Endoplasmic reticulum expansion throughout the differentiation of teleost B cells to plasmablasts
The differentiation of B cells into antibody-secreting cells is fundamental for the generation of humoral immunity. In mammals, this process involves a series of metabolic and intracellular changes, not studied to date in teleost fish, where a clear distinction between naive B cells and plasmablasts...
Saved in:
| Published in: | iScience Vol. 26; no. 1; p. 105854 |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Elsevier Inc
20-01-2023
Elsevier |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | The differentiation of B cells into antibody-secreting cells is fundamental for the generation of humoral immunity. In mammals, this process involves a series of metabolic and intracellular changes, not studied to date in teleost fish, where a clear distinction between naive B cells and plasmablasts/plasma cells (PCs) is still missing. Thus, in the current study, we have established that upon activation, teleost B cells undergo an expansion of the endoplasmic reticulum (ER) but experience no significant changes in mitochondria content. In parallel, the transcription of genes implicated in B cell differentiation increases, while that of mitochondrial genes decreases. In this context, ER monitoring has allowed us to distinguish between small cells with low amounts of ER (FSCloERlo B cells), that correspond to undifferentiated cells, and large cells with expanded ER (FSChiERhi B cells), characterized as plasmablasts. The results shed new light on the B cell differentiation process in teleosts and provide us with novel tools to study B cell function in these species.
[Display omitted]
•Fish B cells expand the ER in response to different stimuli in different tissues•Mitochondria content did not vary significantly in activated fish B cells•Transcription of mitochondrial genes decreases during fish B cell differentiation•ER monitorization allows us to differentiate fish naive B cells from plasmablasts
Biological sciences; Molecular biology; Immunology |
|---|---|
| AbstractList | The differentiation of B cells into antibody-secreting cells is fundamental for the generation of humoral immunity. In mammals, this process involves a series of metabolic and intracellular changes, not studied to date in teleost fish, where a clear distinction between naive B cells and plasmablasts/plasma cells (PCs) is still missing. Thus, in the current study, we have established that upon activation, teleost B cells undergo an expansion of the endoplasmic reticulum (ER) but experience no significant changes in mitochondria content. In parallel, the transcription of genes implicated in B cell differentiation increases, while that of mitochondrial genes decreases. In this context, ER monitoring has allowed us to distinguish between small cells with low amounts of ER (FSC
lo
ER
lo
B cells), that correspond to undifferentiated cells, and large cells with expanded ER (FSC
hi
ER
hi
B cells), characterized as plasmablasts. The results shed new light on the B cell differentiation process in teleosts and provide us with novel tools to study B cell function in these species.
•
Fish B cells expand the ER in response to different stimuli in different tissues
•
Mitochondria content did not vary significantly in activated fish B cells
•
Transcription of mitochondrial genes decreases during fish B cell differentiation
•
ER monitorization allows us to differentiate fish naive B cells from plasmablasts
Biological sciences; Molecular biology; Immunology The differentiation of B cells into antibody-secreting cells is fundamental for the generation of humoral immunity. In mammals, this process involves a series of metabolic and intracellular changes, not studied to date in teleost fish, where a clear distinction between naive B cells and plasmablasts/plasma cells (PCs) is still missing. Thus, in the current study, we have established that upon activation, teleost B cells undergo an expansion of the endoplasmic reticulum (ER) but experience no significant changes in mitochondria content. In parallel, the transcription of genes implicated in B cell differentiation increases, while that of mitochondrial genes decreases. In this context, ER monitoring has allowed us to distinguish between small cells with low amounts of ER (FSCloERlo B cells), that correspond to undifferentiated cells, and large cells with expanded ER (FSChiERhi B cells), characterized as plasmablasts. The results shed new light on the B cell differentiation process in teleosts and provide us with novel tools to study B cell function in these species. [Display omitted] •Fish B cells expand the ER in response to different stimuli in different tissues•Mitochondria content did not vary significantly in activated fish B cells•Transcription of mitochondrial genes decreases during fish B cell differentiation•ER monitorization allows us to differentiate fish naive B cells from plasmablasts Biological sciences; Molecular biology; Immunology The differentiation of B cells into antibody-secreting cells is fundamental for the generation of humoral immunity. In mammals, this process involves a series of metabolic and intracellular changes, not studied to date in teleost fish, where a clear distinction between naive B cells and plasmablasts/plasma cells (PCs) is still missing. Thus, in the current study, we have established that upon activation, teleost B cells undergo an expansion of the endoplasmic reticulum (ER) but experience no significant changes in mitochondria content. In