Neuroendocrine Changes and Natriuresis in Response to Social Stress in Rats

• Published in: Stress and health Vol. 28; no. 3; pp. 179 - 185
• Main Authors: Niebylski, A., Boccolini, A., Bensi, N., Binotti, S., Hansen, C., Yaciuk, R., Gauna, H.
• Format: Journal Article
• Language: English
• Published: Malden, MA Blackwell Publishing Ltd 01-08-2012; Wiley; Wiley Subscription Services, Inc
• Subjects: aldosterone; Aldosterone - blood; Analysis of Variance; Animals; Arterial hypertension. Arterial hypotension; Behavior, Animal - physiology; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; catecholamines; Catecholamines - urine; Chronic Disease; Corticosterone - blood; Disease Models, Animal; Endocrinology; Female; Hormones; Housing, Animal; Hypertension; Hypertension - metabolism; Kidney - physiopathology; Male; Medical sciences; natriuresis; Natriuresis - physiology; Nervous system; Neurosecretory Systems - metabolism; Neurosecretory Systems - physiopathology; Primates; Rats; Rats, Wistar; Rodents; social stress; Sodium; Sodium, Dietary - administration & dosage; Sodium, Dietary - metabolism; Stress; Stress, Psychological - blood; Stress, Psychological - metabolism; Stress, Psychological - urine; Sympathetic Nervous System - physiopathology; Hypertension; natriuresis; catecholamines; Rat; Steroid hormone; Mineralocorticoid; Rodentia; Natriuria; Cardiovascular disease; Aldosterone; Catecholamine; Stress; Vertebrata; Mammalia; Animal; Adrenal hormone; social stress
• ISSN: 1532-3005; 1532-2998
• DOI: 10.1002/smi.1411

Sympathetic activation is detected by the tachycardic, hypertensive and hyperthermic responses during social conflicts in rodents and primates. Sympathetic nervous system activation promoting sodium retention has long been recognized to play a significant role in the development and maintenance of salt‐sensitive hypertension. The objective was to investigate neuroendocrine activation and renal sodium excretion in response to chronic social stress. Male Wistar rats were subjected to social stress in accordance with the resident–intruder paradigm. Intruder rats were subjected to social confrontation once daily for 6 days. After the last confrontation, plasma corticosterone and urinary catecholamines were determined to assess the neuroendocrine activation. Plasma aldosterone, plasma and urinary creatinine, Na+, K+ and urinary volume were also measured. Chronic social stress increased the urinary norepinephrine, dopamine and plasma corticosterone levels, with no changes in epinephrine levels. On the other hand, high plasma aldosterone levels and low urinary sodium excretion without differences in creatinine clearance were observed. In conclusion, social stress had a strong antinatriuretic effect, which is coincident with noradrenergic and corticoadrenal activation and an increase in plasma aldosterone levels. Activation of these factors may promote sodium retention, which has long been recognized to play a significant role in the development and maintenance of hypertension. Copyright © 2011 John Wiley & Sons, Ltd.