A Human Variant of Glucose-Regulated Protein 94 That Inefficiently Supports IGF Production
IGFs are critical for normal intrauterine and childhood growth and sustaining health throughout life. We showed previously that the production of IGF-1 and IGF-2 requires interaction with the chaperone glucose-regulated protein 94 (GRP94) and that the amount of secreted IGFs is proportional to the G...
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| Published in: | Endocrinology (Philadelphia) Vol. 157; no. 5; pp. 1914 - 1928 |
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| Main Authors: | , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Endocrine Society
01-05-2016
Oxford University Press |
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| Abstract | IGFs are critical for normal intrauterine and childhood growth and sustaining health throughout life. We showed previously that the production of IGF-1 and IGF-2 requires interaction with the chaperone glucose-regulated protein 94 (GRP94) and that the amount of secreted IGFs is proportional to the GRP94 activity. Therefore, we tested the hypothesis that functional polymorphisms of human GRP94 affect IGF production and thereby human health. We describe a hypomorphic variant of human GRP94, P300L, whose heterozygous carriers have 9% lower circulating IGF-1 concentration. P300L was found first in a child with primary IGF deficiency and was later shown to be a noncommon single-nucleotide polymorphism with frequencies of 1%–4% in various populations. When tested in the grp94−/− cell-based complementation assay, P300L supported only approximately 58% of IGF secretion relative to wild-type GRP94. Furthermore, recombinant P300L showed impaired nucleotide binding activity. These in vitro data strongly support a causal relationship between the GRP94 variant and the decreased concentration of circulating IGF-1, as observed in human carriers of P300L. Thus, mutations in GRP94 that affect its IGF chaperone activity represent a novel causal genetic mechanism that limits IGF biosynthesis, quite a distinct mechanism from the known genes in the GH/IGF signaling network. |
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| AbstractList | IGFs are critical for normal intrauterine and childhood growth and sustaining health throughout life. We showed previously that the production of IGF-1 and IGF-2 requires interaction with the chaperone glucose-regulated protein 94 (GRP94) and that the amount of secreted IGFs is proportional to the GRP94 activity. Therefore, we tested the hypothesis that functional polymorphisms of human GRP94 affect IGF production and thereby human health. We describe a hypomorphic variant of human GRP94, P300L, whose heterozygous carriers have 9% lower circulating IGF-1 concentration. P300L was found first in a child with primary IGF deficiency and was later shown to be a noncommon single-nucleotide polymorphism with frequencies of 1%–4% in various populations. When tested in the grp94−/− cell-based complementation assay, P300L supported only approximately 58% of IGF secretion relative to wild-type GRP94. Furthermore, recombinant P300L showed impaired nucleotide binding activity. These in vitro data strongly support a causal relationship between the GRP94 variant and the decreased concentration of circulating IGF-1, as observed in human carriers of P300L. Thus, mutations in GRP94 that affect its IGF chaperone activity represent a novel causal genetic mechanism that limits IGF biosynthesis, quite a distinct mechanism from the known genes in the GH/IGF signaling network. IGFs are critical for normal intrauterine and childhood growth and sustaining health throughout life. We showed previously that the production of IGF-1 and IGF-2 requires interaction with the chaperone glucose-regulated protein 94 (GRP94) and that the amount of secreted IGFs is proportional to the GRP94 activity. Therefore, we tested the hypothesis that functional polymorphisms of human GRP94 affect IGF production and thereby human health. We describe a hypomorphic variant of human GRP94, P300L, whose heterozygous carriers have 9% lower circulating IGF-1 concentration. P300L was found first in a child with primary IGF deficiency and was later shown to be a noncommon single-nucleotide polymorphism with frequencies of 1%-4% in various populations. When tested in the grp94(-/-) cell-based complementation assay, P300L supported only approximately 58% of IGF secretion relative to wild-type GRP94. Furthermore, recombinant P300L showed impaired nucleotide binding activity. These in vitro data strongly support a causal relationship between the GRP94 variant and the decreased concentration of circulating IGF-1, as observed in human carriers of P300L. Thus, mutations in GRP94 that affect its IGF chaperone activity represent a novel causal genetic mechanism that limits IGF biosynthesis, quite a distinct mechanism from the known genes in the GH/IGF signaling network. IGFs are critical for normal intrauterine and childhood growth and sustaining health throughout life. We showed previously that the production of IGF-1 and IGF-2 requires interaction with the chaperone glucose-regulated protein 94 (GRP94) and that the amount of secreted IGFs is proportional to the GRP94 activity. Therefore, we tested the hypothesis that functional polymorphisms of human GRP94 affect IGF production and thereby human health. We describe a hypomorphic variant of human GRP94, P300L, whose heterozygous carriers have 9% lower circulating IGF-1 concentration. P300L was found first in a child with primary IGF deficiency and was later shown to be a noncommon single-nucleotide polymorphism with frequencies of 1%–4% in various populations. When tested in the grp94 −/− cell-based complementation assay, P300L supported only approximately 58% of IGF secretion relative to wild-type GRP94. Furthermore, recombinant P300L showed impaired nucleotide binding activity. These in vitro data strongly support a causal relationship between the GRP94 variant and the decreased concentration of circulating IGF-1, as observed in human carriers of P300L. Thus, mutations in GRP94 that affect its IGF chaperone activity represent a novel causal genetic mechanism that limits IGF biosynthesis, quite a distinct mechanism from the known genes in the GH/IGF signaling network. IGFs are critical for normal intrauterine and childhood growth and sustaining health throughout life. We showed previously that the production of IGF-1 and IGF-2 requires interaction with the chaperone glucose-regulated protein 94 (GRP94) and that the amount of secreted IGFs is proportional to the GRP94 activity. Therefore, we tested the hypothesis that functional polymorphisms of human GRP94 affect IGF production and thereby human health. We describe a hypomorphic variant of human GRP94, P300L, whose heterozygous carriers have 9% lower circulating IGF-1 concentration. P300L was found first in a child with primary IGF deficiency and was later shown to be a noncommon single-nucleotide polymorphism with frequencies of 1%-4% in various populations. When tested in the grp94(-/-) cell-based complementation assay, P300L supported only approximately 58% of IGF secretion relative to wild-type GRP94. Furthermore, recombinant P300L showed impaired nucleotide binding activity. These in vitro data strongly support a causal relationship between the GRP94 