Association of LIPC and advanced age-related macular degeneration

Purpose To determine whether there is an association between hepatic lipase ( LIPC ) and age-related macular degeneration (AMD) in two independent Caucasian cohorts. Methods A discovery cohort of 1626 patients with advanced AMD and 859 normal controls and a replication cohort of 2159 cases and 1150...

Full description

Saved in:

Bibliographic Details
Published in:	Eye (London) Vol. 27; no. 2; pp. 265 - 271
Main Authors:	Lee, J, Zeng, J, Hughes, G, Chen, Y, Grob, S, Zhao, L, Lee, C, Krupa, M, Quach, J, Luo, J, Wei, X, Zhang, X, Zhu, J, Duan, Y, Ferreyra, H, Goldbaum, M, Haw, W, Shaw, P X, Tang, L, Zhang, K
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-02-2013 Nature Publishing Group
Subjects:	631/208/205 631/208/726/649 631/378/1689/1626 692/499 Aged Aged, 80 and over Alleles Cohort Studies Female Gene Frequency Genetic Predisposition to Disease Humans Laboratory Medicine Laboratory Study Lipase - genetics Macular Degeneration - genetics Male Medicine Medicine & Public Health Middle Aged Ophthalmology Pharmaceutical Sciences/Technology Polymorphism, Single Nucleotide Promoter Regions, Genetic - genetics Surgery Surgical Oncology advanced age-related macular degeneration genetics hepatic lipase
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Purpose To determine whether there is an association between hepatic lipase ( LIPC ) and age-related macular degeneration (AMD) in two independent Caucasian cohorts. Methods A discovery cohort of 1626 patients with advanced AMD and 859 normal controls and a replication cohort of 2159 cases and 1150 controls were genotyped for two single-nucleotide polymorphisms (SNPs) in the promoter region of LIPC . The associations between the SNPs and AMD were examined by χ 2 tests. Results In the discovery cohort, rs493258 and rs10468017 were both associated with advanced AMD ( P =9.63E−3 and P =0.048, respectively). The association was corroborated in the replication cohort ( P =4.48E−03 for rs493258 and P =0.015 for rs10468017). Combined analysis resulted in even more significant associations ( P =1.21E−04 for rs493258 and P =1.67E−03 for rs10468017). Conclusion The LIPC promoter variants rs493258 and rs10468017 were associated with advanced AMD in two independent Caucasian populations, confirming that LIPC polymorphisms may be a genetic risk factor for AMD in the Caucasian population.
AbstractList	Purpose To determine whether there is an association between hepatic lipase ( LIPC ) and age-related macular degeneration (AMD) in two independent Caucasian cohorts. Methods A discovery cohort of 1626 patients with advanced AMD and 859 normal controls and a replication cohort of 2159 cases and 1150 controls were genotyped for two single-nucleotide polymorphisms (SNPs) in the promoter region of LIPC . The associations between the SNPs and AMD were examined by χ 2 tests. Results In the discovery cohort, rs493258 and rs10468017 were both associated with advanced AMD ( P =9.63E−3 and P =0.048, respectively). The association was corroborated in the replication cohort ( P =4.48E−03 for rs493258 and P =0.015 for rs10468017). Combined analysis resulted in even more significant associations ( P =1.21E−04 for rs493258 and P =1.67E−03 for rs10468017). Conclusion The LIPC promoter variants rs493258 and rs10468017 were associated with advanced AMD in two independent Caucasian populations, confirming that LIPC polymorphisms may be a genetic risk factor for AMD in the Caucasian population. PURPOSETo determine whether there is an association between hepatic lipase (LIPC) and age-related macular degeneration (AMD) in two independent Caucasian cohorts. METHODSA discovery cohort of 1626 patients with advanced AMD and 859 normal controls and a replication cohort of 2159 cases and 1150 controls were genotyped for two single-nucleotide polymorphisms (SNPs) in the promoter region of LIPC. The associations between the SNPs and AMD were examined by χ(2) tests. RESULTSIn the discovery cohort, rs493258 and rs10468017 were both associated with advanced AMD (P=9.63E-3 and P=0.048, respectively). The association was corroborated in the replication cohort (P=4.48E-03 for rs493258 and P=0.015 for rs10468017). Combined analysis resulted in even more significant associations (P=1.21E-04 for rs493258 and P=1.67E-03 for rs10468017). CONCLUSIONThe LIPC promoter variants rs493258 and rs10468017 were associated with advanced AMD in two independent Caucasian populations, confirming that LIPC polymorphisms may be a genetic risk factor for AMD in the Caucasian population. To determine whether there is an association between hepatic lipase (LIPC) and age-related macular degeneration (AMD) in two independent Caucasian cohorts. A discovery cohort of 1626 patients with advanced AMD and 859 normal controls and a replication cohort of 2159 cases and 1150 controls were genotyped for two single-nucleotide polymorphisms (SNPs) in the promoter region of LIPC. The associations between the SNPs and AMD were examined by χ(2) tests. In the discovery cohort, rs493258 and rs10468017 were both associated with advanced AMD (P=9.63E-3 and P=0.048, respectively). The association was corroborated in the replication cohort (P=4.48E-03 for rs493258 and P=0.015 for rs10468017). Combined analysis resulted in even more significant associations (P=1.21E-04 for rs493258 and P=1.67E-03 for rs10468017). The LIPC promoter variants rs493258 and rs10468017 were associated with advanced AMD in two independent Caucasian populations, confirming that LIPC polymorphisms may be a genetic risk factor for AMD in the Caucasian population. To determine whether there is an association between hepatic lipase (LIPC) and age-related macular degeneration (AMD) in two independent Caucasian cohorts. A discovery cohort of 1626 patients with advanced AMD and 859 normal controls and a replication cohort of 2159 cases and 1150 controls were genotyped for two single-nucleotide polymorphisms (SNPs) in the promoter region of LIPC. The associations between the SNPs and AMD were examined by χ(2) tests. In the discovery cohort, rs493258 and rs10468017 were both associated with advanced AMD (P=9.63E-3 and P=0.048, respectively). The association was corroborated in the replication cohort (P=4.48E-03 for rs493258 and P=0.015 for rs10468017). Combined analysis resulted in even more significant associations (P=1.21E-04 for rs493258 and P=1.67E-03 for rs10468017). The LIPC promoter variants rs493258 and rs10468017 were associated with advanced AMD in two independent Caucasian populations, confirming that LIPC polymorphisms may be a genetic risk factor for AMD in the Caucasian population.
