Potent nonopioid antinociceptive activity of telocinobufagin in models of acute pain in mice
In recent decades, several researches have been conducted in search of new analgesics that do not present the side effects of opioids. In this context, animal venoms contain natural painkillers that have been used for the development of new analgesics. The aims of this study were to evaluate the ant...
Saved in:
| Published in: | Pain reports Vol. 4; no. 6; p. e791 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Wolters Kluwer
01-11-2019
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | In recent decades, several researches have been conducted in search of new analgesics that do not present the side effects of opioids. In this context, animal venoms contain natural painkillers that have been used for the development of new analgesics.
The aims of this study were to evaluate the antinociceptive effects of telocinobufagin (TCB), a bufadienolide isolated from
venom, in murine acute pain models, and to verify the participation of the opioid system in these effects.
TCB was purified from
venom by high-performance liquid chromatography, and its structure was confirmed by spectrometric techniques. TCB was administered intraperitoneally (i.p.) (0.062, 0.125, 0.25, 0.5, and 1 mg·kg
) and orally (p.o.) (0.625, 1.125, 2.5, 5, and 10 mg·kg
) in mice, which were then subjected to pain tests: acetic acid-induced writhing, formalin, tail-flick, and hot-plate. Involvement of the opioid system in TCB action was evaluated by naloxone i.p. injected (2.5 mg·kg
) 20 minutes before TCB administration. In addition, the TCB action on the μ, δ, and κ opioid receptors was performed by radioligand binding assays.
In all the tests used, TCB showed dose-dependent antinociceptive activity with more than 90% inhibition of the nociceptive responses at the doses of 1 mg·kg
(i.p.) and 10 mg·kg
(p.o.). Naloxone did not alter the effect of TCB. In addition, TCB did not act on the μ, δ, and κ opioid receptors.
The results suggest that TCB may represent a novel potential nonopioid therapeutic analgesic for treatment of acute pains. |
|---|---|
| AbstractList | Introduction:. In recent decades, several researches have been conducted in search of new analgesics that do not present the side effects of opioids. In this context, animal venoms contain natural painkillers that have been used for the development of new analgesics. Objective:. The aims of this study were to evaluate the antinociceptive effects of telocinobufagin (TCB), a bufadienolide isolated from Rhinella jimi venom, in murine acute pain models, and to verify the participation of the opioid system in these effects. Methods:. TCB was purified from R. jimi venom by high-performance liquid chromatography, and its structure was confirmed by spectrometric techniques. TCB was administered intraperitoneally (i.p.) (0.062, 0.125, 0.25, 0.5, and 1 mg·kg−1) and orally (p.o.) (0.625, 1.125, 2.5, 5, and 10 mg·kg−1) in mice, which were then subjected to pain tests: acetic acid–induced writhing, formalin, tail-flick, and hot-plate. Involvement of the opioid system in TCB action was evaluated by naloxone i.p. injected (2.5 mg·kg−1) 20 minutes before TCB administration. In addition, the TCB action on the μ, δ, and κ opioid receptors was performed by radioligand binding assays. Results:. In all the tests used, TCB showed dose-dependent antinociceptive activity with more than 90% inhibition of the nociceptive responses at the doses of 1 mg·kg−1 (i.p.) and 10 mg·kg−1 (p.o.). Naloxone did not alter the effect of TCB. In addition, TCB did not act on the μ, δ, and κ opioid receptors. Conclusion:. The results suggest that TCB may represent a novel potential nonopioid therapeutic analgesic for treatment of acute pains. In recent decades, several researches have been conducted in search of new analgesics that do not present the side effects of opioids. In this context, animal venoms contain natural painkillers that have been used for the development of new analgesics. The aims of this study were to evaluate the antinociceptive effects of telocinobufagin (TCB), a bufadienolide isolated from venom, in murine acute pain models, and to verify the participation of the opioid system in these effects. TCB was