variant and the decreased concentration of circulating IGF-1, as observed in human carriers of P300L. Thus, mutations in GRP94 that affect its IGF chaperone activity represent a novel causal genetic mechanism that limits IGF biosynthesis, quite a distinct mechanism from the known genes in the GH/IGF signaling network.IGFs are critical for normal intrauterine and childhood growth and sustaining health throughout life. We showed previously that the production of IGF-1 and IGF-2 requires interaction with the chaperone glucose-regulated protein 94 (GRP94) and that the amount of secreted IGFs is proportional to the GRP94 activity. Therefore, we tested the hypothesis that functional polymorphisms of human GRP94 affect IGF production and thereby human health. We describe a hypomorphic variant of human GRP94, P300L, whose heterozygous carriers have 9% lower circulating IGF-1 concentration. P300L was found first in a child with primary IGF deficiency and was later shown to be a noncommon single-nucleotide polymorphism with frequencies of 1%-4% in various populations. When tested in the grp94(-/-) cell-based complementation assay, P300L supported only approximately 58% of IGF secretion relative to wild-type GRP94. Furthermore, recombinant P300L showed impaired nucleotide binding activity. These in vitro data strongly support a causal relationship between the GRP94 variant and the decreased concentration of circulating IGF-1, as observed in human carriers of P300L. Thus, mutations in GRP94 that affect its IGF chaperone activity represent a novel causal genetic mechanism that limits IGF biosynthesis, quite a distinct mechanism from the known genes in the GH/IGF signaling network. IGFs are critical for normal intrauterine and childhood growth and sustaining health throughout life. We showed previously that the production of IGF-1 and IGF-2 requires interaction with the chaperone glucose-regulated protein 94 (GRP94) and that the amount of secreted IGFs is proportional to the GRP94 activity. Therefore, we tested the hypothesis that functional polymorphisms of human GRP94 affect IGF production and thereby human health. We describe a hypomorphic variant of human GRP94, P300L, whose heterozygous carriers have 9% lower circulating IGF-1 concentration. P300L was found first in a child with primary IGF deficiency and was later shown to be a noncommon single-nucleotide polymorphism with frequencies of 1%-4% in various populations. When tested in the grp94 super(-/-) cell-based complementation assay, P300L supported only approximately 58% of IGF secretion relative to wild-type GRP94. Furthermore, recombinant P300L showed impaired nucleotide binding activity. These in vitro data strongly support a causal relationship between the GRP94 variant and the decreased concentration of circulating IGF-1, as observed in human carriers of P300L. Thus, mutations in GRP94 that affect its IGF chaperone activity represent a novel causal genetic mechanism that limits IGF biosynthesis, quite a distinct mechanism from the known genes in the GH/IGF signaling network. |
| Author | Marzec, Michal Yeap, Bu Beng Hwa, Vivian van Duyvenvoorde, Hermine A Flicker, Leon Rosenfeld, Ron Atzmon, Gil Grimberg, Adda Hawkes, Colin P Pedersen, Oluf Wit, Jan M Barzilai, Nir Losekoot, Monique Argon, Yair Boyle, Sarah Eletto, Davide Oostdijk, Wilma |
| Author_xml | – sequence: 1 givenname: Michal surname: Marzec fullname: Marzec, Michal – sequence: 2 givenname: Colin P surname: Hawkes fullname: Hawkes, Colin P – sequence: 3 givenname: Davide surname: Eletto fullname: Eletto, Davide – sequence: 4 givenname: Sarah surname: Boyle fullname: Boyle, Sarah – sequence: 5 givenname: Ron surname: Rosenfeld fullname: Rosenfeld, Ron – sequence: 6 givenname: Vivian surname: Hwa fullname: Hwa, Vivian – sequence: 7 givenname: Jan M surname: Wit fullname: Wit, Jan M – sequence: 8 givenname: Hermine A surname: van Duyvenvoorde fullname: van Duyvenvoorde, Hermine A – sequence: 9 givenname: Wilma surname: Oostdijk fullname: Oostdijk, Wilma – sequence: 10 givenname: Monique surname: Losekoot fullname: Losekoot, Monique – sequence: 11 givenname: Oluf surname: Pedersen fullname: Pedersen, Oluf – sequence: 12 givenname: Bu Beng surname: Yeap fullname: Yeap, Bu Beng – sequence: 13 givenname: Leon surname: Flicker fullname: Flicker, Leon – sequence: 14 givenname: Nir surname: Barzilai fullname: Barzilai, Nir – sequence: 15 givenname: Gil surname: Atzmon fullname: Atzmon, Gil – sequence: 16 givenname: Adda surname: Grimberg fullname: Grimberg, Adda – sequence: 17 givenname: Yair surname: Argon fullname: Argon, Yair email: yargon@mail.med.upenn.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26982636$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1515/jpem-2014-0132 10.1242/jcs.109.3.551 10.1111/acel.12213 10.1146/annurev.ph.47.030185.002411 10.1093/ije/dyn041 10.1136/jmg.40.12.913 10.1210/er.2008-0047 10.1530/EJE-11-0059 10.1073/pnas.0902626106 10.1172/JCI0215463 10.1073/pnas.89.20.9826 10.1038/370373a0 10.1074/jbc.274.40.28476 10.1074/jbc.M001477200 10.1038/nature04716 10.1210/jc.2002-021938 10.1016/j.molcel.2007.08.024 10.1038/nchembio.1335 10.1016/j.bbamcr.2009.11.005 10.1182/blood-2011-01-330464 10.1016/0165-1781(86)90042-9 10.1007/s00467-004-1613-y 10.1111/j.1651-2227.1997.tb18366.x 10.1096/fj.11-203026 10.1016/S0092-8674(00)81444-0 10.1210/jc.2004-1254 10.1007/s00125-012-2756-1 10.1091/mbc.e08-04-0346 10.1126/science.6262917 10.1159/000338462 10.1128/MCB.9.5.2153 10.1016/j.bmc.2012.03.043 10.1021/bi9801006 10.1056/NEJMoa1415227 10.1016/j.immuni.2006.12.005 10.1242/jcs.108928 10.1021/acs.jmedchem.5b00197 10.1007/BF03354435 10.1111/j.1474-9726.2011.00697.x 10.1159/000337249 10.1056/NEJMoa013100 10.1210/jc.2007-0526 10.1210/jc.2014-1506 10.1530/EJE-09-0852 10.1038/nrendo.2010.123 10.1073/pnas.83.20.7932 10.1074/jbc.M308661200 10.1128/MCB.00171-12 10.1074/jbc.M205323200 10.1042/BJ20061867 10.1126/science.7079756 10.1056/NEJMoa022926 10.1001/jama.290.15.2030 10.1073/pnas.0705467105 10.1073/pnas.94.14.7239 10.1016/j.ymeth.2015.04.029 10.1016/S0092-8674(05)80085-6 10.1016/j.bbamcr.2011.10.013 10.1091/mbc.e07-03-0275 10.1159/000355543 10.1056/NEJM199610313351805 10.1126/scitranslmed.3001845 10.1021/ja303477g 10.1074/jbc.M313060200 10.1210/endo-116-6-2563 10.1210/jc.2003-031033 10.1210/mend.13.9.0339 |
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| Copyright | Copyright © 2016 by the Endocrine Society Copyright © 2016 by the Endocrine Society 2016 |
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| Notes | This work was supported by Grants AG18001 and GM-077480 (to Y.A.) as well as Award KO1 AG-040153 and the Junior Investigator Pilot Grant Program Grant UL1 RR024134 (to M.M.). The IGF-1 and IGF binding protein-1 and BP3 assays in the Health In Men Study were supported by Project Grant 513823 from the National Health and Medical Research Council of Australia. The Health, Aging, and Body Composition Study Project was supported by National Institute on Aging Contracts N 01-AG-6-2101; N01-AG-6-2103; N01-AG-6-2106; National Institute on Aging Grant AG-028050, and National Institute of Nursing Research Grant NR-012459. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
