Terpene-Containing Analogues of Glitazars as Potential Therapeutic Agents for Metabolic Syndrome
Metabolic syndrome is a complex of abnormalities involving impaired glucose and lipid metabolism, which needs effective pharmacotherapy. One way to reduce lipid and glucose levels associated with this pathology is the simultaneous activation of nuclear PPAR-alpha and gamma. For this purpose, we synt...
Saved in:
| Published in: | Current issues in molecular biology Vol. 45; no. 3; pp. 2230 - 2247 |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Switzerland
MDPI
01-03-2023
MDPI AG |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Metabolic syndrome is a complex of abnormalities involving impaired glucose and lipid metabolism, which needs effective pharmacotherapy. One way to reduce lipid and glucose levels associated with this pathology is the simultaneous activation of nuclear PPAR-alpha and gamma. For this purpose, we synthesized a number of potential agonists based on the pharmacophore fragment of glitazars with the inclusion of mono- or diterpenic moiety in the molecular structure. The study of their pharmacological activity in mice with obesity and type 2 diabetes mellitus (C57Bl/6
) revealed one substance that was capable of reducing the triglyceride levels in the liver and adipose tissue of mice by enhancing their catabolism and expressing a hypoglycemic effect connected with the sensitization of mice tissue to insulin. It has also been shown to have no toxic effects on the liver. |
|---|---|
| AbstractList | Metabolic syndrome is a complex of abnormalities involving impaired glucose and lipid metabolism, which needs effective pharmacotherapy. One way to reduce lipid and glucose levels associated with this pathology is the simultaneous activation of nuclear PPAR-alpha and gamma. For this purpose, we synthesized a number of potential agonists based on the pharmacophore fragment of glitazars with the inclusion of mono- or diterpenic moiety in the molecular structure. The study of their pharmacological activity in mice with obesity and type 2 diabetes mellitus (C57Bl/6
) revealed one substance that was capable of reducing the triglyceride levels in the liver and adipose tissue of mice by enhancing their catabolism and expressing a hypoglycemic effect connected with the sensitization of mice tissue to insulin. It has also been shown to have no toxic effects on the liver. Metabolic syndrome is a complex of abnormalities involving impaired glucose and lipid metabolism, which needs effective pharmacotherapy. One way to reduce lipid and glucose levels associated with this pathology is the simultaneous activation of nuclear PPAR-alpha and gamma. For this purpose, we synthesized a number of potential agonists based on the pharmacophore fragment of glitazars with the inclusion of mono- or diterpenic moiety in the molecular structure. The study of their pharmacological activity in mice with obesity and type 2 diabetes mellitus (C57Bl/6Ay) revealed one substance that was capable of reducing the triglyceride levels in the liver and adipose tissue of mice by enhancing their catabolism and expressing a hypoglycemic effect connected with the sensitization of mice tissue to insulin. It has also been shown to have no toxic effects