purified from venom by high-performance liquid chromatography, and its structure was confirmed by spectrometric techniques. TCB was administered intraperitoneally (i.p.) (0.062, 0.125, 0.25, 0.5, and 1 mg·kg ) and orally (p.o.) (0.625, 1.125, 2.5, 5, and 10 mg·kg ) in mice, which were then subjected to pain tests: acetic acid-induced writhing, formalin, tail-flick, and hot-plate. Involvement of the opioid system in TCB action was evaluated by naloxone i.p. injected (2.5 mg·kg ) 20 minutes before TCB administration. In addition, the TCB action on the μ, δ, and κ opioid receptors was performed by radioligand binding assays. In all the tests used, TCB showed dose-dependent antinociceptive activity with more than 90% inhibition of the nociceptive responses at the doses of 1 mg·kg (i.p.) and 10 mg·kg (p.o.). Naloxone did not alter the effect of TCB. In addition, TCB did not act on the μ, δ, and κ opioid receptors. The results suggest that TCB may represent a novel potential nonopioid therapeutic analgesic for treatment of acute pains. INTRODUCTIONIn recent decades, several researches have been conducted in search of new analgesics that do not present the side effects of opioids. In this context, animal venoms contain natural painkillers that have been used for the development of new analgesics. OBJECTIVEThe aims of this study were to evaluate the antinociceptive effects of telocinobufagin (TCB), a bufadienolide isolated from Rhinella jimi venom, in murine acute pain models, and to verify the participation of the opioid system in these effects. METHODSTCB was purified from R. jimi venom by high-performance liquid chromatography, and its structure was confirmed by spectrometric techniques. TCB was administered intraperitoneally (i.p.) (0.062, 0.125, 0.25, 0.5, and 1 mg·kg-1) and orally (p.o.) (0.625, 1.125, 2.5, 5, and 10 mg·kg-1) in mice, which were then subjected to pain tests: acetic acid-induced writhing, formalin, tail-flick, and hot-plate. Involvement of the opioid system in TCB action was evaluated by naloxone i.p. injected (2.5 mg·kg-1) 20 minutes before TCB administration. In addition, the TCB action on the μ, δ, and κ opioid receptors was performed by radioligand binding assays. RESULTSIn all the tests used, TCB showed dose-dependent antinociceptive activity with more than 90% inhibition of the nociceptive responses at the doses of 1 mg·kg-1 (i.p.) and 10 mg·kg-1 (p.o.). Naloxone did not alter the effect of TCB. In addition, TCB did not act on the μ, δ, and κ opioid receptors. CONCLUSIONThe results suggest that TCB may represent a novel potential nonopioid therapeutic analgesic for treatment of acute pains. |
| Author | Carvalho, Isabella F. Medeiros, Rafael L. Carvalho, Ellaine D.F. Santos, Cláudia F. Carvalho, Krishnamurti M. Nascimento, Nilberto R. Silveira, Edilberto R. Feitosa, Geissy I.M.C. Uchoa, Daniel E.A. Coelho, Edivaldo B.S. Monteiro, Marla R.B. Carvalho, Maria-Denise F. A. Silva, Paulo T. Cardi, Bruno A. Carvalho, Dóris M.F. |
| AuthorAffiliation | Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil Laboratório de Toxinologia e Farmacologia Molecular, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Brazil Genpharma Consultoria Farmacêutica e Genética LTDA, Fortaleza, Ceará, Brazil |
| AuthorAffiliation_xml | – name: Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil – name: Laboratório de Toxinologia e Farmacologia Molecular, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Brazil – name: Genpharma Consultoria Farmacêutica e Genética LTDA, Fortaleza, Ceará, Brazil |
| Author_xml | – sequence: 1 givenname: Geissy I.M.C. surname: Feitosa fullname: Feitosa, Geissy I.M.C. organization: Laboratório de Toxinologia e Farmacologia Molecular, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Brazil – sequence: 2 givenname: Isabella F. surname: Carvalho fullname: Carvalho, Isabella F. organization: Genpharma Consultoria Farmacêutica e Genética LTDA, Fortaleza, Ceará, Brazil – sequence: 3 givenname: Edivaldo B.S. surname: Coelho fullname: Coelho, Edivaldo B.S. organization: Laboratório de Toxinologia e Farmacologia Molecular, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Brazil – sequence: 4 givenname: Marla R.B. surname: Monteiro fullname: Monteiro, Marla R.B. organization: Laboratório de Toxinologia e Farmacologia Molecular, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Brazil – sequence: 5 givenname: Rafael L. surname: Medeiros fullname: Medeiros, Rafael L. organization: Laboratório de Toxinologia e Farmacologia Molecular, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Brazil – sequence: 6 givenname: Ellaine D.F. surname: Carvalho fullname: Carvalho, Ellaine D.F. organization: Genpharma Consultoria Farmacêutica e Genética LTDA, Fortaleza, Ceará, Brazil – sequence: 7 givenname: Paulo T. surname: A. Silva fullname: A. Silva, Paulo T. organization: Genpharma Consultoria Farmacêutica e Genética LTDA, Fortaleza, Ceará, Brazil – sequence: 8 givenname: Dóris M.F. surname: Carvalho fullname: Carvalho, Dóris M.F. organization: Genpharma Consultoria Farmacêutica e Genética LTDA, Fortaleza, Ceará, Brazil – sequence: 9 givenname: Daniel E.A. surname: Uchoa fullname: Uchoa, Daniel E.A. organization: Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil – sequence: 10 givenname: Edilberto R. surname: Silveira fullname: Silveira, Edilberto R. organization: Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil – sequence: 11 givenname: Cláudia F. surname: Santos fullname: Santos, Cláudia F. organization: Laboratório de Toxinologia e Farmacologia Molecular, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Brazil – sequence: 12 givenname: Nilberto R. surname: Nascimento fullname: Nascimento, Nilberto R. organization: Laboratório de Toxinologia e Farmacologia Molecular, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Brazil – sequence: 13 givenname: Maria-Denise F. surname: Carvalho fullname: Carvalho, Maria-Denise F. organization: Laboratório de Toxinologia e Farmacologia Molecular, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Brazil – sequence: 14 givenname: Bruno A. surname: Cardi fullname: Cardi, Bruno A. organization: Laboratório de Toxinologia e Farmacologia Molecular, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Brazil – sequence: 15 givenname: Krishnamurti M. surname: Carvalho fullname: Carvalho, Krishnamurti M. organization: Laboratório de Toxinologia e Farmacologia Molecular, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31984296$$D View this record in MEDLINE/PubMed |
| BookMark | eNpdkl1rFDEUhoNUbK39ByJz6c3UfM1MciNIqVooWETvhHAmc2Y3NTsZk0xL_71Zd61bQ-Aczsdzkrx5SY6mMCEhrxk9Z1R3726-6nN6uDrNnpETLjtW80awowP_mJyldFtqmJaaNu0LciyYVpLr9oT8uAkZp1wVfphdcEMFU3ZTsM7inN0dVmCLcfmhCmOV0ZfMFPplhJWbqrI3YUCftkmwS8Zqhn28AF6R5yP4hGd7e0q-f7z8dvG5vv7y6eriw3VtG6ZFDZq1FFotZIOiQaVHhFGi6vXQKavK5ZSUXAneDKhB9AiKAWuRWkobsFKckqsddwhwa-boNhAfTABn_gRCXBmI2VmPplccOyrtKHsmRd-VQXJosO0loMJxKKz3O9a89BscbHmcCP4J9GlmcmuzCnem1VSIjhfA2z0ghl8Lpmw2Lln0HiYMSzJcyJarRilWSuWu1MaQUsTxcQyjZquzKTqb_3UubW8Oj_jY9FfVf9z74DPG9NMv9xjNGsHntSn_QCgt2poXj_ECrbefQ4jfOIa2UA |
| CitedBy_id | crossref_primary_10_1016_j_peptides_2021_170547 |
| Cites_doi | 10.1093/ndt/gfn325 10.1093/ilar.43.4.244 10.1155/2014/171839 10.1093/ilar.43.4.202 10.1124/pr.108.000711 10.1111/j.2042-7158.1986.tb04594.x 10.1161/01.HYP.26.5.781 10.1161/01.HYP.31.5.1097 10.1016/j.biopha.2016.10.030 10.1039/a815397y 10.1016/S0008-6363(95)00208-1 10.1039/b402985m 10.1161/01.HYP.37.2.462 10.1016/j.clinbiochem.2004.08.005 10.1016/S1090-3801(98)90033-7 10.1016/0014-2999(94)00735-P 10.1046/j.1432-1033.2002.02911.x 10.36076/ppj.2008/11/S105 10.1124/jpet.102.046870 10.1111/j.2042-7158.1968.tb09743.x 10.1053/j.ajkd.2010.01.023 10.4331/wjbc.v6.i2.28 10.1016/j.bbagen.2017.05.012 10.1016/0304-3959(89)90222-4 10.1152/ajprenal.00130.2011 10.1016/S0014-2999(99)00790-6 10.3390/ijms19092566 10.1016/j.yrtph.2010.03.008 10.1016/j.toxicon.2014.10.020 10.3109/10641969809053240 10.2220/biomedres.6.437 10.1016/0006-2952(86)90416-8 10.1097/PR9.0000000000000589 10.1074/jbc.M609181200 10.1016/0091-3057(89)90327-4 10.1037/0033-2909.83.3.482 10.1111/j.1749-6632.1969.tb12983.x |
| ContentType | Journal Article |
| Copyright | Wolters Kluwer Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain. Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain. 2019 |
| Copyright_xml | – notice: Wolters Kluwer – notice: Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain. – notice: Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain. 2019 |
| DBID | NPM AAYXX CITATION 7X8 5PM DOA |
