Stevens-Johnson syndrome and toxic epidermal necrolysis: epidemiological and clinical outcomes analysis in public hospitals
Adverse drug reactions are harmful and involuntary responses to drugs that occur at doses normally used for a given condition. Among them are Stevens-Johnson syndrome and toxic epidermal necrolysis, both rare and potentially fatal conditions. To analyze the epidemiological and clinical characteristi...
Saved in:
| Published in: | Anais brasileiros de dermatología Vol. 92; no. 5; pp. 661 - 667 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Brazil
Sociedade Brasileira de Dermatologia
01-09-2017
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Adverse drug reactions are harmful and involuntary responses to drugs that occur at doses normally used for a given condition. Among them are Stevens-Johnson syndrome and toxic epidermal necrolysis, both rare and potentially fatal conditions.
To analyze the epidemiological and clinical characteristics related to patients diagnosed with Stevens-Johnson syndrome and toxic epidermal necrolysis in public hospitals in the Federal District - Brazil.
Retrospective, cross-sectional and descriptive study, in which data were collected referring to patients hospitalized in the public healthcare system of the Federal District from 1999 to 2014. Results: Between 1999 and 2014, 86 cases of hospitalized patients with diagnosis of Stevens-Johnson syndrome and toxic epidermal necrolysis in the Federal District were reported. The majority of patients were women; the most affected age group was 0 to 10 years. Patients older than 60 years (elderly) represent 6.98% of the cases. Most patients admitted to the referral hospital were discharged. However, occurrence of deaths exceeded that of discharge in elderly patients.
There is fragility in the registry of hospitalization of patients, both in the hospital information system and in the medical records of the reference hospital.
There is a need for greater production and better dissemination of information on the incidence of adverse drug reactions. |
|---|---|
| AbstractList | Adverse drug reactions are harmful and involuntary responses to drugs that occur at doses normally used for a given condition. Among them are Stevens-Johnson syndrome and toxic epidermal necrolysis, both rare and potentially fatal conditions.
To analyze the epidemiological and clinical characteristics related to patients diagnosed with Stevens-Johnson syndrome and toxic epidermal necrolysis in public hospitals in the Federal District - Brazil.
Retrospective, cross-sectional and descriptive study, in which data were collected referring to patients hospitalized in the public healthcare system of the Federal District from 1999 to 2014. Results: Between 1999 and 2014, 86 cases of hospitalized patients with diagnosis of Stevens-Johnson syndrome and toxic epidermal necrolysis in the Federal District were reported. The majority of patients were women; the most affected age group was 0 to 10 years. Patients older than 60 years (elderly) represent 6.98% of the cases. Most patients admitted to the referral hospital were discharged. However, occurrence of deaths exceeded that of discharge in elderly patients.
There is fragility in the registry of hospitalization of patients, both in the hospital information system and in the medical records of the reference hospital.
There is a need for greater production and better dissemination of information on the incidence of adverse drug reactions. BACKGROUNDAdverse drug reactions are harmful and involuntary responses to drugs that occur at doses normally used for a given condition. Among them are Stevens-Johnson syndrome and toxic epidermal necrolysis, both rare and potentially fatal conditions. OBJECTIVESTo analyze the epidemiological and clinical characteristics related to patients diagnosed with Stevens-Johnson syndrome and toxic epidermal necrolysis in public hospitals in the Federal District - Brazil. METHODSRetrospective, cross-sectional and descriptive study, in which data were collected referring to patients hospitalized in the public healthcare system of the Federal District from 1999 to 2014. Results: Between 1999 and 2014, 86 cases of hospitalized patients with diagnosis of