PARP1 enhances lung adenocarcinoma metastasis by novel mechanisms independent of DNA repair

The role of poly (ADP-ribose) polymerase 1 (PARP1) in cancer has been extensively studied in the context of DNA repair, leading to clinical trials of PARP1 inhibitors in cancers defective in homologous recombination. However, the DNA repair-independent roles of PARP1 in carcinogenesis and metastasis...

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Published in:	Oncogene Vol. 35; no. 35; pp. 4569 - 4579
Main Authors:	Choi, E-B, Yang, A-Y, Kim, S C, Lee, J, Choi, J K, Choi, C, Kim, M-Y
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-09-2016 Nature Publishing Group
Subjects:	13/1 13/109 13/89 14/5 38/61 45/90 631/154/53/2422 631/67/1612/1350 631/67/322 82/51 Adenocarcinoma Adenocarcinoma - genetics Adenocarcinoma - pathology Adenocarcinoma of Lung Anoikis Apoptosis Cancer Carcinogenesis Carcinogenesis - genetics Cell Biology Cell Line, Tumor Claudins - genetics Clinical trials Deoxyribonucleic acid Development and progression DNA DNA repair DNA Repair - genetics DNA-Binding Proteins - genetics Extravasation Gene expression Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Genetic aspects Health aspects Homologous Recombination Human Genetics Humans Internal Medicine Lung cancer Lung Neoplasms - genetics Lung Neoplasms - pathology Medicine Medicine & Public Health Metastases Metastasis Microenvironments Molecular modelling Neoplasm Metastasis Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Oncology original-article Patients Poly(ADP-ribose) Polymerase 1 Polymerase chain reaction Properties Ribose S100 Calcium-Binding Protein A4 - genetics S100A4 protein Transcription Transferases
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Abstract	The role of poly (ADP-ribose) polymerase 1 (PARP1) in cancer has been extensively studied in the context of DNA repair, leading to clinical trials of PARP1 inhibitors in cancers defective in homologous recombination. However, the DNA repair-independent roles of PARP1 in carcinogenesis and metastasis, particularly in lung cancer metastasis, remain largely uncharacterized. Here, we report that PARP1 promotes lung adenocarcinoma relapse to the brain and bones by regulating several steps of the metastatic process in a DNA repair-independent manner. We find that PARP1 expression is associated with overall and distant metastasis-free survival in lung adenocarcinoma patients. Consistent with this, genetic knockdown and pharmacological inhibition of PARP1 significantly attenuated the metastatic potential of lung adenocarcinoma cells. Further investigation revealed that PARP1 potentiates lung adenocarcinoma metastasis by promoting invasion, anoikis resistance, extravasation and self-renewal of lung adenocarcinoma cells and also by modifying the brain microenvironment. Finally, we identified S100A4 and CLDN7 as novel transcriptional targets and clinically relevant effectors of PARP1. Collectively, our study not only revealed previously unknown functions of PARP1 in lung adenocarcinoma metastasis but also delineated the molecular mechanisms underlying the pro-metastatic function of PARP1. Furthermore, these findings provide a foundation for the potential use of PARP1 inhibitors as a new treatment option for lung adenocarcinoma patients with elevated PARP1 expression.
AbstractList	The role of poly (ADP-ribose) polymerase 1 (PARP1) in cancer has been extensively studied in the context of DNA repair, leading to clinical trials of PARP1 inhibitors in cancers defective in homologous recombination. However, the DNA repair-independent roles of PARP1 in carcinogenesis and metastasis, particularly in lung cancer metastasis, remain largely uncharacterized. Here, we report that PARP1 promotes lung adenocarcinoma relapse to the brain and bones by regulating several steps of the metastatic process in a DNA repair-independent manner. We find that PARP1 expression is associated with overall and distant metastasis-free survival in lung adenocarcinoma patients. Consistent with this, genetic knockdown and pharmacological inhibition of PARP1 significantly attenuated the metastatic potential of lung adenocarcinoma cells. Further investigation revealed that PARP1 potentiates lung adenocarcinoma metastasis by promoting invasion, anoikis resistance, extravasation and self-renewal of lung adenocarcinoma cells and also by modifying the brain microenvironment. Finally, we identified S100A4 and CLDN7 as novel transcriptional targets and clinically relevant effectors of PARP1. Collectively, our study not only revealed previously unknown functions of PARP1 in lung adenocarcinoma metastasis but also delineated the molecular mechanisms underlying the pro-metastatic function of PARP1. Furthermore, these findings provide a foundation for the potential use of PARP1 inhibitors as a new treatment option for lung adenocarcinoma patients with elevated PARP1 expression. The role of poly (ADP-ribose) polymerase 1 (PARP1) in cancer has been extensively studied in the context of DNA repair, leading to clinical trials of PARP1 inhibitors in cancers defective in homologous recombination. However, the DNA repair-independent roles of PARP1 in carcinogenesis and metastasis, particularly in lung cancer metastasis, remain largely uncharacterized. Here, we report that PARP1 promotes lung adenocarcinoma relapse to the brain and bones by regulating several steps of the metastatic process in a DNA repair-independent manner. We find that PARP1 expression is