| DOI | 10.1097/PR9.0000000000000791 |
| DatabaseName | PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) Directory of Open Access Journals |
| DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals url: http://www.doaj.org/ sourceTypes: Open Website |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2471-2531 |
| EndPage | e791 |
| ExternalDocumentID | oai_doaj_org_article_b82e704cf4b143b7af44d5e6b4ae8efd 10_1097_PR9_0000000000000791 31984296 01938936-201912000-00013 |
| Genre | Journal Article |
| GroupedDBID | 026 0R~ AAAAV AAGIX AAHPQ AAIQE AAMOA AAQKA AASCR AASXQ AAUEB ABASU ABDIG ABVCZ ACEWG ACGFS ACILI ACLDA ACNWC ACOAL ACXJB ADBBV ADGGA ADHPY ADPDF AFDTB AFSOK AHOMT AHQNM AHVBC AHXIK AIJEX AINUH AJIOK AJNWD AJZMW AKULP ALMA_UNASSIGNED_HOLDINGS ALMTX AMJPA AMKUR AMNEI AOHHW AOIJS BCNDV BQLVK BYPQX DIWNM EBS EEVPB EJD ERAAH FCALG GNXGY GQDEL GROUPED_DOAJ HLJTE HYE IKREB IKYAY M~E O9- OBH OK1 OPUJH OVD OVDNE OVEED OVIDH OVLEI OVOZU OXXIT RLZ RPM TEORI TSPGW NPM AAYXX CITATION 7X8 5PM |
| ID | FETCH-LOGICAL-c5193-a9160a69345e35e89feaf4e8b9d78c800784428325de9a3bea81a16e0c005ac43 |
| IEDL.DBID | RPM |
| ISSN | 2471-2531 |
| IngestDate | Tue Oct 22 14:54:49 EDT 2024 Tue Sep 17 21:26:59 EDT 2024 Thu Oct 24 23:33:45 EDT 2024 Fri Nov 22 01:01:28 EST 2024 Wed Oct 16 00:41:03 EDT 2024 Thu Nov 14 18:58:56 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Keywords | Bufadienolides Analgesics Animal venoms Telocinobufagin |
| Language | English |
| License | Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c5193-a9160a69345e35e89feaf4e8b9d78c800784428325de9a3bea81a16e0c005ac43 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6903372/ |
| PMID | 31984296 |
| PQID | 2346285881 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_b82e704cf4b143b7af44d5e6b4ae8efd pubmedcentral_primary_oai_pubmedcentral_nih_gov_6903372 proquest_miscellaneous_2346285881 crossref_primary_10_1097_PR9_0000000000000791 pubmed_primary_31984296 wolterskluwer_health_01938936-201912000-00013 |
| PublicationCentury | 2000 |
| PublicationDate | 2019-November/December-01 |
| PublicationDateYYYYMMDD | 2019-11-01 |
| PublicationDate_xml | – month: 11 year: 2019 text: 2019-November/December-01 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Philadelphia, PA |
| PublicationTitle | Pain reports |
| PublicationTitleAlternate | Pain Rep |
| PublicationYear | 2019 |
| Publisher | Wolters Kluwer |
| Publisher_xml | – name: Wolters Kluwer |
| References | Schoner (R43-20230824) 2008; 23 Upadhyay (R50-20230824) 2018; 2 O'Callaghan (R39-20230824) 1975; 192 Komiyama (R35-20230824) 2005; 38 Bagrov (R5-20230824) 1996; 206 Denenberg (R22-20230824) 1969; 159 Patel (R40-20230824) 2016; 84 Schönfeld (R44-20230824) 1986; 35 Johnson (R31-20230824) 2002; 43 Kennedy (R34-20230824) 2018; 19 Ribeiro (R42-20230824) 2000; 387 Wang (R54-20230824) 1994; 14 Akizawa (R1-20230824) 1985; 6 Godinho (R25-20230824) 2017; 1861 Sewell (R46-20230824) 1974; 51 D'Amato (R19-20230824) 1989; 34 Bagrov (R4-20230824) 1995; 26 Cichewicz (R16-20230824) 2003; 305 Gomes (R26-20230824) 2007; 45 Schoner (R45-20230824) 2002; 269 Delongeas (R21-20230824) 2010; 57 Walsh (R53-20230824) 1976; 83 Azuma (R3-20230824) 1986; 38 Festing (R24-20230824) 2002; 43 Bagrov (R7-20230824) 1995; 274 Butler (R12-20230824) 2005; 22 Jones (R32-20230824) 1968; 20 Bagrov (R8-20230824) 2009; 61 Steyn (R48-20230824) 1998; 15 Gonick (R27-20230824) 1998; 20 Bayazit (R10-20230824) 2010; 5 Fedorova (R23-20230824) 2001; 37 Harvey (R28-20230824) 2014; 92 Shibata (R47-20230824) 1989; 38 Benyamin (R11-20230824) 2008; 11 Collier (R17-20230824) 1968; 32 Bagrov (R6-20230824) 1998; 31 Irwin (R29-20230824) 1951; 101 Arnaud-Batista (R2-20230824) 2012; 302 Wen (R55-20230824) 2014; 2014 Meyer (R38-20230824) 1949; 24 Baldini (R9-20230824) 2012; 14 Puschett (R41-20230824) 2010; 56 Le Bars (R36-20230824) 2001; 53 Kamboj (R33-20230824) 2013; 5 Liang (R37-20230824) 2007; 282 Jamison (R30-20230824) 2017; 2 Sufka (R49-20230824) 1998; 2 Utkin (R51-20230824) 2015; 6 |
