oral Health Research, College of Dentistry, University of Kentucky, KY, Lexington, USA – sequence: 7 givenname: J. L. surname: Ebersole fullname: Ebersole, J. L. email: jleber2@uky.edu organization: Center for Oral Health Research, College of Dentistry, University of Kentucky, KY, Lexington, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26077888$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kUtP3DAUha2Kqgy0i_6BKst2EfAjfmRTqR3xFKJSRcXS8jjXg2liT-2EMv8ew8CoXeDNleXvnnt87h7aCTEAQh8JPiDlHN4mOCCUtuwNmhGBcY2l4DtohjGlNWtUs4v2cr7F5S5k-w7tUoGlVErN0PnZMEwBqrzOIwzVmEzINvnVGAeofKiWPiz9nemr0ec8Qa6iq9ZxCsuqeLiZBhOqVfKDGSG_R2-d6TN8eK776Nfx0dX8tL74cXI2_3ZRW04Zq12nlFywjkjTukbZhlKjeAOOWLAcFKEKREvbBggW3DXYCscdJ4sOFqZrOdtHXze6q2kxQGchFNe9frKR1joar_9_Cf5GL-OdboQiEtMi8PlZIMU_5U-jHny20PcmQJyyJlJiJYRqWUG_bFCbYs4J3HYMwfoxe12y10_ZF_bTv7625EvYBTjcAH99D-vXlfT5z6MXyXrT4ct27rcdJv3WQjLJ9fXlib7i16ff2znRnD0AzhKhKw |
| CitedBy_id | crossref_primary_10_1111_prd_12331 crossref_primary_10_3389_froh_2022_817249 crossref_primary_10_1111_jcpe_12675 crossref_primary_10_1111_prd_12222 crossref_primary_10_1111_omi_12377 crossref_primary_10_1111_imm_12894 crossref_primary_10_1111_odi_14222 crossref_primary_10_1128_IAI_00067_19 crossref_primary_10_3389_froh_2023_1320083 crossref_primary_10_1016_j_molimm_2022_05_006 crossref_primary_10_1111_jre_12610 |
| Cites_doi | 10.1111/odi.12018 10.1093/biostatistics/4.2.249 10.1034/j.1600-0757.2001.2260104.x 10.1016/j.phrs.2012.11.006 10.1111/j.1754-4505.2009.00082.x 10.1111/j.1600-0757.2012.00457.x 10.2174/1874210600802010049 10.1111/j.1600-0757.2006.00169.x 10.1111/j.1601-0825.2011.01830.x 10.5051/jpis.2013.43.1.3 10.1111/j.2041-1014.2009.00555.x 10.1111/j.1601-0825.2011.01851.x 10.1007/s10495-013-0806-x 10.1159/000329669 10.1016/S0300-5712(96)00019-X 10.1038/nrd3669 10.1152/ajpendo.00531.2011 10.1902/annals.2002.7.1.102 10.1609/icwsm.v3i1.13937 10.1038/modpathol.3800079 10.1016/0076-6879(94)35135-X 10.1177/0022034511403744 10.1016/j.cden.2012.09.009 10.17796/jcpd.38.2.j525742137780336 10.1902/jop.2012.110676 10.1088/1742-5468/2008/10/P10008 10.1902/jop.1993.64.6.497 10.1111/j.1399-302X.1994.tb00043.x 10.1111/j.2041-1014.2009.00562.x 10.1111/j.1600-0757.2010.00353.x 10.1128/CVI.00258-07 10.1111/j.1600-0757.2009.00316.x 10.4049/jimmunol.168.2.744 10.1159/000329675 10.1177/0022034510387794 10.3402/jom.v6.22962 10.1128/CVI.00291-13 10.1177/0022034512457373 10.1155/2011/754857 10.1371/journal.pone.0022788 10.1111/jcpe.12212 10.2174/1874210601004010037 |
| ContentType | Journal Article |
| Copyright | 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
| Copyright_xml | – notice: 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd – notice: 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
| DBID | BSCLL CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 5PM |
| DOI | 10.1111/jre.12293 |
| DatabaseName | Istex Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Dentistry |
| EISSN | 1600-0765 |
| EndPage | 163 |
| ExternalDocumentID | 10_1111_jre_12293 26077888 JRE12293 ark_67375_WNG_T5WHB9C1_5 |
| Genre | article Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: National Institute of Health funderid: P20GM103538; UL1TR000117 – fundername: Microarray Core of University Kentucky – fundername: Caribbean Primate Research Center (CPRC) funderid: P40RR03640 – fundername: NIGMS NIH HHS grantid: P20GM103538 – fundername: NCATS NIH HHS grantid: UL1TR000117 – fundername: NCATS NIH HHS grantid: UL1 TR000117 – fundername: NIGMS NIH HHS grantid: P30 GM110788 – fundername: NCRR NIH HHS grantid: P40RR03640 – fundername: NIGMS NIH HHS grantid: P20 GM103538 – fundername: NCRR NIH HHS grantid: P40 RR003640 |
