Distinct characteristics of central serous chorioretinopathy according to gender

• Published in: Scientific reports Vol. 12; no. 1; p. 10565
• Main Authors: Yoneyama, Seigo, Fukui, Ayumi, Sakurada, Yoichi, Terao, Nobuhiro, Shijo, Taiyo, Kusada, Natsuki, Sugiyama, Atsushi, Matsubara, Mio, Fukuda, Yoshiko, Kikushima, Wataru, Parikh, Ravi, Mabuchi, Fumihiko, Sotozono, Chie, Kashiwagi, Kenji
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22-06-2022; Nature Publishing Group; Nature Portfolio
• Subjects: 692/308; 692/420; Alleles; Angiography; Females; Fluorescein; Gene frequency; Humanities and Social Sciences; Males; Medical imaging; multidisciplinary; Patients; Retina; Science; Science (multidisciplinary); Sex differences
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-14777-8

To investigate the differences in clinical and genetic characteristics between males and females with central serous chorioretinopathy (CSC). Consecutive 302 patients (mean age; 56.3 ± 11.7, male/female: 249/53) with CSC were evaluated on the initial presentation. All CSC patients underwent fluorescein angiography and indocyanine green angiography (FA/ICGA), swept-source or spectral-domain optical coherence tomography (OCT), and fundus autofluorescence (FAF) to confirm a diagnosis. All patients were genotyped for rs800292 and rs1329428 variants of
CFH
using TaqMan technology. On the initial presentation, female patients were significantly older (p = 2.1 × 10
–4
, female 61.6 ± 12.4 vs male 55.1 ± 11.3) and had thinner subfoveal choroidal thickness (p = 3.8 × 10
–5
) and higher central retinal thickness (p = 3.0 × 10
–3
) compared to males. A descending tract was more frequently seen in males than in females (p = 8.0 × 10
–4
, 18.1% vs 0%). Other clinical characteristics were comparable between the sexes. The risk allele frequency of both variants including
CFH
rs800292 and
CFH
rs1329428 was comparable between males and females (
CFH
rs800292 A allele male 51.2% vs female 47.2%,
CFH
rs1329428 T allele male 56.2% vs 52.8%). On the initial presentation, age, subfoveal choroidal thickness and central retinal thickness differ between males and females in eyes with CSC. A descending tract may be a strong male finding in CSC.