| References_xml | – volume: 23 start-page: 2723 year: 2008 ident: R43-20230824 article-title: Role of endogenous cardiotonic steroids in sodium homeostasis publication-title: Nephrol Dial Transpl doi: 10.1093/ndt/gfn325 contributor: fullname: Schoner – volume: 43 start-page: 244 year: 2002 ident: R24-20230824 article-title: Guidelines for the design and statistical analysis for experiments using laboratory animals publication-title: ILAR J doi: 10.1093/ilar.43.4.244 contributor: fullname: Festing – volume: 2014 start-page: 171839 year: 2014 ident: R55-20230824 article-title: Anti-inflammatory and antinociceptive activities of bufalin in rodents publication-title: Mediators Inflamm doi: 10.1155/2014/171839 contributor: fullname: Wen – volume: 43 start-page: 202 year: 2002 ident: R31-20230824 article-title: Practical aspects of experimental designs in animal research publication-title: ILAR J doi: 10.1093/ilar.43.4.202 contributor: fullname: Johnson – volume: 61 start-page: 9 year: 2009 ident: R8-20230824 article-title: Endogenous cardiotonic steroids: physiology, pharmacology, and novel therapeutic targets publication-title: Pharmacol Rev doi: 10.1124/pr.108.000711 contributor: fullname: Bagrov – volume: 38 start-page: 388 year: 1986 ident: R3-20230824 article-title: Activities of novel polyhydroxylated cardiotonic steroids purified from nuchal glands of the snake Rhabdophis tigrinus publication-title: J Pharm Pharmacol doi: 10.1111/j.2042-7158.1986.tb04594.x contributor: fullname: Azuma – volume: 26 start-page: 781 year: 1995 ident: R4-20230824 article-title: Endogenous marinobufagenin-like immunoreactive factor and Na,K-ATPase inhibition during voluntary hypoventilation publication-title: Hypertension doi: 10.1161/01.HYP.26.5.781 contributor: fullname: Bagrov – volume: 5 start-page: 20 year: 2013 ident: R33-20230824 article-title: Bufadienolides and their medicinal utility: a review publication-title: Int J Pharm Pharm Sci contributor: fullname: Kamboj – volume: 192 start-page: 497 year: 1975 ident: R39-20230824 article-title: Quantification of the analgesic activity of narcotic antagonists by a modified hot plate procedure publication-title: J Pharmacol Exp Ther contributor: fullname: O'Callaghan – volume: 5 start-page: 457 year: 2010 ident: R10-20230824 article-title: Analgesic effects of scilliroside, proscillaridin-A and taxifolin from squill bulb (Urginea maritima) on pains publication-title: Dig J Nanomater Bios contributor: fullname: Bayazit – volume: 31 start-page: 1097 year: 1998 ident: R6-20230824 article-title: Characterization of a urinary bufodienolide Na,K-ATPase inhibitor in patients after acute myocardial infarction publication-title: Hypertension doi: 10.1161/01.HYP.31.5.1097 contributor: fullname: Bagrov – volume: 84 start-page: 1036 year: 2016 ident: R40-20230824 article-title: Plant-derived cardiac glycosides: role in heart ailments and cancer management publication-title: Biomed Pharmacother doi: 10.1016/j.biopha.2016.10.030 contributor: fullname: Patel – volume: 15 start-page: 397 year: 1998 ident: R48-20230824 article-title: Bufadienolides of plant and animal origin publication-title: Nat Prod Rep doi: 10.1039/a815397y contributor: fullname: Steyn – volume: 206 start-page: 296 year: 1996 ident: R5-20230824 article-title: Plasma marinobufagenin-like and ouabain-like immunoreactivity during acute saline volume expansion in anesthetized dogs publication-title: Cardiovasc Res doi: 10.1016/S0008-6363(95)00208-1 contributor: fullname: Bagrov – volume: 22 start-page: 162 year: 2005 ident: R12-20230824 article-title: Natural products to drugs: natural product derived compounds in clinical trials publication-title: Nat Prod Rep doi: 10.1039/b402985m contributor: fullname: Butler – volume: 14 start-page: 3 year: 2012 ident: R9-20230824 article-title: A review of potential adverse effects of long-term opioid therapy: a practitioner's guide publication-title: Prim Care Companion CNS Disord contributor: fullname: Baldini – volume: 32 start-page: 295 year: 1968 ident: R17-20230824 article-title: The abdominal constriction response and its suppression by analgesic drugs in mouse publication-title: Br J Pharmacol contributor: fullname: Collier – volume: 37 start-page: 462 year: 2001 ident: R23-20230824 article-title: Marinobufagenin, an endogenous α-1 sodium pump ligand, in hypertensive Dahl salt-sensitive rats publication-title: Hypertension doi: 10.1161/01.HYP.37.2.462 contributor: fullname: Fedorova – volume: 38 start-page: 36 