| GroupedDBID | --- .3N .GA .GJ .Y3 05W 0R~ 10A 1OB 1OC 29L 31~ 33P 34H 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A03 AAESR AAEVG AAHHS AAKAS AANLZ AAONW AASGY AAWTL AAXRX AAZKR ABCQN ABCUV ABEML ABJNI ABLJU ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFS ACGOF ACMXC ACPOU ACPRK ACSCC ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZCM ADZMN AEEZP AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFEBI AFFNX AFFPM AFGKR AFPWT AFZJQ AHBTC AHEFC AIACR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BSCLL BY8 C45 CAG COF CS3 CWXXS D-E D-F DC6 DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 EBD EBS EJD F00 F01 F04 F5P FEDTE FUBAC FZ0 G-S G.N GODZA H.T H.X HF~ HGLYW HVGLF HZI HZ~ IHE IX1 J0M K48 KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OIG OVD P2P P2W P2X P4D PALCI Q.N Q11 QB0 R.K RIWAO RJQFR ROL RX1 SAMSI SUPJJ TEORI UB1 W8V W99 WBKPD WBNRW WIH WIJ WIK WOHZO WPGGZ WQJ WRC WXSBR XG1 YFH ZGI ZZTAW ~IA ~WT CGR CUY CVF ECM EIF NPM AAMNL AAYXX CITATION 7X8 5PM |
| ID | FETCH-LOGICAL-c5233-fd887b3d17a9f48c422a854ef1cec5e8128e69294e1065f40c6f5f51bdebad953 |
| IEDL.DBID | 33P |
| ISSN | 0022-3484 |
| IngestDate | Tue Sep 17 20:53:29 EDT 2024 Sat Aug 17 05:49:05 EDT 2024 Thu Nov 21 23:27:37 EST 2024 Sat Nov 02 12:29:39 EDT 2024 Sat Aug 24 01:06:05 EDT 2024 Wed Oct 30 09:49:18 EDT 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | aging nonhuman primates inflammation periodontitis |
| Language | English |
| License | 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c5233-fd887b3d17a9f48c422a854ef1cec5e8128e69294e1065f40c6f5f51bdebad953 |
| Notes | Microarray Core of University Kentucky istex:7D11C10F982DF590D4DE9073148E3AE8F3B22A90 National Institute of Health - No. P20GM103538; No. UL1TR000117 Caribbean Primate Research Center (CPRC) - No. P40RR03640 ark:/67375/WNG-T5WHB9C1-5 ArticleID:JRE12293 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://europepmc.org/articles/pmc4681702?pdf=render |
| PMID | 26077888 |
| PQID | 1770866893 |
| PQPubID | 23479 |
| PageCount | 12 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4681702 proquest_miscellaneous_1770866893 crossref_primary_10_1111_jre_12293 pubmed_primary_26077888 wiley_primary_10_1111_jre_12293_JRE12293 istex_primary_ark_67375_WNG_T5WHB9C1_5 |
| PublicationCentury | 2000 |
| PublicationDate | April 2016 |
| PublicationDateYYYYMMDD | 2016-04-01 |
| PublicationDate_xml | – month: 04 year: 2016 text: April 2016 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Journal of periodontal research |
| PublicationTitleAlternate | J Periodont Res |
| PublicationYear | 2016 |
| Publisher | Blackwell Publishing Ltd |
| Publisher_xml | – name: Blackwell Publishing Ltd |
| References | Bimstein E, Ram D, Irshied J, Naor R, Sela MN. Periodontal diseases, caries, and microbial composition of the subgingival plaque in children: a longitudinal study. ASDC J Dent Child 2002;69:133-137, 123. Zarco MF, Vess TJ, Ginsburg GS. The oral microbiome in health and disease and the potential impact on personalized dental medicine. Oral Dis 2012;18:109-120. Eke PI, Dye BA, Wei L, Thornton-Evans GO, Genco RJ. Cdc Periodontal Disease Surveillance workgroup: James Beck GDRP. Prevalence of periodontitis in adults in the United States: 2009 and 2010. J Dent Res 2012;91:914-920. Ebersole JL, Steffen MJ, Gonzalez-Martinez J, Novak MJ. Effects of age and oral disease on systemic inflammatory and immune parameters in nonhuman primates. Clin Vaccine Immunol 2008;15:1067-1075. Nibali L, Henderson B, Sadiq ST, Donos N. Genetic dysbiosis: the role of microbial insults in chronic inflammatory diseases. J Oral Microbiol 2014;6:1-10. Kirakodu SS, Govindaswami M, Novak MJ, Ebersole JL, Novak KF. Optimizing qPCR for the quantification of periodontal pathogens in a complex plaque biofilm. Open Dent J 2008;2:49-55. Kiyokawa N, Sekino T, Matsui T et al. Diagnostic importance of CD179a/b as markers of precursor B-cell lymphoblastic lymphoma. Mod Pathol 2004;17:423-429. Struillou X, Boutigny H, Soueidan A, Layrolle P. Experimental animal models in periodontology: a review. Open Dent J 2010;4:37-47. Redlich K, Smolen JS. Inflammatory bone loss: pathogenesis and