Innate and adaptive immune responses to an intracellular bacterium, Francisella tularensis live vaccine strain

• Published in: Microbes and Infection Vol. 5; no. 2; pp. 135 - 142
• Main Authors: Elkins, Karen L., Cowley, Siobhán C., Bosio, Catharine M.
• Format: Book Review Journal Article
• Language: English
• Published: Lausanne Elsevier SAS 01-02-2003; Amsterdam Elsevier; Paris
• Subjects: Animals; Antibodies, Bacterial - blood; B-lymphocytes; Bacterial vaccines; Bacterial Vaccines - administration & dosage; Bacterial Vaccines - immunology; Bacteriology; Biological and medical sciences; Disease Models, Animal; Francisella tularensis; Francisella tularensis - immunology; Fundamental and applied biological sciences. Psychology; Immunity, Cellular; Immunity, Innate; Immunity, natural; Interferon type II; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Knockout; Microbiology; T-lymphocytes; Tularemia - immunology; Tularemia - prevention & control; Vaccination; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies; Vaccines, Attenuated - administration & dosage; Vaccines, Attenuated - immunology; T-lymphocytes; B-lymphocytes; Immunity, natural; Bacterial vaccines; Mice; Interferon type II; Francisella tularensis; Natural immunity; Review; T-Lymphocyte; Bacteria; Immunoprotection; Immune response; Acquired immunity; Vaccine strain; Cytokine; Rodentia; Tularemia; B-Lymphocyte; Infection; Vertebrata; Mammalia; Mouse; Bacteriosis; Interferon; Attenuated strain
• ISSN: 1286-4579; 1769-714X
• DOI: 10.1016/S1286-4579(02)00084-9

The immune response to intracellular bacterium,
Francisella tularensis, which causes tularemia and is proposed to be a potential bioterrorism pathogen, has been studied in mice using the attenuated live vaccine strain (LVS). Here we review this infection model, which provides a convenient means of studying protective immune mechanisms not only for
Francisella, but also for the large and important class of intracellular pathogens.