Genetic factors influencing alpha-particle-induced chromosomal instability

• Published in: International journal of radiation biology Vol. 71; no. 5; pp. 497 - 503
• Main Authors: WATSON, G. E, LORIMORE, S. A, CLUTTON, S. M, KADHIM, M. A, WRIGHT, E. G
• Format: Journal Article
• Language: English
• Published: London Informa UK Ltd 1997; Taylor & Francis
• Subjects: Alpha Particles; Animals; Biological and medical sciences; Cells, Cultured; Chromosome Aberrations; Fundamental and applied biological sciences. Psychology; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Molecular and cellular biology; Molecular genetics; Mutagenesis. Repair; Space life sciences; Chromosomal aberration; Cell culture; Radiosensitivity; Hematopoietic cell; Chromosome; Genotype; Oxides; Genetic parameter; Linear energy transfer; Free radical; Radiation resistance; Cytogenetics; Radiation injury; Instability; Alpha particle
• ISSN: 0955-3002; 1362-3095
• DOI: 10.1080/095530097143824

Alpha-particle-induced chromosomal instability in haemopoietic cells obtained from the CBA/H, DBA/2 and C57BL/6 inbred strains of mouse has been demonstrated at frequencies dependent on genotype. The CBA/H and DBA/2 strains may be regarded as 'sensitive' and the C57BL/6 strain as 'resistant'; resistance was dominant in cells from F1 hybrids. Previously, in cultures where we demonstrated radiation-induced chromosomal instability we also demonstrated an enhanced and persisting oxyradical activity. Quantitative differences in superoxide generation have now been correlated with genetically determined differences in the expression of chromosomal instability. Our findings demonstrate an important influence of genetic factors in alpha -particle-induced chromosomal instability.