Transcription-replication encounters, consequences and genomic instability

To ensure replication success, DNA polymerases must negotiate encounters with actively transcribing RNA polymerases that share the genome. This Review highlights the strategies used by prokaryotic and eukaryotic cells to minimize the consequences of collisions between replication forks and transcrip...

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Published in:	Nature structural & molecular biology Vol. 20; no. 4; pp. 412 - 418
Main Authors:	Helmrich, Anne, Ballarino, Monica, Nudler, Evgeny, Tora, Laszlo
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01-04-2013 Nature Publishing Group
Subjects:	631/80/86 Biochemistry Biological Microscopy Chromatin Deoxyribonucleic acid DNA DNA polymerase DNA Replication Genetic transcription Genomic Instability Genomics Life Sciences Membrane Biology Molecular biology Physiological aspects Protein Structure review-article RNA polymerase RNA polymerases Structure Transcription, Genetic United States
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Abstract	To ensure replication success, DNA polymerases must negotiate encounters with actively transcribing RNA polymerases that share the genome. This Review highlights the strategies used by prokaryotic and eukaryotic cells to minimize the consequences of collisions between replication forks and transcription complexes to effect faithful DNA replication without compromising gene expression. To ensure accurate duplication of genetic material, the replication fork must overcome numerous natural obstacles on its way, including transcription complexes engaged along the same template. Here we review the various levels of interdependence between transcription and replication processes and how different types of encounters between RNA- and DNA-polymerase complexes may result in clashes of those machineries on the DNA template and thus increase genomic instability. In addition, we summarize strategies evolved in bacteria and eukaryotes to minimize the consequences of collisions, including R-loop formation and topological stresses.
AbstractList	To ensure replication success, DNA polymerases must negotiate encounters with actively transcribing RNA polymerases that share the genome. This Review highlights the strategies used by prokaryotic and eukaryotic cells to minimize the consequences of collisions between replication forks and transcription complexes to effect faithful DNA replication without compromising gene expression. To ensure accurate duplication of genetic material, the replication fork must overcome numerous natural obstacles on its way, including transcription complexes engaged along the same template. Here we review the various levels of interdependence between transcription and replication processes and how different types of encounters between RNA- and DNA-polymerase complexes may result in clashes of those machineries on the DNA template and thus increase genomic instability. In addition, we summarize strategies evolved in bacteria and eukaryotes to minimize the consequences of collisions, including R-loop formation and topological stresses. To ensure accurate duplication of genetic material, the replication fork must overcome numerous natural obstacles on its way, including transcription complexes engaged along the same template. Here we review the various levels of interdependence between transcription and replication processes and how different types of encounters between RNA- and DNA-polymerase complexes may result in clashes of those machineries on the DNA template and thus increase genomic instability. In addition, we summarize strategies evolved in bacteria and eukaryotes to minimize the consequences of collisions, including R-loop formation and topological stresses. To ensure accurate duplication of genetic material, the replication fork must overcome numerous natural obstacles on its way, including transcription complexes engaged along the same template. Here we review the various levels of interdependence between transcription and replication processes and how different types of encounters between RNA- and DNA-polymerase complexes may result in clashes of those machineries on the DNA template and thus increase genomic instability. In addition, we summarize strategies evolved in bacteria and eukaryotes to minimize the consequences of collisions, including R-loop formation and topological stresses. [PUBLICATION ABSTRACT]
Audience	Academic
Author	Ballarino, Monica Tora, Laszlo Nudler, Evgeny Helmrich, Anne
Author_xml	– sequence: 1 givenname: Anne surname: Helmrich fullname: Helmrich, Anne organization: Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique UMR 7104, Institut National de la Santé et de la Recherche Médicale U 964, Université de Strasbourg, Present addresses: Institute of Cell Biology, University of Bern, Bern, Switzerland (A.H.) and Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, Rome, Italy (M.B.) – sequence: 2 givenname: Monica surname: Ballarino fullname: Ballarino, Monica organization: Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique UMR 7104, Institut National de la Santé et de la Recherche Médicale U 964, Université de Strasbourg, Present addresses: Institute of Cell Biology, University of Bern, Bern, Switzerland (A.H.) and Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, Rome, Italy (M.B.) – sequence: 3 givenname: Evgeny surname: Nudler fullname: Nudler, Evgeny organization: Department of Biochemistry, New York University School of Medicine – sequence: 4 givenname: Laszlo surname: Tora fullname: Tora, Laszlo email: laszlo@igbmc.fr organization: Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique UMR 7104, Institut National de la Santé et de la Recherche Médicale U 964, Université de Strasbourg
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PublicationTitle	Nature structural & molecular biology
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Snippet	To ensure replication success, DNA polymerases must negotiate encounters with actively transcribing RNA polymerases that share the genome. This Review... To ensure accurate duplication of genetic material, the replication fork must overcome numerous natural obstacles on its way, including transcription complexes...
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SubjectTerms	631/80/86 Biochemistry Biological Microscopy Chromatin Deoxyribonucleic acid DNA DNA polymerase DNA Replication Genetic transcription Genomic Instability Genomics Life Sciences Membrane Biology Molecular biology Physiological aspects Protein Structure review-article RNA polymerase RNA polymerases Structure Transcription, Genetic
Title	Transcription-replication encounters, consequences and genomic instability
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