Author	Lee, J Luo, J Krupa, M Goldbaum, M Chen, Y Zhu, J Grob, S Lee, C Zhang, X Zhao, L Haw, W Hughes, G Zeng, J Quach, J Ferreyra, H Shaw, P X Wei, X Tang, L Zhang, K Duan, Y
Author_xml	– sequence: 1 givenname: J surname: Lee fullname: Lee, J organization: Department of Ophthalmology and Shiley Eye Center and Institute for Genomic Medicine, University of California, San Diego – sequence: 2 givenname: J surname: Zeng fullname: Zeng, J organization: Department of Ophthalmology and Shiley Eye Center and Institute for Genomic Medicine, University of California, San Diego, Department of Ophthalmology, Second Xiangya Hospital, Central South University, Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine – sequence: 3 givenname: G surname: Hughes fullname: Hughes, G organization: Department of Ophthalmology and Shiley Eye Center and Institute for Genomic Medicine, University of California, San Diego – sequence: 4 givenname: Y surname: Chen fullname: Chen, Y organization: Department of Ophthalmology and Shiley Eye Center and Institute for Genomic Medicine, University of California, San Diego, Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Shanghai Medical School, Fudan University – sequence: 5 givenname: S surname: Grob fullname: Grob, S organization: Department of Ophthalmology and Shiley Eye Center and Institute for Genomic Medicine, University of California, San Diego – sequence: 6 givenname: L surname: Zhao fullname: Zhao, L organization: Department of Ophthalmology and Shiley Eye Center and Institute for Genomic Medicine, University of California, San Diego – sequence: 7 givenname: C surname: Lee fullname: Lee, C organization: Department of Ophthalmology and Shiley Eye Center and Institute for Genomic Medicine, University of California, San Diego – sequence: 8 givenname: M surname: Krupa fullname: Krupa, M organization: Department of Ophthalmology and Shiley Eye Center and Institute for Genomic Medicine, University of California, San Diego – sequence: 9 givenname: J surname: Quach fullname: Quach, J organization: Department of Ophthalmology and Shiley Eye Center and Institute for Genomic Medicine, University of California, San Diego – sequence: 10 givenname: J surname: Luo fullname: Luo, J organization: Department of Ophthalmology and Shiley Eye Center and Institute for Genomic Medicine, University of California, San Diego – sequence: 11 givenname: J surname: Zeng fullname: Zeng, J organization: Department of Ophthalmology and Shiley Eye Center and Institute for Genomic Medicine, University of California, San Diego – sequence: 12 givenname: X surname: Wei fullname: Wei, X organization: Department of Ophthalmology and Shiley Eye Center and Institute for Genomic Medicine, University of California, San Diego – sequence: 13 givenname: X surname: Zhang fullname: Zhang, X organization: Department of Ophthalmology and Shiley Eye Center and Institute for Genomic Medicine, University of California, San Diego – sequence: 14 givenname: J surname: Zhu fullname: Zhu, J organization: Department of Ophthalmology and Shiley Eye Center and Institute for Genomic Medicine, University of California, San Diego – sequence: 15 givenname: Y surname: Duan fullname: Duan, Y organization: Department of Ophthalmology and Shiley Eye Center and Institute for Genomic Medicine, University of California, San Diego – sequence: 16 givenname: H surname: Ferreyra fullname: Ferreyra, H organization: Department of Ophthalmology and Shiley Eye Center and Institute for Genomic Medicine, University of California, San Diego – sequence: 17 givenname: M surname: Goldbaum fullname: Goldbaum, M organization: Department of Ophthalmology and Shiley Eye Center and Institute for Genomic Medicine, University of California, San Diego – sequence: 18 givenname: W surname: Haw fullname: Haw, W organization: Department of Ophthalmology and Shiley Eye Center and Institute for Genomic Medicine, University of California, San Diego – sequence: 19 givenname: P X surname: Shaw fullname: Shaw, P X organization: Department of Ophthalmology and Shiley Eye Center and Institute for Genomic Medicine, University of California, San Diego, Department of Ophthalmology, Second Xiangya Hospital, Central South University, Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Shanghai Medical School, Fudan University – sequence: 20 givenname: L surname: Tang fullname: Tang, L organization: Department of Ophthalmology, Second Xiangya Hospital, Central South University – sequence: 21 givenname: K surname: Zhang fullname: Zhang, K email: kangzhang@ucsd.edu organization: Department of Ophthalmology and Shiley Eye Center and Institute for Genomic Medicine, University of California, San Diego, Veterans Administration Healthcare System
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/23348725$$D View this record in MEDLINE/PubMed
BookMark	eNptkUtLAzEURoMoWqs71zLgxoVT856ZjVCKLyjoQsFdSDM3dWSaaDJT8N-bWi0qrnLhO_mSy9lH2847QOiI4BHBrDyHdxhRTOiIFnILDQgvZC644NtogCuBc0rp0x7aj_EF4xQWeBftUcZ4WVAxQONxjN40umu8y7zNprf3k0y7OtP1UjsDaZhDHqDVXZoX2vStDlkNc3AQPm8doB2r2wiHX-cQPV5dPkxu8und9e1kPM2NILLLJdAZrgsrjLFQm5m0dlaUhFDDCa80oVaIiieIyxKEqEvNWGUtZ1ZbjmvJhuhi3fvazxapAVwXdKteQ7PQ4V153ajfiWue1dwvFRMFp5KlgtOvguDfeoidWjTRQNtqB76PitCyZIRRWiX05A_64vvg0norqhBYyoom6mxNmeBjDGA3nyFYrdyo5Eat3KjkJuHHPxfYwN8yEpCvgZgiN4fw49X_Cj8Aj5qbOA
CitedBy_id	crossref_primary_10_1016_j_medici_2016_02_004 crossref_primary_10_1371_journal_pone_0143924 crossref_primary_10_1016_j_xops_2022_100142 crossref_primary_10_1089_jop_2016_0022 crossref_primary_10_1155_2013_435607 crossref_primary_10_3390_ijerph13101022 crossref_primary_10_1038_srep15711 crossref_primary_10_1111_aos_14280 crossref_primary_10_3390_genes13071233 crossref_primary_10_3390_biomedicines12071479 crossref_primary_10_1371_journal_pone_0226763 crossref_primary_10_1002_jcb_25837 crossref_primary_10_1155_2018_9538671
