Data in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-κB activation

• Published in: Data in brief Vol. 24; p. 103965
• Main Authors: Carvalho, Brener C., Oliveira, Leonardo C., Rocha, Carolina D., Fernandes, Heliana B., Oliveira, Isadora M., Leãõ, Felipe B., Valverde, Thalita M., Rego, Igor M.G., Ghosh, Sankar, Silva, Aristóbolo M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01-06-2019; Elsevier
• Subjects: Immunology and Microbiology
• ISSN: 2352-3409; 2352-3409
• DOI: 10.1016/j.dib.2019.103965

We present here the data to support the understanding of the implication of Rap2a GTPase in LPS-induced innate immune response and NF-κB activation. The data presented are related to molecular tools that were generated, acquired, optimized or validated to investigate Rap2a expression, activation and its effects in mammalian cells including RAW264.7 macrophages and THP-1 monocytes under inflammatory conditions. These data supplement important technical and biological information on immune function of Rap2a in macrophages activated by LPS, recently reported by us (Carvalho et al., 2019) [1].