Blood culture versus antibiotic use for neonatal inpatients in 61 hospitals implementing with the NEST360 Alliance in Kenya, Malawi, Nigeria, and Tanzania: a cross-sectional study

• Published in: BMC pediatrics Vol. 23; no. 1; pp. 1 - 568
• Main Authors: Murless-Collins, Sarah, Kawaza, Kondwani, Salim, Nahya, Molyneux, Elizabeth M, Chiume, Msandeni, Aluvaala, Jalemba, Macharia, William M, Ezeaka, Veronica Chinyere, Odedere, Opeyemi, Shamba, Donat, Tillya, Robert, Penzias, Rebecca E, Ezenwa, Beatrice Nkolika, Ohuma, Eric O, Cross, James H, Lawn, Joy E, Bokea, Helen, Bohne, Christine, Waiyego, Mary, Irimu, Grace, Ogueji, Ifeanyichukwu Anthony, Jenkins, Georgia, Tongo, Olukemi O, Fajolu, Iretiola, Olutekunbi, Nike, Paul, Cate, Baraka, Jitihada, Kirby, Rebecca, Palamountain, Kara
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 15-11-2023; BioMed Central; BMC
• Subjects: Antibiotics; Antimicrobial agents; Bacterial infections; Binomial distribution; Blood; Blood culture; Cross-sectional studies; Data collection; Demographic aspects; Dosage and administration; Drug resistance; Drug resistance in microorganisms; Evaluation; Health aspects; Health facilities; Hospital patients; Infants; Infants (Newborn); Infection; Infections; Inpatient care; Laboratories; Low- and middle-income countries; Medical care; Medical examination; Microbiology; Neonatal; Newborn; Newborn babies; Patient outcomes; Pediatrics; Prescription writing; Qualitative research; Quality improvement; Quality management; Surveillance; Kenya; Nigeria; Malawi; Tanzania; Sub-Saharan Africa
• ISSN: 1471-2431; 1471-2431
• DOI: 10.1186/s12887-023-04343-0

Background Thirty million small and sick newborns worldwide require inpatient care each year. Many receive antibiotics for clinically diagnosed infections without blood cultures, the current 'gold standard' for neonatal infection detection. Low neonatal blood culture use hampers appropriate antibiotic use, fuelling antimicrobial resistance (AMR) which threatens newborn survival. This study analysed the gap between blood culture use and antibiotic prescribing in hospitals implementing with Newborn Essential Solutions and Technologies (NEST360) in Kenya, Malawi, Nigeria, and Tanzania. Methods Inpatient data from every newborn admission record (July 2019-August 2022) were included to describe hospital-level blood culture use and antibiotic prescription. Health Facility Assessment data informed performance categorisation of hospitals into four tiers: (Tier 1) no laboratory, (Tier 2) laboratory but no microbiology, (Tier 3) neonatal blood culture use < 50% of newborns receiving antibiotics, and (Tier 4) neonatal blood culture use > 50%. Results A total of 144,146 newborn records from 61 hospitals were analysed. Mean hospital antibiotic prescription was 70% (range = 25-100%), with 6% mean blood culture use (range = 0-56%). Of the 10,575 blood cultures performed, only 24% (95%CI 23-25) had results, with 10% (10-11) positivity. Overall, 40% (24/61) of hospitals performed no blood cultures for newborns. No hospitals were categorised as Tier 1 because all had laboratories. Of Tier 2 hospitals, 87% (20/23) were District hospitals. Most hospitals could do blood cultures (38/61), yet the majority were categorised as Tier 3 (36/61). Only two hospitals performed > 50% blood cultures for newborns on antibiotics (Tier 4). Conclusions The two Tier 4 hospitals, with higher use of blood cultures for newborns, underline potential for higher blood culture coverage in other similar hospitals. Understanding why these hospitals are positive outliers requires more research into local barriers and enablers to performing blood cultures. Tier 3 facilities are missing opportunities for infection detection, and quality improvement strategies in neonatal units could increase coverage rapidly. Tier 2 facilities could close coverage gaps, but further laboratory strengthening is required. Closing this culture gap is doable and a priority for advancing locally-driven antibiotic stewardship programmes, preventing AMR, and reducing infection-related newborn deaths. Keywords: Newborn, Neonatal, Blood culture, Antibiotics, Low- and middle-income countries, Inpatient care, Antimicrobial resistance, Small and sick newborn care, Quality of care, Infection, Sepsis