Associations of Diabetes Mellitus, Insulin, Leptin, and Ghrelin With Gastroesophageal Reflux and Barrett's Esophagus

Background & Aims Insulin and leptin have proliferative and anti-apoptotic effects. Ghrelin promotes gastric emptying and secretion of growth hormone and inhibits inflammation. We assessed whether diabetes mellitus and serum levels of insulin, leptin, and ghrelin are associated with gastroesopha...

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Bibliographic Details
Published in:	Gastroenterology (New York, N.Y. 1943) Vol. 145; no. 6; pp. 1237 - 1244.e5
Main Authors:	Rubenstein, Joel H, Morgenstern, Hal, McConell, Daniel, Scheiman, James M, Schoenfeld, Philip, Appelman, Henry, McMahon, Laurence F, Kao, John Y, Metko, Val, Zhang, Min, Inadomi, John M
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-12-2013
Subjects:	Aged Barrett Esophagus - blood Barrett Esophagus - diagnosis Barrett Esophagus - epidemiology Case-Control Studies Diabetes Complications - blood Diabetes Complications - complications Endoscopy, Gastrointestinal Gastroenterology and Hepatology Gastroesophageal Reflux Gastroesophageal Reflux - blood Gastroesophageal Reflux - diagnosis Gastroesophageal Reflux - epidemiology Ghrelin Ghrelin - blood Humans Incidence Insulin Insulin - blood Leptin Leptin - blood Logistic Models Male Middle Aged Risk Factors BE colorectal cancer OR CI PPI Gastroesophageal Reflux odds ratio Insulin proton pump inhibitor GERD Ghrelin CRC LA Leptin Barrett's esophagus confidence interval Los Angeles gastroesophageal reflux disease
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