Purification of a neuroprotective component of Parawixia bistriata spider venom that enhances glutamate uptake

In this study, we examined the effects of crude venom from the spider Parawixia bistriata on glutamate and GABA uptake into synaptosomes prepared from rat cerebral cortex. Addition of venom to cortical synaptosomes stimulated glutamate uptake and inhibited GABA uptake in a concentration‐dependent ma...

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Bibliographic Details
Published in:	British journal of pharmacology Vol. 139; no. 7; pp. 1297 - 1309
Main Authors:	Fontana, Andréia Cristina Karklin, Guizzo, Renato, Beleboni, Renê de Oliveira, Meirelles e Silva, Antonio Renato, Coimbra, Norberto Cysne, Amara, Susan G, Santos, Wagner Ferreira dos, Coutinho‐Netto, Joaquim
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-08-2003 Nature Publishing
Subjects:	acute glaucoma Animals Biological and medical sciences Brazil Carbon Isotopes Cerebral Cortex - cytology Chromatography, High Pressure Liquid - methods Chromatography, Ion Exchange Disease Models, Animal Dose-Response Relationship, Drug GABA uptake gamma-Aminobutyric Acid - drug effects gamma-Aminobutyric Acid - pharmacokinetics gamma-Aminobutyric Acid - secretion Glaucoma - drug therapy Glaucoma - physiopathology Glutamate uptake Glutamic Acid - drug effects Glutamic Acid - pharmacokinetics Glutamic Acid - secretion Ion Channels - drug effects Ion Channels - metabolism Ion Channels - physiopathology Male Medical sciences neuroprotection Neuroprotective Agents - chemistry Neuroprotective Agents - isolation & purification Neuroprotective Agents - pharmacology neurotransmitter transport Pharmacology. Drug treatments purification Rats Rats, Wistar Receptors, Metabotropic Glutamate - drug effects Receptors, Metabotropic Glutamate - physiology Retina - drug effects Retina - pathology Retina - ultrastructure spider venom Spider Venoms - chemistry Spider Venoms - isolation & purification Spider Venoms - pharmacology Spiders synaptosomes Synaptosomes - drug effects Synaptosomes - secretion Tissue Extracts - pharmacology Tritium Brazil Glaucoma Neuroprotection neurotransmitter transport Biological transport Synaptosome Glaucoma (eye) Neuromediator acute glaucoma spider venom Protozoa Purification synaptosomes Glutamate Glutamate uptake Uptake Eye disease Arachnida Arthropoda Venom Excitatory aminoacid GABA Neurotransmitter Ciliata GABA uptake Invertebrata
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