associated with overall and distant metastasis-free survival in lung adenocarcinoma patients. Consistent with this, genetic knockdown and pharmacological inhibition of PARP1 significantly attenuated the metastatic potential of lung adenocarcinoma cells. Further investigation revealed that PARP1 potentiates lung adenocarcinoma metastasis by promoting invasion, anoikis resistance, extravasation and self-renewal of lung adenocarcinoma cells and also by modifying the brain microenvironment. Finally, we identified S100A4 and CLDN7 as novel transcriptional targets and clinically relevant effectors of PARP1. Collectively, our study not only revealed previously unknown functions of PARP1 in lung adenocarcinoma metastasis but also delineated the molecular mechanisms underlying the pro-metastatic function of PARP1. Furthermore, these findings provide a foundation for the potential use of PARP1 inhibitors as a new treatment option for lung adenocarcinoma patients with elevated PARP1 expression. The role of poly (ADP-ribose) polymerase 1 (PARP1) in cancer has been extensively studied in the context of DNA repair, leading to clinical trials of PARP1 inhibitors in cancers defective in homologous recombination. However, the DNA repair-independent roles of PARP1 in carcinogenesis and metastasis, particularly in lung cancer metastasis, remain largely uncharacterized. Here, we report that PARP1 promotes lung adenocarcinoma relapse to the brain and bones by regulating several steps of the metastatic process in a DNA repair-independent manner. We find that PARP1 expression is associated with overall and distant metastasis-free survival in lung adenocarcinoma patients. Consistent with this, genetic knockdown and pharmacological inhibition of PARP1 significantly attenuated the metastatic potential of lung adenocarcinoma cells. Further investigation revealed that PARP1 potentiates lung adenocarcinoma metastasis by promoting invasion, anoikis resistance, extravasation and self-renewal of lung adenocarcinoma cells and also by modifying the brain microenvironment. Finally, we identified S100A4 and CLDN7 as novel transcriptional targets and clinically relevant effectors of PARP1. Collectively, our study not only revealed previously unknown functions of PARP1 in lung adenocarcinoma metastasis but also delineated the molecular mechanisms underlying the pro-metastatic function of PARP1. Furthermore, these findings provide a foundation for the potential use of PARP1 inhibitors as a new treatment option for lung adenocarcinoma patients with elevated PARP1 expression. Oncogene (2016) 35, 4569-4579; doi: 10.1038/onc.2016.3; published online 22 February 2016 The role of poly (ADP-ribose) polymerase 1 (PARP1) in cancer has been extensively studied in the context of DNA repair, leading to clinical trials of PARP1 inhibitors in cancers defective in homologous recombination. However, the DNA repair-independent roles of PARP1 in carcinogenesis and metastasis, particularly in lung cancer metastasis, remain largely uncharacterized. Here, we report that PARP1 promotes lung adenocarcinoma relapse to the brain and bones by regulating several steps of the metastatic process in a DNA repair-independent manner. We nd that PARP1 expression is associated with overall and distant metastasis-free survival in lung adenocarcinoma patients. Consistent with this, genetic knockdown and pharmacological inhibition of PARP1 signicantly attenuated the metastatic potential of lung adenocarcinoma cells. Further investigation revealed that PARP1 potentiates lung adenocarcinoma metastasis by promoting invasion, anoikis resistance, extravasation and self-renewal of lung adenocarcinoma cells and also by modifying the brain microenvironment. Finally, we identied S100A4 and CLDN7 as novel transcriptional targets and clinically relevant effectors of PARP1. Collectively, our study not only revealed previously unknown functions of PARP1 in lung adenocarcinoma metastasis but also delineated the molecular mechanisms underlying the pro-metastatic function of PARP1. Furthermore, these ndings provide a foundation for the potential use of PARP1 inhibitors as a new treatment option for lung adenocarcinoma patients with elevated PARP1 expression.
Audience	Academic
Author	Yang, A-Y Kim, S C Lee, J Kim, M-Y Choi, C Choi, E-B Choi, J K
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BackLink	https://www.ncbi.nlm.nih.gov/pubmed/26898760$$D View this record in MEDLINE/PubMed
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Cites_doi	10.1016/j.molcel.2006.12.012 10.1002/cncr.21778 10.1038/nature03128 10.1073/pnas.1305823110 10.1126/science.1127196 10.1038/nrc2812 10.1200/JCO.1984.2.12.1352 10.1016/j.molcel.2010.10.029 10.1038/onc.2009.135 10.1016/j.cell.2006.11.001 10.1074/jbc.M109.023879 10.1158/0008-5472.CAN-04-2649 10.1016/S0140-6736(00)82038-3 10.1016/j.canlet.2008.05.029 10.1016/j.ccr.2013.04.009 10.1158/0008-5472.CAN-12-1287 10.1093/carcin/bgs393 10.1016/j.bbrc.2004.02.135 10.1038/nature05384 10.1371/journal.pgen.1003531 10.1038/nrc3775 10.1038/ng1426 10.1002/jemt.10296 10.2353/ajpath.2007.060343 10.1073/pnas.0530291100 10.4161/cc.24034 10.1016/j.ccr.2011.04.010 10.1101/gad.1331805 10.1111/j.1349-7006.2011.01915.x 10.1038/nm.1790 10.1158/1541-7786.MCR-07-0377 10.1038/onc.2012.2 10.1016/S0022-5223(95)70427-2 10.1371/journal.pone.0022119 10.1016/j.cell.2012.10.028 10.1021/cr5004248 10.1056/NEJMct0807960 10.1038/nrc3447 10.1158/1078-0432.CCR-12-1139 10.1158/0008-5472.CAN-13-1896 10.1093/bioinformatics/btu521 10.1038/nature05760 