Mechanosensor Piezo1 mediates bimodal patterns of intracellular calcium and FAK signaling

Piezo1 belongs to mechano‐activatable cation channels serving as biological force sensors. However, the molecular events downstream of Piezo1 activation remain unclear. In this study, we used biosensors based on fluorescence resonance energy transfer (FRET) to investigate the dynamic modes of Piezo1...

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Bibliographic Details
Published in:	The EMBO journal Vol. 41; no. 17; pp. e111799 - n/a
Main Authors:	Pan, Yijia, Shi, Linda Zhixia, Yoon, Chi Woo, Preece, Daryl, Gomez‐Godinez, Veronica, Lu, Shaoying, Carmona, Christopher, Woo, Seung‐Hyun, Chien, Shu, Berns, Michael W, Liu, Longwei, Wang, Yingxiao
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-09-2022 Blackwell Publishing Ltd John Wiley and Sons Inc
Subjects:	Biosensors Calcium Calcium (intracellular) Calcium - metabolism Calcium Signaling Calcium signalling Cations EMBO20 EMBO37 Energy transfer FAK Fluorescence resonance energy transfer Focal adhesion kinase Intracellular Intracellular signalling Ion channels Ion Channels - genetics Ion Channels - metabolism laser‐induced shockwaves Ligands Mechanical stimuli Mechanotransduction, Cellular - physiology Piezo1 Shear stress Shock waves SHP2 Signaling Stimulation FAK SHP2 calcium Piezo1 laser‐induced shockwaves laser-induced shockwaves
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