on the liver. Metabolic syndrome is a complex of abnormalities involving impaired glucose and lipid metabolism, which needs effective pharmacotherapy. One way to reduce lipid and glucose levels associated with this pathology is the simultaneous activation of nuclear PPAR-alpha and gamma. For this purpose, we synthesized a number of potential agonists based on the pharmacophore fragment of glitazars with the inclusion of mono- or diterpenic moiety in the molecular structure. The study of their pharmacological activity in mice with obesity and type 2 diabetes mellitus (C57Bl/6 Ay ) revealed one substance that was capable of reducing the triglyceride levels in the liver and adipose tissue of mice by enhancing their catabolism and expressing a hypoglycemic effect connected with the sensitization of mice tissue to insulin. It has also been shown to have no toxic effects on the liver. |
| Author | Zhukova, Natalia A Elhajjar, Cham Fomenko, Vladislav V Kuranov, Sergey O Blokhin, Mikhail E Khvostov, Mikhail V Tolstikova, Tatiana G Luzina, Olga A Salakhutdinov, Nariman F |
| AuthorAffiliation | N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, 630090 Novosibirsk, Russia |
| AuthorAffiliation_xml | – name: N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, 630090 Novosibirsk, Russia |
| Author_xml | – sequence: 1 givenname: Mikhail E surname: Blokhin fullname: Blokhin, Mikhail E organization: N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, 630090 Novosibirsk, Russia – sequence: 2 givenname: Sergey O surname: Kuranov fullname: Kuranov, Sergey O organization: N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, 630090 Novosibirsk, Russia – sequence: 3 givenname: Mikhail V orcidid: 0000-0002-5906-4223 surname: Khvostov fullname: Khvostov, Mikhail V organization: N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, 630090 Novosibirsk, Russia – sequence: 4 givenname: Vladislav V orcidid: 0000-0003-1827-3309 surname: Fomenko fullname: Fomenko, Vladislav V organization: N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, 630090 Novosibirsk, Russia – sequence: 5 givenname: Olga A orcidid: 0000-0001-8627-3453 surname: Luzina fullname: Luzina, Olga A organization: N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, 630090 Novosibirsk, Russia – sequence: 6 givenname: Natalia A surname: Zhukova fullname: Zhukova, Natalia A organization: N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, 630090 Novosibirsk, Russia – sequence: 7 givenname: Cham surname: Elhajjar fullname: Elhajjar, Cham organization: N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, 630090 Novosibirsk, Russia – sequence: 8 givenname: Tatiana G surname: Tolstikova fullname: Tolstikova, Tatiana G organization: N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, 630090 Novosibirsk, Russia – sequence: 9 givenname: Nariman F surname: Salakhutdinov fullname: Salakhutdinov, Nariman F organization: N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, 630090 Novosibirsk, Russia |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36975514$$D View this record in MEDLINE/PubMed |