Cites_doi	10.1186/1749-8090-4-46 10.4161/cc.6.9.4157 10.1016/j.atherosclerosis.2008.09.007 10.1126/science.1110189 10.1038/ng1873 10.1073/pnas.0501536102 10.1093/hmg/ddh119 10.1167/iovs.11-8657 10.1001/archopht.1941.00870100042005 10.1038/nature10449 10.1194/jlr.R002238 10.1167/iovs.09-4135 10.1016/j.jdiacomp.2007.06.011 10.1001/archopht.121.12.1728 10.1016/j.ophtha.2010.07.009 10.1016/j.ophtha.2007.09.008 10.1016/S0039-6257(05)80092-X 10.1126/science.1133811 10.1073/pnas.0703933104 10.1001/archopht.125.5.671 10.1186/1471-2350-10-111 10.1161/01.ATV.0000140818.00570.2d 10.1073/pnas.0912702107 10.1136/bjo.2005.073643 10.1016/j.ajo.2009.07.002 10.1038/ng1750 10.1126/science.1109557 10.1073/pnas.0912019107 10.1016/S0039-6257(99)00072-7 10.1126/science.1133807 10.1097/FPC.0b013e3283033528 10.1086/378505 10.1007/s00439-003-1026-1 10.1016/j.atherosclerosis.2007.12.045 10.1016/j.exer.2008.10.028 10.1001/archopht.126.10.1396 10.33549/physiolres.930836
ContentType	Journal Article
Copyright	Royal College of Ophthalmologists 2013 Copyright Nature Publishing Group Feb 2013 Copyright © 2013 Royal College of Ophthalmologists 2013 Royal College of Ophthalmologists
Copyright_xml	– notice: Royal College of Ophthalmologists 2013 – notice: Copyright Nature Publishing Group Feb 2013 – notice: Copyright © 2013 Royal College of Ophthalmologists 2013 Royal College of Ophthalmologists
DBID	CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7TK 7X7 7XB 88E 8AO 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M7P PQEST PQQKQ PQUKI PRINS 7X8 5PM
DOI	10.1038/eye.2012.276
DatabaseName	Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Neurosciences Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection AUTh Library subscriptions: ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Biological Science Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles)
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef ProQuest Central Student ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest Medical Library (Alumni) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection Neurosciences Abstracts ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic ProQuest Central Student MEDLINE
Database_xml	– sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
DocumentTitleAlternate	LIPC is associated with age-related macular degeneration
EISSN	1476-5454
EndPage	271
ExternalDocumentID	2891443811 10_1038_eye_2012_276 23348725
Genre	Research Support, Non-U.S. Gov't Journal Article
GroupedDBID	--- -Q- .GJ 0R~ 29G 2WC 36B 39C 3O- 3V. 4.4 406 53G 5RE 6PF 70F 7X7 88E 8AO 8FI 8FJ 8R4 8R5 AACDK AANZL AASML AATNV AAWBL AAWTL AAZLF ABAKF ABAWZ ABCQX ABDBF ABJNI ABLJU ABUWG ABZZP ACAOD ACGFS ACKTT ACPRK ACRQY ACZOJ ADBBV ADHDB AEFQL AEJRE AEMSY AENEX AEVLU AEXYK AFBBN AFFNX AFKRA AFSHS AGAYW AGEZK AGHAI AGQEE AHMBA AHSBF AIGIU AILAN AJRNO ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMYLF AOIJS AXYYD B0M BAWUL BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CAG CCPQU COF CS3 DIK DNIVK DPUIP E3Z EAD EAP EBC EBD EBLON EBS EBX EE. EIOEI EJD EMB EMK EMOBN EPL ESX F5P FDQFY FERAY FIGPU FIZPM FSGXE FYUFA GX1 HCIFZ HMCUK HYE HZ~ IWAJR JSO JZLTJ KQ8 L7B M1P M7P NAO NQJWS O9- OK1 P2P PQQKQ PROAC PSQYO Q2X RNS RNT RNTTT RPM SNX SNYQT SOHCF SRMVM SV3 SWTZT TAOOD TBHMF TDRGL TR2 TUS UKHRP W2D ZGI ZXP ~8M AAYZH CGR CUY CVF ECM EIF NPM AAYXX ACGFO ACMJI ADFRT AGFXM BAI BAW CITATION MV. NFBOU 7TK 7XB 8FE 8FH 8FK AZQEC DWQXO GNUQQ K9. LK8 PQEST PQUKI PRINS 7X8 5PM
ID	FETCH-LOGICAL-c516t-6e2b0d7f5ccfedcb6ffb78112c4149a12f5594e2b468e55d8a339ff43faf40d63
IEDL.DBID	RPM
ISSN	0950-222X
IngestDate	Tue Sep 17 21:27:04 EDT 2024 Sat Oct 26 00:28:35 EDT 2024 Wed Nov 06 09:07:55 EST 2024 Fri Nov 22 01:02:55 EST 2024 Tue Oct 15 23:46:59 EDT 2024 Fri Oct 11 20:50:22 EDT 2024
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	2
Keywords	advanced age-related macular degeneration genetics hepatic lipase
Language	English
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c516t-6e2b0d7f5ccfedcb6ffb78112c4149a12f5594e2b468e55d8a339ff43faf40d63
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work
OpenAccessLink	https://www.nature.com/articles/eye2012276.pdf
PMID	23348725
PQID	1287506692
PQPubID	33647
PageCount	7
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_3574263 proquest_miscellaneous_1288313229 proquest_journals_1287506692 crossref_primary_10_1038_eye_2012_276 pubmed_primary_23348725 springer_journals_10_1038_eye_2012_276
PublicationCentury	2000
PublicationDate	2013-02-01
PublicationDateYYYYMMDD	2013-02-01
PublicationDate_xml	– month: 02 year: 2013 text: 2013-02-01 day: 01
PublicationDecade	2010
PublicationPlace	London
PublicationPlace_xml	– name: London – name: England
PublicationSubtitle	The Scientific Journal of The Royal College of Ophthalmologists
PublicationTitle	Eye (London)
PublicationTitleAbbrev	Eye
PublicationTitleAlternate	Eye (Lond)
PublicationYear	2013
Publisher	Nature Publishing Group UK Nature Publishing Group
Publisher_xml	– name: Nature Publishing Group UK – name: Nature Publishing Group
