A Comprehensive Review of Ovarian Serous Carcinoma

• Published in: Advances in anatomic pathology Vol. 26; no. 5; pp. 329 - 339
• Main Authors: Hatano, Yuichiro, Hatano, Kayoko, Tamada, Maho, Morishige, Ken-ichirou, Tomita, Hiroyuki, Yanai, Hiroyuki, Hara, Akira
• Format: Journal Article
• Language: English
• Published: United States Copyright Wolters Kluwer Health, Inc. All rights reserved 01-09-2019; Lippincott Williams & Wilkins
• Subjects: Carcinoma, Ovarian Epithelial - genetics; Cystadenocarcinoma, Serous - genetics; Female; Humans; Neoplasm Grading; Neoplasms, Glandular and Epithelial - genetics; Ovarian Neoplasms - genetics; Ovarian Neoplasms - pathology; Review; Tumor Suppressor Protein p53 - genetics
• ISSN: 1072-4109; 1533-4031
• DOI: 10.1097/PAP.0000000000000243

Although ovarian serous carcinoma is a well-studied human gynecologic malignancy, this high-grade tumor remains fatal. The main purpose of this review is to summarize the accumulated evidence on serous malignant tumors and to clarify the unresolved issues. We discuss the 8 dichotomies of serous carcinomahigh grade versus low grade, ovarian versus extraovarian primary, extrauterine versus uterine primary, sporadic versus hereditary, orthodox versus alternative histology, p53 overexpression versus complete absence of immunophenotype, TP53-mutated versus intact precursor, and therapy responsive versus refractory. In addition, we summarize the molecular classification of high-grade serous carcinoma. This review would lead readers to rapid and parallel developments in understanding high-grade serous carcinoma.