Pyrophosphate: a key inhibitor of mineralisation

Highlights • Pyrophosphate prevents unwanted calcification making it the body's natural ‘water-softener’. • The breakdown of ATP released from cells represents a key source of extracellular pyrophosphate. • Increased extracellular pyrophosphate lead to impaired skeletal mineralisation. • Reduce...

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Bibliographic Details
Published in:	Current opinion in pharmacology Vol. 28; pp. 57 - 68
Main Authors:	Orriss, Isabel R, Arnett, Timothy R, Russell, R Graham G
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-06-2016
Subjects:	Adenosine Triphosphate - metabolism Animals Calcification, Physiologic - physiology Calcinosis - pathology Diphosphates - metabolism Gene Expression Regulation - physiology Humans Internal Medicine Medical Education Phosphoric Diester Hydrolases - metabolism Pyrophosphatases - metabolism Signal Transduction - physiology
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Summary:	Highlights • Pyrophosphate prevents unwanted calcification making it the body's natural ‘water-softener’. • The breakdown of ATP released from cells represents a key source of extracellular pyrophosphate. • Increased extracellular pyrophosphate lead to impaired skeletal mineralisation. • Reduced pyrophosphate levels can lead to many clinical disorders, for example, vascular calcification. • The drugs, bisphosphonates, are chemically stable analogues of pyrophosphate.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1471-4892 1471-4973
DOI:	10.1016/j.coph.2016.03.003