Stevens-Johnson syndrome and toxic epidermal necrolysis in the Federal District were reported. The majority of patients were women; the most affected age group was 0 to 10 years. Patients older than 60 years (elderly) represent 6.98% of the cases. Most patients admitted to the referral hospital were discharged. However, occurrence of deaths exceeded that of discharge in elderly patients. LIMITATIONS OF THE STUDYThere is fragility in the registry of hospitalization of patients, both in the hospital information system and in the medical records of the reference hospital. CONCLUSIONThere is a need for greater production and better dissemination of information on the incidence of adverse drug reactions. Background: Adverse drug reactions are harmful and involuntary responses to drugs that occur at doses normally used for a given condition. Among them are Stevens-Johnson syndrome and toxic epidermal necrolysis, both rare and potentially fatal conditions. Objectives: To analyze the epidemiological and clinical characteristics related to patients diagnosed with Stevens-Johnson syndrome and toxic epidermal necrolysis in public hospitals in the Federal District - Brazil. Methods: Retrospective, cross-sectional and descriptive study, in which data were collected referring to patients hospitalized in the public healthcare system of the Federal District from 1999 to 2014. Results: Between 1999 and 2014, 86 cases of hospitalized patients with diagnosis of Stevens-Johnson syndrome and toxic epidermal necrolysis in the Federal District were reported. The majority of patients were women; the most affected age group was 0 to 10 years. Patients older than 60 years (elderly) represent 6.98% of the cases. Most patients admitted to the referral hospital were discharged. However, occurrence of deaths exceeded that of discharge in elderly patients. Limitations of the study: There is fragility in the registry of hospitalization of patients, both in the hospital information system and in the medical records of the reference hospital. Conclusion: There is a need for greater production and better dissemination of information on the incidence of adverse drug reactions. |
| Author | Novaes, Alice Garbi Arantes, Luana Bernardes Carvalho, Marta Rodrigues de Reis, Carmélia Santiago Novaes, Maria Rita Carvalho Garbi Göttems, Leila Bernarda Donato |
| AuthorAffiliation | 5 Research and Scientific Communication of College of Health Sciences (ESCS/FEPECS) - Brasília (DF), Brazil 1 Burn sector of Hospital Regional da Asa Norte - Secretaria de Saúde do Distrito Federal (SES-DF) - Brasília (DF), Brazil 2 Department of Dermatology of Hospital Regional da Asa Norte - Secretaria de Estado de Saúde do Distrito Federal (SES-DF) - Brasília (DF), Brazil 6 Universidade Católica de Brasília (UCB) - Brasília (DF), Brazil 4 College of Health Sciences (ESCS/FEPECS) - Brasília (DF), Brazil 3 Stricto Sensu Postgraduate Program In Health Sciences of Fundação de Ensino e Pesquisa em Ciências da Saúde (FEPECS) - Brasília (DF), Brazil |
| AuthorAffiliation_xml | – name: 2 Department of Dermatology of Hospital Regional da Asa Norte - Secretaria de Estado de Saúde do Distrito Federal (SES-DF) - Brasília (DF), Brazil – name: 4 College of Health Sciences (ESCS/FEPECS) - Brasília (DF), Brazil – name: 5 Research and Scientific Communication of College of Health Sciences (ESCS/FEPECS) - Brasília (DF), Brazil – name: 3 Stricto Sensu Postgraduate Program In Health Sciences of Fundação de Ensino e Pesquisa em Ciências da Saúde (FEPECS) - Brasília (DF), Brazil – name: 6 Universidade Católica de Brasília (UCB) - Brasília (DF), Brazil – name: 1 Burn sector of Hospital Regional da Asa Norte - Secretaria de Saúde do Distrito Federal (SES-DF) - Brasília (DF), Brazil – name: Secretaria de Estado de Saúde do Distrito Federal (SES-DF) – name: Fundação de Ensino e Pesquisa em Ciências da Saúde (FEPECS) – name: Universidade Católica de Brasília – name: College of Health Sciences (ESCS/FEPECS) – name: Secretaria de Saúde do Distrito Federal (SES-DF) |
