Improving the Antioxidant Properties of Calophyllum inophyllum Seed Oil from French Polynesia: Development and Biological Applications of Resinous Ethanol-Soluble Extracts

• Published in: Antioxidants Vol. 10; no. 2; p. 199
• Main Authors: Cassien, Mathieu, Mercier, Anne, Thétiot-Laurent, Sophie, Culcasi, Marcel, Ricquebourg, Emilie, Asteian, Alice, Herbette, Gaëtan, Bianchini, Jean-Pierre, Raharivelomanana, Phila, Pietri, Sylvia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30-01-2021; MDPI
• Subjects: Antioxidants; Bioactive compounds; Calophyllum inophyllum; Calophyllum inophyllum L; Chemical Sciences; Chromatography; Ethanol; ethanol-soluble resin extracts; Flavonoids; High-performance liquid chromatography; Inflammation; lipophilic antioxidants; Oils & fats; phenolics; pyranocoumarins; Resins; Seeds; Tamanu oil; France; Germany; French Polynesia; UV protection; antimicrobial; Tamanu oil; EPR spin trapping; ethanol-soluble resin extracts; pyranocoumarins; anti-inflammatory; Calophyllum inophyllum L; lipophilic antioxidants; phenolics
• ISSN: 2076-3921; 2076-3921
• DOI: 10.3390/antiox10020199

Tamanu oil from
L. has long been used in traditional medicine. Ethanol extraction was found the best strategy for recovering bioactive compounds from the resin part of Tamanu oil, yielding two neutral and acidic resins fractions with high phenolics, flavonoids and pyranocoumarins concentrations. A further cascade of LPLC/HPLC separations of neutral and acidic resin fractions allowed identifying fifteen metabolites, and among them, calanolide D and 12-oxocalanolide A (both in neutral fraction) were first identified from a natural source. All these extracts, subfractions and isolated metabolites demonstrated increased free radical scavenging, antioxidant, anti-inflammatory, antimicrobial and antimycobacterial activity compared to Tamanu oil and its de-resinated lipid phase. Overall, these results could promote resinous ethanol-soluble Tamanu oil extracts as a useful multifaceted and renewable medicinal resource.