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| References | Teglund, S; McKay, C; Schuetz, E (B18) 1998; 93 Melnick, J; Dul, JL; Argon, Y (B5) 1994; 370 Rosser, MF; Nicchitta, CV (B54) 2000; 275 Burkhardt, S; Gesing, J; Kapellen, TM (B34) 2015; 28 Ali, MM; Roe, SM; Vaughan, CK (B11) 2006; 440 Fuqua, JS; Derr, M; Rosenfeld, RG; Hwa, V (B30) 2012; 78 Patel, PD; Yan, P; Seidler, PM (B57) 2013; 9 Begemann, M; Zirn, B; Santen, G (B60) 2015; 373 Vogen, S; Gidalevitz, T; Biswas, C (B48) 2002; 277 Krzisnik, C; Grguric, S; Cvijovic, K; Laron, Z (B23) 2010; 7 Ketha, H; Singh, RJ (B50) 2015; 81 Wearsch, PA; Voglino, L; Nicchitta, CV (B52) 1998; 37 Barton, ER; Park, S; James, JK (B4) 2012; 26 Woods, KA; Camacho-Hubner, C; Savage, MO; Clark, AJ (B31) 1996; 335 Laron, Z (B27) 2004; 89 Walenkamp, MJ; Karperien, M; Pereira, AM (B58) 2005; 90 Romero, CJ; Pine-Twaddell, E; Sima, DI (B19) 2012; 32 Besson, A; Salemi, S; Gallati, S (B26) 2003; 88 Staron, M; Wu, S; Hong, F (B7) 2011; 117 Albrechtsen, A; Grarup, N; Li, Y (B44) 2013; 56 Dauber, A; Rosenfeld, RG; Hirschhorn, JN (B22) 2014; 99 Bonapace, G; Concolino, D; Formicola, S; Strisciuglio, P (B32) 2003; 40 Baumann, G; Maheshwari, H (B25) 1997; 423 Eletto, D; Maganty, A; Eletto, D (B13) 2012; 125 Montarras, D; Aurade, F; Johnson, TJ; Gros, F; Pinset, C (B16) 1996; 109 Yang, Y; Liu, B; Dai, J (B8) 2007; 26 Yakar, S; Rosen, CJ; Beamer, WG (B51) 2002; 110 Patel, HJ; Patel, PD; Ochiana, SO (B56) 2015; 58 Gianotti, L; Lanfranco, F; Ramunni, J; Destefanis, S; Ghigo, E; Arvat, E (B63) 2002; 7 Soldano, KL; Jivan, A; Nicchitta, CV; Gewirth, DT (B46) 2003; 278 Milman, S; Atzmon, G; Huffman, DM (B45) 2014; 13 Brooks, AJ; Waters, MJ (B64) 2010; 6 Wanderling, S; Simen, BB; Ostrovsky, O (B1) 2007; 18 Yeap, BB; Chubb, SA; McCaul, KA (B42) 2011; 164 Kaplan, SA; Cohen, P (B21) 2007; 92 Tazearslan, C; Huang, J; Barzilai, N; Suh, Y (B33) 2011; 10 Schlechter, NL; Russell, SM; Spencer, EM; Nicoll, CS (B68) 1986; 83 Yeap, BB; Chubb, SA; Ho, KK (B41) 2010; 162 Isaksson, OG; Jansson, JO; Gause, IA (B70) 1982; 216 Hughes, PF; Barrott, JJ; Carlson, DA (B40) 2012; 20 Baker, J; Liu, JP; Robertson, EJ; Efstratiadis, A (B17) 1993; 75 Gicquel, C; Le Bouc, Y (B59) 2006; 65 Belfiore, A; Frasca, F; Pandini, G; Sciacca, L; Vigneri, R (B14) 2009; 30 Marzec, M; Eletto, D; Argon, Y (B53) 2012; 1823 Isgaard, J; Nilsson, A; Lindahl, A; Jansson, JO; Isaksson, OG (B71) 1986; 250 Duerfeldt, AS; Peterson, LB; Maynard, JC (B55) 2012; 134 Ostrovsky, O; Eletto, D; Makarewich, C; Barton, ER; Argon, Y (B2) 2010; 1803 Barzilai, N; Atzmon, G; Schechter, C (B43) 2003; 290 Norman, PE; Flicker, L; Almeida, OP; Hankey, GJ; Hyde, Z; Jamrozik, K (B49) 2009; 38 Dollins, DE; Warren, JJ; Immormino, RM; Gewirth, DT (B47) 2007; 28 Yakar, S; Kim, H; Zhao, H (B15) 2005; 20 Berelowitz, M; Szabo, M; Frohman, LA; Firestone, S; Chu, L; Hintz, RL (B20) 1981; 212 Kofoed, EM; Hwa, V; Little, B (B29) 2003; 349 Guevara-Aguirre, J; Balasubramanian, P; Guevara-Aguirre, M (B28) 2011; 3 Gidalevitz, T; Biswas, C; Ding, H (B39) 2004; 279 Schulte, TW; Akinaga, S; Murakata, T (B10) 1999; 13 Ostrovsky, O; Makarewich, CA; Snapp, EL; Argon, Y (B12) 2009; 106 Fichter, MM; Pirke, KM; Holsboer, F (B62) 1986; 17 Salvatori, R; Hayashida, CY; Aguiar-Oliveira, MH (B24) 1999; 84 Russell, SM; Spencer, EM (B67) 1985; 116 Biswas, C; Ostrovsky, O; Makarewich, CA; Wanderling, S; Gidalevitz, T; Argon, Y (B38) 2007; 405 Udy, GB; Towers, RP; Snell, RG (B65) 1997; 94 Domene, HM; Bengolea, SV; Martinez, AS (B35) 2004; 350 Wit, JM; van Duyvenvoorde, HA (B37) 2012; 77 Suh, Y; Atzmon, G; Cho, MO (B61) 2008; 105 Isaksson, OG; Eden, S; Jansson, JO (B66) 1985; 47 Ohlsson, C; Nilsson, A; Isaksson, O; Lindahl, A (B69) 1992; 89 Chang, SC; Erwin, AE; Lee, AS (B3) 1989; 9 Reddy, RK; Lu, J; Lee, AS (B6) 1999; 274 Ostrovsky, O; Ahmed, NT; Argon, Y (B9) 2009; 20 Burkhardt (2020071611564878500_B34) 2015; 28 Besson (2020071611564878500_B26) 2003; 88 Ostrovsky (2020071611564878500_B12) 2009; 106 Krzisnik (2020071611564878500_B23) 2010; 7 Biswas (2020071611564878500_B38) 2007; 405 Ostrovsky (2020071611564878500_B2) 2010; 1803 Woods (2020071611564878500_B31) 1996; 335 Yeap (2020071611564878500_B42) 2011; 164 Dollins (2020071611564878500_B47) 2007; 28 Hughes (2020071611564878500_B40) 2012; 20 Schulte (2020071611564878500_B10) 1999; 13 Guevara-Aguirre (2020071611564878500_B28) 2011; 3 Fichter (2020071611564878500_B62) 1986; 17 Ostrovsky (2020071611564878500_B9) 2009; 20 Tazearslan (2020071611564878500_B33) 2011; 10 Salvatori (2020071611564878500_B24) 1999; 84 Bonapace (2020071611564878500_B32) 2003; 40 Melnick (2020071611564878500_B5) 1994; 370 Ali (2020071611564878500_B11) 2006; 440 Wearsch (2020071611564878500_B52) 1998; 37 Marzec (2020071611564878500_B53) 2012; 1823 Suh (2020071611564878500_B61) 2008; 105 Wanderling (2020071611564878500_B1) 2007; 18 Staron (2020071611564878500_B7) 2011; 117 Milman (2020071611564878500_B45) 2014; 13 Baker (2020071611564878500_B17) 1993; 75 Kaplan (2020071611564878500_B21) 2007; 92 Wit (2020071611564878500_B37) 2012; 77 Dauber (2020071611564878500_B22) 2014; 99 Patel (2020071611564878500_B56) 2015; 58 Isaksson (2020071611564878500_B66) 1985; 47 Kofoed (2020071611564878500_B29) 2003; 349 Albrechtsen (2020071611564878500_B44) 2013; 56 Eletto (2020071611564878500_B13) 2012; 125 Soldano (2020071611564878500_B46) 2003; 278 Reddy (2020071611564878500_B6) 1999; 274 Laron (2020071611564878500_B27) 2004; 89 Yakar (2020071611564878500_B51) 2002; 110 Yang (2020071611564878500_B8) 2007; 26 Romero (2020071611564878500_B19) 2012; 32 Belfiore (2020071611564878500_B14) 2009; 30 Teglund (2020071611564878500_B18) 1998; 93 Duerfeldt (2020071611564878500_B55) 2012; 134 Schlechter (2020071611564878500_B68) 1986; 83 Vogen (2020071611564878500_B48) 2002; 277 Gicquel (2020071611564878500_B59) 2006; 65 Norman (2020071611564878500_B49) 2009; 38 Ohlsson (2020071611564878500_B69) 1992; 89 Chang (2020071611564878500_B3) 1989; 9 Barton (2020071611564878500_B4) 2012; 26 Fuqua (2020071611564878500_B30) 2012; 78 Montarras (2020071611564878500_B16) 1996; 109 Berelowitz (2020071611564878500_B20) 1981; 212 Patel (2020071611564878500_B57) 2013; 9 Walenkamp (2020071611564878500_B58) 2005; 90 Isaksson (2020071611564878500_B70) 1982; 216 Udy (2020071611564878500_B65) 1997; 94 Isgaard (2020071611564878500_B71) 1986; 250 Ketha (2020071611564878500_B50) 2015; 81 Yakar (2020071611564878500_B15) 2005; 20 Gidalevitz (2020071611564878500_B39) 2004; 279 Yeap (2020071611564878500_B41) 2010; 162 Barzilai (2020071611564878500_B43) 2003; 290 Baumann (2020071611564878500_B25) 1997; 423 Begemann (2020071611564878500_B60) 2015; 373 Russell (2020071611564878500_B67) 1985; 116 2020071611564878500_B36 Rosser (2020071611564878500_B54) 2000; 275 Domene (2020071611564878500_B35) 2004; 350 Gianotti (2020071611564878500_B63) 2002; 7 Brooks (2020071611564878500_B64) 2010; 6 |
