Mechanisms of burst release from pH-responsive polymeric microparticles

Objectives Microencapsulation of drugs into preformed polymers is commonly achieved through solvent evaporation techniques or spray drying. We compared these encapsulation methods in terms of controlled drug release properties of prepared microparticles and investigated the underlying mechanisms re...

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Bibliographic Details
Published in:	Journal of pharmacy and pharmacology Vol. 63; no. 9; pp. 1141 - 1155
Main Authors:	Rizi, Khalida, Green, Rebecca J., Khutoryanskaya, Olga, Donaldson, Michael, Williams, Adrian C.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-09-2011
Subjects:	burst release Crystallization Delayed-Action Preparations - chemistry Desiccation - methods Drug Administration Schedule Drug Carriers - chemistry Drug Compounding - methods Emulsions Eudragit L100 hydrocortisone Hydrocortisone - administration & dosage Hydrogen-Ion Concentration Hydrophobic and Hydrophilic Interactions microencapsulation Microspheres Oils Polymers - chemistry Polymethacrylic Acids - chemistry Porosity Solutions Solvents - chemistry spray drying
Online Access:	Get full text
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