References	Yu, Reynolds, Rosner, Daly, Seddon (CR38) 2012; 53 Weismann, Hartvigsen, Lauer, Bennett, Scholl, Charbel Issa (CR37) 2011; 478 Bird, Bressler, Bressler, Chisholm, Coscas, Davis (CR21) 1995; 39 Neale, Fagerness, Reynolds, Sobrin, Parker, Raychaudhuri (CR20) 2010; 107 Santamarina-Fojo, Gonzalez-Navarro, Freeman, Wagner, Nong (CR23) 2004; 24 Stancakova, Baldaufova, Javorsky, Kozarova, Salagovic, Tkac (CR28) 2006; 55 Knoblauch, Bauerfeind, Toliat, Becker, Luganskaja, Gunther (CR25) 2004; 13 Feitosa, Myers, Pankow, Province, Borecki (CR24) 2009; 204 SanGiovanni, Chew, Clemons, Davis, Ferris, Gensler (CR16) 2007; 125 Yang, Camp, Sun, Tong, Gibbs, Cameron (CR7) 2006; 314 Friedman, O’Colmain, Munoz, Tomany, McCarty, de Jong (CR1) 2004; 122 Seddon, Santangelo, Book, Chong, Cote (CR4) 2003; 73 Yu, Lorenz, Haritoglou, Kampik, Welge-Lussen (CR19) 2009; 88 Hageman, Anderson, Johnson, Hancox, Taiber, Hardisty (CR5) 2005; 102 Dewan, Liu, Hartman, Zhang, Liu, Zhao (CR8) 2006; 314 Valdivielso, Ariza, de la Vega-Roman, Gonzalez-Alegre, Rioja, Ulzurrun (CR32) 2008; 22 Kanda, Chen, Othman, Branham, Brooks, Khanna (CR14) 2007; 104 Fletcher, Bentham, Agnew, Young, Augood, Chakravarthy (CR17) 2008; 126 Starita, Hussain, Patmore, Marshall (CR35) 1997; 38 Cameron, Yang, Gibbs, Chen, Kaminoh, Jorgensen (CR2) 2007; 6 Curcio, Johnson, Huang, Rudolf (CR36) 2010; 51 Hindorff, Lemaitre, Smith, Bis, Marciante, Rice (CR31) 2008; 18 Seddon, Cote, Rosner (CR18) 2003; 121 Brantley, Fang, King, Tewari, Kymes, Shiels (CR6) 2007; 114 Edwards, Ritter, Abel, Manning, Panhuysen, Farrer (CR13) 2005; 308 Khan, Thurlby, Shahid, Clayton, Yates, Bradley (CR3) 2006; 90 Chen, Stambolian, Edwards, Branham, Othman, Jakobsdottir (CR22) 2010; 107 Chamberlain, Folsom, Schreiner, Boerwinkle, Ballantyne (CR26) 2008; 200 Reynolds, Rosner, Seddon (CR33) 2010; 117 Chen, Cilingiroglu, Todd, Lombardi, Willerson, Gotto (CR29) 2009; 10 Andreoli, Morrison, Kim, Chen, Adams, Miller (CR9) 2009; 148 Kaur, Katta, Reddy, Narayanan, Mathai, Majji (CR11) 2010; 51 Klein, Zeiss, Chew, Tsai, Sackler, Haynes (CR12) 2005; 308 Gold, Merriam, Zernant, Hancox, Taiber, Gehrs (CR10) 2006; 38 Maller, George, Purcell, Fagerness, Altshuler, Daly (CR15) 2006; 38 Eifert, Rasch, Beiras-Fernandez, Nollert, Reichart, Lohse (CR30) 2009; 4 McCarthy, Meyer, Moliterno, Newby, Rogers, Topol (CR27) 2003; 114 Abdelsalam, Del Priore, Zarbin (CR34) 1999; 44 15078675 - Arch Ophthalmol. 2004 Apr;122(4):564-72 15044381 - Hum Mol Genet. 2004 May 15;13(10):993-1004 10466585 - Surv Ophthalmol. 1999 Jul-Aug;44(1):1-29 22247473 - Invest Ophthalmol Vis Sci. 2012 Mar;53(3):1548-56 16518403 - Nat Genet. 2006 Apr;38(4):458-62 16343038 - Physiol Res. 2006;55(5):483-90 17426452 - Cell Cycle. 2007 May 2;6(9):1122-5 21979047 - Nature. 2011 Oct 6;478(7367):76-81 18054635 - Ophthalmology. 2007 Dec;114(12):2168-73 18275964 - Atherosclerosis. 2008 Oct;200(2):322-8 20385819 - Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7401-6 20888482 - Ophthalmology. 2010 Oct;117(10):1989-95 9071230 - Invest Ophthalmol Vis Sci. 1997 Mar;38(3):762-7 19878569 - BMC Med Genet. 2009;10:111 18852418 - Arch Ophthalmol. 2008 Oct;126(10):1396-403 16936732 - Nat Genet. 2006 Sep;38(9):1055-9 19071111 - Exp Eye Res. 2009 Mar;88(3):495-503 19797256 - J Lipid Res. 2010 Mar;51(3):451-67 19696172 - Invest Ophthalmol Vis Sci. 2010 Jan;51(1):59-63 18413186 - J Diabetes Complications. 2008 Jul-Aug;22(4):273-7 20385826 - Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7395-400 15761121 - Science. 2005 Apr 15;308(5720):421-4 17884985 - Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16227-32 19101670 - Atherosclerosis. 2009 May;204(1):171-7 19796758 - Am J Ophthalmol. 2009 Dec;148(6):869-74 19691831 - J Cardiothorac Surg. 2009;4:46 17502507 - Arch Ophthalmol. 2007 May;125(5):671-9 17053109 - Science. 2006 Nov 10;314(5801):992-3 14557872 - Hum Genet. 2003 Dec;114(1):87-98 15284087 - Arterioscler Thromb Vasc Biol. 2004 Oct;24(10):1750-4 15870199 - Proc Natl Acad Sci U S A. 2005 May 17;102(20):7227-32 7604360 - Surv Ophthalmol. 1995 Mar-Apr;39(5):367-74 14662593 - Arch Ophthalmol. 2003 Dec;121(12):1728-37 18622260 - Pharmacogenet Genomics. 2008 Aug;18(8):677-82 12945014 - Am J Hum Genet. 2003 Oct;73(4):780-90 15761122 - Science. 2005 Apr 15;308(5720):385-9 17053108 - Science. 2006 Nov 10;314(5801):989-92 16361672 - Br J Ophthalmol. 2006 Jan;90(1):75-80 JM Seddon (BFeye2012276_CR4) 2003; 73 P Valdivielso (BFeye2012276_CR32) 2008; 22 AO Edwards (BFeye2012276_CR13) 2005; 308 AM Chamberlain (BFeye2012276_CR26) 2008; 200 A Abdelsalam (BFeye2012276_CR34) 1999; 44 B Gold (BFeye2012276_CR10) 2006; 38 Y Yu (BFeye2012276_CR38) 2012; 53 Z Yang (BFeye2012276_CR7) 2006; 314 JP SanGiovanni (BFeye2012276_CR16) 2007; 125 J Maller (BFeye2012276_CR15) 2006; 38 MA Brantley (BFeye2012276_CR6) 2007; 114 A Stancakova (BFeye2012276_CR28) 2006; 55 SN Chen (BFeye2012276_CR29) 2009; 10 GS Hageman (BFeye2012276_CR5) 2005; 102 A Dewan (BFeye2012276_CR8) 2006; 314 AL Yu (BFeye2012276_CR19) 2009; 88 C Starita (BFeye2012276_CR35) 1997; 38 DS Friedman (BFeye2012276_CR1) 2004; 122 AC Bird (BFeye2012276_CR21) 1995; 39 W Chen (BFeye2012276_CR22) 2010; 107 LA Hindorff (BFeye2012276_CR31) 2008; 18 BM Neale (BFeye2012276_CR20) 2010; 107 MF Feitosa (BFeye2012276_CR24) 2009; 204 D Weismann (BFeye2012276_CR37) 2011; 478 JM Seddon (BFeye2012276_CR18) 2003; 121 MT Andreoli (BFeye2012276_CR9) 2009; 148 RJ Klein (BFeye2012276_CR12) 2005; 308 CA Curcio (BFeye2012276_CR36) 2010; 51 DJ Cameron (BFeye2012276_CR2) 2007; 6 S Eifert (BFeye2012276_CR30) 2009; 4 I Kaur (BFeye2012276_CR11) 2010; 51 A Kanda (BFeye2012276_CR14) 2007; 104 JJ McCarthy (BFeye2012276_CR27) 2003; 114 R Reynolds (BFeye2012276_CR33) 2010; 117 JC Khan (BFeye2012276_CR3) 2006; 90 AE Fletcher (BFeye2012276_CR17) 2008; 126 S Santamarina-Fojo (BFeye2012276_CR23) 2004; 24 H Knoblauch (BFeye2012276_CR25) 2004; 13
