Dermatoscopic and clinical features of congenital or congenital-type nail matrix nevi: A multicenter prospective cohort study by the International Dermoscopy Society

• Published in: Journal of the American Academy of Dermatology Vol. 87; no. 3; pp. 551 - 558
• Main Authors: Pham, Félix, Boespflug, Amélie, Duru, Gérard, Phan, Alice, Poulalhon, Nicolas, Weiler, Laura, Tanaka, Masaru, Lallas, Aimilios, Ogata, Dai, Davaine, Anne Céline, Bahadoran, Philippe, Balguerie, Xavier, Kamińska-Winciorek, Grażyna, Tromme, Isabelle, Correia, Osvaldo, Kim, Moon-Bum, Marghoob, Ashfaq A., Linda Martin, Guitera, Pascale, Meziane, Mariame, Miquel, Juliette, Mun, Je-Ho, Argenziano, Giuseppe, Bessis, Didier, Bourke, Johnny, Mijuskovic, Zeljko, Chiaverini, Christine, Corven-Benoit, Cloé, Droitcourt, Catherine, Skowron, François, Marque, Myriam, Zalaudek, Iris, Rosendahl, Cliff, Moreno-Ramirez, David, Vabres, Pierre, Haenssle, Holger, Malvehy, Josep, Puig, Susana, Robert, Caroline, Schopf, Thomas R., Scope, Alon, Dalle, Stéphane, Thomas, Luc
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-09-2022
• Subjects: Adult; Child; Child, Preschool; children; congenital; congenital nail matrix nevus; dermatoscopy; Dermoscopy; Diagnosis, Differential; Humans; Infant, Newborn; longitudinal melanonychia; Melanoma - diagnostic imaging; Melanoma - pathology; melanonychia striata; Nail Diseases - diagnostic imaging; Nail Diseases - pathology; Nevus - diagnosis; nevus of the nail unit; pediatric; Prospective Studies; Skin Neoplasms - diagnostic imaging; Skin Neoplasms - pathology; subungual melanoma; dermatoscopy; longitudinal melanonychia; LM; SUM; congenital; subungual melanoma; NMN; pediatric; SD; children; melanonychia striata; nevus of the nail unit; IDS; congenital nail matrix nevus
• ISSN: 0190-9622; 1097-6787
• DOI: 10.1016/j.jaad.2022.01.028

Congenital nail matrix nevi (NMN) are difficult to diagnose because they feature clinical characteristics suggestive of adult subungual melanoma. Nail matrix biopsy is difficult to perform, especially in children.
To describe the initial clinical and dermatoscopic features of NMN appearing at birth (congenital) or after birth but before the age of 5 years (congenital-type).
We conducted a prospective, international, and consecutive data collection in 102 hospitals or private medical offices across 30 countries from 2009 to 2019.
There were 69 congenital and 161 congenital-type NMNs. Congenital and congenital-type NMN predominantly displayed an irregular pattern of longitudinal microlines (n = 146, 64%), reminiscent of subungual melanoma in adults. The distal fibrillar (“brush-like”) pattern, present in 63 patients (27.8%), was more frequently encountered in congenital NMN than in congenital-type NMN (P = .012). Moreover, congenital NMN more frequently displayed a periungual pigmentation (P = .029) and Hutchinson’s sign (P = .027) than did congenital-type NMN.
Lack of systematic biopsy-proven diagnosis and heterogeneity of clinical and dermatoscopic photographs.
Congenital and congenital-type NMN showed worrisome clinical and dermatoscopic features similar to those observed in adulthood subungual melanoma. The distal fibrillar (“brush-like”) pattern is a suggestive feature of congenital and congenital-type NMN.