Insulin Receptor-Related Receptor as an Extracellular Alkali Sensor

The insulin receptor-related receptor (IRR), an orphan receptor tyrosine kinase of the insulin receptor family, can be activated by alkaline media both in vitro and in vivo at pH >7.9. The alkali-sensing property of IRR is conserved in frog, mouse, and human. IRR activation is specific, dose-depe...

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Bibliographic Details
Published in:	Cell metabolism Vol. 13; no. 6; pp. 679 - 689
Main Authors:	Deyev, Igor E., Sohet, Fabien, Vassilenko, Konstantin P., Serova, Oxana V., Popova, Nadezhda V., Zozulya, Sergey A., Burova, Elena B., Houillier, Pascal, Rzhevsky, Dmitry I., Berchatova, Anastasiya A., Murashev, Arkady N., Chugunov, Anton O., Efremov, Roman G., Nikol'sky, Nikolai N., Bertelli, Eugenio, Eladari, Dominique, Petrenko, Alexander G.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 08-06-2011
Subjects:	Animals Cell Line Culture Media Humans Hydrogen-Ion Concentration Kidney - drug effects Kidney - metabolism Mice Mice, Inbred C57BL Mice, Knockout Mutagenesis, Site-Directed Phosphorylation Protein Processing, Post-Translational Protein Structure, Tertiary Rats Receptor, Insulin - genetics Receptor, Insulin - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Signal Transduction Sodium Bicarbonate - pharmacology Sodium Bicarbonate - urine Xenopus laevis
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