| References_xml | – volume: 28 start-page: 41 year: 2007 end-page: 56 ident: B47 article-title: Structures of GRP94-nucleotide complexes reveal mechanistic differences between the hsp90 chaperones publication-title: Mol Cell contributor: fullname: Dollins, DE; Warren, JJ; Immormino, RM; Gewirth, DT – volume: 20 start-page: 3298 year: 2012 end-page: 3305 ident: B40 article-title: A highly selective Hsp90 affinity chromatography resin with a cleavable linker publication-title: Bioorg Med Chem contributor: fullname: Hughes, PF; Barrott, JJ; Carlson, DA – volume: 81 start-page: 93 year: 2015 end-page: 98 ident: B50 article-title: Clinical assays for quantitation of insulin-like-growth-factor-1 (IGF1) publication-title: Methods contributor: fullname: Ketha, H; Singh, RJ – volume: 93 start-page: 841 year: 1998 end-page: 850 ident: B18 article-title: Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses publication-title: Cell contributor: fullname: Teglund, S; McKay, C; Schuetz, E – volume: 65 start-page: 28 year: 2006 end-page: 33 ident: B59 article-title: Hormonal regulation of fetal growth publication-title: Horm Res contributor: fullname: Gicquel, C; Le Bouc, Y – volume: 56 start-page: 298 year: 2013 end-page: 310 ident: B44 article-title: Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes publication-title: Diabetologia contributor: fullname: Albrechtsen, A; Grarup, N; Li, Y – volume: 89 start-page: 1031 year: 2004 end-page: 1044 ident: B27 article-title: Laron syndrome (primary growth hormone resistance or insensitivity): the personal experience 1958–2003 publication-title: J Clin Endocrinol Metab contributor: fullname: Laron, Z – volume: 216 start-page: 1237 year: 1982 end-page: 1239 ident: B70 article-title: Growth hormone stimulates longitudinal bone growth directly publication-title: Science contributor: fullname: Isaksson, OG; Jansson, JO; Gause, IA – volume: 7 start-page: 357 year: 2010 end-page: 362 ident: B23 article-title: Longevity of the hypopituitary patients from the island Krk: a follow-up study publication-title: Pediatr Endocrinol Rev contributor: fullname: Krzisnik, C; Grguric, S; Cvijovic, K; Laron, Z – volume: 349 start-page: 1139 year: 2003 end-page: 1147 ident: B29 article-title: Growth hormone insensitivity associated with a STAT5b mutation publication-title: N Engl J Med contributor: fullname: Kofoed, EM; Hwa, V; Little, B – volume: 250 start-page: E367 year: 1986 end-page: E372 ident: B71 article-title: Effects of local administration of GH and IGF-1 on longitudinal bone growth in rats publication-title: Am J Physiol contributor: fullname: Isgaard, J; Nilsson, A; Lindahl, A; Jansson, JO; Isaksson, OG – volume: 335 start-page: 1363 year: 1996 end-page: 1367 ident: B31 article-title: Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene publication-title: N Engl J Med contributor: fullname: Woods, KA; Camacho-Hubner, C; Savage, MO; Clark, AJ – volume: 17 start-page: 61 year: 1986 end-page: 72 ident: B62 article-title: Weight loss causes neuroendocrine disturbances: experimental study in healthy starving subjects publication-title: Psychiatry Res contributor: fullname: Fichter, MM; Pirke, KM; Holsboer, F – volume: 20 start-page: 251 year: 2005 end-page: 254 ident: B15 article-title: The growth hormone-insulin like growth factor axis revisited: lessons from IGF-1 and IGF-1 receptor gene targeting publication-title: Pediatr Nephrol contributor: fullname: Yakar, S; Kim, H; Zhao, H – volume: 275 start-page: 22798 year: 2000 end-page: 22805 ident: B54 article-title: Ligand interactions in the adenosine nucleotide-binding domain of the Hsp90 chaperone, GRP94. I. Evidence for allosteric regulation of ligand binding publication-title: J Biol Chem contributor: fullname: Rosser, MF; Nicchitta, CV – volume: 13 start-page: 1435 year: 1999 end-page: 1448 ident: B10 article-title: Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones publication-title: Mol Endocrinol contributor: fullname: Schulte, TW; Akinaga, S; Murakata, T – volume: 109 start-page: 551 year: 1996 end-page: 560 ident: B16 article-title: Autonomous differentiation in the mouse myogenic cell line, C2, involves a mutual positive control between insulin-like growth factor II and MyoD, operating as early as at the myoblast stage publication-title: J Cell Sci contributor: fullname: Montarras, D; Aurade, F; Johnson, TJ; Gros, F; Pinset, C – volume: 277 start-page: 40742 year: 2002 end-page: 40750 ident: B48 article-title: Radicicol-sensitive peptide binding to the N-terminal portion of GRP94 publication-title: J Biol Chem contributor: fullname: Vogen, S; Gidalevitz, T; Biswas, C – volume: 88 start-page: 3664 year: 2003 end-page: 3667 ident: B26 article-title: Reduced longevity in untreated patients with isolated growth hormone deficiency publication-title: J Clin Endocrinol Metab contributor: fullname: Besson, A; Salemi, S; Gallati, S – volume: 117 start-page: 7136 year: 2011 end-page: 7144 ident: B7 article-title: Heat-shock protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V complex publication-title: Blood contributor: fullname: Staron, M; Wu, S; Hong, F – volume: 77 start-page: 320 year: 2012 end-page: 333 ident: B37 article-title: Genetic analysis of short children with apparent growth hormone insensitivity publication-title: Horm Res Paediatr contributor: fullname: Wit, JM; van Duyvenvoorde, HA – volume: 13 start-page: 769 year: 2014 end-page: 771 ident: B45 article-title: Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity publication-title: Aging Cell contributor: fullname: Milman, S; Atzmon, G; Huffman, DM – volume: 350 start-page: 570 year: 2004 end-page: 577 ident: B35 article-title: Deficiency of the circulating insulin-like growth factor system associated with inactivation of the acid-labile subunit gene publication-title: N Engl J Med contributor: fullname: Domene, HM; Bengolea, SV; Martinez, AS – volume: 423 start-page: 33 year: 1997 end-page: 38 ident: B25 article-title: The Dwarfs of Sindh: severe growth hormone (GH) deficiency caused by a mutation in the GH-releasing hormone receptor gene publication-title: Acta Paediatr Suppl contributor: fullname: Baumann, G; Maheshwari, H – volume: 90 start-page: 2855 year: 2005 end-page: 2864 ident: B58 article-title: Homozygous and heterozygous expression of a novel insulin-like growth factor-I mutation publication-title: J Clin Endocrinol Metab contributor: fullname: Walenkamp, MJ; Karperien, M; Pereira, AM – volume: 78 start-page: 59 year: 2012 end-page: 66 ident: B30 article-title: Identification of a novel heterozygous IGF1 splicing mutation in a large kindred with familial short stature publication-title: Horm Res Paediatr contributor: fullname: Fuqua, JS; Derr, M; Rosenfeld, RG; Hwa, V – volume: 279 start-page: 16543 year: 2004 end-page: 16552 ident: B39 article-title: Identification of the N-terminal peptide binding site of glucose-regulated protein 94 publication-title: J Biol Chem contributor: fullname: Gidalevitz, T; Biswas, C; Ding, H – volume: 290 start-page: 2030 year: 2003 end-page: 2040 ident: B43 article-title: Unique lipoprotein phenotype and genotype associated with exceptional longevity publication-title: JAMA contributor: fullname: Barzilai, N; Atzmon, G; Schechter, C – volume: 47 start-page: 483 year: 1985 end-page: 499 ident: B66 article-title: Mode of action of pituitary growth hormone on target cells publication-title: Annu Rev Physiol contributor: fullname: Isaksson, OG; Eden, S; Jansson, JO – volume: 162 start-page: 249 year: 2010 end-page: 257 ident: B41 article-title: IGF1 and its binding proteins 3 and 1 are differentially associated with metabolic syndrome in older men publication-title: Eur J Endocrinol contributor: fullname: Yeap, BB; Chubb, SA; Ho, KK – volume: 83 start-page: 7932 year: 1986 end-page: 7934 ident: B68 article-title: Evidence suggesting that the direct growth-promoting effect of growth hormone on cartilage in vivo is mediated by local production of somatomedin publication-title: Proc Natl Acad Sci USA contributor: fullname: Schlechter, NL; Russell, SM; Spencer, EM; Nicoll, CS – volume: 89 start-page: 9826 year: 1992 end-page: 9830 ident: B69 article-title: Growth hormone induces multiplication of the slowly cycling germinal cells of the rat tibial growth plate publication-title: Proc Natl Acad Sci USA contributor: fullname: Ohlsson, C; Nilsson, A; Isaksson, O; Lindahl, A – volume: 32 start-page: 4258 year: 2012 end-page: 4269 ident: B19 article-title: Insulin-like growth factor 1 mediates negative feedback to somatotroph GH expression via POU1F1/CREB binding protein interactions publication-title: Mol Cell Biol contributor: fullname: Romero, CJ; Pine-Twaddell, E; Sima, DI – volume: 125 start-page: 4865 year: 2012 end-page: 4875 ident: B13 article-title: Limitation of individual folding resources in the ER leads to outcomes distinct from the unfolded protein response publication-title: J Cell Sci contributor: fullname: Eletto, D; Maganty, A; Eletto, D – volume: 212 start-page: 1279 year: 1981 end-page: 1281 ident: B20 article-title: Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary publication-title: Science contributor: fullname: Berelowitz, M; Szabo, M; Frohman, LA; Firestone, S; Chu, L; Hintz, RL – volume: 110 start-page: 771 year: 2002 end-page: 781 ident: B51 article-title: Circulating levels of IGF-1 directly regulate bone growth and density publication-title: J Clin Invest contributor: fullname: Yakar, S; Rosen, CJ; Beamer, WG – volume: 20 start-page: 1855 year: 2009 end-page: 1864 ident: B9 article-title: The chaperone activity of GRP94 toward insulin-like growth factor II is necessary for the stress response to serum deprivation publication-title: Mol Biol Cell contributor: fullname: Ostrovsky, O; Ahmed, NT; Argon, Y – volume: 1803 start-page: 333 year: 2010 end-page: 341 ident: B2 article-title: Glucose regulated protein 94 is required for muscle differentiation through its control of the autocrine production of insulin-like growth factors publication-title: Biochim Biophys Acta contributor: fullname: Ostrovsky, O; Eletto, D; Makarewich, C; Barton, ER; Argon, Y – volume: 116 start-page: 2563 year: 1985 end-page: 2567 ident: B67 article-title: Local injections of human or rat growth hormone or of purified human somatomedin-C stimulate unilateral tibial epiphyseal growth in hypophysectomized rats publication-title: Endocrinology contributor: fullname: Russell, SM; Spencer, EM – volume: 274 start-page: 28476 year: 1999 end-page: 28483 ident: B6 article-title: The endoplasmic reticulum chaperone glycoprotein GRP94 with Ca(2+)-binding and antiapoptotic properties is a novel proteolytic target of calpain during etoposide-induced apoptosis publication-title: J Biol Chem contributor: fullname: Reddy, RK; Lu, J; Lee, AS – volume: 106 start-page: 11600 year: 2009 end-page: 11605 ident: B12 article-title: An essential role for ATP binding and hydrolysis in the chaperone activity of GRP94 in cells publication-title: Proc Natl Acad Sci USA contributor: fullname: Ostrovsky, O; Makarewich, CA; Snapp, EL; Argon, Y – volume: 9 start-page: 677 year: 2013 end-page: 684 ident: B57 article-title: Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2 publication-title: Nat Chem Biol contributor: fullname: Patel, PD; Yan, P; Seidler, PM – volume: 37 start-page: 5709 year: 1998 end-page: 5719 ident: B52 article-title: Structural transitions accompanying the activation of peptide binding to the endoplasmic reticulum Hsp90 chaperone GRP94 publication-title: Biochemistry contributor: fullname: Wearsch, PA; Voglino, L; Nicchitta, CV – volume: 58 start-page: 3922 year: 2015 end-page: 3943 ident: B56 article-title: Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum hsp90 paralog grp94 publication-title: J Med Chem contributor: fullname: Patel, HJ; Patel, PD; Ochiana, SO – volume: 84 start-page: 917 year: 1999 end-page: 923 ident: B24 article-title: Familial dwarfism due to a novel mutation of the growth hormone-releasing hormone receptor gene publication-title: J Clin Endocrinol Metab contributor: fullname: Salvatori, R; Hayashida, CY; Aguiar-Oliveira, MH – volume: 440 start-page: 1013 year: 2006 end-page: 1017 ident: B11 article-title: Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex publication-title: Nature contributor: fullname: Ali, MM; Roe, SM; Vaughan, CK – volume: 373 start-page: 349 year: 2015 end-page: 356 ident: B60 article-title: Paternally inherited IGF2 mutation and growth restriction publication-title: N Engl J Med contributor: fullname: Begemann, M; Zirn, B; Santen, G – volume: 94 start-page: 7239 year: 1997 end-page: 7244 ident: B65 article-title: Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression publication-title: Proc Natl Acad Sci USA contributor: fullname: Udy, GB; Towers, RP; Snell, RG – volume: 30 start-page: 586 year: 2009 end-page: 623 ident: B14 article-title: Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease publication-title: Endocr Rev contributor: fullname: Belfiore, A; Frasca, F; Pandini, G; Sciacca, L; Vigneri, R – volume: 7 start-page: 94 year: 2002 end-page: 105 ident: B63 article-title: GH/IGF-1 axis in anorexia nervosa publication-title: Eat Weight Disord contributor: fullname: Gianotti, L; Lanfranco, F; Ramunni, J; Destefanis, S; Ghigo, E; Arvat, E – volume: 26 start-page: 215 year: 2007 end-page: 226 ident: B8 article-title: Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages publication-title: Immunity contributor: fullname: Yang, Y; Liu, B; Dai, J – volume: 1823 start-page: 774 year: 2012 end-page: 787 ident: B53 article-title: GRP94: an HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum publication-title: Biochim Biophys Acta contributor: fullname: Marzec, M; Eletto, D; Argon, Y – volume: 10 start-page: 551 year: 2011 end-page: 554 ident: B33 article-title: Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles publication-title: Aging Cell contributor: fullname: Tazearslan, C; Huang, J; Barzilai, N; Suh, Y – volume: 405 start-page: 233 year: 2007 end-page: 241 ident: B38 article-title: The peptide-binding activity of GRP94 is regulated by calcium publication-title: Biochem J contributor: fullname: Biswas, C; Ostrovsky, O; Makarewich, CA; Wanderling, S; Gidalevitz, T; Argon, Y – volume: 28 start-page: 217 year: 2015 end-page: 225 ident: B34 article-title: Novel heterozygous IGF1R mutation in two brothers with developing impaired glucose tolerance publication-title: J Pediatr Endocrinol Metab contributor: fullname: Burkhardt, S; Gesing, J; Kapellen, TM – volume: 38 start-page: 48 year: 2009 end-page: 52 ident: B49 article-title: Cohort profile: The Health In Men Study (HIMS) publication-title: Int J Epidemiol contributor: fullname: Norman, PE; Flicker, L; Almeida, OP; Hankey, GJ; Hyde, Z; Jamrozik, K – volume: 75 start-page: 73 year: 1993 end-page: 82 ident: B17 article-title: Role of insulin-like growth factors in embryonic and postnatal growth publication-title: Cell contributor: fullname: Baker, J; Liu, JP; Robertson, EJ; Efstratiadis, A – volume: 18 start-page: 3764 year: 2007 end-page: 3775 ident: B1 article-title: GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion publication-title: Mol Biol Cell contributor: fullname: Wanderling, S; Simen, BB; Ostrovsky, O – volume: 164 start-page: 715 year: 2011 end-page: 723 ident: B42 article-title: Associations of IGF1 and IGFBPs 1 and 3 with all-cause and cardiovascular mortality in older men: the