year: 2005 ident: R35-20230824 article-title: A novel endogenous digitalis, telocinobufagin, exhibits elevated plasma levels in patients with terminal renal failure publication-title: Clin Biochem doi: 10.1016/j.clinbiochem.2004.08.005 contributor: fullname: Komiyama – volume: 2 start-page: 351 year: 1998 ident: R49-20230824 article-title: Scoring the mouse formalin test: validation study publication-title: Eur J Pain doi: 10.1016/S1090-3801(98)90033-7 contributor: fullname: Sufka – volume: 274 start-page: 151 year: 1995 ident: R7-20230824 article-title: Effects of two endogenous digitalis-like factors, ouabain and marinobufagenin in isolated rat aorta publication-title: Eur J Pharmacol doi: 10.1016/0014-2999(94)00735-P contributor: fullname: Bagrov – volume: 51 start-page: 140P year: 1974 ident: R46-20230824 article-title: Modification of the antinociceptive activity of narcotic agonists and antagonists by intraventricular injection of biogenic amines in mice publication-title: Br J Pharmacol contributor: fullname: Sewell – volume: 2 start-page: 6 year: 2018 ident: R50-20230824 article-title: Animal venom derived toxins are novel analgesics for treatment of arthritis publication-title: J Mol Sci contributor: fullname: Upadhyay – volume: 14 start-page: 132 year: 1994 ident: R54-20230824 article-title: The application of traditional Chinese medicine to the management of hepatic cancerous pain publication-title: J Tradit Chin Med contributor: fullname: Wang – volume: 269 start-page: 2440 year: 2002 ident: R45-20230824 article-title: Endogenous cardiac glycosides, a new class of steroid hormones publication-title: Eur J Biochem doi: 10.1046/j.1432-1033.2002.02911.x contributor: fullname: Schoner – volume: 11 start-page: S105 year: 2008 ident: R11-20230824 article-title: Opioid complications and side effects publication-title: Pain Physician doi: 10.36076/ppj.2008/11/S105 contributor: fullname: Benyamin – volume: 305 start-page: 812 year: 2003 ident: R16-20230824 article-title: Modulation of oral morphine antinociceptive tolerance and naloxone-precipitated withdrawal signs by oral Δ9-tetrahydrocannabinol publication-title: J Pharmacol Exp Ther doi: 10.1124/jpet.102.046870 contributor: fullname: Cichewicz – volume: 20 start-page: 302 year: 1968 ident: R32-20230824 article-title: The quantitative measurement of motor inco-ordination in naive mice using an accelerating rotarod publication-title: J Pharm Pharmacol doi: 10.1111/j.2042-7158.1968.tb09743.x contributor: fullname: Jones – volume: 56 start-page: 359 year: 2010 ident: R41-20230824 article-title: Emerging role of the bufadienolides in cardiovascular and kidney diseases publication-title: Am J Kidney Dis doi: 10.1053/j.ajkd.2010.01.023 contributor: fullname: Puschett – volume: 6 start-page: 28 year: 2015 ident: R51-20230824 article-title: Animal venom studies: current benefits and future developments publication-title: World J Biol Chem doi: 10.4331/wjbc.v6.i2.28 contributor: fullname: Utkin – volume: 1861 start-page: 1943 year: 2017 ident: R25-20230824 article-title: Effects of cardiotonic steroids on isolated perfused kidney and NHE3 activity in renal proximal tubules publication-title: Biochim Biophys Acta Gen Subj doi: 10.1016/j.bbagen.2017.05.012 contributor: fullname: Godinho – volume: 24 start-page: 222 year: 1949 ident: R38-20230824 article-title: Cardioactive toad poisons (bufogenin). I. Isolation of the cardioactive principles of Ch'an Su (senso) publication-title: Pharm Acta Helv contributor: fullname: Meyer – volume: 38 start-page: 347 year: 1989 ident: R47-20230824 article-title: Modified formalin test: characteristic biphasic pain response publication-title: PAIN doi: 10.1016/0304-3959(89)90222-4 contributor: fullname: Shibata – volume: 302 start-page: F959 year: 2012 ident: R2-20230824 article-title: Natriuretic effect of bufalin in isolated rat kidneys involves activation of the Na-K-ATPase-Src kinase pathway publication-title: Am J Physiol Ren Physiol doi: 10.1152/ajprenal.00130.2011 contributor: fullname: Arnaud-Batista – volume: 387 start-page: 111 year: 2000 ident: R42-20230824 article-title: Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice publication-title: Eur J Pharmacol doi: 10.1016/S0014-2999(99)00790-6 contributor: fullname: Ribeiro – volume: 45 start-page: 579 year: 2007 ident: R26-20230824 article-title: Bioactive molecules from amphibian skin: their biological activities with reference to therapeutic potentials for possible drug development publication-title: Indian J Exp Biol contributor: fullname: Gomes – volume: 19 start-page: 2566 year: 2018 ident: R34-20230824 article-title: Telocinobufagin, a novel cardiotonic steroid, promotes renal fibrosis via Na+/K+-ATPase profibrotic signaling pathways publication-title: Int J Mol Sci doi: 10.3390/ijms19092566 contributor: fullname: Kennedy – volume: 57 start-page: 284 year: 2010 ident: R21-20230824 article-title: Assessment of labrasol/labrafil/transcutol (4/4/2,v/v/v) as a non-clinical vehicle for poorly water-soluble compounds after 4-week oral toxicity study in Wistar rats publication-title: Regul Toxicol Pharmacol doi: 10.1016/j.yrtph.2010.03.008 contributor: fullname: Delongeas – volume: 53 start-page: 597 year: 2001 ident: R36-20230824 article-title: Animal models of nociception publication-title: Pharmacol Rev contributor: fullname: Le Bars – volume: 92 start-page: 193 year: 2014 ident: R28-20230824 article-title: Toxins and drug discovery publication-title: Toxicon doi: 10.1016/j.toxicon.2014.10.020 contributor: fullname: Harvey – volume: 20 start-page: 617 year: 1998 ident: R27-20230824 article-title: Simultaneous measurement of marinobufagenin, ouabain, and hypertension-associated protein in various disease states publication-title: Clin Exp Hypertens doi: 10.3109/10641969809053240 contributor: fullname: Gonick – volume: 6 start-page: 437 year: 1985 ident: R1-20230824 article-title: Novel polyhydroxylated cardiac steroids in the nuchal glands of the snake, Rhabdophis tigrinus publication-title: Biomed Res doi: 10.2220/biomedres.6.437 contributor: fullname: Akizawa – volume: 35 start-page: 3221 year: 1986 ident: R44-20230824 article-title: Origin of differences of inhibitory potency of cardiac glycosides in Na+/K+-transporting ATPase from human cardiac muscle, human brain cortex and guinea-pig cardiac muscle publication-title: Biochem Pharmacol doi: 10.1016/0006-2952(86)90416-8 contributor: fullname: Schönfeld – volume: 2 start-page: e589 year: 2017 ident: R30-20230824 article-title: Influence of opioid-related side effects on disability, mood, and opioid misuse risk among patients with chronic pain in primary care publication-title: Pain Rep doi: 10.1097/PR9.0000000000000589 contributor: fullname: Jamison – volume: 282 start-page: 10585 year: 2007 ident: R37-20230824 article-title: Identification of a pool of non pumping Na-K-ATPase publication-title: J Biol Chem doi: 10.1074/jbc.M609181200 contributor: fullname: Liang – volume: 34 start-page: 361 year: 1989 ident: R19-20230824 article-title: Behavioral effects of morphine in mice: role of experimental housing publication-title: Pharmacol Biochem Behav doi: 10.1016/0091-3057(89)90327-4 contributor: fullname: D'Amato – volume: 83 start-page: 482 year: 1976 ident: R53-20230824 article-title: The open-field test: a critical review publication-title: Psychol Bull doi: 10.1037/0033-2909.83.3.482 contributor: fullname: Walsh – volume: 159 start-page: 852 year: 1969 ident: R22-20230824 article-title: Open field behavior in the rat: what does it mean? publication-title: Ann NY Acad Sci doi: 10.1111/j.1749-6632.1969.tb12983.x contributor: fullname: Denenberg – volume: 101 start-page: 132 year: 1951 ident: R29-20230824 article-title: The effects of morphine, methadone and meperidine on some reflex responses of spinal animals to nociceptive stimulation publication-title: J Pharmacol Exp Ther contributor: fullname: Irwin |
| SSID | ssj0001949056 |
| Score | 2.1528244 |
| Snippet | In recent decades, several researches have been conducted in search of new analgesics that do not present the side effects of opioids. In this context, animal... INTRODUCTIONIn recent decades, several researches have been conducted in search of new analgesics that do not present the side effects of opioids. In this... Introduction:. In recent decades, several researches have been conducted in search of new analgesics that do not present the side effects of opioids. In this... |
| SourceID | doaj pubmedcentral proquest crossref pubmed wolterskluwer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | e791 |