parallel, the transcription of genes implicated in B cell differentiation increases, while that of mitochondrial genes decreases. In this context, ER monitoring has allowed us to distinguish between small cells with low amounts of ER (FSC ER B cells), that correspond to undifferentiated cells, and large cells with expanded ER (FSC ER B cells), characterized as plasmablasts. The results shed new light on the B cell differentiation process in teleosts and provide us with novel tools to study B cell function in these species. The differentiation of B cells into antibody-secreting cells is fundamental for the generation of humoral immunity. In mammals, this process involves a series of metabolic and intracellular changes, not studied to date in teleost fish, where a clear distinction between naive B cells and plasmablasts/plasma cells (PCs) is still missing. Thus, in the current study, we have established that upon activation, teleost B cells undergo an expansion of the endoplasmic reticulum (ER) but experience no significant changes in mitochondria content. In parallel, the transcription of genes implicated in B cell differentiation increases, while that of mitochondrial genes decreases. In this context, ER monitoring has allowed us to distinguish between small cells with low amounts of ER (FSCloERlo B cells), that correspond to undifferentiated cells, and large cells with expanded ER (FSChiERhi B cells), characterized as plasmablasts. The results shed new light on the B cell differentiation process in teleosts and provide us with novel tools to study B cell function in these species. |
| ArticleNumber | 105854 |
| Author | Simón, Rocío Perdiguero, Pedro Muñoz-Atienza, Estefanía Andrés, Germán Martín-Martín, Alba Guerra Rodriguez, Milagros Abós, Beatriz Herranz-Jusdado, J. Germán Morel, Esther Díaz-Rosales, Patricia Tafalla, Carolina |
| Author_xml | – sequence: 1 givenname: Esther surname: Morel fullname: Morel, Esther organization: Animal Health Research Center (CISA-INIA), Valdeolmos, Madrid 28130, Spain – sequence: 2 givenname: J. Germán surname: Herranz-Jusdado fullname: Herranz-Jusdado, J. Germán organization: Animal Health Research Center (CISA-INIA), Valdeolmos, Madrid 28130, Spain – sequence: 3 givenname: Rocío surname: Simón fullname: Simón, Rocío organization: Animal Health Research Center (CISA-INIA), Valdeolmos, Madrid 28130, Spain – sequence: 4 givenname: Beatriz surname: Abós fullname: Abós, Beatriz organization: Animal Health Research Center (CISA-INIA), Valdeolmos, Madrid 28130, Spain – sequence: 5 givenname: Pedro surname: Perdiguero fullname: Perdiguero, Pedro organization: Animal Health Research Center (CISA-INIA), Valdeolmos, Madrid 28130, Spain – sequence: 6 givenname: Alba surname: Martín-Martín fullname: Martín-Martín, Alba organization: Animal Health Research Center (CISA-INIA), Valdeolmos, Madrid 28130, Spain – sequence: 7 givenname: Germán surname: Andrés fullname: Andrés, Germán organization: Animal Health Research Center (CISA-INIA), Valdeolmos, Madrid 28130, Spain – sequence: 8 givenname: Estefanía surname: Muñoz-Atienza fullname: Muñoz-Atienza, Estefanía organization: Veterinary Faculty, Complutense University of Madrid (UCM), Madrid 28040, Spain – sequence: 9 givenname: Milagros surname: Guerra Rodriguez fullname: Guerra Rodriguez, Milagros organization: Centre for Molecular Biology Severo Ochoa (CBMSO), Madrid 28049, Spain – sequence: 10 givenname: Patricia surname: Díaz-Rosales fullname: Díaz-Rosales, Patricia organization: Animal Health Research Center (CISA-INIA), Valdeolmos, Madrid 28130, Spain – sequence: 11 givenname: Carolina surname: Tafalla fullname: Tafalla, Carolina email: tafalla@inia.csic.es organization: Animal Health Research Center (CISA-INIA), Valdeolmos, Madrid 28130, Spain |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36619985$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kV1rFDEUhoNUbK39A17IXHqza74nARG0VC0UvNHrkE1OdrPMTNYkU-q_N9uppb0RQnI4OedJzvu-RidTmgChtwSvCSbyw34di4triiltCaEEf4HOqFB6hTGnJ0_iU3RRyh5jTNviWr5Cp0xKorUSZ8heTT4dBlvG6LoMNbp5mMcO7g52KjFNXd3lNG93aa4thM7HECDDVKOtx-sUugoDpFK7L52DYShdTd090G7aXssb9DLYocDFw3mOfn29-nn5fXXz49v15eeblROU1JXinHIvesWsgABBUeGUFIzhXgdpnRA8eA1ccWGxdJQFvdGUEfCYC0k5O0fXC9cnuzeHHEeb_5hko7lPpLw1Nrf5BjA9Icop75Vgmmtqlce2yWW9d5ueY9FYnxbWYd6M4F2bN9vhGfT5zRR3ZptujVaE9oQ1wPsHQE6_ZyjVjM2uJo-dIM3F0F5SRXHP-1ZKl1KXUykZwuMzBJuj1WZvjlabo9Vmsbo1vXv6wceWf8a2go9LATTJbyNk0xAwOfAxg6tNk_g__l87sr1g |
| CitedBy_id | crossref_primary_10_1016_j_fsi_2024_109740 crossref_primary_10_1016_j_fsi_2024_109358 crossref_primary_10_1016_j_fsi_2023_109273 crossref_primary_10_3389_fimmu_2024_1404209 crossref_primary_10_48045_001c_116253 crossref_primary_10_3389_fimmu_2024_1407237 |
| Cites_doi | 10.3390/biology10060511 10.1038/ncomms7750 10.1038/ni.2549 10.1002/eji.201646547 10.1002/eji.1830130706 10.1038/ni1201-1103 10.1016/j.celrep.2019.11.101 10.1083/jcb.110.5.1501 10.4049/jimmunol.1701546 10.1016/j.dci.2011.01.009 10.1016/j.celrep.2022.110912 10.1371/journal.pone.0174249 10.1016/j.dci.2020.103752 10.4049/jimmunol.1302471 10.1128/MCB.22.13.4771-4780.2002 10.3389/fimmu.2021.773888 10.3389/fimmu.2020.596975 10.4049/jimmunol.171.4.1684 10.1046/j.1432-1327.2001.01996.x 10.4049/jimmunol.174.11.6608 10.3389/fimmu.2019.02902 10.3389/fimmu.2018.01683 10.1038/ni1389 10.1038/ni.1954 10.1038/ni.1913 10.1016/j.dci.2010.08.003 10.1046/j.1432-1327.1999.00121.x 10.1016/j.mito.2017.11.005 10.4049/jimmunol.1000631 10.3389/fimmu.2016.00324 10.4049/jimmunol.1500322 10.1016/j.fsi.2017.10.003 10.1189/jlb.1208774 10.1002/eji.201242570 10.1016/j.dci.2008.06.008 10.1182/blood-2002-10-3161 10.1038/srep30004 10.1016/j.isci.2018.07.005 10.1073/pnas.0903036106 10.1111/sji.12336 10.1016/0145-305X(90)90034-C |