| BookMark | eNpVkc1v3CAQxVGVqPlobz1XPvZQt7CAwadqtWqTSKkSqdszHduDQ4RhC95I6V8fkk2jjTiA3jz9ZoZ3Qg5CDEjIB0a_cN7Sr72bOiEpp0yIN-SYiUbVnAp5sPc-Iic531IqlVbsLTniTaukZOKY_Flj2mDAehXDDC64MFbLAD6OW8xVtNWZdzP8g5QryNV1nDHMDny1vsEEG9zOrq-WYxFzZWOqfuIMXfRF_HUfhhQnfEcOLfiM75_vU_L7x_f16ry-vDq7WC0v614yPddCg7ZKyaETXAMu7MCbRmqKfSM6BGl1wxj0C9vwQZd1i9ei0sBYKVnG-Sm52HGHCLdmk9wE6d5EcOZJiGk0kMq0Hg1jAwiOSrTlgG2gpZYNFCjnjCN9ZH3bsTbbbsKhL-sl8K-gryvB3Zgx3hlGqVCai0L49ExI8W_5ydlMLvfoPQSM22wWql1I2khGi_XzztqnmHNC-9KHUfOYsNlPuNg_7s_2Yv4fKX8Ao9qkkg |
| CitedBy_id | crossref_primary_10_3390_cimb45070359 |
| Cites_doi | 10.1007/s00114-011-0770-7 10.3390/cells9020352 10.1038/nm1029 10.2337/diacare.17.2.152 10.3390/scipharm89010004 10.1097/FJC.0000000000000891 10.1248/bpb.b19-00986 10.1080/10575630108041297 10.1177/1753944717711379 10.1016/j.ijpharm.2012.08.021 10.1007/s10600-019-02613-x 10.1021/acs.biochem.8b00655 10.2337/dcS13-2003 10.2174/13894501113149990199 10.1002/ptr.1711 10.1016/j.bbadis.2011.02.014 10.1007/s10600-021-03391-1 10.1016/j.cbi.2016.02.020 10.1016/0026-0495(92)90185-D 10.1016/j.biopha.2020.110155 10.2174/1874467212666190111165015 10.3390/ijms19082189 10.1016/j.dsx.2014.09.015 10.3390/molecules27248663 10.1007/s10600-018-2448-2 10.3389/fendo.2020.00222 10.1016/S0014-5793(03)00859-7 |
| ContentType | Journal Article |
| Copyright | 2023 by the authors. 2023 |
| Copyright_xml | – notice: 2023 by the authors. 2023 |
| DBID | NPM AAYXX CITATION 7X8 5PM DOA |
| DOI | 10.3390/cimb45030144 |
| DatabaseName | PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) Directory of Open Access Journals |
| DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
| DatabaseTitleList | PubMed CrossRef |
| Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals url: http://www.doaj.org/ sourceTypes: Open Website |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1467-3045 |
| EndPage | 2247 |
| ExternalDocumentID | oai_doaj_org_article_11da43e749494af6a90f1d0a03313e03 10_3390_cimb45030144 36975514 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: state assignments to N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS grantid: project No. 1021051402785-4-1.4.1 – fundername: N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS grantid: 1021051402785-4-1.4.1; 1021051703312-0-1.4.1 |
| GroupedDBID | --- 36B 53G 5GY AENEX AFZYC ALMA_UNASSIGNED_HOLDINGS DIK E3Z EMB F5P FRP GROUPED_DOAJ GX1 IAO IHR INH ITC MODMG M~E NPM OK1 PGMZT RNS RPM TR2 AAYXX CITATION 7X8 5PM |
| ID | FETCH-LOGICAL-c518t-48a8f775db438ae2fd366580ec64bea5f8611ac2f63d8450f77fe78a115f8f133 |
| IEDL.DBID | RPM |
| ISSN | 1467-3045 1467-3037 |
| IngestDate | Tue Oct 22 15:14:28 EDT 2024 Tue Sep 17 21:35:32 EDT 2024 Fri Oct 25 04:42:23 EDT 2024 Thu Sep 26 15:54:28 EDT 2024 Sat Sep 28 08:16:30 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | metabolic syndrome ITT terpenic derivatives OGTT glitazars isopimaric acid |
| Language | English |
| License | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c518t-48a8f775db438ae2fd366580ec64bea5f8611ac2f63d8450f77fe78a115f8f133 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0003-1827-3309 0000-0002-5906-4223 0000-0001-8627-3453 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047834/ |
| PMID | 36975514 |
| PQID | 2792506510 |
| PQPubID | 23479 |
| PageCount | 18 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_11da43e749494af6a90f1d0a03313e03 pubmedcentral_primary_oai_pubmedcentral_nih_gov_10047834 proquest_miscellaneous_2792506510 crossref_primary_10_3390_cimb45030144 pubmed_primary_36975514 |