Health In Men Study publication-title: Eur J Endocrinol contributor: fullname: Yeap, BB; Chubb, SA; McCaul, KA – volume: 105 start-page: 3438 year: 2008 end-page: 3442 ident: B61 article-title: Functionally significant insulin-like growth factor I receptor mutations in centenarians publication-title: Proc Natl Acad Sci USA contributor: fullname: Suh, Y; Atzmon, G; Cho, MO – volume: 370 start-page: 373 year: 1994 end-page: 375 ident: B5 article-title: Sequential interaction of the chaperones BiP and GRP94 with immunoglobulin chains in the endoplasmic reticulum publication-title: Nature contributor: fullname: Melnick, J; Dul, JL; Argon, Y – volume: 3 start-page: 70ra13 year: 2011 ident: B28 article-title: Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans publication-title: Sci Transl Med contributor: fullname: Guevara-Aguirre, J; Balasubramanian, P; Guevara-Aguirre, M – volume: 6 start-page: 515 year: 2010 end-page: 525 ident: B64 article-title: The growth hormone receptor: mechanism of activation and clinical implications publication-title: Nat Rev Endocrinol contributor: fullname: Brooks, AJ; Waters, MJ – volume: 99 start-page: 3080 year: 2014 end-page: 3092 ident: B22 article-title: Genetic evaluation of short stature publication-title: J Clin Endocrinol Metab contributor: fullname: Dauber, A; Rosenfeld, RG; Hirschhorn, JN – volume: 278 start-page: 48330 year: 2003 end-page: 48338 ident: B46 article-title: Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation publication-title: J Biol Chem contributor: fullname: Soldano, KL; Jivan, A; Nicchitta, CV; Gewirth, DT – volume: 26 start-page: 3691 year: 2012 end-page: 3702 ident: B4 article-title: Deletion of muscle GRP94 impairs both muscle and body growth by inhibiting local IGF production publication-title: FASEB J contributor: fullname: Barton, ER; Park, S; James, JK – volume: 40 start-page: 913 year: 2003 end-page: 917 ident: B32 article-title: A novel mutation in a patient with insulin-like growth factor 1 (IGF1) deficiency publication-title: J Med Genet contributor: fullname: Bonapace, G; Concolino, D; Formicola, S; Strisciuglio, P – volume: 92 start-page: 4529 year: 2007 end-page: 4535 ident: B21 article-title: The somatomedin hypothesis 2007: 50 years later publication-title: J Clin Endocrinol Metab contributor: fullname: Kaplan, SA; Cohen, P – volume: 134 start-page: 9796 year: 2012 end-page: 9804 ident: B55 article-title: Development of a Grp94 inhibitor publication-title: J Am Chem Soc contributor: fullname: Duerfeldt, AS; Peterson, LB; Maynard, JC – volume: 9 start-page: 2153 year: 1989 end-page: 2162 ident: B3 article-title: Glucose-regulated protein (GRP94 and GRP78) genes share common regulatory domains and are coordinately regulated by common trans-acting factors publication-title: Mol Cell Biol contributor: fullname: Chang, SC; Erwin, AE; Lee, AS – volume: 28 start-page: 217 year: 2015 ident: 2020071611564878500_B34 article-title: Novel heterozygous IGF1R mutation in two brothers with developing impaired glucose tolerance publication-title: J Pediatr Endocrinol Metab doi: 10.1515/jpem-2014-0132 contributor: fullname: Burkhardt – volume: 65 start-page: 28 year: 2006 ident: 2020071611564878500_B59 article-title: Hormonal regulation of fetal growth publication-title: Horm Res contributor: fullname: Gicquel – volume: 109 start-page: 551 issue: Pt 3 year: 1996 ident: 2020071611564878500_B16 article-title: Autonomous differentiation in the mouse myogenic cell line, C2, involves a mutual positive control between insulin-like growth factor II and MyoD, operating as early as at the myoblast stage publication-title: J Cell Sci doi: 10.1242/jcs.109.3.551 contributor: fullname: Montarras – volume: 13 start-page: 769 year: 2014 ident: 2020071611564878500_B45 article-title: Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity publication-title: Aging Cell doi: 10.1111/acel.12213 contributor: fullname: Milman – volume: 47 start-page: 483 year: 1985 ident: 2020071611564878500_B66 article-title: Mode of action of pituitary growth hormone on target cells publication-title: Annu Rev Physiol doi: 10.1146/annurev.ph.47.030185.002411 contributor: fullname: Isaksson – volume: 38 start-page: 48 year: 2009 ident: 2020071611564878500_B49 article-title: Cohort profile: The Health In Men Study (HIMS) publication-title: Int J Epidemiol doi: 10.1093/ije/dyn041 contributor: fullname: Norman – volume: 40 start-page: 913 year: 2003 ident: 2020071611564878500_B32 article-title: A novel mutation in a patient with insulin-like growth factor 1 (IGF1) deficiency publication-title: J Med Genet doi: 10.1136/jmg.40.12.913 contributor: fullname: Bonapace – volume: 30 start-page: 586 year: 2009 ident: 2020071611564878500_B14 article-title: Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease publication-title: Endocr Rev doi: 10.1210/er.2008-0047 contributor: fullname: Belfiore – volume: 164 start-page: 715 year: 2011 ident: 2020071611564878500_B42 article-title: Associations of IGF1 and IGFBPs 1 and 3 with all-cause and cardiovascular mortality in older men: the Health In Men Study publication-title: Eur J Endocrinol doi: 10.1530/EJE-11-0059 contributor: fullname: Yeap – volume: 106 start-page: 11600 year: 2009 ident: 2020071611564878500_B12 article-title: An essential role for ATP binding and hydrolysis in the chaperone activity of GRP94 in cells publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0902626106 contributor: fullname: Ostrovsky – volume: 110 start-page: 771 year: 2002 ident: 2020071611564878500_B51 article-title: Circulating levels of IGF-1 directly regulate bone growth and density publication-title: J Clin Invest doi: 10.1172/JCI0215463 contributor: fullname: Yakar – volume: 89 start-page: 9826 year: 1992 ident: 2020071611564878500_B69 article-title: Growth hormone induces multiplication of the slowly cycling germinal cells of the rat tibial growth plate publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.89.20.9826 contributor: fullname: Ohlsson – volume: 370 start-page: 373 year: 1994 ident: 2020071611564878500_B5 article-title: Sequential interaction of the chaperones BiP and GRP94 with immunoglobulin chains in the endoplasmic reticulum publication-title: Nature doi: 10.1038/370373a0 contributor: fullname: Melnick – volume: 274 start-page: 28476 year: 1999 ident: 2020071611564878500_B6 article-title: The endoplasmic reticulum chaperone glycoprotein GRP94 with Ca(2+)-binding and antiapoptotic properties is a novel proteolytic target of calpain during etoposide-induced apoptosis publication-title: J Biol Chem doi: 10.1074/jbc.274.40.28476 contributor: fullname: Reddy – volume: 275 start-page: 22798 year: 2000 ident: 2020071611564878500_B54 article-title: Ligand interactions in the adenosine nucleotide-binding domain of the Hsp90 chaperone, GRP94. I. Evidence for allosteric regulation of ligand binding publication-title: J Biol Chem doi: 10.1074/jbc.M001477200 contributor: fullname: Rosser – volume: 440 start-page: 1013 year: 2006 ident: 2020071611564878500_B11 article-title: Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex publication-title: Nature doi: 10.1038/nature04716 contributor: fullname: Ali – volume: 88 start-page: 3664 year: 2003 ident: 2020071611564878500_B26 article-title: Reduced longevity in untreated patients with isolated growth hormone deficiency publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2002-021938 