therapeutic intervention. Nat Rev Drug Discov 2012;11:234-250. Bimstein E, Ebersole JL. Serum antibody levels to oral microorganisms in children and young adults with relation to the severity of gingival disease. Pediatr Dent 1991;13:267-272. Ahn J, Yang L, Paster BJ et al. Oral microbiome profiles: 16S rRNA pyrosequencing and microarray assay comparison. PLoS One 2011;6:e22788. Armitage GC, Cullinan MP. Comparison of the clinical features of chronic and aggressive periodontitis. Periodontol 2000 2010;53:12-27. Wade WG. The oral microbiome in health and disease. Pharmacol Res 2013;69:137-143. Huttner EA, Machado DC, de Oliveira RB, Antunes AG, Hebling E. Effects of human aging on periodontal tissues. Spec Care Dentist 2009;29:149-155. Gonsalves WC, Wrightson AS, Henry RG. Common oral conditions in older persons. Am Fam Physician 2008;78:845-852. Song HJ. Periodontal considerations for children. Dent Clin North Am 2013;57:17-37. Gonzalez OA, Novak MJ, Kirakodu S et al. Comparative analysis of gingival tissue antigen presentation pathways in ageing and periodontitis. J Clin Periodontol 2014;41:327-339. Paster BJ, Dewhirst FE. Molecular microbial diagnosis. Periodontol 2000 2009;51:38-44. Chung HY, Lee EK, Choi YJ et al. Molecular inflammation as an underlying mechanism of the aging process and age-related diseases. J Dent Res 2011;90:830-840. Genco RJ, Borgnakke WS. Risk factors for periodontal disease. Periodontol 2000 2013;62:59-94. Hajishengallis G. Too old to fight? Aging and its toll on innate immunity. Mol Oral Microbiol 2010;25:25-37. Ji S, Choi Y. Innate immune response to oral bacteria and the immune evasive characteristics of periodontal pathogens. J Periodontal Implant Sci 2013;43:3-11. Bimstein E, Huja PE, Ebersole JL. The potential lifespan impact of gingivitis and periodontitis in children. J Clin Pediatr Dent 2013;38:95-99. Persson GR, Engel LD, Whitney CW et al. Macaca fascicularis as a model in which to assess the safety and efficacy of a vaccine for periodontitis. Oral Microbiol Immunol 1994;9:104-111. Meka A, Bakthavatchalu V, Sathishkumar S et al. Porphyromonas gingivalis infection-induced tissue and bone transcriptional profiles. Mol Oral Microbiol 2010;25:61-74. Irizarry RA, Hobbs B, Collin F et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 2003;4:249-264. Eke PI, Thornton-Evans G, Dye B, Genco R. Advances in surveillance of periodontitis: the Centers for Disease Control and prevention periodontal disease surveillance project. J Periodontol 2012;83:1337-1342. Madden TE, Caton JG. Animal models for periodontal disease. Methods Enzymol 1994;235:106-119. Gonzalez OA, Stromberg AJ, Huggins PM, Gonzalez-Martinez J, Novak MJ, Ebersole JL. Apoptotic genes are differentially expressed in aged gingival tissue. J Dent Res 2011;90:880-886. Ebersole JL, Cappelli D, Mathys EC et al. Periodontitis in humans and non-human primates: oral-systemic linkage inducing acute phase proteins. Ann Periodontol 2002;7:102-111. Diaz PI. Microbial diversity and interactions in subgingival biofilm communities. Front Oral Biol 2012;15:17-40. Henley KD, Gooding KA, Economides AN, Gannon M. Inactivation of the dual Bmp/Wnt inhibitor Sostdc1 enhances pancreatic islet function. Am J Physiol Endocrinol Metab 2012;303:E752-E761. Blondel VD, Guillaume J-L, Lambiotte R, Lefebvre E. Fast unfolding of communities in large networks. J Stat Mech: Theory Exp 2008;10:P10008. Gonzalez O, Novak MJ, Orraca L, Martinez-Gonzalez J, Stromberg AJ, Ebersole JL. Apopotosis gene expression in healthy and oral mucosal tissues with aging. Apoptosis 2013;18:249-259. Ebersole JL, Holt SC, Delaney JE. Acquisition of oral microbes and associated systemic responses of newborn nonhuman primates. Clin Vaccine Immunol 2014;21:21-28. Butte AJ, Kohane IS. Mutual information relevance networks: functional genomic clustering using pairwise entropy measurements. Pac Symp Biocomput 2000;418-429. Dibart