Mapping of the C5a Receptor Signal Transduction Network in Human Neutrophils

Human neutrophils respond to chemoattractants, resulting in their accumulation at an inflammatory site. Chemoattractants such as the C5a peptide, derived from the C5 complement factor, bind to inhibitory guanine nucleotide binding protein (Gi)-coupled seven membrane-spanning receptors expressed in n...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 91; no. 19; pp. 9190 - 9194
Main Authors:	Buhl, Anne Mette, Avdi, Natalie, Worthen, G. Scott, Johnson, Gary L.
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences of the United States of America 13-09-1994 National Acad Sciences National Academy of Sciences
Subjects:	Biochemistry Calcium-Calmodulin-Dependent Protein Kinases - physiology Chemotactic factors Chemotaxis, Leukocyte Cyclic AMP-Dependent Protein Kinases - physiology Enzyme Activation GTP-Binding Proteins - physiology Guanine nucleotides Humans Immunity (Disease) In Vitro Techniques Ligation Neutrophils Neutrophils - physiology Phorbol Esters - pharmacology Phosphorylation Physiological regulation Protease inhibitors Protein-Serine-Threonine Kinases - physiology Proteins Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-raf Proto-Oncogene Proteins p21(ras) - metabolism Receptor, Anaphylatoxin C5a Receptors Receptors, Complement - physiology Signal Transduction
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