Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction

Many approaches to identify therapeutically relevant neoantigens couple tumor sequencing with bioinformatic algorithms and inferred rules of tumor epitope immunogenicity. However, there are no reference data to compare these approaches, and the parameters governing tumor epitope immunogenicity remai...

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Published in:	Cell Vol. 183; no. 3; pp. 818 - 834.e13
Main Authors:	Wells, Daniel K., Dang, Kristen K., Sheehan, Kathleen C.F., Campbell, Katie M., Lamb, Andrew, Ward, Jeffrey P., Sidney, John, Blazquez, Ana B., Rech, Andrew J., Zaretsky, Jesse M., Ng, Alphonsus H.C., Yu, Thomas V., Manning, Patrice, Steiner, Gabriela M., Khan, Aly A., Lugade, Amit, Frentzen, Angela A. Elizabeth, Tadmor, Arbel D., Sasson, Ariella S., Rao, Arjun A., Pei, Baikang, Schrörs, Barbara, Peters, Bjoern, Li, Bo, Stevenson, Brian J., Iseli, Christian, Morehouse, Christopher A., Melief, Cornelis J.M., Puig-Saus, Cristina, van Beek, Daphne, Balli, David, Gfeller, David, Haussler, David, Jäger, Dirk, Cortes, Eduardo, Esaulova, Ekaterina, Sherafat, Elham, Bartha, Gabor, Liu, Geng, Coukos, George, Xenarios, Ioannis, Mandoiu, Ion, Kooi, Irsan, Kessler, Jan H., Greenbaum, Jason A., Perera, Jason F., Harris, Jason, Hundal, Jasreet, Shelton, Jennifer M., Wang, Jianmin, Wang, Jiaqian, Szustakowski, Joseph, Kodysh, Julia, Forman, Juliet, Wei, Lei, Lee, Leo J., Slagter, Maarten, Mueller, Markus, Lower, Martin, Vormehr, Mathias, Artyomov, Maxim N., Yang, Naibo, Raicevic, Nevena M. Ilic, Guex, Nicolas, Robine, Nicolas, Halama, Niels, Skundric, Nikola M., Milicevic, Ognjen S., Gellert, Pascal, Jongeneel, Patrick, Charoentong, Pornpimol, Tanden, Prateek, Hu, Qiang, Gupta, Ravi, Petit, Robert, Ziman, Robert, Hilker, Rolf, Shukla, Sachet A., Boyle, Sean M., Qiu, Si, Salama, Sofie, Liu, Song, Wu, Song, Ketelaars, Steven L.C., Jhunjhunwala, Suchit, Shcheglova, Tatiana, Schuepbach, Thierry, Creasy, Todd H., Kovacevic, Vladimir B., Krebber, Willem-Jan, Sebastian, Yinong, Yalcin, Zeynep Kosaloglu, Selinsky, Cheryl, Ribas, Antoni, Hellmann, Matthew D., Hacohen, Nir, Sette, Alessandro, Heath, James R., Schreiber, Robert D., Kvistborg, Pia
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 29-10-2020
Subjects:	Alleles Antigen Presentation - immunology Antigens, Neoplasm - immunology Cohort Studies epitope Epitopes - immunology Humans immunogenicity immunogenomics immunotherapy neoantigen Neoplasms - immunology Peptides - immunology Programmed Cell Death 1 Receptor Reproducibility of Results TESLA neoantigen immunogenomics epitope immunogenicity immunotherapy TESLA
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