S. Children, adolescents and periodontal diseases. J Dent 1997;25:79-89. Schou S, Holmstrup P, Kornman KS. Non-human primates used in studies of periodontal disease pathogenesis: a review of the literature. J Periodontol 1993;64:497-508. Gonzalez OA, Kirakodu S, Novak MJ et al. Effects of aging in the expression of NOD-like receptors adn inflammasome-related genes in the oral mucosa. Mol Oral Microbiol 2015. in press. Gonzalez OA, John Novak M, Kirakodu S et al. Effects of aging on apoptosis gene expression in oral mucosal tissues. Apoptosis 2013;18:249-259. Zhu N, Ramirez LM, Lee RL, Magnuson NS, Bishop GA, Gold MR. CD40 signaling in B cells regulates the expression of the Pim-1 kinase via the NF-kappa B pathway. J Immunol 2002;168:744-754. Gonzalez O, Tobia C, Ebersole J, Novak MJ. Caloric restriction and chronic inflammatory diseases. Oral Dis 2012;18:16-31. Xin B, Luo A, Qin J et al. Microbial diversity in the oral cavity of healthy Chinese Han children. Oral Dis 2013;19:401-405. Kinane DF, Bartold PM. Clinical relevance of the host responses of periodontitis. Periodontol 2000 2007;43:278-293. Waly MI, Hornig M, Trivedi M et al. Prenatal and postnatal epigenetic programming: implications for GI, immune, and neuronal function in autism. Autism Res Treat 2012;2012:190930. Kinane DF, Podmore M, Murray MC, Hodge PJ, Ebersole J. Etiopathogenesis of periodontitis in children and adolescents. Periodontol 2000 2001;26:54-91. Oz HS, Puleo DA. Animal models for periodontal disease. J Biomed Biotechnol 2011;2011:754857. Graves DT, Kang J, Andriankaja O, Wada K, Rossa C Jr. Animal models to study host-bacteria interactions involved in periodontitis. Front Oral Biol 2012;15:117-132. 2012; 83 2010; 53 2013; 69 2012; 2012 1994; 235 2013; 43 1991; 13 2013; 62 1997; 25 1993; 64 2002; 7 2009 2008; 15 2008; 78 2012; 18 2008; 10 2001; 26 2012; 15 2014; 41 2008; 2 2011; 6 2012; 303 2012; 11 2009; 29 2014; 21 1994; 9 2013; 19 2011; 2011 2013; 18 2002; 69 2012; 91 2009; 51 2010; 25 2013; 38 2000 2013; 57 2011; 90 2004; 17 2002; 168 2003; 4 2015 2007; 43 2010; 4 2014; 6 e_1_2_7_5_1 e_1_2_7_3_1 e_1_2_7_9_1 e_1_2_7_7_1 e_1_2_7_19_1 e_1_2_7_17_1 e_1_2_7_15_1 e_1_2_7_41_1 e_1_2_7_13_1 e_1_2_7_43_1 e_1_2_7_11_1 e_1_2_7_45_1 e_1_2_7_47_1 e_1_2_7_49_1 e_1_2_7_28_1 Gonzalez OA (e_1_2_7_18_1) 2015 e_1_2_7_50_1 e_1_2_7_25_1 e_1_2_7_31_1 e_1_2_7_23_1 e_1_2_7_33_1 e_1_2_7_21_1 e_1_2_7_35_1 e_1_2_7_37_1 e_1_2_7_39_1 e_1_2_7_6_1 e_1_2_7_4_1 e_1_2_7_8_1 e_1_2_7_16_1 e_1_2_7_40_1 e_1_2_7_2_1 e_1_2_7_14_1 e_1_2_7_42_1 e_1_2_7_12_1 e_1_2_7_10_1 e_1_2_7_46_1 e_1_2_7_27_1 e_1_2_7_29_1 Butte AJ (e_1_2_7_26_1) 2000 Bimstein E (e_1_2_7_20_1) 2002; 69 e_1_2_7_30_1 e_1_2_7_24_1 e_1_2_7_22_1 e_1_2_7_34_1 Nibali L (e_1_2_7_48_1) 2014; 6 e_1_2_7_36_1 Waly MI (e_1_2_7_32_1) 2012; 2012 Gonsalves WC (e_1_2_7_38_1) 2008; 78 Bimstein E (e_1_2_7_44_1) 1991; 13 |
| References_xml | – volume: 10 start-page: P10008 year: 2008 article-title: Fast unfolding of communities in large networks publication-title: J Stat Mech: Theory Exp – year: 2009 – volume: 168 start-page: 744 year: 2002 end-page: 754 article-title: CD40 signaling in B cells regulates the expression of the Pim‐1 kinase via the NF‐kappa B pathway publication-title: J Immunol – volume: 15 start-page: 1067 year: 2008 end-page: 1075 article-title: Effects of age and oral disease on systemic inflammatory and immune parameters in nonhuman primates publication-title: Clin Vaccine Immunol – volume: 17 start-page: 423 year: 2004 end-page: 429 article-title: Diagnostic importance of CD179a/b as markers of precursor B‐cell lymphoblastic lymphoma publication-title: Mod Pathol – volume: 9 start-page: 104 year: 1994 end-page: 111 article-title: Macaca fascicularis as a model in which to assess the safety and efficacy of a vaccine for periodontitis publication-title: Oral Microbiol Immunol – volume: 2012 start-page: 190930 year: 2012 article-title: Prenatal and postnatal