Merkel cells in the human oesophagus

Merkel cells (MCs) are well recognized in the basal layers of the skin and oral mucosa, but this paper describes for the first time the presence of MCs in the human oesophagus. These cells are not identified in neonatal oesophagus, but are seen singly and in clusters in adult specimens. Application...

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Published in:	The Journal of pathology Vol. 189; no. 2; pp. 176 - 179
Main Authors:	Harmse, J. L., Carey, F. A., Baird, A. R., Craig, S. R., Christie, K. N., Hopwood, D., Lucocq, J.
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 01-10-1999 Wiley
Subjects:	Adult Biological and medical sciences Biomarkers, Tumor - metabolism Carcinoma, Small Cell - metabolism Carcinoma, Small Cell - pathology Cell Count cytokeratin 20 Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophagus Esophagus - ultrastructure Gastroenterology. Liver. Pancreas. Abdomen Humans Infant Intermediate Filament Proteins - metabolism Keratin-20 Medical sciences Merkel cells Merkel Cells - metabolism Merkel Cells - ultrastructure Neoplasm Proteins - metabolism oesophagus small cell carcinoma Tumors Human Immunohistochemistry Pathology Eye disease Merkel cell Digestive diseases Malignant tumor Electron microscopy Neuroendocrine tumor Small cell carcinoma Esophagus
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Abstract	Merkel cells (MCs) are well recognized in the basal layers of the skin and oral mucosa, but this paper describes for the first time the presence of MCs in the human oesophagus. These cells are not identified in neonatal oesophagus, but are seen singly and in clusters in adult specimens. Application of stereological techniques shows that MCs are more numerous in the mid‐oesophageal region. Cells expressing established markers of MCs have also been demonstrated in two out of six primary small cell carcinomas of the oesophagus. Further investigation of the role of MCs in oesophageal innervation and epithelial biology will be of interest. Copyright © 1999 John Wiley & Sons, Ltd.
AbstractList	Merkel cells (MCs) are well recognized in the basal layers of the skin and oral mucosa, but this paper describes for the first time the presence of MCs in the human oesophagus. These cells are not identified in neonatal oesophagus, but are seen singly and in clusters in adult specimens. Application of stereological techniques shows that MCs are more numerous in the mid‐oesophageal region. Cells expressing established markers of MCs have also been demonstrated in two out of six primary small cell carcinomas of the oesophagus. Further investigation of the role of MCs in oesophageal innervation and epithelial biology will be of interest. Copyright © 1999 John Wiley & Sons, Ltd. Merkel cells (MCs) are well recognized in the basal layers of the skin and oral mucosa, but this paper describes for the first time the presence of MCs in the human oesophagus. These cells are not identified in neonatal oesophagus, but are seen singly and in clusters in adult specimens. Application of stereological techniques shows that MCs are more numerous in the mid-oesophageal region. Cells expressing established markers of MCs have also been demonstrated in two out of six primary small cell carcinomas of the oesophagus. Further investigation of the role of MCs in oesophageal innervation and epithelial biology will be of interest.
Author	Lucocq, J. Harmse, J. L. Craig, S. R. Baird, A. R. Christie, K. N. Carey, F. A. Hopwood, D.