| Author_xml | – sequence: 1 givenname: Luana Bernardes surname: Arantes fullname: Arantes, Luana Bernardes organization: Burn sector of Hospital Regional da Asa Norte - Secretaria de Saúde do Distrito Federal (SES-DF) - Brasília (DF), Brazil – sequence: 2 givenname: Carmélia Santiago surname: Reis fullname: Reis, Carmélia Santiago organization: Stricto Sensu Postgraduate Program In Health Sciences of Fundação de Ensino e Pesquisa em Ciências da Saúde (FEPECS) - Brasília (DF), Brazil – sequence: 3 givenname: Alice Garbi surname: Novaes fullname: Novaes, Alice Garbi organization: Universidade Católica de Brasília (UCB) - Brasília (DF), Brazil – sequence: 4 givenname: Marta Rodrigues de surname: Carvalho fullname: Carvalho, Marta Rodrigues de organization: College of Health Sciences (ESCS/FEPECS) - Brasília (DF), Brazil – sequence: 5 givenname: Leila Bernarda Donato surname: Göttems fullname: Göttems, Leila Bernarda Donato organization: College of Health Sciences (ESCS/FEPECS) - Brasília (DF), Brazil – sequence: 6 givenname: Maria Rita Carvalho Garbi surname: Novaes fullname: Novaes, Maria Rita Carvalho Garbi organization: Research and Scientific Communication of College of Health Sciences (ESCS/FEPECS) - Brasília (DF), Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29166503$$D View this record in MEDLINE/PubMed |
| BookMark | eNpVUk2P0zAQtdAitrvwE0A5ckkZJ7ETc0BCKz4WrcRh4WxNbKd15djFTldb8edx2m7FnkZ-8-Z5Pt4VufDBG0LeUlhSJuAD9pp2wMuma-iyAtpyTuEFWZzBC7KAmrMSmOCX5CqlDUDViFa8IpeVoJwzqBfk7_1kHoxP5Y-w9in4Iu29jmE0BXpdTOHRqsJsrTZxRFd4o2Jw-2TTxyM62uDCyqqcm_nKWX94hN2kskjKKB74hfXFdte7LLcOaWsndOk1eTnkYN6c4jX5_fXLr5vv5d3Pb7c3n-9KxSifym6goGpmKo1Nb1CIegBkGeBgqkr3A616iqyrKHQ9dC0XrNNcdRSxEdiK-prcHnV1wI3cRjti3MuAVh6AEFcS42SVM7IWDZhWdYiDajQ3SHFADroRakDsMWstj1pJWeOC3IRdzCMmeT8vW87Lno8BAAwgnyQXfDoW5OlHo5XxU0T3rIvnGW_XchUeJONtw8Xc_fuTQAx_diZNcrRJGefQm7BLkgredrymvMlUdqTmK6UUzXD-hoKcXSNPrpGzQeSTa3Ldu_97PFc92aT-B8rpwkQ |
| CitedBy_id | crossref_primary_10_1093_jbcr_iraa183 crossref_primary_10_1177_00099228231189644 crossref_primary_10_7759_cureus_32303 crossref_primary_10_5897_AJPP2017_4873 crossref_primary_10_1016_j_jemermed_2020_06_005 crossref_primary_10_1007_s40801_019_00174_7 crossref_primary_10_1111_jocd_13864 crossref_primary_10_1177_1535759719835672 crossref_primary_10_1111_cea_13513 crossref_primary_10_3390_ph17060675 crossref_primary_10_1038_s41397_018_0052_2 crossref_primary_10_1111_ijd_14544 crossref_primary_10_3389_fmed_2021_644795 |
| Cites_doi | 10.1590/0034-7167.2014670606 10.1124/pr.113.007450 10.4103/0378-6323.102367 10.1111/j.1365-4632.2010.04785.x 10.1056/NEJM199411103311906 10.1586/eci.11.66 10.1016/j.jaip.2014.10.002 10.1001/archderm.136.3.323 10.2217/pgs.15.128 10.1016/j.jaad.2015.08.008 10.1111/j.1398-9995.2006.01295.x 10.1007/s40257-015-0158-0 10.2340/00015555-0143 10.4103/0019-5154.117319 10.1186/1750-1172-5-39 10.1016/j.amjsurg.2015.12.011 10.1590/S0034-71672010000100023 10.4103/0253-7613.99344 |
| ContentType | Journal Article |
| Copyright | 2017 by Anais Brasileiros de
Dermatologia 2017 Anais Brasileiros de Dermatologia This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
| Copyright_xml | – notice: 2017 by Anais Brasileiros de Dermatologia 2017 Anais Brasileiros de Dermatologia – notice: This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 5PM GPN DOA |
| DOI | 10.1590/abd1806-4841.20176610 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) SciELO Directory of Open Access Journals |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals url: http://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1806-4841 0365-0596 |
| EndPage | 667 |
| ExternalDocumentID | oai_doaj_org_article_3940e7c8aafc4d6ea1afa60d49cfaaba S0365_05962017000500661 10_1590_abd1806_4841_20176610 29166503 |
| Genre | Journal Article |
| GroupedDBID | 0SF 2WC 53G 5GY 5VS 6J9 AAEDW AALRI AAXUO ABXHO ACGFO ACLIJ ADBBV ADRAZ ADVLN AENEX AITUG AKRWK ALMA_UNASSIGNED_HOLDINGS AMRAJ AOIJS APOWU AZFZN BAWUL BCNDV C1A CGR CS3 CUY CVF DIK E3Z EBS ECM EIF EJD F5P FDB GROUPED_DOAJ GX1 HYE IPNFZ KQ8 M41 M48 M~E NCXOZ NPM OK1 P2P PGMZT RIG RNS ROL RPM RSC SCD XSB AAYXX CITATION 7X8 5PM GPN |
| ID | FETCH-LOGICAL-c516t-8f10c35e2da4bea993f0a535e60e22dbf12b1a582108b0876958d6c81aa49a793 |
| IEDL.DBID | RPM |
| ISSN | 0365-0596 1806-4841 |
| IngestDate | Tue Oct 22 15:06:45 EDT 2024 Tue Nov 19 22:08:56 EST 2024 Tue Sep 17 21:04:54 EDT 2024 Fri Aug 16 11:20:52 EDT 2024 Thu Nov 21 22:15:27 EST 2024 Tue Aug 27 13:44:52 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Keywords | Drug eruptions Stevens-Johnson syndrome Epidemiology |