| ContentType | Journal Article |
| Copyright | 2022 The Authors 2022 The Authors. 2022 The Authors 2022 |
| Copyright_xml | – notice: 2022 The Authors – notice: 2022 The Authors. – notice: 2022 The Authors 2022 |
| DBID | 6I. AAFTH NPM AAYXX CITATION 7X8 5PM DOA |
| DOI | 10.1016/j.isci.2022.105854 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) Directory of Open Access Journals |
| DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
| DatabaseTitleList | PubMed |
| Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals url: http://www.doaj.org/ sourceTypes: Open Website |
| DeliveryMethod | fulltext_linktorsrc |
| EISSN | 2589-0042 |
| EndPage | 105854 |
| ExternalDocumentID | oai_doaj_org_article_7118c8dd8539492a8d0a258addcb7405 10_1016_j_isci_2022_105854 36619985 S2589004222021277 |
| Genre | Journal Article |
| GroupedDBID | 0R~ 0SF 53G 6I. AACTN AAEDW AAFTH AALRI AAXUO ABMAC ADBBV ADVLN AEXQZ AFTJW AITUG ALMA_UNASSIGNED_HOLDINGS AMRAJ AOIJS BCNDV EBS FDB GROUPED_DOAJ HYE M41 NCXOZ OK1 ROL RPM SSZ AAMRU NPM AAYXX CITATION EJD 7X8 5PM |
| ID | FETCH-LOGICAL-c521t-84424d5783a5efef825c86533079f6ac554fd9e4845a06c23f9b9231ed0456243 |
| IEDL.DBID | RPM |
| ISSN | 2589-0042 |
| IngestDate | Tue Oct 22 15:14:45 EDT 2024 Tue Sep 17 21:30:12 EDT 2024 Fri Oct 25 02:50:25 EDT 2024 Thu Nov 21 23:26:22 EST 2024 Sat Sep 28 08:19:46 EDT 2024 Tue Jul 16 14:14:56 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Molecular biology Biological sciences Immunology |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. 2022 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c521t-84424d5783a5efef825c86533079f6ac554fd9e4845a06c23f9b9231ed0456243 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Lead contact |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812713/ |
| PMID | 36619985 |
| PQID | 2762820747 |
| PQPubID | 23479 |
| PageCount | 1 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_7118c8dd8539492a8d0a258addcb7405 pubmedcentral_primary_oai_pubmedcentral_nih_gov_9812713 proquest_miscellaneous_2762820747 crossref_primary_10_1016_j_isci_2022_105854 pubmed_primary_36619985 elsevier_sciencedirect_doi_10_1016_j_isci_2022_105854 |
| PublicationCentury | 2000 |
| PublicationDate | 2023-01-20 |
| PublicationDateYYYYMMDD | 2023-01-20 |
| PublicationDate_xml | – month: 01 year: 2023 text: 2023-01-20 day: 20 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | iScience |
| PublicationTitleAlternate | iScience |
| PublicationYear | 2023 |
| Publisher | Elsevier Inc Elsevier |
| Publisher_xml | – name: Elsevier Inc – name: Elsevier |
| References | Cassese, Arce, Hauser, Lehnert, Moewes, Mostarac, Muehlinghaus, Szyska, Radbruch, Manz (bib4) 2003; 171 Kirk, Cliff, Thomas, Ward (bib9) 2010; 87 Thuvander, Fossum, Lorenzen (bib35) 1990; 14 Li, Barreda, Zhang, Boshra, Gelman, Lapatra, Tort, Sunyer (bib12) 2006; 7 DeLuca, Wilson, Warr (bib33) 1983; 13 Abos, Wang, Secombes, Tafalla (bib23) 2020; 111 Zhang, Salinas, Li, Parra, Bjork, Xu, LaPatra, Bartholomew, Sunyer (bib22) 2010; 11 Perdiguero, Martín-Martín, Benedicenti, Díaz-Rosales, Morel, Muñoz-Atienza, García-Flores, Simón, Soleto, Cerutti, Tafalla (bib17) 2019; 29 Urbanczyk, Baris, Hofmann, Taudte, Guegen, Golombek, Castiglione, Meng, Bozec, Thomas (bib27) 2022; 39 Waters, Ahsan, Wolf, Shirihai, Teitell (bib24) 2018; 5 Castro, Bromage, Abós, Pignatelli, González Granja, Luque, Tafalla (bib36) 2014; 192 Zwollo, Cole, Bromage, Kaattari (bib41) 2005; 174 Granja, Leal, Pignatelli, Castro, Abós, Kato, Fischer, Tafalla (bib34) 2015; 195 Tarte, Zhan, De Vos, Klein, Shaughnessy (bib6) 2003; 102 Baumgarth (bib11) 2016; 7 Abós, Bird, Granja, Morel, More Bayona, Barreda, Tafalla (bib13) 2018; 201 Calame (bib1) 2001; 2 Zwollo, Haines, Rosato, Gumulak-Smith (bib28) 2008; 32 Zwollo (bib15) 2011; 35 Zwollo, Mott, Barr (bib29) 2010; 34 Perdiguero, Goméz-Esparza, Martín, Bird, Soleto, Morel, Díaz-Rosales, Tafalla (bib37) 2020; 11 Jang, Mano, Aoki, Hayashi, Muto, Nambu, Takahashi, Itoh, Taketani, Nutt (bib8) 2015; 6 Sunyer (bib10) 2013; 14 van Anken, Pena, Hafkemeijer, Christis, Romijn, Grauschopf, Oorschot, Pertel, Engels, Ora (bib25) 2009; 106 Abós, Wang, Castro, Granja, Leal, Havixbeck, Luque, Barreda, Secombes, Tafalla (bib21) 2016; 6 Martín, Perdiguero, Morel, Soleto, Herranz-Jusdado, Ramón, Abós, Wang, Díaz-Rosales, Tafalla (bib20) 2021; 12 Ma, Ye, Kaattari (bib30) 2013; 43 Granja, Perdiguero, Martín-Martín, Díaz-Rosales, Soleto, Tafalla (bib31) 2019; 10 Granja, Tafalla (bib18) 2019; 85 Laing, Wang, Zou, Holland, Hong, Bols, Hirono, Aoki, Secombes (bib40) 2001; 268 Edholm, Bengtén, Stafford, Sahoo, Taylor, Miller, Wilson (bib16) 2010; 185 Nera, Kyläniemi, Lassila (bib2) 2015; 82 Gutzeit, Chen, Cerutti (bib19) 2018; 48 Pelletier, McHeyzer-Williams, Wong, Urich, Fazilleau, McHeyzer-Williams (bib3) 2010; 11 Granja, Holland, Pignatelli, Secombes, Tafalla (bib38) 2017; 12 Zou, Cunningham, Secombes (bib39) 1999; 259 Wang, Hu, Wangkahart, Liu, Wang, Zahran, Maisey, Liu, Xu, Imarai, Secombes (bib32) 2018; 9 Wiest, Burkhardt, Hester, Hortsch, Meyer, Argon (bib26) 1990; 110 Lin, Angelin-Duclos, Kuo, Calame (bib7) 2002; 22 Sandoval, Kodali, Wang (bib5) 2018; 41 Perdiguero, Morel, Tafalla (bib14) 2021; 10 Perdiguero (10.1016/j.isci.2022.105854_bib14) 2021; 10 Laing (10.1016/j.isci.2022.105854_bib40) 2001; 268 Wiest (10.1016/j.isci.2022.105854_bib26) 1990; 110 Perdiguero (10.1016/j.isci.2022.105854_bib37) 2020; 11 van Anken (10.1016/j.isci.2022.105854_bib25) 2009; 106 Zwollo (10.1016/j.isci.2022.105854_bib29) 2010; 34 Abos (10.1016/j.isci.2022.105854_bib23) 2020; 111 Sandoval (10.1016/j.isci.2022.105854_bib5) 2018; 41 Zwollo (10.1016/j.isci.2022.105854_bib41) 2005; 174 Nera (10.1016/j.isci.2022.105854_bib2) 2015; 82 Zwollo (10.1016/j.isci.2022.105854_bib28) 2008; 32 Granja (10.1016/j.isci.2022.105854_bib18) 2019; 85 Thuvander (10.1016/j.isci.2022.105854_bib35) 1990; 14 Ma (10.1016/j.isci.2022.105854_bib30) 2013; 43 Wang (10.1016/j.isci.2022.105854_bib32) 2018; 9 Granja (10.1016/j.isci.2022.105854_bib31) 2019; 10 Sunyer (10.1016/j.isci.2022.105854_bib10) 2013; 14 Jang (10.1016/j.isci.2022.105854_bib8) 2015; 6 Urbanczyk (10.1016/j.isci.2022.105854_bib27) 2022; 39 Baumgarth (10.1016/j.isci.2022.105854_bib11) 2016; 7 Abós (10.1016/j.isci.2022.105854_bib21) 2016; 6 Gutzeit (10.1016/j.isci.2022.105854_bib19) 2018; 48 Zhang (10.1016/j.isci.2022.105854_bib22) 2010; 11 Castro (10.1016/j.isci.2022.105854_bib36) 2014; 192 Zou (10.1016/j.isci.2022.105854_bib39) 1999; 259 Abós (10.1016/j.isci.2022.105854_bib13) 2018; 201 Tarte (10.1016/j.isci.2022.105854_bib6) 2003; 102 Kirk (10.1016/j.isci.2022.105854_bib9) 2010; 87 Zwollo (10.1016/j.isci.2022.105854_bib15) 2011; 35 Martín (10.1016/j.isci.2022.105854_bib20) 2021; 12 Pelletier (10.1016/j.isci.2022.105854_bib3) 2010; 11 Granja (10.1016/j.isci.2022.105854_bib34) 2015; 195 DeLuca (10.1016/j.isci.2022.105854_bib33) 1983; 13 Granja (10.1016/j.isci.2022.105854_bib38) 2017; 12 Perdiguero (10.1016/j.isci.2022.105854_bib17) 2019; 29 Waters (10.1016/j.isci.2022.105854_bib24) 2018; 5 Li (10.1016/j.isci.2022.105854_bib12) 2006; 7 Cassese (10.1016/j.isci.2022.105854_bib4) 2003; 171 Lin (10.1016/j.isci.2022.105854_bib7) 2002; 22 Calame (10.1016/j.isci.2022.105854_bib1) 2001; 2 Edholm (10.1016/j.isci.2022.105854_bib16) 2010; 185 |
| References_xml | – volume: 39 year: 2022 ident: bib27 article-title: Mitochondrial respiration in B lymphocytes is essential for humoral immunity by controlling the flux of the TCA cycle publication-title: Cell Rep. contributor: fullname: Thomas – volume: 7 start-page: 324 year: 2016 ident: bib11 article-title: B-1 cell heterogeneity and the regulation of natural and antigen-induced IgM production publication-title: Front. Immunol. contributor: fullname: Baumgarth – volume: 48 start-page: 1101 year: 2018 end-page: 1113 ident: bib19 article-title: The enigmatic function of IgD: some answers at last publication-title: Eur. J. Immunol. contributor: fullname: Cerutti – volume: 14 start-page: 320 year: 2013 end-page: 326 ident: bib10 article-title: Fishing for mammalian paradigms in the teleost immune system publication-title: Nat. Immunol. contributor: fullname: Sunyer – volume: 22 start-page: 4771 year: 2002 end-page: 4780 ident: bib7 article-title: Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells publication-title: Mol. Cell Biol. contributor: fullname: Calame – volume: 106 start-page: 17019 year: 2009 end-page: 17024 ident: bib25 article-title: Efficient IgM assembly and secretion require the plasma cell induced endoplasmic reticulum protein pERp1 publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Ora – volume: 110 start-page: 1501 year: 1990 end-page: 1511 ident: bib26 article-title: Membrane biogenesis during B cell differentiation: most endoplasmic reticulum proteins are expressed coordinately publication-title: J. Cell Biol. contributor: fullname: Argon – volume: 195 start-page: 1825 year: 2015 end-page: 1837 ident: bib34 article-title: Identification of teleost skin CD8alpha+ dendritic-like cells, representing a potential common ancestor for mammalian cross-presenting dendritic cells publication-title: J. Immunol. contributor: fullname: Tafalla – volume: 201 start-page: 465 year: 2018 end-page: 480 ident: bib13 article-title: Identification of the first teleost CD5 molecule: additional evidence on phenotypical and functional similarities between fish IgM(+) B cells and mammalian B1 cells publication-title: J. Immunol. contributor: fullname: Tafalla – volume: 11 start-page: 827 year: 2010 end-page: 835 ident: bib22 article-title: IgT, a primitive immunoglobulin class specialized in mucosal immunity publication-title: Nat. Immunol. contributor: fullname: Sunyer – volume: 11 start-page: 596975 year: 2020 ident: bib37 article-title: Insights into the evolution of the prdm1/Blimp1 gene family in teleost fish publication-title: Front. Immunol. contributor: fullname: Tafalla – volume: 171 start-page: 1684 year: 2003 end-page: 1690 ident: bib4 article-title: Plasma cell survival is mediated by synergistic effects of cytokines and adhesion-dependent signals publication-title: J. Immunol. contributor: fullname: Manz – volume: 111 year: 2020 ident: bib23 article-title: Distinct modes of action of CD40L and adaptive cytokines IL-2, IL-4/13, IL-10 and IL-21 on rainbow trout IgM(+) B cells publication-title: Dev. Comp. Immunol. contributor: fullname: Tafalla – volume: 35 start-page: 898 year: 2011 end-page: 905 ident: bib15 article-title: Dissecting teleost B cell differentiation using transcription factors publication-title: Dev. Comp. Immunol. contributor: fullname: Zwollo – volume: 6 year: 2016 ident: bib21 article-title: Distinct differentiation programs triggered by IL-6 and LPS in teleost IgM(+) B cells in the absence of germinal centers publication-title: Sci. Rep. contributor: fullname: Tafalla – volume: 32 start-page: 1482 year: 2008 end-page: 1496 ident: bib28 article-title: Molecular and cellular analysis of B-cell populations in the rainbow trout using Pax5 and immunoglobulin markers publication-title: Dev. Comp. Immunol. contributor: fullname: Gumulak-Smith – volume: 12 year: 2021 ident: bib20 article-title: CD38 defines a subset of B cells in rainbow trout kidney with high IgM secreting capacities publication-title: Front. Immunol. contributor: fullname: Tafalla – volume: 2 start-page: 1103 year: 2001 end-page: 1108 ident: bib1 article-title: Plasma cells: finding new light at the end of B cell development publication-title: Nat. Immunol. contributor: fullname: Calame – volume: 102 start-page: 592 year: 2003 end-page: 600 ident: bib6 article-title: Gene expression profiling of plasma cells and plasmablasts: toward a better understanding of the late stages of B-cell differentiation publication-title: Blood contributor: fullname: Shaughnessy – volume: 13 start-page: 546 year: 1983 end-page: 551 ident: bib33 article-title: Lymphocyte heterogeneity in the trout, publication-title: Eur. J. Immunol. contributor: fullname: Warr – volume: 9 start-page: 1683 year: 2018 ident: bib32 article-title: Interleukin (IL)-2 is a key regulator of T helper 1 and T helper 2 cytokine expression in fish: functional characterization of two divergent IL2 paralogs in salmonids publication-title: Front. Immunol. contributor: fullname: Secombes – volume: 85 start-page: 9 year: 2019 end-page: 17 ident: bib18 article-title: Different IgM(+) B cell subpopulations residing within the peritoneal cavity of vaccinated rainbow trout are differently regulated by BAFF publication-title: Fish Shellfish Immunol. contributor: fullname: Tafalla – volume: 34 start-page: 1291 year: 2010 end-page: 1299 ident: bib29 article-title: Comparative analyses of B cell populations in trout kidney and mouse bone marrow: establishing "B cell signatures publication-title: Dev. Comp. Immunol. contributor: fullname: Barr – volume: 192 start-page: 1257 year: 2014 end-page: 1266 ident: bib36 article-title: CCR7 is mainly expressed in teleost gills, where it defines an IgD publication-title: J. Immunol. contributor: fullname: Tafalla – volume: 87 start-page: 245 year: 2010 end-page: 255 ident: bib9 article-title: Biogenesis of secretory organelles during B cell differentiation publication-title: J. Leukoc. Biol. contributor: fullname: Ward – volume: 259 start-page: 901 year: 1999 end-page: 908 ident: bib39 article-title: The rainbow trout publication-title: Eur. J. Biochem. contributor: fullname: Secombes – volume: 10 start-page: 511 year: 2021 ident: bib14 article-title: Diversity of rainbow trout blood B cells revealed by single cell RNA sequencing publication-title: Biology contributor: fullname: Tafalla – volume: 7 start-page: 1116 year: 2006 end-page: 1124 ident: bib12 article-title: B lymphocytes from early vertebrates have potent phagocytic and microbicidal abilities publication-title: Nat. Immunol. contributor: fullname: Sunyer – volume: 41 start-page: 58 year: 2018 end-page: 65 ident: bib5 article-title: Regulation of B cell fate, survival, and function by mitochondria and autophagy publication-title: Mitochondrion contributor: fullname: Wang – volume: 268 start-page: 1315 year: 2001 end-page: 1322 ident: bib40 article-title: Cloning and expression analysis of rainbow trout publication-title: Eur. J. Biochem. contributor: fullname: Secombes – volume: 11 start-page: 1110 year: 2010 end-page: 1118 ident: bib3 article-title: Plasma cells negatively regulate the follicular helper T cell program publication-title: Nat. Immunol. contributor: fullname: McHeyzer-Williams – volume: 82 start-page: 225 year: 2015 end-page: 234 ident: bib2 article-title: Regulation of B cell to plasma cell transition within the follicular B cell response publication-title: Scand. J. Immunol. contributor: fullname: Lassila – volume: 29 start-page: 4223 year: 2019 end-page: 4235.e5 ident: bib17 article-title: Teleost IgD(+)IgM(-) B cells mount clonally expanded and mildly mutated intestinal IgD responses in the absence of lymphoid follicles publication-title: Cell Rep. contributor: fullname: Tafalla – volume: 43 start-page: 360 year: 2013 end-page: 370 ident: bib30 article-title: Differential compartmentalization of memory B cells versus plasma cells in salmonid fish publication-title: Eur. J. Immunol. contributor: fullname: Kaattari – volume: 174 start-page: 6608 year: 2005 end-page: 6616 ident: bib41 article-title: B cell heterogeneity in the teleost kidney: evidence for a maturation gradient from anterior to posterior kidney publication-title: J. Immunol. contributor: fullname: Kaattari – volume: 12 year: 2017 ident: bib38 article-title: Characterization of BAFF and APRIL subfamily receptors in rainbow trout publication-title: PLoS One contributor: fullname: Tafalla – volume: 6 start-page: 6750 year: 2015 ident: bib8 article-title: Mitochondrial function provides instructive signals for activation-induced B-cell fates publication-title: Nat. Commun. contributor: fullname: Nutt – volume: 185 start-page: 4082 year: 2010 end-page: 4094 ident: bib16 article-title: Identification of two IgD+ B cell populations in channel catfish, publication-title: J. Immunol. contributor: fullname: Wilson – volume: 10 start-page: 2902 year: 2019 ident: bib31 article-title: Rainbow trout IgM(+) B cells preferentially respond to thymus-independent antigens but are activated by CD40L publication-title: Front. Immunol. contributor: fullname: Tafalla – volume: 5 start-page: 99 year: 2018 end-page: 109 ident: bib24 article-title: Initial B cell activation