Advances of stem cell based-therapeutic approaches for tendon repair

• Published in: Journal of orthopaedic translation Vol. 9; no. C; pp. 69 - 75
• Main Authors: Liu, Lidi, Hindieh, Jennifer, Leong, Daniel J., Sun, Hui B.
• Format: Journal Article
• Language: English
• Published: Singapore Elsevier (Singapore) Pte Ltd 01-04-2017; Chinese Speaking Orthopaedic Society; Elsevier
• Subjects: Review; stem cells; tendinopathy; tendon repair; tendon repair; stem cells; tendinopathy
• ISSN: 2214-031X; 2214-0328
• DOI: 10.1016/j.jot.2017.03.007

Tendon injuries are significant clinical problems. Current treatments often result in incomplete repair or healing, which may lead to reduced function and rupture. Stem cell-based therapy is a promising intervention for tendon repair. In this article, we attempt to provide a brief overview on the recent progress in the field, current understanding of the underlying mechanisms of the approach, and the potential of stem cell-based therapies beyond cell implantation. We conclude the review by sharing our viewpoints on the challenges, opportunities, and future directions of this approach.
The translational potential of this article: This paper reviews recent progress on stem cell-based therapeutic approaches for tendon repair, which highlights its translational potential and challenges.