| Language | English |
| License | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. http://creativecommons.org/licenses/by-nc/4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c516t-8f10c35e2da4bea993f0a535e60e22dbf12b1a582108b0876958d6c81aa49a793 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674699/ |
| PMID | 29166503 |
| PQID | 1967863164 |
| PQPubID | 23479 |
| PageCount | 7 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_3940e7c8aafc4d6ea1afa60d49cfaaba scielo_journals_S0365_05962017000500661 pubmedcentral_primary_oai_pubmedcentral_nih_gov_5674699 proquest_miscellaneous_1967863164 crossref_primary_10_1590_abd1806_4841_20176610 pubmed_primary_29166503 |
| PublicationCentury | 2000 |
| PublicationDate | 2017-09-01 |
| PublicationDateYYYYMMDD | 2017-09-01 |
| PublicationDate_xml | – month: 09 year: 2017 text: 2017-09-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Brazil |
| PublicationPlace_xml | – name: Brazil |
| PublicationTitle | Anais brasileiros de dermatología |
| PublicationTitleAlternate | An Bras Dermatol |
| PublicationYear | 2017 |
| Publisher | Sociedade Brasileira de Dermatologia |
| Publisher_xml | – name: Sociedade Brasileira de Dermatologia |
| References | Zaraa I (ref26) 2011; 50 (ref1) 1972 Cabral L (ref16) 2004; 17 Blumenthal KG (ref17) 2015; 3 (ref14) 2016 Secoli SR (ref19) 2010; 63 Oliveira A (ref7) 2011; 24 Roujeau JC (ref21) 1994; 331 Dodiuk-Gad RP (ref8) 2015; 16 Mockenhaupt M (ref10) 2011; 7 Gaur S (ref4) 2012; 44 Rufini S (ref15) 2015; 16 Dodiuk-Gad RP (ref11) 2015; 73 Yip LW (ref24) 2007; 62 Uetrecht J (ref2) 2013; 65 Upadhyaya SK (ref3) 2012; 3 Kaur S (ref20) 2013; 58 Harr T (ref6) 2010; 5 Williams R (ref12) 2016; 211 Fracaroli TS (ref13) 2013; 88 Emerick MFB (ref9) 2014; 67 Choon SE (ref18) 2012; 78 Borch JE (ref25) 2006; 86 Garcia-Doval I (ref23) 2000; 136 Ensina LF (ref5) 2009; 32 Wiffen PJ (ref22) 2011 Blumenthal, KG; Wickner, PG; Lau, JJ; Zhou, L 2015; 3 Uetrecht, J; Naisbitt, DJ 2013; 65 Garcia-Doval, I; LeCleach, L; Bocquet, H; Otero, XL; Roujeau, JC 2000; 136 Choon, SE; Lai, NM 2012; 78 Oliveira, A; Sanches, M; Selores, M 2011; 24 1972 Kaur, S; Dogra, A 2013; 58 Wiffen, PJ; Derry, S; Moore, RA; McQuay, HJ 2011 Emerick, MFB; Rodrigues, MMT; Pedrosa, DMAS; Novaes, MRCG; Gottems, LBD 2014; 67 Cabral, L; Diogo, C; Riobom, F; Teles, L; Cruzeiro, C 2004; 17 Gaur, S; Agnihotri, R 2012; 44 Secoli, SR 2010; 63 Rufini, S; Ciccacci, C; Politi, C; Giardina, E; Novelli, G; Borgiani, P 2015; 16 Zaraa, I; Jones, M; Trojjet, S; Cheikh Rouhou, R; El Euch, D; Mokni, M 2011; 50 Harr, T; French, LE 2010; 5 Ensina, LF; Fernandes, FR; Di Gesu, G; Malaman, MF; Chavarria, ML; Bernd, LAG 2009; 32 Fracaroli, TS; Miranda, LQ; Sodré, JL; Chaves, M; Gripp, A 2013; 88 Borch, JE; Andersen, KE; Bindslev-Jensen, C 2006; 86 Upadhyaya, SK; Raina, RS; Sharma, A; Thawani, V; Dimari, D 2012; 3 2016 Roujeau, JC; Stern, RS 1994; 331 Dodiuk-Gad, RP; Olteanu, C; Jeschke, MG; Cartotto, R; Fish, J; Shear, NH 2015; 73 Mockenhaupt, M 2011; 7 Yip, LW; Thong, BY; Lim, J; Tan, AW; Wong, HB; Handa, S 2007; 62 Williams, R; Hodge, J; Ingram, W 2016; 211 Dodiuk-Gad, RP; Chung, WH; Valeyrie-Allanore, L; Shear, NH 2015; 16 |
| References_xml | – volume: 3 start-page: 202 year: 2012 ident: ref3 article-title: Carbamazepine-induced erythema multiforme major in an epileptic patient with bipolar affective disorder publication-title: J Pharmacol Pharmacother contributor: fullname: Upadhyaya SK – volume: 67 start-page: 898 year: 2014 ident: ref9 article-title: Síndrome de Stevens-Johnson e Necrólise Epidérmica Tóxica em um hospital do Distrito Federal publication-title: Rev Bras Enferm doi: 10.1590/0034-7167.2014670606 contributor: fullname: Emerick MFB – volume: 88 start-page: 117 year: 2013 ident: ref13 article-title: Necrólise epidérmica tóxica induzida pelo lansoprazol publication-title: An Bras Dermatol contributor: fullname: Fracaroli TS – volume: 32 start-page: 178 year: 2009 ident: ref5 article-title: Reações de Hipersensibilidade a Medicamentos - Parte III publication-title: Rev Bras Alerg Imunopatol contributor: fullname: Ensina LF – volume: 65 start-page: 779 year: 2013 ident: ref2 article-title: Idiosyncratic adverse drug reactions: current concepts publication-title: Pharmacol Rev doi: 10.1124/pr.113.007450 contributor: fullname: Uetrecht J – volume: 78 start-page: 734 year: 2012 ident: ref18 article-title: An epidemiological and clinical analysis of cutaneous adverse drug reactions seen in a tertiary hospital in Johor, Malaysia publication-title: Indian J Dermatol Venereol Leprol doi: 10.4103/0378-6323.102367 contributor: fullname: Choon SE – volume: 24 start-page: 995 year: 2011 ident: ref7 article-title: O espectro clínico da sindrome de stevens johnson e necrólise epidérmica tóxica publication-title: Acta Med Port contributor: fullname: Oliveira A – year: 2016 ident: ref14 – volume: 50 start-page: 877 year: 2011 ident: ref26 article-title: Severe adverse cutaneous drug eruptions: epidemiological and clinical features publication-title: Int J Dermatol doi: 10.1111/j.1365-4632.2010.04785.x contributor: fullname: Zaraa I – volume: 17 start-page: 129 year: 2004 ident: ref16 article-title: Necrólise Epidérmica Tóxica (Síndrome de Lyell): uma patologia para as Unidades de Queimados publication-title: Acta Med Port contributor: fullname: Cabral L – volume: 331 start-page: 1272 year: 1994 ident: ref21 article-title: Severe adverse cutaneous reactions to drugs publication-title: N Engl J Med doi: 10.1056/NEJM199411103311906 contributor: fullname: Roujeau JC – volume: 7 start-page: 803 year: 2011 ident: ref10 article-title: The current understanding of Stevens-Johnson syndrome and toxic epidermal necrolysis publication-title: Expert Rev Clin Immunol doi: 10.1586/eci.11.66 contributor: fullname: Mockenhaupt M – volume: 3 start-page: 277 issue: 2 year: 2015 ident: ref17 article-title: Stevens-Johnson syndrome and toxic epidermal necrolysis: a cross-sectional analysis of patients in an integrated allergy repository of a large health care system publication-title: J Allergy Clin Immunol Pract doi: 10.1016/j.jaip.2014.10.002 contributor: fullname: Blumenthal KG – volume: 136 start-page: 323 year: 2000 ident: ref23 article-title: Toxic epidermal necrolysis and Stevens-Johnson syndrome: does early withdrawal of causative drugs decrease the risk of death? publication-title: Arch Dermatol doi: 10.1001/archderm.136.3.323 contributor: fullname: Garcia-Doval I – volume: 16 start-page: 1989 year: 2015 ident: ref15 article-title: Stevens-Johnson syndrome and toxic epidermal necrolysis: an update on pharmacogenetics studies in drug-induced severe skin reaction publication-title: Pharmacogenomics doi: 10.2217/pgs.15.128 contributor: fullname: Rufini S – volume: 73 start-page: 876 year: 2015 ident: ref11 article-title: Treatment of toxic epidermal necrolysis in North America publication-title: J Am Acad Dermatol doi: 10.1016/j.jaad.2015.08.008 contributor: fullname: Dodiuk-Gad RP – volume: 62 start-page: 527 year: 2007 ident: ref24 article-title: Ocular manifestations and complications of Stevens-Johnson syndrome and toxic epidermal necrolysis: an Asian series publication-title: Allergy doi: 10.1111/j.1398-9995.2006.01295.x contributor: fullname: Yip LW – volume: 16 start-page: 475 year: 2015 ident: ref8 article-title: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: An Update publication-title: Am J Clin Dermatol doi: 10.1007/s40257-015-0158-0 contributor: fullname: Dodiuk-Gad RP – volume: 86 start-page: 518 year: 2006 ident: ref25 article-title: The prevalence of acute cutaneous drug reactions in a Scandinavian university hospital publication-title: Acta Derm Venereol doi: 10.2340/00015555-0143 contributor: fullname: Borch JE – volume: 58 start-page: 406 year: 2013 ident: ref20 article-title: Toxic Epidermal Necrolysis due to concomitant use of lamotrigine and valproic acid publication-title: Indian J Dermatol doi: 10.4103/0019-5154.117319 contributor: fullname: Kaur S – volume: 5 start-page: 39 year: 2010 ident: ref6 article-title: Toxic epidermal necrolysis and Stevens-Johnson syndrome publication-title: Orphanet J Rare Dis doi: 10.1186/1750-1172-5-39 contributor: fullname: Harr T – volume: 211 start-page: 684 issue: 4 year: 2016 ident: ref12 article-title: Indications for intubation and early tracheostomy in patients with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis publication-title: Am J Surg doi: 10.1016/j.amjsurg.2015.12.011 contributor: fullname: Williams R – year: 2011 ident: ref22 article-title: Carbamazepine for acute and chronic pain in adults publication-title: Cochrane Database Syst Rev contributor: fullname: Wiffen PJ – volume: 63 start-page: 136 year: 2010 ident: ref19 article-title: Polifarmácia: interações e reações adversas no uso de medicamentos por idosos publication-title: Rev Bras Enferm doi: 10.1590/S0034-71672010000100023 contributor: fullname: Secoli SR – volume: 44 start-page: 531 year: 2012 ident: ref4 article-title: Phenobarbital induced Stevens-Johnson syndrome in a child publication-title: Indian J Pharmacol doi: 10.4103/0253-7613.99344 contributor: fullname: Gaur S – year: 1972 ident: ref1 – volume: 88 start-page: 117 year: 2013 end-page: 120 article-title: Necrólise epidérmica tóxica induzida pelo lansoprazol publication-title: An Bras Dermatol contributor: fullname: Fracaroli, TS; Miranda, LQ; Sodré, JL; Chaves, M; Gripp, A – volume: 3 start-page: 202 year: 2012 end-page: 204 article-title: Carbamazepine-induced erythema multiforme major in an epileptic patient with bipolar affective disorder publication-title: J Pharmacol Pharmacother contributor: fullname: Upadhyaya, SK; Raina, RS; Sharma, A; Thawani, V; Dimari, D – year: 2011 article-title: Carbamazepine for acute and chronic pain in adults publication-title: Cochrane Database Syst Rev contributor: fullname: Wiffen, PJ; Derry, S; Moore, RA; McQuay, HJ – year: 2016 publication-title: Norway: Anatomical Therapeutic Chemical (ATC) Classification System. World Health Organization Collaborating Centre for Drug Statistics Methodology – volume: 17 start-page: 129 year: 2004 end-page: 140 article-title: Necrólise Epidérmica Tóxica (Síndrome de Lyell): uma patologia para as Unidades de Queimados publication-title: Acta Med Port contributor: fullname: Cabral, L; Diogo, C; Riobom, F; Teles, L; Cruzeiro, C – volume: 58 start-page: 406 year: 2013 end-page: 406 article-title: Toxic Epidermal Necrolysis due to concomitant use of lamotrigine and valproic acid publication-title: Indian J Dermatol contributor: fullname: Kaur, S; Dogra, A – volume: 50 start-page: 877 year: 2011 end-page: 880 article-title: Severe adverse cutaneous drug eruptions: epidemiological and clinical features publication-title: Int J Dermatol contributor: fullname: Zaraa, I; Jones, M; Trojjet, S; Cheikh Rouhou, R; El Euch, D; Mokni, M – volume: 136 start-page: 323 year: 2000 end-page: 327 article-title: Toxic epidermal necrolysis and Stevens-Johnson syndrome: does early withdrawal of causative drugs decrease the risk of death? publication-title: Arch Dermatol contributor: fullname: Garcia-Doval, I; LeCleach, L; Bocquet, H; Otero, XL; Roujeau, JC – volume: 62 start-page: 527 year: 2007 end-page: 531 article-title: Ocular manifestations and complications of Stevens-Johnson syndrome and toxic epidermal necrolysis: an Asian series publication-title: Allergy contributor: fullname: Yip, LW; Thong, BY; Lim, J; Tan, AW; Wong, HB; Handa, S – volume: 86 start-page: 518 year: 2006 end-page: 522 article-title: The prevalence of acute cutaneous drug reactions in a Scandinavian university hospital publication-title: Acta Derm Venereol contributor: fullname: Borch, JE; Andersen, KE; Bindslev-Jensen, C – volume: 65 start-page: 779 year: 2013 end-page: 808 article-title: Idiosyncratic adverse drug reactions: current concepts publication-title: Pharmacol Rev contributor: fullname: Uetrecht, J; Naisbitt, DJ – volume: 73 start-page: 876 year: 2015 end-page: 877.e2 article-title: Treatment of toxic epidermal necrolysis in North America publication-title: J Am Acad Dermatol contributor: fullname: Dodiuk-Gad, RP; Olteanu, C; Jeschke, MG; Cartotto, R; Fish, J; Shear, NH – year: 1972 publication-title: International drug monitoring: the role of national centres. Rep Ser WHO 1972, n. 498 – volume: 211 start-page: 684 issue: 4 year: 2016 end-page: 688 article-title: Indications for intubation and early tracheostomy in patients with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis publication-title: Am J Surg contributor: fullname: Williams, R; Hodge, J; Ingram, W – volume: 7 start-page: 803 year: 2011 end-page: 813 article-title: The current understanding of Stevens-Johnson syndrome and toxic epidermal necrolysis publication-title: Expert Rev Clin Immunol contributor: fullname: Mockenhaupt, M – volume: 44 start-page: 531 year: 2012 end-page: 532 article-title: Phenobarbital induced Stevens-Johnson syndrome in a child publication-title: Indian J Pharmacol contributor: fullname: Gaur, S; Agnihotri, R – volume: 24 start-page: 995 year: 2011 end-page: 1002 article-title: O espectro clínico da sindrome de stevens johnson e necrólise epidérmica tóxica publication-title: Acta Med Port contributor: fullname: Oliveira, A; Sanches, M; Selores, M – volume: 78 start-page: 734 year: 2012 end-page: 739 article-title: An epidemiological and clinical analysis of cutaneous adverse drug reactions seen in a tertiary hospital in Johor, Malaysia publication-title: Indian J Dermatol Venereol Leprol contributor: fullname: Choon, SE; Lai, NM – volume: 3 start-page: 277 issue: 2 year: 2015 end-page: 280 article-title: Stevens-Johnson syndrome and toxic epidermal necrolysis: a cross-sectional analysis of patients in an integrated allergy repository of a large health care system publication-title: J Allergy Clin Immunol Pract contributor: fullname: Blumenthal, KG; Wickner, PG; Lau, JJ; Zhou, L – volume: 32 start-page: 178 year: 2009 end-page: 183 article-title: Reações de Hipersensibilidade a Medicamentos - Parte III publication-title: Rev Bras Alerg Imunopatol contributor: fullname: Ensina, LF; Fernandes, FR; Di Gesu, G; Malaman, MF; Chavarria, ML; Bernd, LAG – volume: 16 start-page: 475 year: 2015 end-page: 493 article-title: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: An Update publication-title: Am J Clin Dermatol contributor: fullname: Dodiuk-Gad, RP; Chung, WH; Valeyrie-Allanore, L; Shear, NH – volume: 67 start-page: 898 year: 2014 end-page: 904 article-title: Síndrome de Stevens-Johnson e Necrólise Epidérmica Tóxica em um hospital do Distrito Federal publication-title: Rev Bras Enferm contributor: fullname: Emerick, MFB; Rodrigues, MMT; Pedrosa, DMAS; Novaes, MRCG; Gottems, LBD – volume: 63 start-page: 136 year: 2010 end-page: 140 article-title: Polifarmácia: interações e reações adversas no uso de medicamentos por idosos publication-title: Rev Bras Enferm contributor: fullname: Secoli, SR – volume: 5 start-page: 39 year: 2010 end-page: 42 article-title: Toxic epidermal necrolysis and Stevens-Johnson syndrome publication-title: Orphanet J Rare Dis contributor: fullname: Harr, T; French, LE – volume: 331 start-page: 1272 year: 1994 end-page: 1285 article-title: Severe adverse cutaneous reactions to drugs publication-title: N Engl J Med contributor: fullname: Roujeau, JC; Stern, RS – volume: 16 start-page: 1989 year: 2015 end-page: 2002 article-title: Stevens-Johnson syndrome and toxic epidermal necrolysis: an update on pharmacogenetics studies in drug-induced severe skin reaction publication-title: Pharmacogenomics contributor: fullname: Rufini, S; Ciccacci, C; Politi, C; Giardina, E; Novelli, G; Borgiani, P |
| SSID | ssj0024979 |
| Score | 2.2119036 |
| Snippet | Adverse drug reactions are harmful and involuntary responses to drugs that occur at doses normally used for a given condition. Among them are Stevens-Johnson... BACKGROUNDAdverse drug reactions are harmful and involuntary responses to drugs that occur at doses normally used for a given condition. Among them are... Background: Adverse drug reactions are harmful and involuntary responses to drugs that occur at doses normally used for a given condition. Among them are... |
| SourceID | doaj scielo pubmedcentral proquest crossref pubmed |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database |
| StartPage | 661 |
| SubjectTerms | Adolescent Adult Aged Brazil - epidemiology Child Child, Preschool Cross-Sectional Studies DERMATOLOGY Drug eruptions Epidemiology Female Hospitals, Public Humans Infant Infant, Newborn Investigation Male Middle Aged Retrospective Studies Stevens-Johnson syndrome Stevens-Johnson Syndrome - drug therapy Stevens-Johnson Syndrome - epidemiology Stevens-Johnson Syndrome - etiology Young Adult |
| SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Li9UwFA46iLgR39YXEQRXdZImTVN3PmaYjW5GwV04zYO5MLRi7wXBP-85TXqZi4Ibt2noI99J8p0m-T7GXoFKPuBcUHtrMUEJzVDboGOtkMubJGX0gX4NnJ13n7_Zjyckk7O3-qI9YVkeODfcMTl3x85bgOR1MBEkJDAi6N4ngCFTI2HWZGpV2euzyh7t4SKDmXJ2p-3FMQxBWkyjtdWUH5JAIh2fvTIrLeL9f2Ocf26cvEHz1OXVKen0DrtduCR_l7_hLrsWx3vs5qeyWn6f_cqWZXNdbLD4Kk_AYQx8O_3ceB7JIRYH50s-IoGcFoGSt7k0-8YSiEv99Qwln3ZbDNM4Y2kWNOGbkWe5bH5RbEjmB-zr6cmXD2d1MVuofSvNtrZJCq_a2ATQQwSkLUlAiwVGxKYJQ5LNIIGO1Qo7kI5d39pgvJUAugfs5Q_Z0TiN8THjSjVBgEgqWaMDpiC27xSAGRoIMRhTsTdrY7vvWVPDUS6C6LiCjiN03IpOxd4TJPvKJIm9FGCguBIo7l-BUrGXK6AOuxCti8AYp93scBDqrFGYOFbsUQZ4_6gG6TOSWFWx7gD6g3c5vDJuLhaZ7tZ02vR9xV7nIHFldJjdOcWlW4yPSL6INHiQ-ckn_-Mzn7JbdNO8De4ZO9r-2MXn7Pocdi-WLvIb6lIXXw priority: 102 providerName: Directory of Open Access Journals |
| Title | Stevens-Johnson syndrome and toxic epidermal necrolysis: epidemiological and clinical outcomes analysis in public hospitals |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/29166503 https://search.proquest.com/docview/1967863164 https://pubmed.ncbi.nlm.nih.gov/PMC5674699 http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962017000500661&lng=en&tlng=en https://doaj.org/article/3940e7c8aafc4d6ea1afa60d49cfaaba |
| Volume | 92 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1di9QwFA3OIuKLuH5W3SGC4FNnmn6kqW-6H6zIirAKvoXbJN0dmG2X7QwI_nnvTdJlB33yNS1t6LlJzk1vzmHsHRSdsbgWpEYpTFBs3qbKli4tkMvLTghnLG0NnJ7XX3-qo2OSyammszC-aN-0q0W_vlr0q0tfW3l9ZZZTndjy29lhJWvM6prljM2QG04p-iSw1wSBPSrfIm-ZeGynarIltFYozKBLVVJqSNqIgqzgcuRIyFSKnbXJS_j_i3f-XT55n1ar9d2F6eQxexQZJf8Yer7P7rn-CXtwFv-ZP2W_g3HZmEYzLD6JFHDoLd8Mv1aGO_KJxSl6zXukkYOXKfkQWoN7LEHp759OUvJhu8FgdSO2BlkTvup5EM3ml9GMZHzGfpwcfz88TaPlQmoqITep6kRmisrlFsrWAZKXLoMKG2Tm8ty2nchbAXS4NlMtqdk1lbLSKAFQNoBj_Tnb64fevWS8KHKbQdYVnZKlxURENXUBINscrLNSJmwxfWx9HZQ1NGUkCJSOQGkCSk9AJewTQXJ7Mwlj-4bh5kLH8NBk9O5qowA6U1rpQEAHMrNlYzqAFhL2dgJU40CivyPQu2E7apyKaiULTB8T9iIAfPuqKUASVu9Av9OX3SsYu16sO8Zqwt6HINFxjhj1OYWo9vZHJGJESjzI_8Sr_37Ha_aQnhQq4N6wvc3N1h2w2Wi3c0wWPn-Z-w2HuR8ufwCa6xdJ |
| link.rule.ids | 230,315,729,782,786,866,887,2106,27933,27934,53800,53802 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZoQcClvAqE8jASEqfs2nk4Tm-ltFpEt0JqkbhZE9uhK22TqtmVkPjzzMRJxQpOvdpWnGg-2zPxzPcx9gHS2jo8C2KrNQYoLqli7TIfp-jLq1pKbx39GpidFac_9OcjosnJx1qYPmnfVotJs7ycNIuLPrfy6tJOxzyx6bf5Ya4KjOrK6Ra7i-tViDFIHyn2ykCxRwlcpC4zFO7kpZhC5aTGGDrTGQWHxI4oSQwuQS8JfZV043TqSfz_53n-m0B5j86r5d9H0_GjW37UY7Yz-KL8IHQ_YXd885Tdnw-37c_Y7yB51sWDjBYf6Q04NI6v2l8Lyz0pzOLmvuQNOqBtT3CyH1qD7iyBoB8_1mDydr1CmPsOWwMhCl80PNBt84tBxqTbZd-Pj84PZ_Eg1hDbXKpVrGspbJr7xEFWeUC3pxaQY4MSPklcVcukkkBluUJXxINX5topqyVAVgLuEs_ZdtM2_iXjaZo4AaJOa60yhyGMLosUQFUJOO-UithkNJK5CpwchmIZNLAZDGzIwGY0cMQ-kSlvBhOldt_QXv80gw0MScT7wmqA2mZOeZBQgxIuK20NUEHE3o9AMLgE6V4FGt-uO4ObWKFVioFnxF4EYNxMNQIrYsUGZDbeZbMHAdLTfA-AiNjHAC4z7C6dOSNom144ieiPiMMHPUf56tZzvGMPZufzE3Py5fTrHntITw15dK_Z9up67d-wrc6t3_bL7A-iZirx |
| linkToPdf | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1ba9RAFB5sleJLvVbjdQTBp-xmcplMfNO2S0VbClXwbTiZi13YJkuzCwX_vOdkksVFn_R1MuTC-eZcMme-j7G3kHljMRbERiksUGxax8rmLs4wl5deCGcs_Ro4uSjPvqujY6LJ2Uh99U37pp5PmsXVpJlf9r2VyyszHfvEpuenh4UssaqrpkvrpzvsNq7ZJB0L9ZFmrwo0e9TERQozw-GdokqmUFuhsI7OVU4FIjEkChKESzFTwnwl24pQPZH_37LPP5so71DMWvwenmb3_uPD7rP9ISflH8KUB-yWax6yvdNh1_0R-xmkz7p4kNPiI80Bh8byVXszN9yR0iw6-QVvMBFte6KT92E06M8SGPr541lM3q5XCHfX4WggRuHzhgfabX45yJl0j9m32fHXw5N4EG2ITSHkKlZeJCYrXGohrx1g-uMTKHBAJi5Nbe1FWgug47mJqokPryqUlUYJgLwC9BYHbLdpG_eU8SxLbQKJz7ySucVSRlVlBiDrFKyzUkZsMhpKLwM3h6aaBo2sByNrMrIejRyxj2TOzWSi1u4H2usferCDJql4VxoF4E1upQMBHmRi88p4gBoi9mYEg8alSPsr0Lh23Wl0ZqWSGRagEXsSwLF51AiuiJVbsNl6l-0rCJKe7nsARcTeBYDpwct0-oLgrXsBJaJBIi4fzCDFs39-xmu2d340018-nX1-zu7STUM73Qu2u7peu5dsp7PrV_1K-wX8jy1x |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Stevens-Johnson+syndrome+and+toxic+epidermal+necrolysis%3A+epidemiological+and+clinical+outcomes+analysis+in+public+hospitals&rft.jtitle=Anais+brasileiros+de+dermatolog%C3%ADa&rft.au=Arantes%2C+Luana+Bernardes&rft.au=Reis%2C+Carm%C3%A9lia+Santiago&rft.au=Novaes%2C+Alice+Garbi&rft.au=Carvalho%2C+Marta+Rodrigues+de&rft.date=2017-09-01&rft.eissn=1806-4841&rft.volume=92&rft.issue=5&rft.spage=661&rft.epage=667&rft_id=info:doi/10.1590%2Fabd1806-4841.20176610&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0365-0596&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0365-0596&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0365-0596&client=summon |