10.1002/dvdy.21685 10.1371/journal.pone.0082241 10.1073/pnas.79.11.3423 10.1016/j.cell.2004.11.002 10.1038/onc.2011.153 10.1042/0264-6021:3420249 10.1016/j.ejca.2008.03.019 10.1073/pnas.0606747103 10.1038/nrc2618 10.1126/science.1078764 10.1111/j.1349-7006.2005.00121.x 10.1158/1541-7786.MCR-12-0401 10.1038/onc.2013.270 10.1093/annonc/mdv514.33 10.1038/nature03445 10.1038/nature05372 10.1038/nm.2379 10.1158/0008-5472.CAN-12-3000 10.1016/j.stem.2007.06.002 10.1016/j.molcel.2010.08.014 10.1158/1535-7163.MCT-11-0278 10.1200/JCO.2008.19.7053 10.1038/nature03443 10.1016/j.cell.2009.04.030 10.1038/nature11333 10.1016/j.mam.2013.01.005 10.1158/0008-5472.CAN-11-3648 10.1158/0008-5472.CAN-07-5805 10.1016/j.cell.2009.11.025 10.1016/S0962-8924(99)01578-0 10.1016/j.bbrc.2014.04.025 10.1200/JCO.2014.56.2728 10.1038/ncb1998 10.1016/S0021-9258(18)81875-0 10.1016/S0021-9258(19)69404-4
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References	Botling, Edlund, Lohr, Hellwig, Holmberg, Lambe (CR26) 2013; 19 Martini, Bains, Burt, Zakowski, McCormack, Rusch (CR31) 1995; 109 Tsukita, Furuse (CR52) 1999; 9 Ju, Lunyak, Perissi, Garcia-Bassets, Rose, Glass (CR11) 2006; 312 Cataldo, Gibbons, Perez-Soler, Quintas-Cardama (CR60) 2011; 364 Kraus, Hottiger (CR1) 2013; 34 Shedden, Taylor, Enkemann, Tsao, Yeatman (CR28) 2008; 14 De Craene, Berx (CR69) 2013; 13 Tulin, Spradling (CR46) 2003; 299 O’Brien, Pollett, Gallinger, Dick (CR45) 2007; 445 Shen, Chen, Fu, Liu, Sun, Sun (CR55) 2011; 102 Akiyama, Takasawa, Nata, Kobayashi, Abe, Shervani (CR9) 2001; 98 Matsubara, Niki, Ishikawa, Goto, Ohara, Yokomizo (CR49) 2005; 96 Ryu, Kim, Kraus (CR7) 2015; 115 Minami, Takigawa, Takeda, Takata, Ochi, Ichihara (CR25) 2013; 11 Nowsheen, Cooper, Bonner, LoBuglio, Yang (CR16) 2012; 72 Shan, Li, Liu, Ding, Wang, Zheng (CR74) 2014; 33 Poirier, de Murcia, Jongstra-Bilen, Niedergang, Mandel (CR8) 1982; 79 Cheung, Zhao, Liu, Stevens, Cao, Fang (CR72) 2013; 23 Kim, Mauro, Gevry, Lis, Kraus (CR47) 2004; 119 Brenner, Ateeq, Li, Yocum, Cao, Asangani (CR17) 2011; 19 Cohen-Armon, Visochek, Rozensal, Kalal, Geistrikh, Klein (CR12) 2007; 25 Feld, Rubinstein, Weisenberger (CR30) 1984; 2 Michels, Adam, Goubar, Obrist, Damotte, Robin (CR61) 2015; 26 Doege, Inoue, Yamashita, Rhee, Travis, Fujita (CR70) 2012; 488 Joyce, Pollard (CR37) 2009; 9 Rouleau, Patel, Hendzel, Kaufmann, Poirier (CR5) 2010; 10 Kaufman, Shapira-Frommer, Schmutzler, Audeh, Friedlander, Balmana (CR15) 2015; 33 Donato (CR50) 2003; 60 Kim, Sharma, Dhar, Lee, Gu, Chan (CR73) 2014; 74 Chitale, Gong, Taylor, Broderick, Brennan, Somwar (CR34) 2009; 28 Al-Hajj, Wicha, Benito-Hernandez, Morrison, Clarke (CR43) 2003; 100 Farmer, McCabe, Lord, Tutt, Johnson, Richardson (CR14) 2005; 434 Michels, Vitale, Galluzzi, Adam, Olaussen, Kepp (CR20) 2013; 73 Gyorffy, Surowiak, Budczies, Lanczky (CR29) 2013; 8 Chen, Fillmore, Hammerman, Kim, Wong (CR21) 2014; 14 Davies, Rudland, Robertson, Parry, Jolicoeur, Barraclough (CR53) 1996; 13 Frizzell, Gamble, Berrocal, Zhang, Krishnakumar, Cen (CR35) 2009; 284 Singh, Hawkins, Clarke, Squire, Bayani, Hide (CR44) 2004; 432 Berezovskaya, Schimmer, Glinskii, Pinilla, Hoffman, Reed (CR38) 2005; 65 Cheng, Zhang, Borczuk, Powell, Balajee, Lieberman (CR19) 2013; 34 Saleem, Kweon, Johnson, Adhami, Elcheva, Khan (CR54) 2006; 103 Nguyen, Chiang, Zhang, Kim, Kris, Ladanyi (CR33) 2009; 138 Kim, Oskarsson, Acharyya, Nguyen, Zhang, Norton (CR71) 2009; 139 Yu, Ginjala, Pant, Chernukhin, Whitehead, Docquier (CR10) 2004; 36 Hermann, Huber, Herrler, Aicher, Ellwart, Guba (CR41) 2007; 1 Bryant, Schultz, Thomas, Parker, Flower, Lopez (CR13) 2005; 434 Gupta, Massague (CR36) 2006; 127 Hsieh, Schafer, Weigle, Heizmann (CR51) 2004; 316 Lioni, Brafford, Andl, Rustgi, El-Deiry, Herlyn (CR56) 2007; 170 Elser, Borsig, Hassa, Erener, Messner, Valovka (CR62) 2008; 6 Rodriguez, Gonzalez-Flores, Dantzer, Collard, de Herreros, Oliver (CR66) 2011; 30 Simpson, Anyiwe, Schimmer (CR39) 2008; 272 Brenner, Feng, Han, Patel, Goyal, Bou-Maroun (CR18) 2012; 72 Hess, Varadhachary, Taylor, Wei, Raber, Lenzi (CR32) 2006; 106 Gupta, Nguyen, Chiang, Bos, Kim, Nadal (CR75) 2007; 446 D’Amours, Desnoyers, D'Silva, Poirier (CR3) 1999; 342 Michels, Vitale, Senovilla, Enot, Garcia, Lissa (CR24) 2013; 12 Hoffman, Mauer, Vokes (CR22) 2000; 355 Darido, Buchert, Pannequin, Bastide, Zalzali, Mantamadiotis (CR57) 2008; 68 Pencheva, Tran, Buss, Huh, Drobnjak, Busam (CR76) 2012; 151 Tentori, Muzi, Dorio, Bultrini, Mazzon, Lacal (CR63) 2008; 44 Rodriguez, Peralta-Leal, O’Valle, Rodriguez-Vargas, Gonzalez-Flores, Majuelos-Melguizo (CR64) 2013; 9 Lee, Na, Kim, Lee, Lee (CR65) 2012; 31 Ogata, Ueda, Kawaichi, Hayaishi (CR4) 1981; 256 Chen, Sato, Saiki, Sunamura, Fukushige, Horii (CR59) 2014; 447 Senra, Telfer, Cherry, McCrudden, Hirst, O’Connor (CR23) 2011; 10 Dahiya, Becker, Wood, Zhang, Morin (CR58) 2011; 6 McPhee, McDonald, Oloumi, Dedhar (CR67) 2008; 237 Kim, Hwan Kim, Yun, Kim, Kim (CR79) 2014; 30 Tomida, Takeuchi, Shimada, Arima, Matsuo, Mitsudomi (CR27) 2009; 27 Lonn, van der Heide, Dahl, Hellman, Heldin, Moustakas (CR68) 2010; 40 Huletsky, de Murcia, Muller, Hengartner, Menard, Lamarre (CR2) 1989; 264 Kim, Zhang, Kraus (CR6) 2005; 19 Wellner, Schubert, Burk, Schmalhofer, Zhu, Sonntag (CR42) 2009; 11 Oskarsson, Acharyya, Zhang, Vanharanta, Tavazoie, Morris (CR77) 2011; 17 Piccolo, Withers, Francis, Bild, Johnson (CR78) 2013; 110 Ricci-Vitiani, Lombardi, Pilozzi, Biffoni, Todaro, Peschle (CR40) 2007; 445 Krishnakumar, Kraus (CR48) 2010; 39 J Michels (BFonc20163_CR20) 