Metabolic Reprogramming, Questioning, and Implications for Cancer

The expression "metabolic reprogramming" has been encountered more and more in the literature since the mid-1990s. It seems to encompass several notions depending on the author, but the lack of a clear definition allows it to be used as a "catch-all" expression. Our first intenti...

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Bibliographic Details
Published in:	Biology (Basel, Switzerland) Vol. 10; no. 2; p. 129
Main Authors:	Jacquet, Pierre, Stéphanou, Angélique
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 07-02-2021 MDPI
Subjects:	Acidosis Cancer cancer metabolism Communication Fermentation Gene expression Genotype & phenotype Glucose Hypoxia Life Sciences metabolic reprogramming Metabolism Phosphorylation Quantitative Methods Respiration Semantics Tumors Warburg effect cancer metabolism metabolic reprogramming Warburg effect
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Summary:	The expression "metabolic reprogramming" has been encountered more and more in the literature since the mid-1990s. It seems to encompass several notions depending on the author, but the lack of a clear definition allows it to be used as a "catch-all" expression. Our first intention is to point out the inconsistencies in the use of the reprogramming terminology for cancer metabolism. The second is to address the over-focus of the role of mutations in metabolic adaptation. With the increased interest in metabolism and, more specifically, in the Warburg effect in cancer research, it seems appropriate to discuss this terminology and related concepts in detail.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Current address: Pavillon Taillefer, Faculté de Médecine, 38700 La Tronche, France.
ISSN:	2079-7737 2079-7737
DOI:	10.3390/biology10020129