Hypoxic stress induces, but cannot sustain trophoblast stem cell differentiation to labyrinthine placenta due to mitochondrial insufficiency

Dysfunctional stem cell differentiation into placental lineages is associated with gestational diseases. Of the differentiated lineages available to trophoblast stem cells (TSC), elevated O2 and mitochondrial function are necessary to placental lineages at the maternal–placental surface and importan...

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Bibliographic Details
Published in:	Stem cell research Vol. 13; no. 3; pp. 478 - 491
Main Authors:	Xie, Yufen, Zhou, Sichang, Jiang, Zhongliang, Dai, Jing, Puscheck, Elizabeth E., Lee, Icksoo, Parker, Graham, Hüttemann, Maik, Rappolee, Daniel A.
Format:	Journal Article
Language:	English
Published:	England Elsevier B.V 01-11-2014 Elsevier
Subjects:	Adenosine Triphosphate - metabolism Animals Basic Helix-Loop-Helix Transcription Factors - metabolism Cell Differentiation - drug effects Cell Hypoxia Cell Lineage Cell Proliferation - drug effects Cells, Cultured Electron Transport Complex IV - metabolism Female Fibroblast Growth Factor 4 - pharmacology Membrane Potential, Mitochondrial - drug effects Mice Mitochondria - drug effects Mitochondria - metabolism Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors Mitogen-Activated Protein Kinase 8 - metabolism Neuropeptides - metabolism Placenta - cytology Pregnancy Pregnancy Proteins - metabolism Pyruvate Kinase - metabolism Reactive Oxygen Species - metabolism Stem Cells - cytology Stem Cells - metabolism Trophoblasts - cytology
Online Access:	Get full text
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