Update on Biology and Genomics of Adrenocortical Carcinomas: Rationale for Emerging Therapies

Abstract The adrenal glands are paired endocrine organs that produce steroid hormones and catecholamines required for life. Adrenocortical carcinoma (ACC) is a rare and often fatal cancer of the peripheral domain of the gland, the adrenal cortex. Recent research in adrenal development, homeostasis,...

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Bibliographic Details
Published in:	Endocrine reviews Vol. 43; no. 6; pp. 1051 - 1073
Main Authors:	Lerario, Antonio Marcondes, Mohan, Dipika R, Hammer, Gary D
Format:	Journal Article
Language:	English
Published:	US Oxford University Press 01-12-2022
Subjects:	Adrenal cortex Adrenal Cortex Neoplasms - drug therapy Adrenal Cortex Neoplasms - genetics Adrenal Glands Adrenocortical Carcinoma - drug therapy Adrenocortical Carcinoma - genetics Biology Cancer Carcinoma Catecholamines Chemotherapy Cytotoxicity Development and progression Epigenetic inheritance Epigenetics Genetic aspects Genetic research Genomes Genomics Health aspects Homeostasis Hormones Humans Medical research Medicine, Experimental Metastases Metastasis Mitotane - therapeutic use Neuroendocrine tumors Physiological aspects Review Steroid hormones Tumors Michigan adrenocortical carcinoma molecular biomarkers genomics adrenocortical development and homeostasis targeted therapies
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