epigenetic programming: implications for GI, immune, and neuronal function in autism publication-title: Autism Res Treat – volume: 90 start-page: 880 year: 2011 end-page: 886 article-title: Apoptotic genes are differentially expressed in aged gingival tissue publication-title: J Dent Res – volume: 2011 start-page: 754857 year: 2011 article-title: Animal models for periodontal disease publication-title: J Biomed Biotechnol – volume: 7 start-page: 102 year: 2002 end-page: 111 article-title: Periodontitis in humans and non‐human primates: oral‐systemic linkage inducing acute phase proteins publication-title: Ann Periodontol – volume: 4 start-page: 37 year: 2010 end-page: 47 article-title: Experimental animal models in periodontology: a review publication-title: Open Dent J – volume: 43 start-page: 3 year: 2013 end-page: 11 article-title: Innate immune response to oral bacteria and the immune evasive characteristics of periodontal pathogens publication-title: J Periodontal Implant Sci – volume: 25 start-page: 25 year: 2010 end-page: 37 article-title: Too old to fight? Aging and its toll on innate immunity publication-title: Mol Oral Microbiol – volume: 4 start-page: 249 year: 2003 end-page: 264 article-title: Exploration, normalization, and summaries of high density oligonucleotide array probe level data publication-title: Biostatistics – volume: 91 start-page: 914 year: 2012 end-page: 920 article-title: Cdc Periodontal Disease Surveillance workgroup: James Beck GDRP. Prevalence of periodontitis in adults in the United States: 2009 and 2010 publication-title: J Dent Res – volume: 83 start-page: 1337 year: 2012 end-page: 1342 article-title: Advances in surveillance of periodontitis: the Centers for Disease Control and prevention periodontal disease surveillance project publication-title: J Periodontol – volume: 41 start-page: 327 year: 2014 end-page: 339 article-title: Comparative analysis of gingival tissue antigen presentation pathways in ageing and periodontitis publication-title: J Clin Periodontol – volume: 303 start-page: E752 year: 2012 end-page: E761 article-title: Inactivation of the dual Bmp/Wnt inhibitor Sostdc1 enhances pancreatic islet function publication-title: Am J Physiol Endocrinol Metab – start-page: 418 year: 2000 end-page: 429 article-title: Mutual information relevance networks: functional genomic clustering using pairwise entropy measurements publication-title: Pac Symp Biocomput – volume: 38 start-page: 95 year: 2013 end-page: 99 article-title: The potential lifespan impact of gingivitis and periodontitis in children publication-title: J Clin Pediatr Dent – volume: 21 start-page: 21 year: 2014 end-page: 28 article-title: Acquisition of oral microbes and associated systemic responses of newborn nonhuman primates publication-title: Clin Vaccine Immunol – volume: 25 start-page: 79 year: 1997 end-page: 89 article-title: Children, adolescents and periodontal diseases publication-title: J Dent – volume: 69 start-page: 137 year: 2013 end-page: 143 article-title: The oral microbiome in health and disease publication-title: Pharmacol Res – volume: 25 start-page: 61 year: 2010 end-page: 74 article-title: Porphyromonas gingivalis infection‐induced tissue and bone transcriptional profiles publication-title: Mol Oral Microbiol – volume: 18 start-page: 249 year: 2013 end-page: 259 article-title: Apopotosis gene expression in healthy and oral mucosal tissues with aging publication-title: Apoptosis – volume: 43 start-page: 278 year: 2007 end-page: 293 article-title: Clinical relevance of the host responses of periodontitis publication-title: Periodontol 2000 – volume: 64 start-page: 497 year: 1993 end-page: 508 article-title: Non‐human primates used in studies of periodontal disease pathogenesis: a review of the literature publication-title: J Periodontol – volume: 19 start-page: 401 year: 2013 end-page: 405 article-title: Microbial diversity in the oral cavity