| PublicationCentury | 2000 |
| PublicationDate | 2023-03-01 |
| PublicationDateYYYYMMDD | 2023-03-01 |
| PublicationDate_xml | – month: 03 year: 2023 text: 2023-03-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland |
| PublicationTitle | Current issues in molecular biology |
| PublicationTitleAlternate | Curr Issues Mol Biol |
| PublicationYear | 2023 |
| Publisher | MDPI MDPI AG |
| Publisher_xml | – name: MDPI – name: MDPI AG |
| References | Lu (ref_13) 2021; 2021 Kalliora (ref_31) 2020; 76 Varga (ref_4) 2011; 1812 Qi (ref_26) 2004; 10 Agrawal (ref_5) 2014; 15 Gromova (ref_24) 2021; 57 Eldor (ref_27) 2013; 36 ref_11 Rochlani (ref_1) 2017; 11 Hjortness (ref_25) 2018; 57 Xie (ref_15) 2020; 127 Massaro (ref_21) 2011; 98 Saito (ref_28) 2020; 11 Oladejo (ref_2) 2011; 9 Zhang (ref_14) 2020; 43 Ulubelen (ref_20) 2001; 15 Gromova (ref_18) 2019; 55 Lovejoy (ref_30) 1992; 41 Takahashi (ref_16) 2003; 550 Smith (ref_19) 2005; 19 Tai (ref_10) 1994; 17 ref_3 Liu (ref_23) 2018; 54 Balakumar (ref_6) 2019; 12 ref_9 ref_8 Janani (ref_29) 2015; 9 Lee (ref_17) 2016; 16 Gelmini (ref_22) 2013; 440 ref_7 Srinivasan (ref_12) 2016; 250 |
| References_xml | – volume: 98 start-page: 329 year: 2011 ident: ref_21 article-title: Cerumen of Australian stingless bees (Tetragonula carbonaria): Gas chromatography-mass spectrometry fingerprints and potential anti-inflammatory properties publication-title: Naturwissenschaften doi: 10.1007/s00114-011-0770-7 contributor: fullname: Massaro – ident: ref_9 – ident: ref_7 doi: 10.3390/cells9020352 – volume: 10 start-page: 524 year: 2004 ident: ref_26 article-title: Adiponectin acts in the brain to decrease body weight publication-title: Nat. Med. doi: 10.1038/nm1029 contributor: fullname: Qi – volume: 9 start-page: 78 year: 2011 ident: ref_2 article-title: Overview of the metabolic syndrome; an emerging pandemic of public health significance publication-title: Ann. Ib. Postgrad. Med. contributor: fullname: Oladejo – volume: 17 start-page: 152 year: 1994 ident: ref_10 article-title: A Mathematical Model for the Determination of Total Area Under Glucose Tolerance and Other Metabolic Curves publication-title: Diabetes Care doi: 10.2337/diacare.17.2.152 contributor: fullname: Tai – ident: ref_8 doi: 10.3390/scipharm89010004 – volume: 76 start-page: 514 year: 2020 ident: ref_31 article-title: The Glitazars Paradox: Cardiotoxicity of the Metabolically Beneficial Dual PPARα and PPARγ Activation publication-title: J. Cardiovasc. Pharmacol. doi: 10.1097/FJC.0000000000000891 contributor: fullname: Kalliora – volume: 43 start-page: 526 year: 2020 ident: ref_14 article-title: WSF-7 Inhibits Obesity-Mediated PPARγ Phosphorylation and Improves Insulin Sensitivity in 3T3-L1 Adipocytes publication-title: Biol. Pharm. Bull. doi: 10.1248/bpb.b19-00986 contributor: fullname: Zhang – volume: 15 start-page: 307 year: 2001 ident: ref_20 article-title: A New Antibacterial Diterpene from the Roots of Salvia caespitosa publication-title: Nat. Prod. Lett. doi: 10.1080/10575630108041297 contributor: fullname: Ulubelen – volume: 11 start-page: 215 year: 2017 ident: ref_1 article-title: Metabolic syndrome: Pathophysiology, management, and modulation by natural compounds publication-title: Ther. Adv. Cardiovasc. Dis. doi: 10.1177/1753944717711379 contributor: fullname: Rochlani – volume: 2021 start-page: 1 year: 2021 ident: ref_13 article-title: Potential therapeutic effect of Citronellal on diabetic cardiomyopathy in experimental rats publication-title: Evid.