Fungal Metabolites. XVI. Structures of New Peptaibols, Trichokindins I-VII, from the Fungus Trichoderma harzianum

• Published in: Chemical & pharmaceutical bulletin Vol. 42; no. 5; pp. 1070 - 1075
• Main Authors: IIDA, Akira, SANEKATA, Masaki, FUJITA, Tetsuro, TANAKA, Hiromi, ENOKI, Akio, FUSE, Goro, KANAI, Michiko, RUDEWICZ, Patrick J., TACHIKAWA, Eiichi
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 1994; Maruzen; Japan Science and Technology Agency
• Subjects: Adrenal Medulla - cytology; Adrenal Medulla - metabolism; Amino Acid Sequence; amino alcohol; Animals; Antibiotics (antibacterial agents, antifungal agents); Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents; Applied microbiology; Biological and medical sciences; Calcium - pharmacology; catecholamine; Catecholamines - metabolism; Cattle; Fundamental and applied biological sciences. Psychology; isovaline; Microbiology; Molecular Sequence Data; peptaibol; Peptides - chemistry; Peptides - isolation & purification; Peptides - pharmacology; Spectrometry, Mass, Fast Atom Bombardment; Trichoderma - metabolism; Trichoderma harzianum; α-aminoisobutyric acid; Fungi; Peptides; Secretion; Isolation; Catecholamine; Chromaffin cell; In vitro; Biological activity; Thallophyta; Structural analysis
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.42.1070

New peptaibols, trichokindins I-VII, have been isolated from the fungus Trichoderma harzianum. Their structures were characterized by spectrometric methods. Trichokindins, which are 18-residue peptides containing one to three isovaline residues, were found to induce Ca2+-dependent catecholamine secretion from bovine adrenal medullary chromaffin cells.