of healthy Chinese Han children publication-title: Oral Dis – volume: 11 start-page: 234 year: 2012 end-page: 250 article-title: Inflammatory bone loss: pathogenesis and therapeutic intervention publication-title: Nat Rev Drug Discov – volume: 26 start-page: 54 year: 2001 end-page: 91 article-title: Etiopathogenesis of periodontitis in children and adolescents publication-title: Periodontol 2000 – volume: 69 start-page: 133 year: 2002 end-page: 137 article-title: Periodontal diseases, caries, and microbial composition of the subgingival plaque in children: a longitudinal study publication-title: ASDC J Dent Child – volume: 29 start-page: 149 year: 2009 end-page: 155 article-title: Effects of human aging on periodontal tissues publication-title: Spec Care Dentist – volume: 6 start-page: 1 year: 2014 end-page: 10 article-title: Genetic dysbiosis: the role of microbial insults in chronic inflammatory diseases publication-title: J Oral Microbiol – volume: 18 start-page: 16 year: 2012 end-page: 31 article-title: Caloric restriction and chronic inflammatory diseases publication-title: Oral Dis – volume: 15 start-page: 17 year: 2012 end-page: 40 article-title: Microbial diversity and interactions in subgingival biofilm communities publication-title: Front Oral Biol – volume: 90 start-page: 830 year: 2011 end-page: 840 article-title: Molecular inflammation as an underlying mechanism of the aging process and age‐related diseases publication-title: J Dent Res – volume: 78 start-page: 845 year: 2008 end-page: 852 article-title: Common oral conditions in older persons publication-title: Am Fam Physician – volume: 15 start-page: 117 year: 2012 end-page: 132 article-title: Animal models to study host‐bacteria interactions involved in periodontitis publication-title: Front Oral Biol – volume: 2 start-page: 49 year: 2008 end-page: 55 article-title: Optimizing qPCR for the quantification of periodontal pathogens in a complex plaque biofilm publication-title: Open Dent J – volume: 6 start-page: e22788 year: 2011 article-title: Oral microbiome profiles: 16S rRNA pyrosequencing and microarray assay comparison publication-title: PLoS One – volume: 51 start-page: 38 year: 2009 end-page: 44 article-title: Molecular microbial diagnosis publication-title: Periodontol 2000 – volume: 62 start-page: 59 year: 2013 end-page: 94 article-title: Risk factors for periodontal disease publication-title: Periodontol 2000 – volume: 235 start-page: 106 year: 1994 end-page: 119 article-title: Animal models for periodontal disease publication-title: Methods Enzymol – volume: 53 start-page: 12 year: 2010 end-page: 27 article-title: Comparison of the clinical features of chronic and aggressive periodontitis publication-title: Periodontol 2000 – volume: 18 start-page: 249 year: 2013 end-page: 259 article-title: Effects of aging on apoptosis gene expression in oral mucosal tissues publication-title: Apoptosis – year: 2015 article-title: Effects of aging in the expression of NOD‐like receptors adn inflammasome‐related genes in the oral mucosa publication-title: Mol Oral Microbiol – volume: 13 start-page: 267 year: 1991 end-page: 272 article-title: Serum antibody levels to oral microorganisms in children and young adults with relation to the severity of gingival disease publication-title: Pediatr Dent – volume: 57 start-page: 17 year: 2013 end-page: 37 article-title: Periodontal considerations for children publication-title: Dent Clin North Am – volume: 18 start-page: 109 year: 2012 end-page: 120 article-title: The oral microbiome in health and disease and the potential impact on personalized dental medicine publication-title: Oral Dis – ident: e_1_2_7_13_1 doi: 10.1111/odi.12018 – ident: e_1_2_7_25_1 doi: 10.1093/biostatistics/4.2.249 – start-page: 418 year: 2000 ident: e_1_2_7_26_1 article-title: Mutual information relevance networks: functional genomic clustering using pairwise entropy measurements