An Shp2/SFK/Ras/Erk Signaling Pathway Controls Trophoblast Stem Cell Survival

Little is known about how growth factors control tissue stem cell survival and proliferation. We analyzed mice with a null mutation of Shp2 (Ptpn11), a key component of receptor tyrosine kinase signaling. Null embryos die peri-implantation, much earlier than mice that express an Shp2 truncation. Shp...

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Bibliographic Details
Published in:	Developmental cell Vol. 10; no. 3; pp. 317 - 327
Main Authors:	Yang, Wentian, Klaman, Lori D., Chen, Binbin, Araki, Toshiyuki, Harada, Hisashi, Thomas, Sheila M., George, Elizabeth L., Neel, Benjamin G.
Format:	Journal Article
Language:	English
Published:	Cambridge, MA Elsevier Inc 01-03-2006 Cell Press
Subjects:	Animals Apoptosis - physiology Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Bcl-2-Like Protein 11 Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell physiology Cell Survival Cells, Cultured DEVBIO Enzyme Activation Extracellular Signal-Regulated MAP Kinases - genetics Extracellular Signal-Regulated MAP Kinases - metabolism Female Fibroblast Growth Factor 4 - metabolism Fundamental and applied biological sciences. Psychology Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Male Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Knockout Molecular and cellular biology Protein Tyrosine Phosphatase, Non-Receptor Type 11 Protein Tyrosine Phosphatases - genetics Protein Tyrosine Phosphatases - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism ras Proteins - genetics ras Proteins - metabolism SH2 Domain-Containing Protein Tyrosine Phosphatases Signal transduction Signal Transduction - physiology SIGNALING src Homology Domains Stem Cells - cytology Stem Cells - physiology STEMCELL Trophoblasts - cytology Trophoblasts - metabolism STEMCELL DEVBIO SIGNALING Signal transduction Regulation(control) Extracellular signal-regulated protein kinase Enzyme Stem cell Development Survival
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