2013; 73 O Berezovskaya (BFonc20163_CR38) 2005; 65 J Botling (BFonc20163_CR26) 2013; 19 U Wellner (BFonc20163_CR42) 2009; 11 H Cheng (BFonc20163_CR19) 2013; 34 MY Kim (BFonc20163_CR71) 2009; 139 S Nowsheen (BFonc20163_CR16) 2012; 72 P Lonn (BFonc20163_CR68) 2010; 40 L Tentori (BFonc20163_CR63) 2008; 44 Z Chen (BFonc20163_CR21) 2014; 14 M Elser (BFonc20163_CR62) 2008; 6 W Shen (BFonc20163_CR55) 2011; 102 M Saleem (BFonc20163_CR54) 2006; 103 TR McPhee (BFonc20163_CR67) 2008; 237 K Shedden (BFonc20163_CR28) 2008; 14 L Ricci-Vitiani (BFonc20163_CR40) 2007; 445 PC Hermann (BFonc20163_CR41) 2007; 1 D Chitale (BFonc20163_CR34) 2009; 28 L Shan (BFonc20163_CR74) 2014; 33 N Dahiya (BFonc20163_CR58) 2011; 6 B De Craene (BFonc20163_CR69) 2013; 13 A Huletsky (BFonc20163_CR2) 1989; 264 JM Senra (BFonc20163_CR23) 2011; 10 CD Simpson (BFonc20163_CR39) 2008; 272 SK Singh (BFonc20163_CR44) 2004; 432 GP Gupta (BFonc20163_CR36) 2006; 127 WL Kraus (BFonc20163_CR1) 2013; 34 KW Ryu (BFonc20163_CR7) 2015; 115 MI Rodriguez (BFonc20163_CR64) 2013; 9 N Martini (BFonc20163_CR31) 1995; 109 JH Kim (BFonc20163_CR73) 2014; 74 HE Bryant (BFonc20163_CR13) 2005; 434 KM Frizzell (BFonc20163_CR35) 2009; 284 MI Rodriguez (BFonc20163_CR66) 2011; 30 S Tsukita (BFonc20163_CR52) 1999; 9 WK Cheung (BFonc20163_CR72) 2013; 23 A Tulin (BFonc20163_CR46) 2003; 299 DX Nguyen (BFonc20163_CR33) 2009; 138 SR Piccolo (BFonc20163_CR78) 2013; 110 N Chen (BFonc20163_CR59) 2014; 447 CA O’Brien (BFonc20163_CR45) 2007; 445 M Cohen-Armon (BFonc20163_CR12) 2007; 25 S Tomida (BFonc20163_CR27) 2009; 27 J Michels (BFonc20163_CR24) 2013; 12 B Gyorffy (BFonc20163_CR29) 2013; 8 MP Davies (BFonc20163_CR53) 1996; 13 R Feld (BFonc20163_CR30) 1984; 2 D Matsubara (BFonc20163_CR49) 2005; 96 N Pencheva (BFonc20163_CR76) 2012; 151 JC Brenner (BFonc20163_CR17) 2011; 19 W Yu (BFonc20163_CR10) 2004; 36 HL Hsieh (BFonc20163_CR51) 2004; 316 CA Doege (BFonc20163_CR70) 2012; 488 GG Poirier (BFonc20163_CR8) 1982; 79 M Lioni (BFonc20163_CR56) 2007; 170 D Minami (BFonc20163_CR25) 2013; 11 MY Kim (BFonc20163_CR47) 2004; 119 C Darido (BFonc20163_CR57) 2008; 68 R Donato (BFonc20163_CR50) 2003; 60 GP Gupta (BFonc20163_CR75) 2007; 446 M Rouleau (BFonc20163_CR5) 2010; 10 N Ogata (BFonc20163_CR4) 1981; 256 KR Hess (BFonc20163_CR32) 2006; 106 T Akiyama (BFonc20163_CR9) 2001; 98 BG Ju (BFonc20163_CR11) 2006; 312 H Farmer (BFonc20163_CR14) 2005; 434 M Al-Hajj (BFonc20163_CR43) 2003; 100 J Michels (BFonc20163_CR61) 2015; 26 JA Joyce (BFonc20163_CR37) 2009; 9 MY Kim (BFonc20163_CR6) 2005; 19 PC Hoffman (BFonc20163_CR22) 2000; 355 VD Cataldo (BFonc20163_CR60) 2011; 364 T Oskarsson (BFonc20163_CR77) 2011; 17 B Kaufman (BFonc20163_CR15) 2015; 33 R Krishnakumar (BFonc20163_CR48) 2010; 39 MH Lee (BFonc20163_CR65) 2012; 31 D D’Amours (BFonc20163_CR3) 1999; 342 JC Brenner (BFonc20163_CR18) 2012; 72 SK Kim (BFonc20163_CR79) 2014; 30
References_xml	– volume: 25 start-page: 297 year: 2007 end-page: 308 ident: CR12 article-title: DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity: a link to histone acetylation publication-title: Mol Cell doi: 10.1016/j.molcel.2006.12.012 contributor: fullname: Klein – volume: 106 start-page: 1624 year: 2006 end-page: 1633 ident: CR32 article-title: Metastatic patterns in adenocarcinoma publication-title: Cancer doi: 10.1002/cncr.21778 contributor: fullname: Lenzi – volume: 432 start-page: 396 year: 2004 end-page: 401 ident: CR44 article-title: Identification of human brain tumour initiating cells publication-title: Nature doi: 10.1038/nature03128 contributor: fullname: Hide – volume: 110 start-page: 17778 year: 2013 end-page: 17783 ident: CR78 article-title: Multiplatform single-sample estimates of transcriptional activation publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1305823110 contributor: fullname: Johnson – volume: 312 start-page: 1798 year: 2006 end-page: 1802 ident: CR11 article-title: A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription publication-title: Science doi: 10.1126/science.1127196 contributor: fullname: Glass – volume: 10 start-page: 293 year: 2010 end-page: 301 ident: CR5 article-title: PARP inhibition: PARP1 and beyond publication-title: Nat Rev Cancer doi: 10.1038/nrc2812 contributor: fullname: Poirier – volume: 2 start-page: 1352 year: 1984 end-page: 1358 ident: CR30 article-title: Sites of recurrence in resected stage I non-small-cell lung cancer: a guide for future studies publication-title: J Clin Oncol doi: 10.1200/JCO.1984.2.12.1352 contributor: fullname: Weisenberger – volume: 13 start-page: 1631 year: 1996 end-page: 1637 ident: CR53 article-title: Expression of the calcium-binding protein S100A4 (p9Ka) in MMTV-neu transgenic mice induces metastasis of mammary tumours publication-title: Oncogene contributor: fullname: Barraclough – volume: 40 start-page: 521 year: 2010 end-page: 532 ident: CR68 article-title: PARP-1 attenuates Smad-mediated transcription publication-title: Mol Cell doi: 10.1016/j.molcel.2010.10.029 contributor: fullname: Moustakas – volume: 28 start-page: 2773 year: 2009 end-page: 2783 ident: CR34 article-title: An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors publication-title: Oncogene doi: 10.1038/onc.2009.135 contributor: fullname: Somwar – volume: 127 start-page: 679 year: 2006 end-page: 695 ident: CR36 article-title: Cancer metastasis: building a framework publication-title: Cell doi: 10.1016/j.cell.2006.11.001 contributor: fullname: Massague – volume: 284 start-page: 33926 year: 2009 end-page: 33938 ident: CR35 