-Based Complement. Altern. Med. contributor: fullname: Lu – volume: 440 start-page: 170 year: 2013 ident: ref_22 article-title: GC–MS profiling of the phytochemical constituents of the oleoresin from Copaifera langsdorffii Desf. and a preliminary in vivo evaluation of its antipsoriatic effect publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2012.08.021 contributor: fullname: Gelmini – volume: 55 start-page: 52 year: 2019 ident: ref_18 article-title: Synthetic Transformations of Higher Terpenoids. 37. Synthesis and Cytotoxicity of 4-(Oxazol-2-Yl)-18-Norisopimaranes publication-title: Chem. Nat. Compd. doi: 10.1007/s10600-019-02613-x contributor: fullname: Gromova – volume: 57 start-page: 5886 year: 2018 ident: ref_25 article-title: Abietane-Type Diterpenoids Inhibit Protein Tyrosine Phosphatases by Stabilizing an Inactive Enzyme Conformation publication-title: Biochemistry doi: 10.1021/acs.biochem.8b00655 contributor: fullname: Hjortness – volume: 36 start-page: S162 year: 2013 ident: ref_27 article-title: In Vivo Actions of Peroxisome Proliferator–Activated Receptors: Glycemic control, insulin sensitivity, and insulin secretion publication-title: Diabetes Care doi: 10.2337/dcS13-2003 contributor: fullname: Eldor – volume: 15 start-page: 151 year: 2014 ident: ref_5 article-title: The First Approved Agent in the Glitazar’s Class: Saroglitazar publication-title: Curr. Drug Targets doi: 10.2174/13894501113149990199 contributor: fullname: Agrawal – volume: 19 start-page: 538 year: 2005 ident: ref_19 article-title: Isopimaric acid from Pinus nigra shows activity against multidrug-resistant and EMRSA strains of Staphylococcus aureus publication-title: Phytother. Res. doi: 10.1002/ptr.1711 contributor: fullname: Smith – volume: 1812 start-page: 1007 year: 2011 ident: ref_4 article-title: PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation publication-title: Biochim. Biophys. Acta (BBA)—Mol. Basis Dis. doi: 10.1016/j.bbadis.2011.02.014 contributor: fullname: Varga – volume: 57 start-page: 474 year: 2021 ident: ref_24 article-title: Synthetic Transformations of Higher Terpenoids. 39.∗ Synthesis and Analgesic Activity of Isopimaric Acid Derivatives publication-title: Chem. Nat. Compd. doi: 10.1007/s10600-021-03391-1 contributor: fullname: Gromova – volume: 16 start-page: 1 year: 2016 ident: ref_17 article-title: Ethanol extract of Pinus koraiensis leaves containing lambertianic acid exerts anti-obesity and hypolipidemic effects by activating adenosine monophosphate-activated protein kinase (AMPK) publication-title: BMC Complement. Altern. Med. contributor: fullname: Lee – volume: 250 start-page: 38 year: 2016 ident: ref_12 article-title: Antidiabetic efficacy of citronellol, a citrus monoterpene by ameliorating the hepatic key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats publication-title: Chem.