Impaired long-term potentiation-like cortical plasticity in presymptomatic genetic frontotemporal dementia

• Published in: Annals of neurology Vol. 80; no. 3; pp. 472 - 476
• Main Authors: Benussi, Alberto, Cosseddu, Maura, Filareto, Ilaria, Dell'Era, Valentina, Archetti, Silvana, Sofia Cotelli, Maria, Micheli, Anna, Padovani, Alessandro, Borroni, Barbara
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01-09-2016; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; Biomarkers; C9orf72 Protein; Cerebral Cortex - physiopathology; Cortex; Dementia; Dementia disorders; Female; Frontotemporal dementia; Frontotemporal Dementia - genetics; Frontotemporal Dementia - physiopathology; Granulin; Heterozygote; Humans; Intercellular Signaling Peptides and Proteins - genetics; Long-Term Potentiation - physiology; Magnetic fields; Male; Middle Aged; Mutation; Neural plasticity; Potentiation; Prodromal Symptoms; Proteins - genetics; Single-Blind Method; Transcranial magnetic stimulation; Transcranial Magnetic Stimulation - methods
• ISSN: 0364-5134; 1531-8249
• DOI: 10.1002/ana.24731

Neurophysiological biomarkers were assessed using a transcranial magnetic stimulation multiparadigm approach in 13 presymptomatic (n = 13 Granulin) and 14 symptomatic (n = 11 Granulin, n = 3 C9orf72) subjects with a pathogenic mutation for frontotemporal dementia (FTD). Intracortical facilitation and long‐term potentiation–like plasticity were impaired in presymptomatic carriers, compared to healthy controls, more than 15 years before expected symptom onset. In symptomatic carriers, a decrease in short‐interval intracortical inhibition, compared to presymptomatic carriers, was found. In conclusion, these biomarkers could provide the footprints of specific physiopathological processes in the development of this disease and possibly support the diagnosis of autosomal‐dominant FTD. Ann Neurol 2016;80:472–476