article-title: Global analysis of transcriptional regulation by poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in MCF-7 human breast cancer cells publication-title: J Biol Chem doi: 10.1074/jbc.M109.023879 contributor: fullname: Cen – volume: 65 start-page: 2378 year: 2005 end-page: 2386 ident: CR38 article-title: Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer metastasis precursor cells publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-04-2649 contributor: fullname: Reed – volume: 355 start-page: 479 year: 2000 end-page: 485 ident: CR22 article-title: Lung cancer publication-title: Lancet doi: 10.1016/S0140-6736(00)82038-3 contributor: fullname: Vokes – volume: 272 start-page: 177 year: 2008 end-page: 185 ident: CR39 article-title: Anoikis resistance and tumor metastasis publication-title: Cancer Lett doi: 10.1016/j.canlet.2008.05.029 contributor: fullname: Schimmer – volume: 23 start-page: 725 year: 2013 end-page: 738 ident: CR72 article-title: Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis publication-title: Cancer Cell doi: 10.1016/j.ccr.2013.04.009 contributor: fullname: Fang – volume: 72 start-page: 4796 year: 2012 end-page: 4806 ident: CR16 article-title: HER2 overexpression renders human breast cancers sensitive to PARP inhibition independently of any defect in homologous recombination DNA repair publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-12-1287 contributor: fullname: Yang – volume: 34 start-page: 739 year: 2013 end-page: 749 ident: CR19 article-title: PARP inhibition selectively increases sensitivity to cisplatin in ERCC1-low non-small cell lung cancer cells publication-title: Carcinogenesis doi: 10.1093/carcin/bgs393 contributor: fullname: Lieberman – volume: 316 start-page: 949 year: 2004 end-page: 959 ident: CR51 article-title: S100 protein translocation in response to extracellular S100 is mediated by receptor for advanced glycation endproducts in human endothelial cells publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2004.02.135 contributor: fullname: Heizmann – volume: 445 start-page: 111 year: 2007 end-page: 115 ident: CR40 article-title: Identification and expansion of human colon-cancer-initiating cells publication-title: Nature doi: 10.1038/nature05384 contributor: fullname: Peschle – volume: 9 start-page: e1003531 year: 2013 ident: CR64 article-title: PARP-1 regulates metastatic melanoma through modulation of vimentin-induced malignant transformation publication-title: PLoS Genet doi: 10.1371/journal.pgen.1003531 contributor: fullname: Majuelos-Melguizo – volume: 98 start-page: 48 year: 2001 end-page: 53 ident: CR9 article-title: Activation of Reg gene, a gene for insulin-producing beta -cell regeneration: poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation publication-title: Proc Natl Acad Sci USA contributor: fullname: Shervani – volume: 14 start-page: 535 year: 2014 end-page: 546 ident: CR21 article-title: Non-small-cell lung cancers: a heterogeneous set of diseases publication-title: Nat Rev Cancer doi: 10.1038/nrc3775 contributor: fullname: Wong – volume: 36 start-page: 1105 year: 2004 end-page: 1110 ident: CR10 article-title: Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation publication-title: Nat Genet doi: 10.1038/ng1426 contributor: fullname: Docquier – volume: 60 start-page: 540 year: 2003 end-page: 551 ident: CR50 article-title: Intracellular and extracellular roles of S100 proteins publication-title: Microsc Res Tech doi: 10.1002/jemt.10296 contributor: fullname: Donato – volume: 170 start-page: 709 year: 2007 end-page: 721 ident: CR56 article-title: Dysregulation of claudin-7 leads to loss of E-cadherin expression and the increased invasion of esophageal squamous cell carcinoma cells publication-title: Am J Pathol doi: 10.2353/ajpath.2007.060343 contributor: fullname: Herlyn – volume: 100 start-page: 3983 year: 2003 end-page: 3988 ident: CR43 article-title: Prospective identification of tumorigenic breast cancer cells publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0530291100 contributor: fullname: Clarke – volume: 12 start-page: 877 year: 2013 end-page: 883 ident: CR24 article-title: Synergistic interaction between cisplatin and PARP inhibitors in non-small cell lung cancer publication-title: Cell Cycle doi: 10.4161/cc.24034 contributor: fullname: Lissa – volume: 256 start-page: 4135 year: 1981 end-page: 4137 ident: CR4 article-title: Poly(ADP-ribose) synthetase, a main acceptor of poly(ADP-ribose) in isolated nuclei publication-title: J Biol Chem contributor: fullname: Hayaishi – volume: 19 start-page: 664 year: 2011 end-page: 678 ident: CR17 article-title: Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer publication-title: Cancer Cell doi: 10.1016/j.ccr.2011.04.010 contributor: fullname: Asangani – volume: 19 start-page: 1951 year: 2005 end-page: 1967 ident: CR6 article-title: Poly(ADP-ribosyl)ation by PARP-1: ‘PAR-laying’ NAD+ into a nuclear signal publication-title: Genes Dev doi: 10.1101/gad.1331805 contributor: fullname: Kraus – volume: 102 start-page: 1014 year: 2011 end-page: 1018 ident: CR55 article-title: S100A4 protects gastric cancer cells from anoikis through regulation of alphav and alpha5 integrin publication-title: Cancer Sci doi: 10.1111/j.1349-7006.2011.01915.x contributor: fullname: Sun – volume: 14 start-page: 822 year: 2008 end-page: 827 ident: CR28 article-title: Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study publication-title: Nat Med doi: 10.1038/nm.1790 contributor: fullname: Yeatman – volume: 