Changes of the Expression of Neuronal NO-Synthase in Rat Sympathetic Ganglia during Ontogeny

• Published in: Bulletin of experimental biology and medicine Vol. 168; no. 1; pp. 76 - 78
• Main Authors: Moiseev, K. Yu, Yukhmankova, A. V., Masliukov, P. M.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-11-2019; Springer; Springer Nature B.V
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Blotting, Western; Cell Biology; Female; Fibers; Ganglia - metabolism; Ganglia, Sympathetic - metabolism; Immunohistochemistry; Internal Medicine; Laboratory Medicine; Neurons; Nitric Oxide Synthase - metabolism; Nitric-oxide synthase; Ontogeny; Pathology; Rats; Rats, Wistar; Skull; Spinal cord; Stellate ganglion; Sympathetic ganglia; Sympathetic Nervous System - cytology; Western blotting; NO synthase; immunohistochemistry; ontogeny; Western blotting; sympathetic ganglia
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-019-04651-5

Expression of neuronal NO synthase in the sympathetic cranial cervical ganglion and stellate ganglion in rats during postnatal ontogeny was studied by immunohistochemistry and Western blotting. In the sympathetic ganglia, neuronal NO synthase-immunoreactive neurons were absent in all rats. In the stellate and cranial cervical ganglia, the expression of neuronal NO synthase and the density of immunoreactive fibers increased in early postnatal ontogeny from the moment of birth to the age of 30 days and then decreased. Thus, we observed heterochroneous expression of neuronal NOS in the preganglionic somata in the spinal cord and in the preganglionic fibers in the sympathetic ganglia during ontogeny.