Author_xml	– sequence: 1 givenname: J. L. surname: Harmse fullname: Harmse, J. L. organization: Department of Pathology, Ninewells Hospital and Medical School, Dundee DD1 9SY, U.K – sequence: 2 givenname: F. A. surname: Carey fullname: Carey, F. A. organization: Department of Pathology, Ninewells Hospital and Medical School, Dundee DD1 9SY, U.K – sequence: 3 givenname: A. R. surname: Baird fullname: Baird, A. R. organization: Department of Pathology, Ninewells Hospital and Medical School, Dundee DD1 9SY, U.K – sequence: 4 givenname: S. R. surname: Craig fullname: Craig, S. R. organization: Department of Thoracic Surgery, City Hospital, Edinburgh, U.K – sequence: 5 givenname: K. N. surname: Christie fullname: Christie, K. N. organization: Department of Anatomy and Physiology, MSI/WTB Complex, Dow Street, University of Dundee, Dundee DD1 5EH, U.K – sequence: 6 givenname: D. surname: Hopwood fullname: Hopwood, D. organization: Department of Pathology, Ninewells Hospital and Medical School, Dundee DD1 9SY, U.K – sequence: 7 givenname: J. surname: Lucocq fullname: Lucocq, J. organization: Department of Anatomy and Physiology, MSI/WTB Complex, Dow Street, University of Dundee, Dundee DD1 5EH, U.K
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References	Gould VE, Moll R, Moll I, Lee I, Franke WW Biology of disease. Neuroendocrine (Merkel) cells of the skin: hyperplasias, dysplasias and neoplasms. Lab Invest 1985; 52(4): 334-353. Ogawa H The Merkel cell as a possible mechanoreceptor cell. Prog Neurobiol 1996; 49: 317-334. Morohunfola KA, Jones TE, Munger BL The differentiation of the skin and its appendages. Normal development of papillary ridges. Anat Rec 1992; 232(4): 587-598. Craig SR, Carey FA, Walker WS, Cameron EWJ Primary small cell carcinoma of the oesophagus. J Thorac Cardiovasc Surg 1995; 109: 284-288. Tachibana T The Merkel cell: recent findings and unresolved problems. Arch Histol Cytol 1995; 58: 379-396. Hilliges M, Astback J, Wang L, Arvidson K, Johansson O Protein gene product 9·5 immunoreactive nerves and cells in human oral mucosa. Anat Rec 1996; 25: 621-632. Ryukei T, Huroa T, Akira W, Jaleski H, Kenzo T Argyrophil cells and melanocytes in oesophageal mucosa. Arch Pathol 1974; 98: 87-89. Sterio DC The unbiased estimation of number and sizes of arbitrary particles using the dissector. J Microsc 1984; 134: 127-136. Moll I, Kuhn C, Moll R Cytokeratin 20 is a general marker of cutaneous Merkel cells while certain neuronal proteins are absent. J Invest Dermatol 1996; 104: 910-915. Springall DR, Ibrahim NB, Rode J, Sharpe S, Blooms SR, Pilak JM Endocrine differentiation of extrapulmonary small cell carcinoma demonstrated by immunohistochemistry using antibodies to PGP9.5, neuron-specific enolase and C-flanking peptide of human pro-bombesin. J Pathol 1986; 150: 151-162. 1995 1985; 52 1974; 98 1996; 104 1996; 25 1984; 134 1996; 49 1995; 58 1992; 232 1986; 150 1995; 109 Ogawa (10.1002/(SICI)1096-9896(199910)189:2<176::AID-PATH416>3.0.CO;2-U-BIB5) 1996; 49 Ryukei (10.1002/(SICI)1096-9896(199910)189:2<176::AID-PATH416>3.0.CO;2-U-BIB9) 1974; 98 Moll (10.1002/(SICI)1096-9896(199910)189:2<176::AID-PATH416>3.0.CO;2-U-BIB2) 1996; 104 Morohunfola (10.1002/(SICI)1096-9896(199910)189:2<176::AID-PATH416>3.0.CO;2-U-BIB8) 1992; 232 Craig (10.1002/(SICI)1096-9896(199910)189:2<176::AID-PATH416>3.0.CO;2-U-BIB10) 1995; 109 Gould (10.1002/(SICI)1096-9896(199910)189:2<176::AID-PATH416>3.0.CO;2-U-BIB7) 1985; 52(4 Hilliges (10.1002/(SICI)1096-9896(199910)189:2<176::AID-PATH416>3.0.CO;2-U-BIB3) 1996; 25 Tachibana (10.1002/(SICI)1096-9896(199910)189:2<176::AID-PATH416>3.0.CO;2-U-BIB1) 1995; 58 Sterio (10.1002/(SICI)1096-9896(199910)189:2<176::AID-PATH416>3.0.CO;2-U-BIB4) 1984; 134 Berry (10.1002/(SICI)1096-9896(199910)189:2<176::AID-PATH416>3.0.CO;2-U-BIB6) 1995 Springall (10.1002/(SICI)1096-9896(199910)189:2<176::AID-PATH416>3.0.CO;2-U-BIB11) 1986; 150
References_xml	– volume: 58 start-page: 379 year: 1995 end-page: 396 article-title: The Merkel cell: recent findings and unresolved problems publication-title: Arch Histol Cytol – volume: 134 start-page: 127 year: 1984 end-page: 136 article-title: The unbiased estimation of number and sizes of arbitrary particles using the dissector publication-title: J Microsc – volume: 98 start-page: 87 year: 1974 end-page: 89 article-title: Argyrophil cells and melanocytes in oesophageal mucosa publication-title: Arch Pathol – volume: 232 start-page: 587 issue: 4 year: 1992 end-page: 598 article-title: The differentiation of the skin and its appendages. Normal development of papillary ridges publication-title: Anat Rec – start-page: 1252 year: 1995 – volume: 104 start-page: 910 year: 1996 