Chalazion-mimicked eyelid angiosarcoma in a young Asian with good prognosis: a case report

• Published in: BMC ophthalmology Vol. 24; no. 1; p. 1
• Main Authors: Hwang, Gyudeok, Kim, Jong Ok, Paik, Ji-Sun, Yang, Suk-Woo, Cho, Won-Kyung
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 02-01-2024; BioMed Central; BMC
• Subjects: Aged; Angiosarcoma; Antigens; Biopsy; Cancer; Case Report; Case reports; Chalazion; Chalazion - diagnosis; Disease; Eyelid; Eyelid diseases; Eyelid Neoplasms - diagnosis; Eyelid Neoplasms - pathology; Eyelid Neoplasms - surgery; Eyelids - pathology; Eyelids - surgery; Hemangiosarcoma - diagnosis; Hemangiosarcoma - pathology; Hemangiosarcoma - surgery; Hematoma; Humans; Magnetic resonance imaging; Male; Males; Medical prognosis; Melanoma; Metastases; Metastasis; Middle Aged; Misdiagnosis; Musculoskeletal system; Mutation; Patients; Positron Emission Tomography Computed Tomography; Prognosis; Smooth muscle; Stains & staining; Surgical excision; Thyroid gland; Tomography; Tumors; Misdiagnosis; Eyelid; Surgical excision; Chalazion; Angiosarcoma
• DOI: 10.1186/s12886-023-03262-z
• EISSN: 1471-2415

Angiosarcoma is an extremely rare malignant tumor. So far, only about 42 cases of angiosarcoma involving the eyelids have been reported. Eyelid angiosarcoma occurs more frequently in elderly Caucasian males and is prone to misdiagnosis. We present a case report in a young Asian male patient with eyelid angiosarcoma that was misdiagnosed as a chalazion.
A 46-year-old South Korean male with no underlying disease had a right lower lid mass. The lesion was initially misdiagnosed as a chalazion at a local clinic, but a diagnosis of eyelid angiosarcoma was made after the first biopsy trial. PET-CT was performed to ensure that there was no metastasis in the whole body. Surgical excision with enough surgical margin was used alone for treatment and reconstruction was performed with a tarsoconjunctival advancement flap (modified Hughes procedure), which helped ensure good cosmesis. No recurrence was observed 4 years and 5 months after the surgery.
The current study presents the first case of chalazion-mimicked eyelid angiosarcoma in a young Asian male aged under 50 years. This case shows that even if a benign eyelid disease is suspected in a young patient, an incisional biopsy must be performed to confirm whether the lesion is malignant. Since the prognosis is good for the case of eyelid angiosarcoma, if there is no clear evidence of distal metastasis, surgical resection should be performed with an enough safety margin.