publication-title: Pac Symp Biocomput contributor: fullname: Butte AJ – ident: e_1_2_7_43_1 doi: 10.1034/j.1600-0757.2001.2260104.x – ident: e_1_2_7_11_1 doi: 10.1016/j.phrs.2012.11.006 – ident: e_1_2_7_37_1 doi: 10.1111/j.1754-4505.2009.00082.x – ident: e_1_2_7_47_1 doi: 10.1111/j.1600-0757.2012.00457.x – ident: e_1_2_7_24_1 doi: 10.2174/1874210600802010049 – ident: e_1_2_7_35_1 doi: 10.1111/j.1600-0757.2006.00169.x – volume: 13 start-page: 267 year: 1991 ident: e_1_2_7_44_1 article-title: Serum antibody levels to oral microorganisms in children and young adults with relation to the severity of gingival disease publication-title: Pediatr Dent contributor: fullname: Bimstein E – ident: e_1_2_7_2_1 doi: 10.1111/j.1601-0825.2011.01830.x – ident: e_1_2_7_33_1 doi: 10.5051/jpis.2013.43.1.3 – ident: e_1_2_7_23_1 doi: 10.1111/j.2041-1014.2009.00555.x – ident: e_1_2_7_12_1 doi: 10.1111/j.1601-0825.2011.01851.x – ident: e_1_2_7_49_1 doi: 10.1007/s10495-013-0806-x – ident: e_1_2_7_14_1 doi: 10.1159/000329669 – ident: e_1_2_7_16_1 doi: 10.1007/s10495-013-0806-x – volume: 2012 start-page: 190930 year: 2012 ident: e_1_2_7_32_1 article-title: Prenatal and postnatal epigenetic programming: implications for GI, immune, and neuronal function in autism publication-title: Autism Res Treat contributor: fullname: Waly MI – ident: e_1_2_7_40_1 doi: 10.1016/S0300-5712(96)00019-X – year: 2015 ident: e_1_2_7_18_1 article-title: Effects of aging in the expression of NOD‐like receptors adn inflammasome‐related genes in the oral mucosa publication-title: Mol Oral Microbiol contributor: fullname: Gonzalez OA – ident: e_1_2_7_34_1 doi: 10.1038/nrd3669 – ident: e_1_2_7_30_1 doi: 10.1152/ajpendo.00531.2011 – ident: e_1_2_7_15_1 doi: 10.1902/annals.2002.7.1.102 – ident: e_1_2_7_28_1 doi: 10.1609/icwsm.v3i1.13937 – ident: e_1_2_7_31_1 doi: 10.1038/modpathol.3800079 – ident: e_1_2_7_7_1 doi: 10.1016/0076-6879(94)35135-X – ident: e_1_2_7_17_1 doi: 10.1177/0022034511403744 – ident: e_1_2_7_41_1 doi: 10.1016/j.cden.2012.09.009 – ident: e_1_2_7_21_1 doi: 10.17796/jcpd.38.2.j525742137780336 – ident: e_1_2_7_45_1 doi: 10.1902/jop.2012.110676 – ident: e_1_2_7_27_1 doi: 10.1088/1742-5468/2008/10/P10008 – ident: e_1_2_7_6_1 doi: 10.1902/jop.1993.64.6.497 – ident: e_1_2_7_5_1 doi: 10.1111/j.1399-302X.1994.tb00043.x – ident: e_1_2_7_36_1 doi: 10.1111/j.2041-1014.2009.00562.x – ident: e_1_2_7_42_1 doi: 10.1111/j.1600-0757.2010.00353.x – ident: e_1_2_7_22_1 doi: 10.1128/CVI.00258-07 – ident: e_1_2_7_10_1 doi: 10.1111/j.1600-0757.2009.00316.x – ident: e_1_2_7_29_1 doi: 10.4049/jimmunol.168.2.744 – ident: e_1_2_7_8_1 doi: 10.1159/000329675 – ident: e_1_2_7_39_1 doi: 10.1177/0022034510387794 – volume: 6 start-page: 1 year: 2014 ident: e_1_2_7_48_1 article-title: Genetic dysbiosis: the role of microbial insults in chronic inflammatory diseases publication-title: J Oral Microbiol doi: 10.3402/jom.v6.22962 contributor: fullname: Nibali L – ident: e_1_2_7_50_1 doi: 10.1128/CVI.00291-13 – ident: e_1_2_7_46_1 doi: 10.1177/0022034512457373 – ident: e_1_2_7_3_1 doi: 10.1155/2011/754857 – ident: e_1_2_7_9_1 doi: 10.1371/journal.pone.0022788 – ident: e_1_2_7_19_1 doi: 10.1111/jcpe.12212 – ident: e_1_2_7_4_1 doi: 10.2174/1874210601004010037 – volume: 69 start-page: 133 year: 2002 ident: e_1_2_7_20_1 article-title: Periodontal diseases, caries, and microbial composition of the subgingival plaque in children: a longitudinal study publication-title: ASDC J Dent Child contributor: fullname: Bimstein E – volume: 78 start-page: 845 year: 2008 ident: e_1_2_7_38_1 article-title: Common oral conditions in older persons publication-title: Am Fam Physician contributor: fullname: Gonsalves WC |
| SSID | ssj0002679 |
| Score | 2.243203 |
| Snippet | Background and Objective