| SubjectTerms | Pharmacology |
| SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1bq9QwEA56HkQQ8e56I4Kv5XSbtEkevZzDeVEOXsAHIUySCS7CdnG3-vedSdtlVwVfLH1qSm4zyXy5zDdCvADTJACnqmSMqhgyVCFDqlqtI5rYaJV5T_fig3n32b45Y5qcfagvvhM20gOPHXcabIOm1jHrQKY9GMhapxa7oAEt5lRm37o7WEyV3RWnHZn22VfOmdPL927kKpyfQst5YIsKZf_fcOaf1yVv_Oz5KHv7rdxkP7BH57fEzQlIypdjA26LK7i-I669nY7K74ovlz3B4Z2k5X2_WfWrJIGDQpAsykWWHyjZpYEjR8g-yx2SUaPUMGQOWyTpLTFytpwIcdih3MD0nTK4Jz6dn318fVFNoRSqyBCtAkKBNXRO6RZVi9ZlpI5EG1wyNloGCpqp15o2oQMVEOwSlh3WkUYpRK3uixOqLz4UMufcZIgu6ISa50uC58YwBxBYDNEuRDV3qt-MjBl-PukmIfjfhbAQr7jn9_8y33X5QFrgJy3w_9KChXg-y83T-OBDD1hjP2x9o9j7trWWCnowynFfFE0_luxxtxDmSMJHdTlOWa--Fg7uztVKmYYae6QLfvRe9aSAjAQ7moRoQTy77y_Vo__R2MfiOmc7ekQ-ESe77wM-FVe3aXhWRsEv3cwMGw priority: 102 providerName: Directory of Open Access Journals |
| Title | Potent nonopioid antinociceptive activity of telocinobufagin in models of acute pain in mice |
| URI | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=01938936-201912000-00013 https://www.ncbi.nlm.nih.gov/pubmed/31984296 https://search.proquest.com/docview/2346285881 https://pubmed.ncbi.nlm.nih.gov/PMC6903372 https://doaj.org/article/b82e704cf4b143b7af44d5e6b4ae8efd |
| Volume | 4 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwELboIiGkFeJNeVRG4pptGzuxfdxXtZdFFSwSB6TIjzFbwTbVtln-PjNOstoAJ6Kc7Mh2PGPPN_Y8GPtgVR6sNSILSomMIEPmog1ZIaUH5XMpIp3pnn1WH7_qk1MKk1P0vjDJaN-71cH659XBenWZbCs3V37a24lNl-fHqNEJofLpiI0QG95R0dPBipEGpXrvJmfUdPnJtGEK-0cZShCDzKdxNy4HEikF7v8X2vzbaHL_V00X2tsfyZ79jlRaPGaPOjjJD9thP2H3YP2UPTjvLsyfsW_LGkHxjqOSX29W9SpwS6khkCLJnOUGODk2UP4IXke-AxRtWOuaSMmLOL4pU86WKq1vdsA3tivHBp6zL4vTi-OzrEuokHkCaplFLDizpRGyAFGANhFslKCdCUp7TXBBUgC2vAhgrHBg9dzOS5h5XKvWS_GC7eF44RXjMcY8Wm-cDCBp10RCKEWRgKwG5_WYZf2kVps2bkbV33cjPao_6TFmRzTzt99S1OtUUF9_rzraV07noGbSR-kQ5jmFg5ehgNJJCxpiGLP3Pd0qXCV09WHXUDfbKhfkg1tojR29bOl421XPB2OmBhQejGVYg4yZInF3jIg_O-CFqvVhrZAXCQ-WuBWhWtw78c_F6__u6Q17SG21zpBv2d7uuoF3bLQNzYTdP1ycXBxN0qnCJK2J3ySlDX4 |
| link.rule.ids | 230,315,729,782,786,866,887,2106,27933,27934,53800,53802,64549,64569,65344,65364 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Zb9QwELZokQAJcR_LGSRe083GTmw_Qmm1iG61giLxgBT5GMMKmqy6G_j7zDhJ1QBPjfLkiXxkxp7P9hyMvTYy98ZonnopeUqQIbXB-LQQwoF0ueCBznTnn-TxF_XugMLkFIMvTDTad3a1V_883atX36Nt5frUTQc7selysY87Os5lPt1hV3G-ZtmFTXo8WtFCo14fHOW0nC4_6i5Q4fBITSliUPwUrsflSCfF0P3_w5v_mk3e_N3QlfbmR7Rov6CXDm9fckR32K0eiCZvOvJddgXqe-zaor9qv8--LhuE09ukbupmvWpWPjGUVAJ5GQ1hfkFCLhGUeSJpQrIFVIpItW2gtEcJvjHHzoaIxrVbSNamL8cKHrDPhwcn-_O0T8WQOoJ4qUEUmZlSc1EAL0DpACYIUFZ7qZwioCEodFteeNCGWzBqZmYlZA5nuXGCP2S72F94zJIQQh6M01Z4ELTeIryXkmIIGQXWqQlLB2ZU6y7iRjXclCMfq7_5OGFviWPn31K87FjQnH2r-n9cWZWDzIQLwiJAtBI7L3wBpRUGFAQ_Ya8Gflc4v-jSxNTQtJsq5-S9WyiFDT3q-H_e1CA_EyZHkjHqy5iCAhBjePcMx8GOZKjqvF8rlGFCkiUuYrihHtz_Z_zJpVt6ya7PTxZH1dH74w9P2Q2qt3OpfMZ2t2ctPGc7G9--iDPpD0zIIIs |
| linkToPdf | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Zb9QwELZokSokxF1YziDxmu5u7MT2I7RdFUGrFYfEA1LkYwwraBJ1N_D3mXGSVQM8QZSn2PKRGduf7ZlvGHthZOaN0Tz1UvKUIENqg_FpLoQD6TLBA53pnryXZ5_U0THR5GxDfUWjfWdXB9X384Nq9TXaVjbnbjrYiU2Xp4e4o-NcZtPGh-kOu4pjdpZd2qjH4xUtNK7tg7OcltPlO92RFQ6P1BQmBlVQ4ZxcjNalSN__N8z5p-nk9Z81XWuvv0Wr9ktr0-Lmf_TqFrvRA9LkZZflNrsC1R22d9pfud9ln5c1wupNUtVV3azqlU8MBZdAmUaDmB-QkGsERaBI6pBsABdHTLVtoPBHCb4x1s6aEo1rN5A0pv-OBdxjHxfHHw5P0j4kQ-oI6qUG0eTMFJqLHHgOSgcwQYCy2kvlFAEOQRRuWe5BG27BqLmZFzBzONqNE3yf7WJ74QFLQghZME5b4UHQvIswX0riEjIKrFMTlg4CKZuOeaMcbsxRluXvspywVyS1bV7izY4f6osvZf-fS6sykDPhgrAIFK3ExgufQ2GFAQXBT9jzQeYljjO6PDEV1O26zDh58eZKYUX3Ox3YVjXo0ITJkXaM2jJOQSWIXN690LGzIz0qOy_YEvWYEGWBkxlurAcagDl_-M81PWN7y6NF-fb12ZtH7BoV23lWPma7m4sWnrCdtW-fxsH0C2gNIws |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Potent+nonopioid+antinociceptive+activity+of+telocinobufagin+in+models+of+acute+pain+in+mice&rft.jtitle=Pain+reports&rft.au=Feitosa%2C+Geissy+I+M+C&rft.au=Carvalho%2C+Isabella+F&rft.au=Coelho%2C+Edivaldo+B+S&rft.au=Monteiro%2C+Marla+R+B&rft.date=2019-11-01&rft.eissn=2471-2531&rft.volume=4&rft.issue=6&rft.spage=e791&rft.epage=e791&rft_id=info:doi/10.1097%2FPR9.0000000000000791&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2471-2531&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2471-2531&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2471-2531&client=summon |