Neuropsychological Test Norms in Cognitively Intact Oldest-Old

• Published in: Journal of the International Neuropsychological Society Vol. 25; no. 5; p. 530
• Main Authors: Melikyan, Zarui A, Corrada, Maria M, Dick, Malcolm B, Whittle, Christina, Paganini-Hill, Annlia, Kawas, Claudia H
• Format: Journal Article
• Language: English
• Published: England 01-05-2019
• Subjects: Aged, 80 and over; Aging - physiology; Cognition - physiology; Cross-Sectional Studies; Female; Humans; Male; Memory and Learning Tests - statistics & numerical data; Mental Status and Dementia Tests - statistics & numerical data; Neuropsychological Tests - statistics & numerical data; Reference Values; Trail Making Test - statistics & numerical data; 80 and over; Geriatric assessment; Aged; Cognition; Neuropsychology; Reference values
• ISSN: 1469-7661
• DOI: 10.1017/S1355617719000122

Individuals aged 90 or older (oldest-old), the fastest growing segment of the population, are at increased risk of developing cognitive impairment compared with younger old. Neuropsychological evaluation of the oldest-old is important yet challenging in part because of the scarcity of test norms for this group. We provide neuropsychological test norms for cognitively intact oldest-old.
Test norms were derived from 403 cognitively intact participants of The 90+ Study, an ongoing study of aging and dementia in the oldest-old. Cognitive status of intact oldest-old was determined at baseline using cross-sectional approach. Individuals with cognitive impairment no dementia or dementia (according to DSM-IV criteria) were excluded. Participants ranged in age from 90 to 102 years (mean=94). The neuropsychological battery included 11 tests (Mini-Mental Status Examination, Modified Mini-Mental State Examination, Boston Naming Test - Short Form, Letter Fluency Test, Animal Fluency Test, California Verbal Learning Test-II Short Form, Trail Making Tests A/B/C, Digit Span Forward and Backwards Test, Clock Drawing Test, CERAD Construction Subtests), and the Geriatric Depression Scale.
Data show significantly lower scores with increasing age on most tests. Education level, sex, and symptoms of depression were associated with performance on several tests after accounting for age.
Provided test norms will help to distinguish cognitively intact oldest-old from those with cognitive impairment. (JINS, 2019, 25, 530-545).