induces metabolic reprogramming and mitochondrial remodeling publication-title: iScience contributor: fullname: Teitell – volume: 14 start-page: 415 year: 1990 end-page: 423 ident: bib35 article-title: Monoclonal antibodies to salmonid immunoglobulin: characterization and applicability in immunoassays publication-title: Dev. Comp. Immunol. contributor: fullname: Lorenzen – volume: 10 start-page: 511 year: 2021 ident: 10.1016/j.isci.2022.105854_bib14 article-title: Diversity of rainbow trout blood B cells revealed by single cell RNA sequencing publication-title: Biology doi: 10.3390/biology10060511 contributor: fullname: Perdiguero – volume: 6 start-page: 6750 year: 2015 ident: 10.1016/j.isci.2022.105854_bib8 article-title: Mitochondrial function provides instructive signals for activation-induced B-cell fates publication-title: Nat. Commun. doi: 10.1038/ncomms7750 contributor: fullname: Jang – volume: 14 start-page: 320 year: 2013 ident: 10.1016/j.isci.2022.105854_bib10 article-title: Fishing for mammalian paradigms in the teleost immune system publication-title: Nat. Immunol. doi: 10.1038/ni.2549 contributor: fullname: Sunyer – volume: 48 start-page: 1101 year: 2018 ident: 10.1016/j.isci.2022.105854_bib19 article-title: The enigmatic function of IgD: some answers at last publication-title: Eur. J. Immunol. doi: 10.1002/eji.201646547 contributor: fullname: Gutzeit – volume: 13 start-page: 546 year: 1983 ident: 10.1016/j.isci.2022.105854_bib33 article-title: Lymphocyte heterogeneity in the trout, Salmo gairdneri, defined with monoclonal antibodies to IgM publication-title: Eur. J. Immunol. doi: 10.1002/eji.1830130706 contributor: fullname: DeLuca – volume: 2 start-page: 1103 year: 2001 ident: 10.1016/j.isci.2022.105854_bib1 article-title: Plasma cells: finding new light at the end of B cell development publication-title: Nat. Immunol. doi: 10.1038/ni1201-1103 contributor: fullname: Calame – volume: 29 start-page: 4223 year: 2019 ident: 10.1016/j.isci.2022.105854_bib17 article-title: Teleost IgD(+)IgM(-) B cells mount clonally expanded and mildly mutated intestinal IgD responses in the absence of lymphoid follicles publication-title: Cell Rep. doi: 10.1016/j.celrep.2019.11.101 contributor: fullname: Perdiguero – volume: 110 start-page: 1501 year: 1990 ident: 10.1016/j.isci.2022.105854_bib26 article-title: Membrane biogenesis during B cell differentiation: most endoplasmic reticulum proteins are expressed coordinately publication-title: J. Cell Biol. doi: 10.1083/jcb.110.5.1501 contributor: fullname: Wiest – volume: 201 start-page: 465 year: 2018 ident: 10.1016/j.isci.2022.105854_bib13 article-title: Identification of the first teleost CD5 molecule: additional evidence on phenotypical and functional similarities between fish IgM(+) B cells and mammalian B1 cells publication-title: J. Immunol. doi: 10.4049/jimmunol.1701546 contributor: fullname: Abós – volume: 35 start-page: 898 year: 2011 ident: 10.1016/j.isci.2022.105854_bib15 article-title: Dissecting teleost B cell differentiation using transcription factors publication-title: Dev. Comp. Immunol. doi: 10.1016/j.dci.2011.01.009 contributor: fullname: Zwollo – volume: 39 year: 2022 ident: 10.1016/j.isci.2022.105854_bib27 article-title: Mitochondrial respiration in B lymphocytes is essential for humoral immunity by controlling the flux of the TCA cycle publication-title: Cell Rep. doi: 10.1016/j.celrep.2022.110912 contributor: fullname: Urbanczyk – volume: 12 year: 2017 ident: 10.1016/j.isci.2022.105854_bib38 article-title: Characterization of BAFF and APRIL subfamily receptors in rainbow trout (Oncorhynchus mykiss). Potential role of the BAFF/APRIL axis in the pathogenesis of proliferative kidney disease publication-title: PLoS One doi: 10.1371/journal.pone.0174249 contributor: fullname: Granja – volume: 111 year: 2020 ident: 10.1016/j.isci.2022.105854_bib23 article-title: Distinct modes of action of CD40L and adaptive cytokines IL-2, IL-4/13, IL-10 and IL-21 on rainbow trout IgM(+) B cells publication-title: Dev. Comp. Immunol. doi: 10.1016/j.dci.2020.103752 contributor: fullname: Abos – volume: 192 start-page: 1257 year: 2014 ident: 10.1016/j.isci.2022.105854_bib36 article-title: CCR7 is mainly expressed in teleost gills, where it defines an IgD+IgM- B lymphocyte subset publication-title: J. Immunol. doi: 10.4049/jimmunol.1302471 contributor: fullname: Castro – volume: 22 start-page: 4771 year: 2002 ident: 10.1016/j.isci.2022.105854_bib7 article-title: Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells publication-title: Mol. Cell Biol. doi: 10.1128/MCB.22.13.4771-4780.2002 contributor: fullname: Lin – volume: 12 year: 2021 ident: 10.1016/j.isci.2022.105854_bib20 article-title: CD38 defines a subset of B cells in rainbow trout kidney with high IgM secreting capacities publication-title: Front. Immunol. doi: 10.3389/fimmu.2021.773888 contributor: fullname: Martín – volume: 11 start-page: 596975 year: 2020 ident: 10.1016/j.isci.2022.105854_bib37 article-title: Insights into the evolution of the prdm1/Blimp1 gene family in teleost fish publication-title: Front. Immunol. doi: 10.3389/fimmu.2020.596975 contributor: fullname: Perdiguero – volume: 171 start-page: 1684 year: 2003 ident: 10.1016/j.isci.2022.105854_bib4 article-title: Plasma cell survival is mediated by synergistic effects of cytokines and adhesion-dependent signals publication-title: J. Immunol. doi: 10.4049/jimmunol.171.4.1684 contributor: fullname: Cassese – volume: 268 start-page: 1315 year: 2001 ident: 10.1016/j.isci.2022.105854_bib40 article-title: Cloning and expression analysis of rainbow trout Oncorhynchus mykiss tumour necrosis factor-alpha publication-title: Eur. J. Biochem. doi: 10.1046/j.1432-1327.2001.01996.x contributor: fullname: Laing – volume: 174 start-page: 6608 year: 2005 ident: 10.1016/j.isci.2022.105854_bib41 article-title: B cell heterogeneity in the teleost kidney: evidence for a maturation gradient from anterior to posterior kidney publication-title: J. Immunol. doi: 10.4049/jimmunol.174.11.6608 contributor: fullname: Zwollo – volume: 10 start-page: 2902 year: 2019 ident: 10.1016/j.isci.2022.105854_bib31 article-title: Rainbow trout IgM(+) B cells preferentially respond to thymus-independent antigens but are activated by CD40L publication-title: Front. Immunol. doi: 10.3389/fimmu.2019.02902 contributor: fullname: Granja – volume: 9 start-page: 1683 year: 2018 ident: 10.1016/j.isci.2022.105854_bib32 article-title: Interleukin (IL)-2 is a key regulator of T helper 1 and T helper 2 cytokine expression in fish: functional characterization of two divergent IL2 paralogs in salmonids publication-title: Front. Immunol. doi: 10.3389/fimmu.2018.01683 contributor: fullname: Wang – volume: 7 start-page: 1116 year: 2006 ident: 10.1016/j.isci.2022.105854_bib12 article-title: B lymphocytes from early vertebrates have potent phagocytic and microbicidal abilities publication-title: Nat. Immunol. doi: 10.1038/ni1389 contributor: fullname: Li – volume: 11 start-page: 1110 year: 2010 ident: 10.1016/j.isci.2022.105854_bib3 article-title: Plasma cells negatively regulate the follicular helper T cell program publication-title: Nat. Immunol. doi: 10.1038/ni.1954 contributor: fullname: Pelletier – volume: 11 start-page: 827 year: 2010 ident: 10.1016/j.isci.2022.105854_bib22 article-title: IgT, a primitive immunoglobulin class specialized in mucosal immunity publication-title: Nat. Immunol. doi: 10.1038/ni.1913 contributor: fullname: Zhang – volume: 34 start-page: 1291 year: 2010 ident: 10.1016/j.isci.2022.105854_bib29 article-title: Comparative analyses of B cell populations in trout kidney and mouse bone marrow: establishing "B cell signatures publication-title: Dev. Comp. Immunol. doi: 10.1016/j.dci.2010.08.003 contributor: fullname: Zwollo – volume: 259 start-page: 901 year: 1999 ident: 10.1016/j.isci.2022.105854_bib39 article-title: The rainbow trout Oncorhynchus mykiss interleukin-1 beta gene has a differ organization to mammals and undergoes incomplete splicing publication-title: Eur. J. Biochem. doi: 10.1046/j.1432-1327.1999.00121.x contributor: fullname: Zou – volume: 41 start-page: 58 year: 2018 ident: 10.1016/j.isci.2022.105854_bib5 article-title: Regulation of B cell fate, survival, and function by mitochondria and autophagy publication-title: Mitochondrion doi: 10.1016/j.mito.2017.11.005 contributor: fullname: Sandoval – volume: 185 start-page: 4082 year: 2010 ident: 10.1016/j.isci.2022.105854_bib16 article-title: Identification of two IgD+ B cell populations in channel catfish, Ictalurus punctatus publication-title: J. Immunol. doi: 10.4049/jimmunol.1000631 contributor: fullname: Edholm – volume: 7 start-page: 324 year: 2016 ident: 10.1016/j.isci.2022.105854_bib11 article-title: B-1 cell heterogeneity and the regulation of natural and antigen-induced IgM production publication-title: Front. Immunol. doi: 10.3389/fimmu.2016.00324 contributor: fullname: Baumgarth – volume: 195 start-page: 1825 year: 2015 ident: 10.1016/j.isci.2022.105854_bib34 article-title: Identification of teleost skin CD8alpha+ dendritic-like cells, representing a potential common ancestor for mammalian cross-presenting dendritic cells publication-title: J. Immunol. doi: 10.4049/jimmunol.1500322 contributor: fullname: Granja – volume: 85 start-page: 9 year: 2019 ident: 10.1016/j.isci.2022.105854_bib18 article-title: Different IgM(+) B cell subpopulations residing within the peritoneal cavity of vaccinated rainbow trout are differently regulated by BAFF publication-title: Fish Shellfish Immunol. doi: 10.1016/j.fsi.2017.10.003 contributor: fullname: Granja – volume: 87 start-page: 245 year: 2010 ident: 10.1016/j.isci.2022.105854_bib9 article-title: Biogenesis of secretory organelles during B cell differentiation publication-title: J. Leukoc. Biol. doi: 10.1189/jlb.1208774 contributor: fullname: Kirk – volume: 43 start-page: 360 year: 2013 ident: 10.1016/j.isci.2022.105854_bib30 article-title: Differential compartmentalization of memory B cells versus plasma cells in salmonid fish publication-title: Eur. J. Immunol. doi: 10.1002/eji.201242570 contributor: fullname: Ma – volume: 32 start-page: 1482 year: 2008 ident: 10.1016/j.isci.2022.105854_bib28 article-title: Molecular and cellular analysis of B-cell populations in the rainbow trout using Pax5 and immunoglobulin markers publication-title: Dev. Comp. Immunol. doi: 10.1016/j.dci.2008.06.008 contributor: fullname: Zwollo – volume: 102 start-page: 592 year: 2003 ident: 10.1016/j.isci.2022.105854_bib6 article-title: Gene expression profiling of plasma cells and plasmablasts: toward a better understanding of the late stages of B-cell differentiation publication-title: Blood doi: 10.1182/blood-2002-10-3161 contributor: fullname: Tarte – volume: 6 year: 2016 ident: 10.1016/j.isci.2022.105854_bib21 article-title: Distinct differentiation programs triggered by IL-6 and LPS in teleost IgM(+) B cells in the absence of germinal centers publication-title: Sci. Rep. doi: 10.1038/srep30004 contributor: fullname: Abós – volume: 5 start-page: 99 year: 2018 ident: 10.1016/j.isci.2022.105854_bib24 article-title: Initial B cell activation induces metabolic reprogramming and mitochondrial remodeling publication-title: iScience doi: 10.1016/j.isci.2018.07.005 contributor: fullname: Waters – volume: 106 start-page: 17019 year: 2009 ident: 10.1016/j.isci.2022.105854_bib25 article-title: Efficient IgM assembly and secretion require the plasma cell induced endoplasmic reticulum protein pERp1 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0903036106 contributor: fullname: van Anken – volume: 82 start-page: 225 year: 2015 ident: 10.1016/j.isci.2022.105854_bib2 article-title: Regulation of B cell to plasma cell transition within the follicular B cell response publication-title: Scand. J. Immunol. doi: 10.1111/sji.12336 contributor: fullname: Nera – volume: 14 start-page: 415 year: 1990 ident: 10.1016/j.isci.2022.105854_bib35 article-title: Monoclonal antibodies to salmonid immunoglobulin: characterization and applicability in immunoassays publication-title: Dev. Comp. Immunol. doi: 10.1016/0145-305X(90)90034-C contributor: fullname: Thuvander |
| SSID | ssj0002002496 |
| Score | 2.29434 |
| Snippet | The differentiation of B cells into antibody-secreting cells is fundamental for the generation of humoral immunity. In mammals, this process involves a series... |
| SourceID | doaj pubmedcentral proquest crossref pubmed elsevier |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 105854 |
| SubjectTerms | Biological sciences Immunology Molecular biology |
| SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NS-wwEA_qyYv48GvVJxG8SbGbJm16fPtc8eRFBW8hzQeuYCu2C_75ziTtYhX04qWUtqSdr8xv0skMIWdTneYMXE3CmcsTLr1IpM594mSelkZ7YU1oYntb3DzIyzmWyVm1-sKcsFgeODLuogAEbKS14FZKXjItbaqZkGCWpip4X700zT8EU0_h9xqWwgud5QTmBIFq9jtmYnIX7niF4JAx7HMrBR95pVC8f-ScvoLPzzmUH5zS1TbZ6tEk_Rep-EPWXL1D9Ly2zQug4ueFoWGTIq7wUfcGho9rY7TvzdMsOzh1dOiR0kUp0cbTDpxR03Z0RnFhv6VdQ8OAuoJj1-6S-6v53f_rpO-kkBhsWJBIzhm3YJyZFs47D2GhkTkmlhalz7UBTOFt6bjkAmRnWObLCpGfsyFC4tke2aib2h0Q6lJdacAQMi00rwyvpplmldBlpnOYKqcTcj5wUr3EghlqyCR7Ush3hXxXke8TMkNmr57EYtfhAqiA6lVA_aQCEyIGUakeN0Q8AEMtvn356SBXBUaFDNW1a5atYuAiABpBqDUh-1HOq0_MANFAjApvLUYaMKJhfKdePIbC3SWgqWKaHf4G0UdkE0jBXDiY6I7JRve6dH_JemuXJ8EU3gG4Lg2J priority: 102 providerName: Directory of Open Access Journals |
| Title | Endoplasmic reticulum expansion throughout the differentiation of teleost B cells to plasmablasts |
| URI | https://dx.doi.org/10.1016/j.isci.2022.105854 https://www.ncbi.nlm.nih.gov/pubmed/36619985 https://search.proquest.com/docview/2762820747 https://pubmed.ncbi.nlm.nih.gov/PMC9812713 https://doaj.org/article/7118c8dd8539492a8d0a258addcb7405 |
| Volume | 26 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBbZnHIpCUnTTZNFgd6Ks15ZsuVjHhtySSk0gdyErEe7S9deYi_052dGtpd1Cj30Yowfkjwjab4Zz4OQLzMdpwxETcSZSyMuvYikTn3kZBrnRnthTShi-yP79iLv5pgmR_SxMMFp3xSLq_L36qpc_Aq-leuVmfZ-YtPvj7c5SCVQrqYjMgJsuKOiL8OfNcyCl3YBMq0vFwa4gi7IGJa1lYIPhFDI1T-QRX9jzfcukzsy6P6QfOjAI71uB3lE9lx5TPS8tNUaQPBqYWiISUSDHnV_YJ2jKYx2pXiqTQOnjvYlUZqWKbTytAHZU9UNvaFox69pU9HQoC7g2NQn5Pl-_nT7EHWFEyKD9QkiyTnjFtZiooXzzoMWaGSKfqRZ7lNtAEJ4mzsuuQBWGZb4vECg52xQiHjykeyXVek-EepiXWiADDLONC8ML2aJZoXQeaJT2BlnY_K1p6Rat_kxVO84tlRId4V0Vy3dx-QGib19EnNbhwvV60_VcVhloPMYaS0AiZznTEsbayYkbMSmyABfjonoWaU6mNCKf2hq8c_OL3u-KlhDSFBdumpTKwYSAZAQaFZjctryeTvEBAAMqKTQazaYAYNvGN6BaRvydHfT9Oy_3_xMDrC6PVp8WHxO9pvXjbsgo9puJsF2MAkz_w3Efguq |
| link.rule.ids | 230,315,729,782,786,866,887,2106,27933,27934,53800,53802 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwEB6V7QEufQhKt08j9YbCZh07cY5duoiKh5BKpd4sxw9Y1E1WJCvx8xk7CSJU6oFLFMVJ_Jix5xt7HgDfpipOKYqaiFGbRkw4HgmVusiKNM61ctzokMT2V3b-R_yY-zA5vPeFCUb7ulgclH-XB-XiOthWrpZ60tuJTS7ODnOUSqhcTTbgJc7XOH6kpN-EszUfBy_tXGRaay7v4oraIKU-sa3gbCCGQrT-gTT6F20-NZp8JIWOXj-z_W_gVQc7yfe2-C28sOU2qHlpqhXC5-VCk-DN6LcCib3DFcJvopEuiU-1bvDWkj6ZStOSk1SONCi1qrohM-JPAGrSVCT8UBV4beod-H00vzw8jrqUC5H2mQ0iwRhlBmdxorh11qH-qEXqLVCz3KVKI_hwJrdMMI5E1jRxeeEhojVBlWLJOxiVVWnfA7GxKhSCDRFnihWaFdNE0YKrPFEprqnTMez3FJCrNrKG7E3ObqSnl_T0ki29xjDzRHp400fFDg-q2yvZja3MUFvSwhiEIDnLqRImVpQLXMJ1kSEyHQPvSSw7gNECB_zV4r-V7_X8IHH2-QFVpa3WtaQoSxBDoU42ht2WPx6amCD0QWUWa80GnDPow7AEGSZE-O4Y5MOzv_wKm8eXZ6fy9Of5yUfYwr54qzlcEj_BqLld28-wUZv1lzBv7gF3RiA8 |
| linkToPdf | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwED_RTkK8MCYGKxvMSLxNaVPHSZzHfbQaAqZJMGlvluMP6LQmVZNK_PmcnaRahrQHeImixLFj353vd_b5DuDTVIYJRVUTMGqSgHEbB1wmNjA8CTMlbayVT2L7Pb265RczFyZnm-rLO-2rfDEu7pfjYvHL-1aulmrS-YlNrr-dZ6iV0LiarLSdDGAHZTakDwz1O7-_5mLhJe0xmcajyx1zRYuQUpfclsesp4p8xP6eRvobcT52nHygiea7_9GHV_CyhZ_ktCmyB89M8RrkrNDlCmH0cqGIP9XolgSJ-Y0zhVtMI20yn3JT460hXVKVuiErKS2pUXuVVU3OiNsJqEhdEl-hzPFaV_twM5_9OL8M2tQLgXIZDgLOGGUapTmSsbHGoh2peOI8UdPMJlIhCLE6M4yzGImtaGSz3EFFo71JxaI3MCzKwhwAMaHMJYIOHqaS5Yrl00jSPJZZJBOcW6cjOOmoIFZNhA3RuZ7dCUcz4WgmGpqN4MwRalvSRcf2D8r1T9GOr0jRalJca4QiGcuo5DqUNOY4las8RYQ6grgjs2iBRgMgsKrFk41_7HhCoBS6AZWFKTeVoKhTEEuhbTaCtw2PbH8xQgiERi22mva4p9eH_htkGh_pu2WSd__85TE8v76Yi6-fr74cwgvsinOew5nxCIb1emPew6DSmw9edP4AaP8ivA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Endoplasmic+reticulum+expansion+throughout+the+differentiation+of+teleost+B+cells+to+plasmablasts&rft.jtitle=iScience&rft.au=Morel%2C+Esther&rft.au=Herranz-Jusdado%2C+J.+Germ%C3%A1n&rft.au=Sim%C3%B3n%2C+Roc%C3%ADo&rft.au=Ab%C3%B3s%2C+Beatriz&rft.date=2023-01-20&rft.pub=Elsevier+Inc&rft.issn=2589-0042&rft.eissn=2589-0042&rft.volume=26&rft.issue=1&rft_id=info:doi/10.1016%2Fj.isci.2022.105854&rft.externalDocID=S2589004222021277 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2589-0042&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2589-0042&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2589-0042&client=summon |