6 start-page: 282 year: 2008 end-page: 290 ident: CR62 article-title: Poly(ADP-ribose) polymerase 1 promotes tumor cell survival by coactivating hypoxia-inducible factor-1-dependent gene expression publication-title: Mol Cancer Res doi: 10.1158/1541-7786.MCR-07-0377 contributor: fullname: Valovka – volume: 31 start-page: 5099 year: 2012 end-page: 5107 ident: CR65 article-title: Poly(ADP-ribosyl)ation of p53 induces gene-specific transcriptional repression of MTA1 publication-title: Oncogene doi: 10.1038/onc.2012.2 contributor: fullname: Lee – volume: 109 start-page: 120 year: 1995 end-page: 129 ident: CR31 article-title: Incidence of local recurrence and second primary tumors in resected stage I lung cancer publication-title: J Thorac Cardiovasc Surg doi: 10.1016/S0022-5223(95)70427-2 contributor: fullname: Rusch – volume: 6 start-page: e22119 year: 2011 ident: CR58 article-title: Claudin-7 is frequently overexpressed in ovarian cancer and promotes invasion publication-title: PLoS One doi: 10.1371/journal.pone.0022119 contributor: fullname: Morin – volume: 151 start-page: 1068 year: 2012 end-page: 1082 ident: CR76 article-title: Convergent multi-miRNA targeting of ApoE drives LRP1/LRP8-dependent melanoma metastasis and angiogenesis publication-title: Cell doi: 10.1016/j.cell.2012.10.028 contributor: fullname: Busam – volume: 115 start-page: 2453 year: 2015 end-page: 2481 ident: CR7 article-title: New facets in the regulation of gene expression by ADP-ribosylation and poly(ADP-ribose) polymerases publication-title: Chem Rev doi: 10.1021/cr5004248 contributor: fullname: Kraus – volume: 364 start-page: 947 year: 2011 end-page: 955 ident: CR60 article-title: Treatment of non-small-cell lung cancer with erlotinib or gefitinib publication-title: N Engl J Med doi: 10.1056/NEJMct0807960 contributor: fullname: Quintas-Cardama – volume: 13 start-page: 97 year: 2013 end-page: 110 ident: CR69 article-title: Regulatory networks defining EMT during cancer initiation and progression publication-title: Nat Rev Cancer doi: 10.1038/nrc3447 contributor: fullname: Berx – volume: 19 start-page: 194 year: 2013 end-page: 204 ident: CR26 article-title: Biomarker discovery in non-small cell lung cancer: integrating gene expression profiling, meta-analysis, and tissue microarray validation publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-12-1139 contributor: fullname: Lambe – volume: 74 start-page: 1705 year: 2014 end-page: 1717 ident: CR73 article-title: UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-13-1896 contributor: fullname: Chan – volume: 30 start-page: 3284 year: 2014 end-page: 3286 ident: CR79 article-title: APPEX: analysis platform for the identification of prognostic gene expression signatures in cancer publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu521 contributor: fullname: Kim – volume: 446 start-page: 765 year: 2007 end-page: 770 ident: CR75 article-title: Mediators of vascular remodelling co-opted for sequential steps in lung metastasis publication-title: Nature doi: 10.1038/nature05760 contributor: fullname: Nadal – volume: 237 start-page: 2737 year: 2008 end-page: 2747 ident: CR67 article-title: Integrin-linked kinase regulates E-cadherin expression through PARP-1 publication-title: Dev Dyn doi: 10.1002/dvdy.21685 contributor: fullname: Dedhar – volume: 8 start-page: e82241 year: 2013 ident: CR29 article-title: Online survival analysis software to assess the prognostic value of biomarkers using transcriptomic data in non-small-cell lung cancer publication-title: PLoS One doi: 10.1371/journal.pone.0082241 contributor: fullname: Lanczky – volume: 11 start-page: 1487 year: 2009 end-page: 1495 ident: CR42 article-title: The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs publication-title: Nat Cell Biol contributor: fullname: Sonntag – volume: 79 start-page: 3423 year: 1982 end-page: 3427 ident: CR8 article-title: Poly(ADP-ribosyl)ation of polynucleosomes causes relaxation of chromatin structure publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.79.11.3423 contributor: fullname: Mandel – volume: 119 start-page: 803 year: 2004 end-page: 814 ident: CR47 article-title: NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1 publication-title: Cell doi: 10.1016/j.cell.2004.11.002 contributor: fullname: Kraus – volume: 30 start-page: 4365 year: 2011 end-page: 4372 ident: CR66 article-title: Poly(ADP-ribose)-dependent regulation of Snail1 protein stability publication-title: Oncogene doi: 10.1038/onc.2011.153 contributor: fullname: Oliver – volume: 342 start-page: 249 issue: Pt 2 year: 1999 end-page: 268 ident: CR3 article-title: Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions publication-title: Biochem J doi: 10.1042/0264-6021:3420249 contributor: fullname: Poirier – volume: 44 start-page: 1302 year: 2008 end-page: 1314 ident: CR63 article-title: Stable depletion of poly (ADP-ribose) polymerase-1 reduces melanoma growth and increases chemosensitivity publication-title: Eur J Cancer doi: 10.1016/j.ejca.2008.03.019 contributor: fullname: Lacal – volume: 103 start-page: 14825 year: 2006 end-page: 14830 ident: CR54 article-title: S100A4 accelerates tumorigenesis and invasion of human prostate cancer through the transcriptional regulation of matrix metalloproteinase 9 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0606747103 contributor: fullname: Khan – volume: 9 start-page: 239 year: 2009 end-page: 252 ident: CR37 article-title: Microenvironmental regulation of metastasis publication-title: Nat Rev Cancer