-Biol. Interact. doi: 10.1016/j.cbi.2016.02.020 contributor: fullname: Srinivasan – volume: 41 start-page: 22 year: 1992 ident: ref_30 article-title: Insulin resistance in obesity is associated with elevated basal lactate levels and diminished lactate appearance following intravenous glucose and insulin publication-title: Metabolism doi: 10.1016/0026-0495(92)90185-D contributor: fullname: Lovejoy – volume: 127 start-page: 110155 year: 2020 ident: ref_15 article-title: Dehydroabietic acid alleviates high fat diet-induced insulin resistance and hepatic steatosis through dual activation of PPAR-γ and PPAR-α publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2020.110155 contributor: fullname: Xie – volume: 12 start-page: 195 year: 2019 ident: ref_6 article-title: A Contemporary Overview of PPARα/γ Dual Agonists for the Management of Diabetic Dyslipidemia publication-title: Curr. Mol. Pharmacol. doi: 10.2174/1874467212666190111165015 contributor: fullname: Balakumar – ident: ref_3 doi: 10.3390/ijms19082189 – volume: 9 start-page: 46 year: 2015 ident: ref_29 article-title: PPAR Gamma Gene—A Review publication-title: Diabetes Metab. Syndr. Clin. Res. Rev. doi: 10.1016/j.dsx.2014.09.015 contributor: fullname: Janani – ident: ref_11 doi: 10.3390/molecules27248663 – volume: 54 start-page: 695 year: 2018 ident: ref_23 article-title: Synthesis and Cytotoxic Activity of Amides from Isopimaric Acid publication-title: Chem. Nat. Compd. doi: 10.1007/s10600-018-2448-2 contributor: fullname: Liu – volume: 11 start-page: 1 year: 2020 ident: ref_28 article-title: Brown Adipose Tissue, Diet-Induced Thermogenesis, and Thermogenic Food Ingredients: From Mice to Men publication-title: Front. Endocrinol. doi: 10.3389/fendo.2020.00222 contributor: fullname: Saito – volume: 550 start-page: 190 year: 2003 ident: ref_16 article-title: Abietic acid activates peroxisome proliferator-activated receptor-γ (PPARγ) in RAW264.7 macrophages and 3T3-L1 adipocytes to regulate gene expression involved in inflammation and lipid metabolism publication-title: FEBS Lett. doi: 10.1016/S0014-5793(03)00859-7 contributor: fullname: Takahashi |
| SSID | ssj0057871 ssib044733985 |
| Score | 2.3673925 |
| Snippet | Metabolic syndrome is a complex of abnormalities involving impaired glucose and lipid metabolism, which needs effective pharmacotherapy. One way to reduce... |
| SourceID | doaj pubmedcentral proquest crossref pubmed |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database |
| StartPage | 2230 |
| SubjectTerms | glitazars isopimaric acid ITT metabolic syndrome OGTT terpenic derivatives |
| SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LT9wwEB4BEhIXRMuj4VEZCY4R9tqJnSOU16UVEovELdiJLZBKFpHdQ_vrmYnDsouQuHCLHCtxvhnH3yTjbwAOjMgdsgqdVnwQUuV0nTrneaqMcyorkOF3ck2X1_rPrTk9I5mcaakvygmL8sARuCMhaquk16SiomzIbcGDqLnlUgrpe51PbmaCKfQkpbSUxRsRJrcUcZ8RTikudUyBxz78qHp4xFHF0GJuceo0_D8inu_zJ2cWpPM1WO2ZJDuOT_ANFnzzHZZjbcl_63A39M9P-CJLSX8qloFgpEBCn2paNgrsguS5_2Ncy2zLrkZjShvC6w3fNmSxY9p31TLktey3H6O7_MXG617jYANuzs-Gvy7TvpxCWmXCjBF-a4LWWe2UNNYPQi1z5B_cV7ly3mbB5ELYahByWRtEBPsGr41FzhhMwFh2E5aaUeN_AMuctMFVhcj8QHnJEXEdaptnFVoIDxI4fMWxfIqqGSVGG4R3OYt3AicE8rQPaV13DegBZe8B5WcekMD-q4lKnBv0w8M2fjRpSxJHzJBjCZ7AVjTZ9FYyLzSxxQTMnDHnxjJ_pnm47_S3SWSP6pNsf8Xod2CFKtjHtLZdWBo_T_weLLb15Gfn0i_hlfkf priority: 102 providerName: Directory of Open Access Journals |