end-page: 915 article-title: Cytokeratin 20 is a general marker of cutaneous Merkel cells while certain neuronal proteins are absent publication-title: J Invest Dermatol – volume: 52 start-page: 334 issue: 4 year: 1985 end-page: 353 article-title: Biology of disease. Neuroendocrine (Merkel) cells of the skin: hyperplasias, dysplasias and neoplasms publication-title: Lab Invest – volume: 150 start-page: 151 year: 1986 end-page: 162 article-title: Endocrine differentiation of extrapulmonary small cell carcinoma demonstrated by immunohistochemistry using antibodies to PGP9.5, neuron‐specific enolase and C‐flanking peptide of human pro‐bombesin publication-title: J Pathol – volume: 25 start-page: 621 year: 1996 end-page: 632 article-title: Protein gene product 9·5 immunoreactive nerves and cells in human oral mucosa publication-title: Anat Rec – volume: 109 start-page: 284 year: 1995 end-page: 288 article-title: Primary small cell carcinoma of the oesophagus publication-title: J Thorac Cardiovasc Surg – volume: 49 start-page: 317 year: 1996 end-page: 334 article-title: The Merkel cell as a possible mechanoreceptor cell publication-title: Prog Neurobiol – volume: 109 start-page: 284 year: 1995 ident: 10.1002/(SICI)1096-9896(199910)189:2<176::AID-PATH416>3.0.CO;2-U-BIB10 publication-title: J Thorac Cardiovasc Surg doi: 10.1016/S0022-5223(95)70390-X contributor: fullname: Craig – start-page: 1252 volume-title: Gray's Anatomy year: 1995 ident: 10.1002/(SICI)1096-9896(199910)189:2<176::AID-PATH416>3.0.CO;2-U-BIB6 contributor: fullname: Berry – volume: 232 start-page: 587 year: 1992 ident: 10.1002/(SICI)1096-9896(199910)189:2<176::AID-PATH416>3.0.CO;2-U-BIB8 publication-title: Anat Rec doi: 10.1002/ar.1092320414 contributor: fullname: Morohunfola – volume: 104 start-page: 910 year: 1996 ident: 10.1002/(SICI)1096-9896(199910)189:2<176::AID-PATH416>3.0.CO;2-U-BIB2 publication-title: J Invest Dermatol doi: 10.1111/1523-1747.ep12606183 contributor: fullname: Moll – volume: 25 start-page: 621 year: 1996 ident: 10.1002/(SICI)1096-9896(199910)189:2<176::AID-PATH416>3.0.CO;2-U-BIB3 publication-title: Anat Rec doi: 10.1002/(SICI)1097-0185(199608)245:4<621::AID-AR2>3.0.CO;2-R contributor: fullname: Hilliges – volume: 98 start-page: 87 year: 1974 ident: 10.1002/(SICI)1096-9896(199910)189:2<176::AID-PATH416>3.0.CO;2-U-BIB9 publication-title: Arch Pathol contributor: fullname: Ryukei – volume: 52(4 start-page: 334 year: 1985 ident: 10.1002/(SICI)1096-9896(199910)189:2<176::AID-PATH416>3.0.CO;2-U-BIB7 publication-title: Lab Invest contributor: fullname: Gould – volume: 58 start-page: 379 year: 1995 ident: 10.1002/(SICI)1096-9896(199910)189:2<176::AID-PATH416>3.0.CO;2-U-BIB1 publication-title: Arch Histol Cytol doi: 10.1679/aohc.58.379 contributor: fullname: Tachibana – volume: 134 start-page: 127 year: 1984 ident: 10.1002/(SICI)1096-9896(199910)189:2<176::AID-PATH416>3.0.CO;2-U-BIB4 publication-title: J Microsc doi: 10.1111/j.1365-2818.1984.tb02501.x contributor: fullname: Sterio – volume: 150 start-page: 151 year: 1986 ident: 10.1002/(SICI)1096-9896(199910)189:2<176::AID-PATH416>3.0.CO;2-U-BIB11 publication-title: J Pathol doi: 10.1002/path.1711500302 contributor: fullname: Springall – volume: 49 start-page: 317 year: 1996 ident: 10.1002/(SICI)1096-9896(199910)189:2<176::AID-PATH416>3.0.CO;2-U-BIB5 publication-title: Prog Neurobiol doi: 10.1016/0301-0082(96)00018-4 contributor: fullname: Ogawa
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SubjectTerms	Adult Biological and medical sciences Biomarkers, Tumor - metabolism Carcinoma, Small Cell - metabolism Carcinoma, Small Cell - pathology Cell Count cytokeratin 20 Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophagus Esophagus - ultrastructure Gastroenterology. Liver. Pancreas. Abdomen Humans Infant Intermediate Filament Proteins - metabolism Keratin-20 Medical sciences Merkel cells Merkel Cells - metabolism Merkel Cells - ultrastructure Neoplasm Proteins - metabolism oesophagus small cell carcinoma Tumors
Title	Merkel cells in the human oesophagus
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