Young/adolescent humans harbor many microorganisms associated with periodontal disease in adults and show substantial gingival... Young/adolescent humans harbor many microorganisms associated with periodontal disease in adults and show substantial gingival inflammatory responses. However,... BACKGROUND AND OBJECTIVEYoung/adolescent humans harbor many microorganisms associated with periodontal disease in adults and show substantial gingival... Young/adolescent humans demonstrate many microorganisms associated with periodontal disease in adults and substantial gingival inflammatory responses. However,... |
| SourceID | pubmedcentral proquest crossref pubmed wiley istex |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 152 |
| SubjectTerms | aging Animals Gingiva Immune System inflammation Macaca mulatta nonhuman primates Oligonucleotide Array Sequence Analysis Periodontitis Transcriptome |
| Title | Immune system transcriptome in gingival tissues of young nonhuman primates |
| URI | https://api.istex.fr/ark:/67375/WNG-T5WHB9C1-5/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fjre.12293 https://www.ncbi.nlm.nih.gov/pubmed/26077888 https://search.proquest.com/docview/1770866893 https://pubmed.ncbi.nlm.nih.gov/PMC4681702 |
| Volume | 51 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB5BOZRLCxRKykMGoYpLUBK_EnGCdsvSQ4VoUblZTjIWK0S22odU_j0zzm7UFSAhcYsUx5E9nplv7PE3AK9sjpJ57lJZK5kqI0PqjcpSXbWhlk0W2riVPT63Z1_L4xHT5Lxd34Xp-SGGDTfWjGivWcF9Pb-p5DN8kxfkrcj-UpQQr2_IT4MVLoytBqZwVaoVq1DM4ll_ueGL7vC0Xv8JaP6eL3kTx0ZHdLL7X0O4Bzsr_Cne9QvmPtzC7gFsH3POEJd924PTj3xjBEVP8SwW7MuiZZn-QDHpBBc1mtDyFIsosrmYBvGTTYbopl2s-CeumMGCIOxD-HIyujgap6uCC2lD8ahMQ0smp5Ztbn0VVNmoovClVhjyBhuNhAVKNISnFFIgqYPKGhN00HndYu3bSstHsEX_wscgsrLCqvSZCZJ6CpZ5AKVCnyE5w-B9Ai_XU--uel4NN8QjM3RxWhI4jEIZWvjZd05Es9pdnn1wF_py_L46yp1O4MVaao7Ug888fIfT5dzl1lLQZkrubL-X4tAbhXKWdwASsBvyHRow9fbmm27yLVJwK8MDKhJ4HeX79yG408-j-HDw702fwF2CZabPD3oKW4vZEp_B7Xm7fB7X-C9x__7X |
| link.rule.ids | 230,315,782,786,887,1408,27933,27934,46064,46488 |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Zb9QwEB7R9qG80HK16QEGIcRLUBJfidSXHlu2pawQLCpvlpOMxQqRrfaQyr_H4-xGXQESEm-R4jiy5x6PvwF4pVPkhHMX81LwWCjuYqtEEsuidiWvEleHVHb_sx58zc96BJNztLwL0-JDdAk3koygr0nAKSF9V8on-DbNvLlagw2hPCPSBQ7-sdPDmdJFhxUucrHAFQp1PMtPV6zRBm3s7Z9czd8rJu96ssEUnW_93yK24cHCBWXHLc88hHvYPILNMyobos5vj-Hygi6NIGtRntmMzFlQLuMfyEYNo75GI8-hbBaoNmVjx36S1mDNuAlN_9gNgVh4L_YJfDnvDU_78aLnQlz5kJTHrvZap-R1qm3hRF6JLLO5FOjSCiuJ3h3IUXmXSqCPJaUTSaWcdDItayxtXUj-FNb9v3AXWJIXWOQ2UY77mZwmKEAu0Cbo7aGzNoKXy703Ny20hulCkgmasC0RvA5U6UbYyXeqRdPSXA_emaG87p8Up6mREbxYks14CaFjD9vgeD41qdY-blM5TbbTkrGbzUdzmpIAEegVAncDCH179U0z-hZQuIWiBWURvAkE_vsSzOWnXnjY-_ehz2GzP_xwZa4uBu_34b730lRbLnQA67PJHA9hbVrPnwWG_wV71AMO |
| linkToPdf | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3da9RAEB9sC-qL2mo1fm5FxJeUJPuV4JPt3Xlt5Shaad-WTTKLh5g77gP0v3dncxd6VEHwLZDNht3ZmfnN7uxvAN7oFDnx3MW8FDwWirvYKpHEsqhdyavE1WEre_hFj67yXp9oct6v78K0_BDdhhtpRrDXpODT2l1X8hkeppn3VluwIzwMJ-J8zs87M5wpXXRU4SIXK1qhkMaz_nTDGe3QvP78E9K8mTB5HcgGTzS4_19jeAD3VgCUfWhXzC7cwmYP7vQoaYjqvj2E0xO6MoKs5XhmC3JmwbRMfiAbN4yqGo39-mSLILM5mzj2i2wGayZNKPnHpkRh4THsI_g66F8cD-NVxYW48gEpj13tbU7J61Tbwom8EllmcynQpRVWEj0YyFF5QCXQR5LSiaRSTjqZljWWti4k34dt_y98AizJCyxymyjHfU9OExEgF2gT9N7QWRvB6_XUm2lLrGG6gGSGJkxLBG-DULoWdvadMtG0NJejj-ZCXg6PiuPUyAgO1lIzXj_o0MM2OFnOTaq1j9pUTp09bqXY9eZjOU1bABHoDfl2DYh7e_NNM_4WOLiFogFlEbwL8v37EMzp5354ePrvTV_B7fPewHw6GZ09g7seoqk2V-g5bC9mS3wBW_N6-TIs999cEwG0 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Immune+system+transcriptome+in+gingival+tissues+of+young+nonhuman+primates&rft.jtitle=Journal+of+periodontal+research&rft.au=Gonzalez%2C+O.+A.&rft.au=Nagarajan%2C+R.&rft.au=Novak%2C+M.+J.&rft.au=Orraca%2C+L.&rft.date=2016-04-01&rft.issn=0022-3484&rft.eissn=1600-0765&rft.volume=51&rft.issue=2&rft.spage=152&rft.epage=163&rft_id=info:doi/10.1111%2Fjre.12293&rft.externalDBID=10.1111%252Fjre.12293&rft.externalDocID=JRE12293 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-3484&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-3484&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-3484&client=summon |