References_xml	– volume: 4 start-page: 46 year: 2009 ident: CR30 article-title: Gene polymorphisms in APOE, NOS3, and LIPC genes may be risk factors for cardiac adverse events after primary CABG publication-title: J Cardiothorac Surg doi: 10.1186/1749-8090-4-46 contributor: fullname: Lohse – volume: 6 start-page: 1122 issue: 9 year: 2007 end-page: 1125 ident: CR2 article-title: HTRA1 variant confers similar risks to geographic atrophy and neovascular age-related macular degeneration publication-title: Cell Cycle doi: 10.4161/cc.6.9.4157 contributor: fullname: Jorgensen – volume: 204 start-page: 171 issue: 1 year: 2009 end-page: 177 ident: CR24 article-title: LIPC variants in the promoter and intron 1 modify HDL-C levels in a sex-specific fashion publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2008.09.007 contributor: fullname: Borecki – volume: 308 start-page: 421 issue: 5720 year: 2005 end-page: 424 ident: CR13 article-title: Complement factor H polymorphism and age-related macular degeneration publication-title: Science doi: 10.1126/science.1110189 contributor: fullname: Farrer – volume: 38 start-page: 1055 issue: 9 year: 2006 end-page: 1059 ident: CR15 article-title: Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration publication-title: Nat Genet doi: 10.1038/ng1873 contributor: fullname: Daly – volume: 102 start-page: 7227 issue: 20 year: 2005 end-page: 7232 ident: CR5 article-title: A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0501536102 contributor: fullname: Hardisty – volume: 13 start-page: 993 issue: 10 year: 2004 end-page: 1004 ident: CR25 article-title: Haplotypes and SNPs in 13 lipid-relevant genes explain most of the genetic variance in high-density lipoprotein and low-density lipoprotein cholesterol publication-title: Hum Mol Genet doi: 10.1093/hmg/ddh119 contributor: fullname: Gunther – volume: 53 start-page: 1548 issue: 3 year: 2012 end-page: 1556 ident: CR38 article-title: Prospective assessment of genetic effects on progression to different stages of age-related macular degeneration using multistate Markov models publication-title: Invest Ophthalmol Vis Sci doi: 10.1167/iovs.11-8657 contributor: fullname: Seddon – volume: 122 start-page: 564 issue: 4 year: 2004 end-page: 572 ident: CR1 article-title: Prevalence of age-related macular degeneration in the United States publication-title: Arch Ophthalmol doi: 10.1001/archopht.1941.00870100042005 contributor: fullname: de Jong – volume: 478 start-page: 76 issue: 7367 year: 2011 end-page: 81 ident: CR37 article-title: Complement factor H binds malondialdehyde epitopes and protects from oxidative stress publication-title: Nature doi: 10.1038/nature10449 contributor: fullname: Charbel Issa – volume: 51 start-page: 451 issue: 3 year: 2010 end-page: 467 ident: CR36 article-title: Apolipoprotein B-containing lipoproteins in retinal aging and age-related macular degeneration publication-title: J Lipid Res doi: 10.1194/jlr.R002238 contributor: fullname: Rudolf – volume: 55 start-page: 483 issue: 5 year: 2006 end-page: 490 ident: CR28 article-title: Effect of gene polymorphisms on lipoprotein levels in patients with dyslipidemia of metabolic syndrome publication-title: Physiol Res contributor: fullname: Tkac – volume: 51 start-page: 59 issue: 1 year: 2010 end-page: 63 ident: CR11 article-title: The involvement of complement factor B and complement component C2 in an Indian cohort with age-related macular degeneration publication-title: Invest Ophthalmol Vis Sci doi: 10.1167/iovs.09-4135 contributor: fullname: Majji – volume: 22 start-page: 273 issue: 4 year: 2008 end-page: 277 ident: CR32 article-title: Association of the -250 G/A promoter polymorphism of the hepatic lipase gene with the risk of peripheral arterial disease in type 2 diabetic patients publication-title: J Diabetes Complications doi: 10.1016/j.jdiacomp.2007.06.011 contributor: fullname: Ulzurrun – volume: 38 start-page: 762 issue: 3 year: 1997 end-page: 767 ident: CR35 article-title: Localization of the site of major resistance to fluid transport in Bruch's membrane publication-title: Invest Ophthalmol Vis Sci contributor: fullname: Marshall – volume: 121 start-page: 1728 issue: 12 year: 2003 end-page: 1737 ident: CR18 article-title: Progression of age-related macular degeneration: association with dietary fat, transunsaturated fat, nuts, and fish intake publication-title: Arch Ophthalmol doi: 10.1001/archopht.121.12.1728 contributor: fullname: Rosner – volume: 117 start-page: 1989 issue: 10 year: 2010 end-page: 1995 ident: CR33 article-title: Serum lipid biomarkers and hepatic lipase gene associations with age-related macular degeneration publication-title: Ophthalmology doi: 10.1016/j.ophtha.2010.07.009 contributor: fullname: Seddon – volume: 114 start-page: 2168 issue: 12 year: 2007 end-page: 2173 ident: CR6 article-title: Association of complement factor H and LOC387715 genotypes with response of exudative age-related macular degeneration to intravitreal bevacizumab publication-title: Ophthalmology doi: 10.1016/j.ophtha.2007.09.008 contributor: fullname: Shiels – volume: 39 start-page: 367 issue: 5 year: 1995 end-page: 374 ident: CR21 article-title: An international classification and grading system for age-related maculopathy and age-related macular degeneration. The International ARM Epidemiological Study Group publication-title: Surv Ophthalmol doi: 10.1016/S0039-6257(05)80092-X contributor: fullname: Davis – volume: 314 start-page: 992 issue: 5801 year: 2006 end-page: 993 ident: CR7 article-title: A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration publication-title: Science doi: 10.1126/science.1133811 contributor: fullname: Cameron – volume: 104 start-page: 16227 issue: 41 year: 2007 end-page: 16232 ident: CR14 article-title: A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0703933104 contributor: fullname: Khanna – volume: 125 start-page: 671 issue: 5 year: 2007 end-page: 679 ident: CR16 article-title: The relationship of dietary lipid intake and age-related macular degeneration in a case-control study: AREDS report no. 20 publication-title: Arch Ophthalmol doi: 10.1001/archopht.125.5.671 contributor: fullname: Gensler – volume: 10 start-page: 111 year: 2009 ident: CR29 article-title: Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis publication-title: BMC Med Genet doi: 10.1186/1471-2350-10-111 contributor: fullname: Gotto – volume: 24 start-page: 1750 issue: 10 year: 2004 end-page: 1754 ident: CR23 article-title: Hepatic lipase, lipoprotein metabolism, and atherogenesis publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/01.ATV.0000140818.00570.2d contributor: fullname: Nong – volume: 107 start-page: 7401 issue: 16 year: 2010 end-page: 7406 ident: CR22 article-title: Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0912702107 contributor: fullname: Jakobsdottir – volume: 90 start-page: 75 issue: 1 year: 2006 end-page: 80 ident: CR3 article-title: Smoking and age related macular degeneration: the number of pack years of cigarette smoking is a major determinant of risk for both geographic atrophy and choroidal neovascularisation publication-title: Br J Ophthalmol doi: 10.1136/bjo.2005.073643 contributor: fullname: Bradley – volume: 148 start-page: 869 issue: 6 year: 2009 end-page: 874 ident: CR9 article-title: Comprehensive analysis of complement factor H and LOC387715/ARMS2/HTRA1 variants with respect to phenotype in advanced age-related macular degeneration publication-title: Am J Ophthalmol doi: 10.1016/j.ajo.2009.07.002 contributor: fullname: Miller – volume: 38 start-page: 458 issue: 4 year: 2006 end-page: 462 ident: CR10 article-title: Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration publication-title: Nat Genet doi: 10.1038/ng1750 contributor: fullname: Gehrs – volume: 308 start-page: 385 issue: 5720 year: 2005 end-page: 389 ident: CR12 article-title: Complement factor H polymorphism in age-related macular degeneration publication-title: Science doi: 10.1126/science.1109557 contributor: fullname: Haynes – volume: 107 start-page: 7395 issue: 16 year: 2010 end-page: 7400 ident: CR20 article-title: Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC) publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0912019107 contributor: fullname: Raychaudhuri – volume: 44 start-page: 1 issue: 1 year: 1999 end-page: 29 ident: CR34 article-title: Drusen in age-related macular degeneration: pathogenesis, natural course, and laser photocoagulation-induced regression publication-title: Surv Ophthalmol doi: 10.1016/S0039-6257(99)00072-7 contributor: fullname: Zarbin – volume: 314 start-page: 989 issue: 5801 year: 2006 end-page: 992 ident: CR8 article-title: HTRA1 promoter polymorphism in wet age-related macular degeneration publication-title: Science doi: 10.1126/science.1133807 contributor: fullname: Zhao – volume: 18 start-page: 677 issue: 8 year: 2008 end-page: 682 ident: CR31 article-title: Common genetic variation in six lipid-related and statin-related genes, statin use and risk of incident nonfatal myocardial infarction and stroke publication-title: Pharmacogenet Genomics doi: 10.1097/FPC.0b013e3283033528 contributor: fullname: Rice – volume: 73 start-page: 780 issue: 4 year: 2003 end-page: 790 ident: CR4 article-title: A genomewide scan for age-related macular degeneration provides evidence for linkage to several chromosomal regions publication-title: Am J Hum Genet doi: 10.1086/378505 contributor: fullname: Cote – volume: 114 start-page: 87 issue: 1 year: 2003 end-page: 98 ident: CR27 article-title: Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients publication-title: Hum Genet doi: 10.1007/s00439-003-1026-1 contributor: fullname: Topol – volume: 200 start-page: 322 issue: 2 year: 2008 end-page: 328 ident: CR26 article-title: Low-density lipoprotein and high-density lipoprotein cholesterol levels in relation to genetic polymorphisms and menopausal status: the Atherosclerosis Risk in Communities (ARIC) Study publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2007.12.045 contributor: fullname: Ballantyne – volume: 88 start-page: 495 issue: 3 year: 2009 end-page: 503 ident: CR19 article-title: Biological effects of native and oxidized low-density lipoproteins in cultured human retinal pigment epithelial cells publication-title: Exp Eye Res doi: 10.1016/j.exer.2008.10.028 contributor: fullname: Welge-Lussen – volume: 126 start-page: 1396 issue: 10 year: 2008 end-page: 1403 ident: CR17 article-title: Sunlight exposure, antioxidants, and age-related macular degeneration publication-title: Arch Ophthalmol doi: 10.1001/archopht.126.10.1396 contributor: fullname: Chakravarthy – volume: 478 start-page: 76 issue: 7367 year: 2011 ident: BFeye2012276_CR37 publication-title: Nature doi: 10.1038/nature10449 contributor: fullname: D Weismann – volume: 121 start-page: 1728 issue: 12 year: 2003 ident: BFeye2012276_CR18 publication-title: Arch Ophthalmol doi: 10.1001/archopht.121.12.1728 contributor: fullname: JM Seddon – volume: 308 start-page: 385 issue: 5720 year: 2005 ident: BFeye2012276_CR12 publication-title: Science doi: 10.1126/science.1109557 contributor: fullname: RJ Klein – volume: 126 start-page: 1396 issue: 10 year: 2008 ident: BFeye2012276_CR17 publication-title: Arch Ophthalmol doi: 10.1001/archopht.126.10.1396 contributor: fullname: AE Fletcher – volume: 53 start-page: 1548 issue: 3 year: 2012 ident: BFeye2012276_CR38 publication-title: Invest Ophthalmol Vis Sci doi: 10.1167/iovs.11-8657 contributor: fullname: Y Yu – volume: 200 start-page: 322 issue: 2 year: 2008 ident: BFeye2012276_CR26 publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2007.12.045 contributor: fullname: AM Chamberlain – volume: 38 start-page: 1055 issue: 9 year: 2006 ident: BFeye2012276_CR15 publication-title: Nat Genet doi: 10.1038/ng1873 contributor: fullname: J Maller – volume: 22 start-page: 273 issue: 4 year: 2008 ident: BFeye2012276_CR32 publication-title: J Diabetes Complications doi: 10.1016/j.jdiacomp.2007.06.011 contributor: fullname: P Valdivielso – volume: 24 start-page: 