| Title | Terpene-Containing Analogues of Glitazars as Potential Therapeutic Agents for Metabolic Syndrome |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/36975514 https://search.proquest.com/docview/2792506510 https://pubmed.ncbi.nlm.nih.gov/PMC10047834 https://doaj.org/article/11da43e749494af6a90f1d0a03313e03 |
| Volume | 45 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9QwEB2xlUC9IL5JgcpIcEzXXju2cyylpZeiSl0kbsF2bFipm6w2uwf66xnHm7ZBnLhFjuNYM-P4jTPzBuCDZtIiqlC5o7OQC6vq3FpPc6GtFUWJCL-nazq_Ul-_68-nkSZHDrkwfdC-s4uj5np51Cx-9bGVq6WbDnFi08uLk8hyFgtETCcwQXA49tGFUJyXdyA4miRLOUa4nChXKfwd-9CpWyxxRsmt2IdHXJYqIojRHtVT-f8Lf_4dRnlvXzp7Ao93gJIcp4k_hQe-eQYPU4nJ38_hx9yvV_g9yyMNVaoGQSIRSTyx6UgbyJfI0n2D7i0xHblsNzF6CMeb3-VlkeOYftURhLfkwm_Qaq6x8WpHdfACvp2dzk_O811VhdwVTG9QC0YHpYraCq6Nn4WaS4Qh1DsprDdF0JIx42ZB8lqjcLBv8EobhI5BB3RpX8Je0zb-NZDCchOsK1nhZ8JzisJXoTaycCZIvMjg4yDHapXIMyp0OqLoq_uiz-BTFPJtn0h53Te065_VTvHoqtRGcK8inY7A8U1JA6upoZwz7inP4P2gogqXSPzvYRrfbrsqciQWCLUYzeBVUtntqwaVZ6BHyhzNZXwHrbKn4R6s8OD_H30D-7F8fYppewt7m_XWv4NJV28P-8OBw96y_wAziPvA |
| link.rule.ids | 230,315,729,782,786,866,887,2108,27935,27936,53803,53805 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9QwEB3RImgvfLYQPo0Ex3Sd2LGdYykti-hWlbpI3ILt2LBSN1ltdg_w6xknm7ZBnHqLbMdx_GaSN8n4GeC9SoRBViFjS1MfcyPL2BhHY66M4VmODL-VaxpfyLPv6tNxkMkR_VqYNmnfmtlBdTk_qGa_2tzKxdyO-jyx0fnkKKichQ0iRltwFx2WsmGUzrlkLL-mwcEok26VEToUZbJLgMc2dGRncxxTF1jswn0mchk4xOAt1Yr5_4-B_ptIeePNdPLwtvf0CB5suCg57Oofwx1XPYF73e6Uv5_Cj6lbLvBRGAcFq24jCRI0TMLHnobUnnwOAt9_MDImuiHn9SokHmF_0-slXeQwrNxqCDJjMnErNLhLLLzYqCTswbeT4-nRON5syBDbLFErBFArL2VWGs6UdqkvmUAGQ50V3DideSWSRNvUC1YqnFVs651UGlmnVx6j4X3YrurKPQeSGaa9sXmSuZQ7RhE16UstMqu9wIMIPvQAFItOd6PAeCVgVtzELIKPAZ2rNkEtuy2olz-LzfxilFNqzpwMSjwc-9c59UlJNWUsYY6yCN712BboXeGXia5cvW6KIK-YIUtLaATPOqyvLtXbSgRqYAWDsQxrEPxWwbsH-8XtT30LO-Pp5LQ4_XL29SXspsi9utS4V7C9Wq7da9hqyvWb1jH-AvgDEJE |
| linkToPdf | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb5wwEB41qRrlkvQdmj5cqT0SDDbY5JbXNlWbaKVspd6oje12pSyslt1D--s7hiUJVU_tDRljjL8x_gZmPgO8k3GmkVWIsKSJC7kWJtTa0pBLrXmaI8Nv5ZrOr8TlV3l65mVyDvtcmDZov9TTg-p6dlBNf7SxlfNZGfVxYtH44sSrnPkNIqK5cdEG3MdJS9Ohp865YCy_pcLeMOMu0wgnFWWiC4LHOjQqpzPsV-dcbMMWy3LhecRgpWoF_f_GQv8MpryzOo12_-e5HsLOmpOSo67OI7hnq8fwoNul8ucT-Daxizm-EkOvZNVtKEG8lon_6NOQ2pEPXuj7F3rIRDVkXC99ABK2N7lN7SJHPoOrIciQyYVdouFdY-HVWi3hKXwZnU1OzsP1xgxhmcZyiUAq6YRIjeZMKps4wzJkMtSWGddWpU5mcazKxGXMSBxZrOuskArZp5MOveJnsFnVld0DkmqmnC7zOLUJt4wicsIZlaWlchkeBPC-B6GYd_obBfotHrfiLm4BHHuEbup41ey2oF58L9ZjjN6OUZxZ4RV5OLavcupiQxVlLGaWsgDe9vgWOMv8rxNV2XrVFF5mMUW2FtMAnnd439yqt5cA5MASBn0ZnkEDaJW8e8Bf_Pulb2BrfDoqPn-8_LQP2wlSsC5C7iVsLhcr-wo2GrN63c6N34rMExE |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Terpene-Containing+Analogues+of+Glitazars+as+Potential+Therapeutic+Agents+for+Metabolic+Syndrome&rft.jtitle=Current+issues+in+molecular+biology&rft.au=Blokhin%2C+Mikhail+E&rft.au=Kuranov%2C+Sergey+O&rft.au=Khvostov%2C+Mikhail+V&rft.au=Fomenko%2C+Vladislav+V&rft.date=2023-03-01&rft.eissn=1467-3045&rft.volume=45&rft.issue=3&rft.spage=2230&rft.epage=2247&rft_id=info:doi/10.3390%2Fcimb45030144&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1467-3045&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1467-3045&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1467-3045&client=summon |