Potential Lipolytic Effect of Panduratin A Loaded Microspicule Serum as a Transdermal Delivery Approach for Subcutaneous Fat Reduction
Boesenbergia rotunda (L.) Mansf contained a potent anti-obesity agent. The objectives of this study were to investigate the anti-adipogenesis and lipolysis effects of panduratin A from B. rotunda extract and develop extract-loaded lipolytic body microspicule (MS) serum. Panduratin A that was separat...
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| Published in: | Biological & pharmaceutical bulletin Vol. 46; no. 12; pp. 1761 - 1768 |
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The Pharmaceutical Society of Japan
01-12-2023
Japan Science and Technology Agency |
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| Abstract | Boesenbergia rotunda (L.) Mansf contained a potent anti-obesity agent. The objectives of this study were to investigate the anti-adipogenesis and lipolysis effects of panduratin A from B. rotunda extract and develop extract-loaded lipolytic body microspicule (MS) serum. Panduratin A that was separated from the ethanolic extract of B. rotunda in fraction 3 (BP-3) were studied the bioactivity of 3T3-L1 preadipocyte cells. The extract-loaded MS serum was formulated and evaluated for safety and efficacy. The BP-3 extract containing panduratin A at 0.29 g per g of the extract was not toxic to the cells at concentrations lower than 10 µg/mL, and the antiadipogenesis and lipolysis effects of the BP-3 extract were strong at 10 µg/mL. To deliver bioactive panduratin A into and through the skin, MS serum was successfully formulated. Application of BP-3 extract-loaded MS serum to the human thigh for 14 d reduced the thigh circumference and increased skin hydration and firmness. Although the skin erythema was increased, no severe redness or pain was found. In conclusion, BP-3 extract acts as a potent bioactive compound to inhibit adipocyte cells, and the antiadipogenesis and lipolysis effects of BP-3 extract in MS serum might play an important role as a potential lipolytic body product for reducing human subcutaneous fat mass. |
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| AbstractList | Boesenbergia rotunda (L.) Mansf contained a potent anti-obesity agent. The objectives of this study were to investigate the anti-adipogenesis and lipolysis effects of panduratin A from B. rotunda extract and develop extract-loaded lipolytic body microspicule (MS) serum. Panduratin A that was separated from the ethanolic extract of B. rotunda in fraction 3 (BP-3) were studied the bioactivity of 3T3-L1 preadipocyte cells. The extract-loaded MS serum was formulated and evaluated for safety and efficacy. The BP-3 extract containing panduratin A at 0.29 g per g of the extract was not toxic to the cells at concentrations lower than 10 µg/mL, and the antiadipogenesis and lipolysis effects of the BP-3 extract were strong at 10 µg/mL. To deliver bioactive panduratin A into and through the skin, MS serum was successfully formulated. Application of BP-3 extract-loaded MS serum to the human thigh for 14 d reduced the thigh circumference and increased skin hydration and firmness. Although the skin erythema was increased, no severe redness or pain was found. In conclusion, BP-3 extract acts as a potent bioactive compound to inhibit adipocyte cells, and the antiadipogenesis and lipolysis effects of BP-3 extract in MS serum might play an important role as a potential lipolytic body product for reducing human subcutaneous fat mass. |
| ArticleNumber | b23-00491 |
| Author | Sritananuwat, Phaijit Rangsimawong, Worranan Opanasopit, Praneet Tansathien, Kritsanaporn Jitsaeng, Kusuma Duangjit, Sureewan |
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| Cites_doi | 10.1093/asj/sjaa226 10.4103/0970-0358.118617 10.1038/nbt.1504 10.1021/acs.molpharmaceut.7b00468 10.1016/j.bbrc.2007.08.038 10.1159/000360009 10.1016/j.ijpharm.2021.120352 10.1248/bpb.b14-00321 10.3390/foods12051014 10.1016/j.phrs.2006.03.009 10.1248/bpb.b19-00158 10.1007/s10068-013-0075-z 10.3746/pnf.2015.20.1.15 10.1007/s00441-008-0593-9 10.1111/jocd.12801 10.1016/j.micron.2007.01.006 10.1016/j.ijpharm.2011.01.034 10.5021/ad.2017.29.2.187 10.3390/molecules26216642 10.1016/j.asj.2008.07.011 10.4103/ijmr.IJMR_1910_18 10.3390/ijms13010994 |
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| SubjectTerms | Adipogenesis antiadipogenesis Bioactive compounds Biological activity Body fat Boesenbergia rotunda extract Drug delivery Erythema Hydration Lipolysis lipolytic body product microspicule panduratin A Skin |
| Title | Potential Lipolytic Effect of Panduratin A Loaded Microspicule Serum as a Transdermal Delivery Approach for Subcutaneous Fat Reduction |
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