contributor: fullname: Besson – volume: 28 start-page: 41 year: 2007 ident: 2020071611564878500_B47 article-title: Structures of GRP94-nucleotide complexes reveal mechanistic differences between the hsp90 chaperones publication-title: Mol Cell doi: 10.1016/j.molcel.2007.08.024 contributor: fullname: Dollins – volume: 9 start-page: 677 year: 2013 ident: 2020071611564878500_B57 article-title: Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2 publication-title: Nat Chem Biol doi: 10.1038/nchembio.1335 contributor: fullname: Patel – volume: 1803 start-page: 333 year: 2010 ident: 2020071611564878500_B2 article-title: Glucose regulated protein 94 is required for muscle differentiation through its control of the autocrine production of insulin-like growth factors publication-title: Biochim Biophys Acta doi: 10.1016/j.bbamcr.2009.11.005 contributor: fullname: Ostrovsky – volume: 117 start-page: 7136 year: 2011 ident: 2020071611564878500_B7 article-title: Heat-shock protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V complex publication-title: Blood doi: 10.1182/blood-2011-01-330464 contributor: fullname: Staron – volume: 17 start-page: 61 year: 1986 ident: 2020071611564878500_B62 article-title: Weight loss causes neuroendocrine disturbances: experimental study in healthy starving subjects publication-title: Psychiatry Res doi: 10.1016/0165-1781(86)90042-9 contributor: fullname: Fichter – volume: 20 start-page: 251 year: 2005 ident: 2020071611564878500_B15 article-title: The growth hormone-insulin like growth factor axis revisited: lessons from IGF-1 and IGF-1 receptor gene targeting publication-title: Pediatr Nephrol doi: 10.1007/s00467-004-1613-y contributor: fullname: Yakar – volume: 423 start-page: 33 year: 1997 ident: 2020071611564878500_B25 article-title: The Dwarfs of Sindh: severe growth hormone (GH) deficiency caused by a mutation in the GH-releasing hormone receptor gene publication-title: Acta Paediatr Suppl doi: 10.1111/j.1651-2227.1997.tb18366.x contributor: fullname: Baumann – volume: 26 start-page: 3691 year: 2012 ident: 2020071611564878500_B4 article-title: Deletion of muscle GRP94 impairs both muscle and body growth by inhibiting local IGF production publication-title: FASEB J doi: 10.1096/fj.11-203026 contributor: fullname: Barton – volume: 93 start-page: 841 year: 1998 ident: 2020071611564878500_B18 article-title: Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses publication-title: Cell doi: 10.1016/S0092-8674(00)81444-0 contributor: fullname: Teglund – volume: 90 start-page: 2855 year: 2005 ident: 2020071611564878500_B58 article-title: Homozygous and heterozygous expression of a novel insulin-like growth factor-I mutation publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2004-1254 contributor: fullname: Walenkamp – volume: 56 start-page: 298 year: 2013 ident: 2020071611564878500_B44 article-title: Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes publication-title: Diabetologia doi: 10.1007/s00125-012-2756-1 contributor: fullname: Albrechtsen – volume: 20 start-page: 1855 year: 2009 ident: 2020071611564878500_B9 article-title: The chaperone activity of GRP94 toward insulin-like growth factor II is necessary for the stress response to serum deprivation publication-title: Mol Biol Cell doi: 10.1091/mbc.e08-04-0346 contributor: fullname: Ostrovsky – volume: 212 start-page: 1279 year: 1981 ident: 2020071611564878500_B20 article-title: Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary publication-title: Science doi: 10.1126/science.6262917 contributor: fullname: Berelowitz – volume: 84 start-page: 917 year: 1999 ident: 2020071611564878500_B24 article-title: Familial dwarfism due to a novel mutation of the growth hormone-releasing hormone receptor gene publication-title: J Clin Endocrinol Metab contributor: fullname: Salvatori – volume: 77 start-page: 320 year: 2012 ident: 2020071611564878500_B37 article-title: Genetic analysis of short children with apparent growth hormone insensitivity publication-title: Horm Res Paediatr doi: 10.1159/000338462 contributor: fullname: Wit – volume: 9 start-page: 2153 year: 1989 ident: 2020071611564878500_B3 article-title: Glucose-regulated protein (GRP94 and GRP78) genes share common regulatory domains and are coordinately regulated by common trans-acting factors publication-title: Mol Cell Biol doi: 10.1128/MCB.9.5.2153 contributor: fullname: Chang – volume: 20 start-page: 3298 year: 2012 ident: 2020071611564878500_B40 article-title: A highly selective Hsp90 affinity chromatography resin with a cleavable linker publication-title: Bioorg Med Chem doi: 10.1016/j.bmc.2012.03.043 contributor: fullname: Hughes – volume: 37 start-page: 5709 year: 1998 ident: 2020071611564878500_B52 article-title: Structural transitions accompanying the activation of peptide binding to the endoplasmic reticulum Hsp90 chaperone GRP94 publication-title: Biochemistry doi: 10.1021/bi9801006 contributor: fullname: Wearsch – volume: 373 start-page: 349 year: 2015 ident: 2020071611564878500_B60 article-title: Paternally inherited IGF2 mutation and growth restriction publication-title: N Engl J Med doi: 10.1056/NEJMoa1415227 contributor: fullname: Begemann – volume: 26 start-page: 215 year: 2007 ident: 2020071611564878500_B8 article-title: Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages publication-title: Immunity doi: 10.1016/j.immuni.2006.12.005 contributor: fullname: Yang – volume: 125 start-page: 4865 year: 2012 ident: 2020071611564878500_B13 article-title: Limitation of individual folding resources in the ER leads to outcomes distinct from the unfolded protein response publication-title: J Cell Sci doi: 10.1242/jcs.108928 contributor: fullname: Eletto – volume: 58 start-page: 3922 year: 2015 ident: 2020071611564878500_B56 article-title: Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum hsp90 paralog grp94 publication-title: J Med Chem doi: 10.1021/acs.jmedchem.5b00197 contributor: fullname: Patel – volume: 7 start-page: 94 year: 2002 ident: 2020071611564878500_B63 article-title: GH/IGF-1 axis in anorexia nervosa publication-title: Eat Weight Disord doi: 10.1007/BF03354435 contributor: fullname: Gianotti – volume: 10 start-page: 551 year: 2011 ident: 2020071611564878500_B33 article-title: Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles publication-title: Aging Cell doi: 10.1111/j.1474-9726.2011.00697.x contributor: fullname: Tazearslan – volume: 78 start-page: 59 year: 2012 ident: 2020071611564878500_B30 article-title: Identification of a novel heterozygous IGF1 splicing mutation in a large kindred with familial short stature publication-title: Horm Res Paediatr doi: 10.1159/000337249 contributor: fullname: Fuqua – volume: 350 start-page: 570 year: 2004 ident: 2020071611564878500_B35 article-title: Deficiency of the circulating insulin-like growth factor system associated with inactivation of the acid-labile subunit gene publication-title: N Engl J Med doi: 10.1056/NEJMoa013100 contributor: fullname: Domene – volume: 92 start-page: 4529 year: 2007 ident: 2020071611564878500_B21 article-title: The somatomedin hypothesis 2007: 50 years later publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2007-0526 contributor: fullname: Kaplan – volume: 99 start-page: 3080 year: 2014 ident: 2020071611564878500_B22 article-title: Genetic evaluation of short stature publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2014-1506 contributor: fullname: Dauber – volume: 7 start-page: 357 year: 2010 ident: 2020071611564878500_B23 article-title: Longevity of the hypopituitary patients from the island Krk: a follow-up study publication-title: Pediatr Endocrinol Rev contributor: fullname: Krzisnik – volume: 162 start-page: 249 year: 2010 ident: 2020071611564878500_B41 article-title: IGF1 and its binding proteins 3 and 1 are differentially associated with metabolic syndrome in older men publication-title: Eur J Endocrinol doi: 10.1530/EJE-09-0852 contributor: fullname: Yeap – volume: 6 start-page: 515 year: 2010 ident: 2020071611564878500_B64 article-title: The growth hormone receptor: mechanism of activation and clinical implications publication-title: Nat Rev Endocrinol doi: 10.1038/nrendo.2010.123 contributor: fullname: Brooks – volume: 83 start-page: 7932 year: 1986 ident: 2020071611564878500_B68 article-title: Evidence suggesting that the direct growth-promoting effect of growth hormone on cartilage in vivo is mediated by local production of somatomedin publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.83.20.7932 contributor: fullname: Schlechter – volume: 278 start-page: 48330 year: 2003 ident: 2020071611564878500_B46 article-title: Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation publication-title: J Biol Chem doi: 10.1074/jbc.M308661200 contributor: fullname: Soldano – volume: 32 start-page: 4258 year: 2012 ident: 2020071611564878500_B19 article-title: Insulin-like growth factor 1 mediates negative feedback to somatotroph GH expression via POU1F1/CREB binding protein interactions publication-title: Mol Cell Biol doi: 10.1128/MCB.00171-12 contributor: fullname: Romero – volume: 277 start-page: 40742 year: 2002 ident: 2020071611564878500_B48 article-title: Radicicol-sensitive peptide binding to the N-terminal portion of GRP94 publication-title: J Biol Chem doi: 10.1074/jbc.M205323200 contributor: fullname: Vogen – volume: 405 start-page: 233 year: 2007 ident: 2020071611564878500_B38 article-title: The peptide-binding activity of GRP94 is regulated by calcium publication-title: Biochem J doi: 10.1042/BJ20061867 contributor: fullname: Biswas – volume: 216 start-page: 1237 year: 1982 ident: 2020071611564878500_B70 article-title: Growth hormone stimulates longitudinal bone growth directly publication-title: Science doi: 10.1126/science.7079756 contributor: fullname: Isaksson – volume: 349 start-page: 1139 year: 2003 ident: 2020071611564878500_B29 article-title: Growth hormone insensitivity associated with a STAT5b mutation publication-title: N Engl J Med doi: 10.1056/NEJMoa022926 contributor: fullname: Kofoed – volume: 290 start-page: 2030 year: 2003 ident: 2020071611564878500_B43 article-title: Unique lipoprotein phenotype and genotype associated with exceptional longevity publication-title: JAMA doi: 10.1001/jama.290.15.2030 contributor: fullname: Barzilai – volume: 105 start-page: 3438 year: 2008 ident: 2020071611564878500_B61 article-title: Functionally significant insulin-like growth factor I receptor mutations in centenarians publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0705467105 contributor: fullname: Suh – volume: 94 start-page: 7239 year: 1997 ident: 2020071611564878500_B65 article-title: Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.94.14.7239 contributor: fullname: Udy – volume: 81 start-page: 93 year: 2015 ident: 2020071611564878500_B50 article-title: Clinical assays for quantitation of insulin-like-growth-factor-1 (IGF1) publication-title: Methods doi: 10.1016/j.ymeth.2015.04.029 contributor: fullname: Ketha – volume: 75 start-page: 73 year: 1993 ident: 2020071611564878500_B17 article-title: Role of insulin-like growth factors in embryonic and postnatal growth publication-title: Cell doi: 10.1016/S0092-8674(05)80085-6 contributor: fullname: Baker – volume: 1823 start-page: 774 year: 2012 ident: 2020071611564878500_B53 article-title: GRP94: an HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum publication-title: Biochim Biophys Acta doi: 10.1016/j.bbamcr.2011.10.013 contributor: fullname: Marzec – volume: 250 start-page: E367 year: 1986 ident: 2020071611564878500_B71 article-title: Effects of local administration of GH and IGF-1 on longitudinal bone growth in rats publication-title: Am J Physiol contributor: fullname: Isgaard – volume: 18 start-page: 3764 year: 2007 ident: 2020071611564878500_B1 article-title: GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion publication-title: Mol Biol Cell doi: 10.1091/mbc.e07-03-0275 contributor: fullname: Wanderling – ident: 2020071611564878500_B36 doi: 10.1159/000355543 – volume: 335 start-page: 1363 year: 1996 ident: 2020071611564878500_B31 article-title: Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene publication-title: N Engl J Med doi: 10.1056/NEJM199610313351805 contributor: fullname: Woods – volume: 3 start-page: 70ra13 year: 2011 ident: 2020071611564878500_B28 article-title: Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans publication-title: Sci Transl Med doi: 10.1126/scitranslmed.3001845 contributor: fullname: Guevara-Aguirre – volume: 134 start-page: 9796 year: 2012 ident: 2020071611564878500_B55 article-title: Development of a Grp94 inhibitor publication-title: J Am Chem Soc doi: 10.1021/ja303477g contributor: fullname: Duerfeldt – volume: 279 start-page: 16543 year: 2004 ident: 2020071611564878500_B39 article-title: Identification of the N-terminal peptide binding site of glucose-regulated protein 94 publication-title: J Biol Chem doi: 10.1074/jbc.M313060200 contributor: fullname: Gidalevitz – volume: 116 start-page: 2563 year: 1985 ident: 2020071611564878500_B67 article-title: Local injections of human or rat growth hormone or of purified human somatomedin-C stimulate unilateral tibial epiphyseal growth in hypophysectomized rats publication-title: Endocrinology doi: 10.1210/endo-116-6-2563 contributor: fullname: Russell – volume: 89 start-page: 1031 year: 2004 ident: 2020071611564878500_B27 article-title: Laron syndrome (primary growth hormone resistance or insensitivity): the personal experience 1958–2003 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2003-031033 contributor: fullname: Laron – volume: 13 start-page: 1435 year: 1999 ident: 2020071611564878500_B10 article-title: Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones publication-title: Mol Endocrinol doi: 10.1210/mend.13.9.0339 contributor: fullname: Schulte |
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| Snippet | IGFs are critical for normal intrauterine and childhood growth and sustaining health throughout life. We showed previously that the production of IGF-1 and... |
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| SubjectTerms | Alleles Biosynthesis Children Complementation DNA Mutational Analysis Gene Frequency Glucose Growth hormones HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - metabolism Humans Insulin-like growth factor I Insulin-like growth factors Membrane Proteins - genetics Membrane Proteins - metabolism Mutation Nucleotides Original Research Polymorphism Polymorphism, Single Nucleotide Proteins Single-nucleotide polymorphism Somatomedins - biosynthesis |
| Title | A Human Variant of Glucose-Regulated Protein 94 That Inefficiently Supports IGF Production |
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