Stevens-Johnson syndrome and toxic epidermal necrolysis: epidemiological and clinical outcomes analysis in public hospitals

• Published in: Anais brasileiros de dermatología Vol. 92; no. 5; pp. 661 - 667
• Main Authors: Arantes, Luana Bernardes, Reis, Carmélia Santiago, Novaes, Alice Garbi, Carvalho, Marta Rodrigues de, Göttems, Leila Bernarda Donato, Novaes, Maria Rita Carvalho Garbi
• Format: Journal Article
• Language: English
• Published: Brazil Sociedade Brasileira de Dermatologia 01-09-2017
• Subjects: Adolescent; Adult; Aged; Brazil - epidemiology; Child; Child, Preschool; Cross-Sectional Studies; DERMATOLOGY; Drug eruptions; Epidemiology; Female; Hospitals, Public; Humans; Infant; Infant, Newborn; Investigation; Male; Middle Aged; Retrospective Studies; Stevens-Johnson syndrome; Stevens-Johnson Syndrome - drug therapy; Stevens-Johnson Syndrome - epidemiology; Stevens-Johnson Syndrome - etiology; Young Adult; Drug eruptions; Stevens-Johnson syndrome; Epidemiology
• ISSN: 0365-0596; 1806-4841; 1806-4841; 0365-0596
• DOI: 10.1590/abd1806-4841.20176610

Adverse drug reactions are harmful and involuntary responses to drugs that occur at doses normally used for a given condition. Among them are Stevens-Johnson syndrome and toxic epidermal necrolysis, both rare and potentially fatal conditions.
To analyze the epidemiological and clinical characteristics related to patients diagnosed with Stevens-Johnson syndrome and toxic epidermal necrolysis in public hospitals in the Federal District - Brazil.
Retrospective, cross-sectional and descriptive study, in which data were collected referring to patients hospitalized in the public healthcare system of the Federal District from 1999 to 2014. Results: Between 1999 and 2014, 86 cases of hospitalized patients with diagnosis of Stevens-Johnson syndrome and toxic epidermal necrolysis in the Federal District were reported. The majority of patients were women; the most affected age group was 0 to 10 years. Patients older than 60 years (elderly) represent 6.98% of the cases. Most patients admitted to the referral hospital were discharged. However, occurrence of deaths exceeded that of discharge in elderly patients.
There is fragility in the registry of hospitalization of patients, both in the hospital information system and in the medical records of the reference hospital.
There is a need for greater production and better dissemination of information on the incidence of adverse drug reactions.