1750 issue: 10 year: 2004 ident: BFeye2012276_CR23 publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/01.ATV.0000140818.00570.2d contributor: fullname: S Santamarina-Fojo – volume: 44 start-page: 1 issue: 1 year: 1999 ident: BFeye2012276_CR34 publication-title: Surv Ophthalmol doi: 10.1016/S0039-6257(99)00072-7 contributor: fullname: A Abdelsalam – volume: 114 start-page: 87 issue: 1 year: 2003 ident: BFeye2012276_CR27 publication-title: Hum Genet doi: 10.1007/s00439-003-1026-1 contributor: fullname: JJ McCarthy – volume: 55 start-page: 483 issue: 5 year: 2006 ident: BFeye2012276_CR28 publication-title: Physiol Res doi: 10.33549/physiolres.930836 contributor: fullname: A Stancakova – volume: 73 start-page: 780 issue: 4 year: 2003 ident: BFeye2012276_CR4 publication-title: Am J Hum Genet doi: 10.1086/378505 contributor: fullname: JM Seddon – volume: 107 start-page: 7401 issue: 16 year: 2010 ident: BFeye2012276_CR22 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0912702107 contributor: fullname: W Chen – volume: 204 start-page: 171 issue: 1 year: 2009 ident: BFeye2012276_CR24 publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2008.09.007 contributor: fullname: MF Feitosa – volume: 88 start-page: 495 issue: 3 year: 2009 ident: BFeye2012276_CR19 publication-title: Exp Eye Res doi: 10.1016/j.exer.2008.10.028 contributor: fullname: AL Yu – volume: 104 start-page: 16227 issue: 41 year: 2007 ident: BFeye2012276_CR14 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0703933104 contributor: fullname: A Kanda – volume: 122 start-page: 564 issue: 4 year: 2004 ident: BFeye2012276_CR1 publication-title: Arch Ophthalmol doi: 10.1001/archopht.1941.00870100042005 contributor: fullname: DS Friedman – volume: 314 start-page: 989 issue: 5801 year: 2006 ident: BFeye2012276_CR8 publication-title: Science doi: 10.1126/science.1133807 contributor: fullname: A Dewan – volume: 6 start-page: 1122 issue: 9 year: 2007 ident: BFeye2012276_CR2 publication-title: Cell Cycle doi: 10.4161/cc.6.9.4157 contributor: fullname: DJ Cameron – volume: 102 start-page: 7227 issue: 20 year: 2005 ident: BFeye2012276_CR5 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0501536102 contributor: fullname: GS Hageman – volume: 39 start-page: 367 issue: 5 year: 1995 ident: BFeye2012276_CR21 publication-title: Surv Ophthalmol doi: 10.1016/S0039-6257(05)80092-X contributor: fullname: AC Bird – volume: 107 start-page: 7395 issue: 16 year: 2010 ident: BFeye2012276_CR20 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0912019107 contributor: fullname: BM Neale – volume: 38 start-page: 762 issue: 3 year: 1997 ident: BFeye2012276_CR35 publication-title: Invest Ophthalmol Vis Sci contributor: fullname: C Starita – volume: 18 start-page: 677 issue: 8 year: 2008 ident: BFeye2012276_CR31 publication-title: Pharmacogenet Genomics doi: 10.1097/FPC.0b013e3283033528 contributor: fullname: LA Hindorff – volume: 51 start-page: 451 issue: 3 year: 2010 ident: BFeye2012276_CR36 publication-title: J Lipid Res doi: 10.1194/jlr.R002238 contributor: fullname: CA Curcio – volume: 90 start-page: 75 issue: 1 year: 2006 ident: BFeye2012276_CR3 publication-title: Br J Ophthalmol doi: 10.1136/bjo.2005.073643 contributor: fullname: JC Khan – volume: 314 start-page: 992 issue: 5801 year: 2006 ident: BFeye2012276_CR7 publication-title: Science doi: 10.1126/science.1133811 contributor: fullname: Z Yang – volume: 308 start-page: 421 issue: 5720 year: 2005 ident: BFeye2012276_CR13 publication-title: Science doi: 10.1126/science.1110189 contributor: fullname: AO Edwards – volume: 13 start-page: 993 issue: 10 year: 2004 ident: BFeye2012276_CR25 publication-title: Hum Mol Genet doi: 10.1093/hmg/ddh119 contributor: fullname: H Knoblauch – volume: 38 start-page: 458 issue: 4 year: 2006 ident: BFeye2012276_CR10 publication-title: Nat Genet doi: 10.1038/ng1750 contributor: fullname: B Gold – volume: 114 start-page: 2168 issue: 12 year: 2007 ident: BFeye2012276_CR6 publication-title: Ophthalmology doi: 10.1016/j.ophtha.2007.09.008 contributor: fullname: MA Brantley – volume: 51 start-page: 59 issue: 1 year: 2010 ident: BFeye2012276_CR11 publication-title: Invest Ophthalmol Vis Sci doi: 10.1167/iovs.09-4135 contributor: fullname: I Kaur – volume: 125 start-page: 671 issue: 5 year: 2007 ident: BFeye2012276_CR16 publication-title: Arch Ophthalmol doi: 10.1001/archopht.125.5.671 contributor: fullname: JP SanGiovanni – volume: 10 start-page: 111 year: 2009 ident: BFeye2012276_CR29 publication-title: BMC Med Genet doi: 10.1186/1471-2350-10-111 contributor: fullname: SN Chen – volume: 4 start-page: 46 year: 2009 ident: BFeye2012276_CR30 publication-title: J Cardiothorac Surg doi: 10.1186/1749-8090-4-46 contributor: fullname: S Eifert – volume: 148 start-page: 869 issue: 6 year: 2009 ident: BFeye2012276_CR9 publication-title: Am J Ophthalmol doi: 10.1016/j.ajo.2009.07.002 contributor: fullname: MT Andreoli – volume: 117 start-page: 1989 issue: 10 year: 2010 ident: BFeye2012276_CR33 publication-title: Ophthalmology doi: 10.1016/j.ophtha.2010.07.009 contributor: fullname: R Reynolds
SSID	ssj0014770
Score	2.1452684
Snippet	Purpose To determine whether there is an association between hepatic lipase ( LIPC ) and age-related macular degeneration (AMD) in two independent Caucasian... To determine whether there is an association between hepatic lipase (LIPC) and age-related macular degeneration (AMD) in two independent Caucasian cohorts. A... To determine whether there is an association between hepatic lipase (LIPC) and age-related macular degeneration (AMD) in two independent Caucasian cohorts. A... PURPOSETo determine whether there is an association between hepatic lipase (LIPC) and age-related macular degeneration (AMD) in two independent Caucasian...
