Regulation of CXCR2 expression and function by a disintegrin and metalloprotease‐17 (ADAM17)

ADAM17 regulates CXCR2 surface levels in circulating neutrophils and their infiltration into sites of inflammation. The chemokine receptor CXCR2 is expressed at high levels on circulating neutrophils and is critical for directing their migration to sites of inflammation. CXCR2 surface levels are rap...

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Bibliographic Details
Published in:	Journal of leukocyte biology Vol. 97; no. 3; pp. 447 - 454
Main Authors:	Mishra, Hemant K., Long, Chunmei, Bahaie, Nooshin S., Walcheck, Bruce
Format:	Journal Article
Language:	English
Published:	United States Society for Leukocyte Biology 01-03-2015
Subjects:	ADAM Proteins - antagonists & inhibitors ADAM Proteins - deficiency ADAM Proteins - metabolism ADAM17 Protein Animals Cell Membrane - metabolism chemokines Down-Regulation Humans inflammation Ligands Mice, Inbred C57BL Mice, Knockout neutrophil Neutrophil Infiltration Neutrophils - cytology Neutrophils - metabolism Receptors, Interleukin-8B - metabolism Spotlight on Leading Edge Research chemokines inflammation neutrophil
Online Access:	Get full text
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