Con-Struct Map: a comparative contact map analysis tool

• Published in: Bioinformatics Vol. 23; no. 18; pp. 2491 - 2492
• Main Authors: Chung, Jo-Lan, Beaver, John E., Scheeff, Eric D., Bourne, Philip E.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 15-09-2007; Oxford Publishing Limited (England)
• Subjects: Algorithms; Amino Acid Sequence; Binding Sites; Biological and medical sciences; Computer Graphics; Computer Simulation; Fundamental and applied biological sciences. Psychology; General aspects; Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects); Models, Chemical; Models, Molecular; Molecular Sequence Data; Protein Binding; Protein Interaction Mapping - methods; Proteins - chemistry; Proteins - ultrastructure; Sequence Alignment - methods; Sequence Analysis, Protein - methods; Software; User-Computer Interface; Conserved sequence; JAVA language; Computer program; Substitution; Aminoacid; Graphical system; Structure; Bioinformatics; Scope note; Protein; Contact
• ISSN: 1367-4803; 1460-2059; 1367-4811
• DOI: 10.1093/bioinformatics/btm356

Con-Struct Map is a graphical tool for the comparative study of protein structures. The tool detects potential conserved residue contacts shared by multiple protein structures by superimposing their contact maps according to a multiple structure alignment. In general, Con-Struct Map allows the study of structural changes resulting from, e.g. sequence substitutions, or alternatively, the study of conserved components of a structure framework across structurally aligned proteins. Specific applications include the study of sequence-structure relationship in distantly related proteins and the comparisons of wild type and mutant proteins. Availability: http://pdbrs3.sdsc.edu/ConStructMap/viewer_argument_generator/singleArguments Contact: [e-mail] Supplementary information: Supplementary data are available at Bioinformatics online.