SourceID	pubmedcentral proquest crossref pubmed springer
SourceType	Open Access Repository Aggregation Database Index Database Publisher
StartPage	265
SubjectTerms	631/208/205 631/208/726/649 631/378/1689/1626 692/499 Aged Aged, 80 and over Alleles Cohort Studies Female Gene Frequency Genetic Predisposition to Disease Humans Laboratory Medicine Laboratory Study Lipase - genetics Macular Degeneration - genetics Male Medicine Medicine & Public Health Middle Aged Ophthalmology Pharmaceutical Sciences/Technology Polymorphism, Single Nucleotide Promoter Regions, Genetic - genetics Surgery Surgical Oncology
Title	Association of LIPC and advanced age-related macular degeneration
URI	https://link.springer.com/article/10.1038/eye.2012.276 https://www.ncbi.nlm.nih.gov/pubmed/23348725 https://www.proquest.com/docview/1287506692 https://search.proquest.com/docview/1288313229 https://pubmed.ncbi.nlm.nih.gov/PMC3574263
Volume	27
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9tAEB41VEJcEC0UzCMyEvS2ib3vHCElihQBlUolbtbau9siEQcBOfDvmd3YUYCeerPktXb07axnRjPzDcAJmsDMSUlJxTJPeF56YkSVE6MdKpjUVqrQKDz-pa5u9Y-LQJMj2l6YWLRflXe9-n7aq-_-xtrKh2nVb-vE-j8vh0yowDPe70AHfcM2RG9SB1zFCXHoOmQEjd9tU-2eMd13L4EYM6c9qsLoIhq6UFUYkr1qkj74mR_LJd_lTKMpGm3BZuNDpmcLWb_AJ1d_hfXLJku-DWcrmKczn2LwPkxNbdM24Z_iT4TELhZ8nppYippa9ydSUIevduD36OJmOCbNqARSiVw-E-lomVnlRVV5FLSU3pehh5RWHEMgk1OPkQPHRVxqJ4TVhrGB95x543lmJfsGa_WsdnuQKmeEUBYDMcY5k1YLipdaDyhGs1Q7m8Bpi1bxsGDEKGImm-kCAS4CwAUCnMBhC2XR3IunAq0huihSDmgCx8vXqNEhTWFqN5vHNToQStJBArsL5JcbtUeWgHpzJssFgS377RtUosia3ShNAt_b01sR6x_y7__3FgewQePQjFD0cghrz49zdwSdJzvvwufzyeTquhtV9hWu4u2b
link.rule.ids	230,315,729,782,786,887,27933,27934,48284,48346,48347,48358,49590,49651,49652,49663,53800,53802
linkProvider	National Library of Medicine
linkToHtml	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LTxsxEB4BkVouUNoCWyhdpLY3w67fOVJKlCqPHppKua2ctQ0c2CAgB_59x85ulJAe2ttKHsvembFnRjPzGeAzmsDMSUlJyTJPeD7xxIgyJ0Y7VDCprVShUbj7Sw3H-vtVgMk5a3phYrV7k5KMN_W8MVyfu-eAapnTM6rkJrQCzjkexNa3Xm_4c5E34Co-D4d-Q0bQ8o3rUveX81eN0JpnuV4g-SJLGo1PZ_d_t_0Gdmo3M72Y68UebLjqLbwa1In0d3CxJJZ06lOM7y9TU9m0qQlI8Z4hsdEFv-9MrFZNrbuOKNVh1nv43bkaXXZJ_ZoCKUUun4h0dJJZ5UVZevyzifR-EtpMackxSjI59RhccCTiUjshrDaMtb3nzBvPMyvZPmxV08odQqqcEUJZjNUY50xaLSiee92mGPBS7WwCXxr2Fvdz0IwiJruZLpAfReBHgfxI4LjhfVEfnccCDSZ6MVK2aQKni2FU-pDJMJWbziKNDpiTtJ3AwVxUi4Vo6C1WVCSgVoS4IAiA2qsj1e1NBNZmQgX8-gS-NqJc2tZf9v_hXwk_wevuaNAv-j-GvSPYpvFJjVAScwxbTw8z9xE2H-3spNbmP2Ti8P8
linkToPdf	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3dT9swED-NIiFeYBtfYWUL0uDNkPi7e2NAxVRWkACJt8iNbeCBFEH7wH_P2U0qCjxM2lsknxXn7uy7y939DPATTWDmpKSkZJknPB94YkSZE6MdKpjUVqrQKHxyofrX-ug4wOT8anphYrV7k5Kc9DQElKZqtP9gfd0krvfdc0C4zOkeVXIO5sMPMdTu-d-9Xv9smkPgKl4Vhz5ERtAKXtdl72_nzxqkd17m-2LJNxnTaIi6y__zCZ9hqXY_04OJvnyBT676Cgt_6wT7Chy8Elc69CnG_YepqWza1AqkeP6Q2ACDz_cmVrGm1t1E9OowaxWuuseXhyekvmWBlCKXIyIdHWRWeVGWHr9yIL0fhPZTWnKMnkxOPQYdHIm41E4Iqw1jHe8588bzzEq2Bq1qWLkNSJUzQiiLMRzjnEmrBcXzQHcoBsJUO5vATsPq4mECplHEJDjTBfKjCPwokB8JtBs5FPWWeirQkKJ3I2WHJrA9HcbNEDIcpnLDcaTRAYuSdhJYn4ht-iIaeo4VFQmoGYFOCQLQ9uxIdXcbAbeZUAHXPoHdRqyvlvXB-jf_lfAHLJwfdYvTP_3eN1ik8aaNUCnThtbocey2YO7Jjr_Xiv0CAkL54Q
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Association+of+LIPC+and+advanced+age-related+macular+degeneration&rft.jtitle=Eye+%28London%29&rft.au=Lee%2C+J&rft.au=Zeng%2C+J&rft.au=Hughes%2C+G&rft.au=Chen%2C+Y&rft.date=2013-02-01&rft.pub=Nature+Publishing+Group+UK&rft.issn=0950-222X&rft.eissn=1476-5454&rft.volume=27&rft.issue=2&rft.spage=265&rft.epage=271&rft_id=info:doi/10.1038%2Feye.2012.276&rft.externalDocID=10_1038_eye_2012_276
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0950-222X&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0950-222X&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0950-222X&client=summon