Can Cerebral Blood Volume Be Measured Reproducibly With an Improved Near Infrared Spectroscopy System?

• Published in: Journal of cerebral blood flow and metabolism Vol. 21; no. 2; pp. 110 - 113
• Main Authors: Van de Ven, Marjo J. T., Colier, Willy N. J. M., van der Sluijs, Marco C., Walraven, Diederik, Oeseburg, Berend, Folgering, Hans
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01-02-2001; Lippincott Williams & Wilkins; Sage Publications Ltd
• Subjects: Adult; Biological and medical sciences; Blood Volume; Brain; Brain - blood supply; Female; Hemoglobins - analysis; Humans; Investigative techniques of hemodynamics; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Oxyhemoglobins - analysis; Reproducibility of Results; Spectroscopy, Near-Infrared; Near infrared spectroscopy; Brain; Cerebral blood volume; Human studies; Human; Regional blood flow; Near infrared spectrometry; Central nervous system; Exploration; Hemodynamics; Brain (vertebrata)
• ISSN: 0271-678X; 1559-7016
• DOI: 10.1097/00004647-200102000-00002

In some circumstances, cerebral blood volume (CBV) can be used as a measure for cerebral blood flow. A new near infrared spectroscope was used for determining the reproducibility of CBV measurements assessed by the O2-method. Twenty-seven healthy subjects were investigated. An intrasubject coefficient of variation (CV) was calculated, based on four identical episodes of desaturation–resaturation (O2-method) procedures for CBV measurements. Two trials were performed, with (trial 1) and without (trial 2) disconnecting the equipment. A mean CV of 12.6% and 10.0% was found in trial 1 and 2, respectively. Cerebral blood volume values yield 3.60 ± 0.82 mL 100 g−1. Cerebral blood volume could be measured reproducible in adults using near infrared spectroscopy, if the arterial desaturation is limited to approximately 5% from baseline level.