Single molecule force spectroscopy for in-situ probing oridonin inhibited ROS-mediated EGF-EGFR interactions in living KYSE-150 cells

[Display omitted] As the active anticancer component of Rabdosia Rubescens, oridonin has been proved to show strong anticancer activity in cancer cells, which is also found to be closely related to its specific inhibition effects on the EGFR tyrosine kinase activity. In this study, atomic force micr...

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Bibliographic Details
Published in:	Pharmacological research Vol. 119; pp. 479 - 489
Main Authors:	Pi, Jiang, Jin, Hua, Jiang, Jinhuan, Yang, Fen, Cai, Huaihong, Yang, Peihui, Cai, Jiye, Chen, Zheng W.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01-05-2017
Subjects:	Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Apoptosis - drug effects Atomic force microscopy Cell Line, Tumor Diterpenes, Kaurane - chemistry Diterpenes, Kaurane - pharmacology EGFR Epidermal Growth Factor - metabolism ErbB Receptors - metabolism Esophageal cancer Esophageal Neoplasms - drug therapy Esophageal Neoplasms - metabolism Esophagus - drug effects Esophagus - metabolism Humans Isodon - chemistry Microscopy, Atomic Force Oridonin Reactive Oxygen Species - metabolism Single molecule force spectroscopy Single molecule force spectroscopy Atomic force microscopy Esophageal cancer EGFR Oridonin
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