Effects of Monoacyltrehalose Fraction of Rhodococcus Biosurfactant on the Innate and Adaptive Immunity Parameters In Vivo

Effects of Monoacyltrehalose Fraction of Rhodococcus Biosurfactant on the Innate and Adaptive Immunity Parameters In Vivo

The biosurfactant monoacyltrehalose fraction isolated from Rhodococcus ruber IEGM 231 actinobacterium suppresses antibody production, bactericidal potential, and production of IL-1β by mouse peritoneal cells after intraperitoneal and intramuscular injection and stimulates the production of IL-10 aft...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine Vol. 169; no. 4; pp. 474 - 477
Main Authors: Gein, S. V., Kochina, O. A., Kuyukina, M. S., Klimenko, D. P., Ivshina, I. B.
Format: Journal Article
Language:English
Published: New York Springer US 01-08-2020
Springer
Subjects:
Antibodies
Biomedical and Life Sciences
Biomedicine
Cell Biology
Internal Medicine
Laboratory Medicine
Membrane lipids
Pathology
Viral antibodies
Rhodococcus
antibody production
macrophages
cytokines
monoacyltrehalose
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Summary:The biosurfactant monoacyltrehalose fraction isolated from Rhodococcus ruber IEGM 231 actinobacterium suppresses antibody production, bactericidal potential, and production of IL-1β by mouse peritoneal cells after intraperitoneal and intramuscular injection and stimulates the production of IL-10 after intraperitoneal injection. The data of in vitro experiments attest to an important role of bacterial glycolipids in the regulation of the functions of splenocytes and peritoneal macrophages.
Bibliography:ObjectType-Article-1
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-020-04912-8