doi: 10.1038/nrc2618 contributor: fullname: Pollard – volume: 299 start-page: 560 year: 2003 end-page: 562 ident: CR46 article-title: Chromatin loosening by poly(ADP)-ribose polymerase (PARP) at Drosophila puff loci publication-title: Science doi: 10.1126/science.1078764 contributor: fullname: Spradling – volume: 96 start-page: 844 year: 2005 end-page: 857 ident: CR49 article-title: Differential expression of S100A2 and S100A4 in lung adenocarcinomas: clinicopathological significance, relationship to p53 and identification of their target genes publication-title: Cancer Sci doi: 10.1111/j.1349-7006.2005.00121.x contributor: fullname: Yokomizo – volume: 11 start-page: 140 year: 2013 end-page: 148 ident: CR25 article-title: Synergistic effect of olaparib with combination of cisplatin on PTEN-deficient lung cancer cells publication-title: Mol Cancer Res doi: 10.1158/1541-7786.MCR-12-0401 contributor: fullname: Ichihara – volume: 33 start-page: 3205 year: 2014 end-page: 3216 ident: CR74 article-title: GATA3 cooperates with PARP1 to regulate CCND1 transcription through modulating histone H1 incorporation publication-title: Oncogene doi: 10.1038/onc.2013.270 contributor: fullname: Zheng – volume: 26 start-page: 2470 year: 2015 end-page: 2477 ident: CR61 article-title: Negative prognostic value of high levels of intracellular poly(ADP-ribose) in non-small cell lung cancer publication-title: Ann Oncol doi: 10.1093/annonc/mdv514.33 contributor: fullname: Robin – volume: 434 start-page: 917 year: 2005 end-page: 921 ident: CR14 article-title: Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy publication-title: Nature doi: 10.1038/nature03445 contributor: fullname: Richardson – volume: 445 start-page: 106 year: 2007 end-page: 110 ident: CR45 article-title: A human colon cancer cell capable of initiating tumour growth in immunodeficient mice publication-title: Nature doi: 10.1038/nature05372 contributor: fullname: Dick – volume: 17 start-page: 867 year: 2011 end-page: 874 ident: CR77 article-title: Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs publication-title: Nat Med doi: 10.1038/nm.2379 contributor: fullname: Morris – volume: 73 start-page: 2271 year: 2013 end-page: 2280 ident: CR20 article-title: Cisplatin resistance associated with PARP hyperactivation publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-12-3000 contributor: fullname: Kepp – volume: 1 start-page: 313 year: 2007 end-page: 323 ident: CR41 article-title: Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer publication-title: Cell Stem Cell doi: 10.1016/j.stem.2007.06.002 contributor: fullname: Guba – volume: 39 start-page: 736 year: 2010 end-page: 749 ident: CR48 article-title: PARP-1 regulates chromatin structure and transcription through a KDM5B-dependent pathway publication-title: Mol Cell doi: 10.1016/j.molcel.2010.08.014 contributor: fullname: Kraus – volume: 10 start-page: 1949 year: 2011 end-page: 1958 ident: CR23 article-title: Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft publication-title: Mol Cancer Ther doi: 10.1158/1535-7163.MCT-11-0278 contributor: fullname: O’Connor – volume: 27 start-page: 2793 year: 2009 end-page: 2799 ident: CR27 article-title: Relapse-related molecular signature in lung adenocarcinomas identifies patients with dismal prognosis publication-title: J Clin Oncol doi: 10.1200/JCO.2008.19.7053 contributor: fullname: Mitsudomi – volume: 434 start-page: 913 year: 2005 end-page: 917 ident: CR13 article-title: Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase publication-title: Nature doi: 10.1038/nature03443 contributor: fullname: Lopez – volume: 138 start-page: 51 year: 2009 end-page: 62 ident: CR33 article-title: WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis publication-title: Cell doi: 10.1016/j.cell.2009.04.030 contributor: fullname: Ladanyi – volume: 488 start-page: 652 year: 2012 end-page: 655 ident: CR70 article-title: Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2 publication-title: Nature doi: 10.1038/nature11333 contributor: fullname: Fujita – volume: 34 start-page: 1109 year: 2013 end-page: 1123 ident: CR1 article-title: PARP-1 and gene regulation: progress and puzzles publication-title: Mol Aspects Med doi: 10.1016/j.mam.2013.01.005 contributor: fullname: Hottiger – volume: 72 start-page: 1608 year: 2012 end-page: 1613 ident: CR18 article-title: PARP-1 inhibition as a targeted strategy to treat Ewing’s sarcoma publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-11-3648 contributor: fullname: Bou-Maroun – volume: 68 start-page: 4258 year: 2008 end-page: 4268 ident: CR57 article-title: Defective claudin-7 regulation by Tcf-4 and Sox-9 disrupts the polarity and increases the tumorigenicity of colorectal cancer cells publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-07-5805 contributor: fullname: Mantamadiotis – volume: 139 start-page: 1315 year: 2009 end-page: 1326 ident: CR71 article-title: Tumor self-seeding by circulating cancer cells publication-title: Cell doi: 10.1016/j.cell.2009.11.025 contributor: fullname: Norton – volume: 9 start-page: 268 year: 1999 end-page: 273 ident: CR52 article-title: Occludin and claudins in tight-junction strands: leading or supporting players? publication-title: Trends Cell Biol doi: 10.1016/S0962-8924(99)01578-0 contributor: fullname: Furuse – volume: 447 start-page: 459 year: 2014 end-page: 464 ident: CR59 article-title: S100A4 is frequently overexpressed in lung cancer cells and promotes cell growth and cell motility publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2014.04.025 contributor: fullname: Horii – volume: 264 start-page: 8878 year: 1989 end-page: 8886 ident: CR2 article-title: The effect of poly(ADP-ribosyl)ation on native and H1-depleted chromatin. A role of poly(ADP-ribosyl)ation on core nucleosome structure publication-title: J Biol Chem contributor: fullname: Lamarre – volume: 33 start-page: 244 year: 2015 end-page: 250 ident: CR15 article-title: Olaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 mutation publication-title: J Clin Oncol doi: 10.1200/JCO.2014.56.2728 contributor: fullname: Balmana – volume: 65 start-page: 2378 year: 2005 ident: BFonc20163_CR38 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-04-2649 contributor: fullname: O Berezovskaya – volume: 355 start-page: 479 year: 2000 ident: BFonc20163_CR22 publication-title: Lancet doi: 10.1016/S0140-6736(00)82038-3 contributor: fullname: PC Hoffman – volume: 284 start-page: 33926 year: 2009 ident: BFonc20163_CR35 publication-title: J Biol Chem doi: 10.1074/jbc.M109.023879 contributor: fullname: KM Frizzell – volume: 17 start-page: 867 year: 2011 ident: BFonc20163_CR77 publication-title: Nat Med doi: 10.1038/nm.2379 contributor: fullname: T Oskarsson – volume: 10 start-page: 1949 year: 2011 ident: BFonc20163_CR23 publication-title: Mol Cancer Ther doi: 10.1158/1535-7163.MCT-11-0278 contributor: fullname: JM Senra – volume: 14 start-page: 535 year: 2014 ident: BFonc20163_CR21 publication-title: Nat Rev Cancer doi: 10.1038/nrc3775 contributor: fullname: Z Chen – volume: 13 start-page: 1631 year: 1996 ident: BFonc20163_CR53 publication-title: Oncogene contributor: fullname: MP Davies – volume: 109 start-page: 120 year: 1995 ident: BFonc20163_CR31 publication-title: J Thorac Cardiovasc Surg doi: 10.1016/S0022-5223(95)70427-2 contributor: fullname: N Martini – volume: 72 start-page: 4796 year: 2012 ident: BFonc20163_CR16 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-12-1287 contributor: fullname: S Nowsheen – volume: 446 start-page: 765 year: 2007 ident: BFonc20163_CR75 publication-title: Nature doi: 10.1038/nature05760 contributor: fullname: GP Gupta – volume: 14 start-page: 822 year: 2008 ident: BFonc20163_CR28 publication-title: Nat Med doi: 10.1038/nm.1790 contributor: fullname: K Shedden – volume: 2 start-page: 1352 year: 1984 ident: BFonc20163_CR30 publication-title: J Clin Oncol doi: 10.1200/JCO.1984.2.12.1352 contributor: fullname: R Feld – volume: 445 start-page: 111 year: 2007 ident: BFonc20163_CR40 publication-title: Nature doi: 10.1038/nature05384 contributor: fullname: L Ricci-Vitiani – volume: 316 start-page: 949 year: 2004 ident: BFonc20163_CR51 publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2004.02.135 contributor: fullname: HL Hsieh – volume: 138 start-page: 51 year: 2009 ident: BFonc20163_CR33 publication-title: Cell doi: 10.1016/j.cell.2009.04.030 contributor: fullname: DX Nguyen – volume: 434 start-page: 917 year: 2005 ident: BFonc20163_CR14 publication-title: Nature doi: 10.1038/nature03445 contributor: fullname: H Farmer – volume: 299 start-page: 560 year: 2003 ident: BFonc20163_CR46 publication-title: Science doi: 10.1126/science.1078764 contributor: fullname: A Tulin – volume: 26 start-page: 2470 year: 2015 ident: BFonc20163_CR61 publication-title: Ann Oncol doi: 10.1093/annonc/mdv514.33 contributor: fullname: J Michels – volume: 342 start-page: 249 issue: Pt 2 year: 1999 ident: BFonc20163_CR3 publication-title: Biochem J doi: 10.1042/0264-6021:3420249 contributor: fullname: D D’Amours – volume: 106 start-page: 1624 year: 2006 ident: BFonc20163_CR32 publication-title: Cancer doi: 10.1002/cncr.21778 contributor: fullname: KR Hess – volume: 102 start-page: 1014 year: 2011 ident: BFonc20163_CR55 publication-title: Cancer Sci doi: 10.1111/j.1349-7006.2011.01915.x contributor: fullname: W Shen – volume: 151 start-page: 1068 year: 2012 ident: BFonc20163_CR76 publication-title: Cell doi: 10.1016/j.cell.2012.10.028 contributor: fullname: N Pencheva – volume: 6 start-page: 282 year: 2008 ident: BFonc20163_CR62 publication-title: Mol Cancer Res doi: 10.1158/1541-7786.MCR-07-0377 contributor: fullname: M Elser – volume: 98 start-page: 48 year: 2001 ident: BFonc20163_CR9 publication-title: Proc Natl Acad Sci USA contributor: fullname: T Akiyama – volume: 33 start-page: 244 year: 2015 ident: BFonc20163_CR15 publication-title: J Clin Oncol doi: 10.1200/JCO.2014.56.2728 contributor: fullname: B Kaufman – volume: 28 start-page: 2773 year: 2009 ident: BFonc20163_CR34 publication-title: Oncogene doi: 10.1038/onc.2009.135 contributor: fullname: D Chitale – volume: 40 start-page: 521 year: 2010 ident: BFonc20163_CR68 publication-title: Mol Cell doi: 10.1016/j.molcel.2010.10.029 contributor: fullname: P Lonn – volume: 30 start-page: 3284 year: 2014 ident: BFonc20163_CR79 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu521 contributor: fullname: SK Kim – volume: 34 start-page: 1109 year: 2013 ident: BFonc20163_CR1 publication-title: Mol Aspects Med doi: 10.1016/j.mam.2013.01.005 contributor: fullname: WL Kraus – volume: 25 start-page: 297 year: 2007 ident: BFonc20163_CR12 publication-title: Mol Cell doi: 10.1016/j.molcel.2006.12.012 contributor: fullname: M Cohen-Armon – volume: 72 start-page: 1608 year: 2012 ident: BFonc20163_CR18 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-11-3648 contributor: fullname: JC Brenner – volume: 39 start-page: 736 year: 2010 ident: BFonc20163_CR48 publication-title: Mol Cell doi: 10.1016/j.molcel.2010.08.014 contributor: fullname: R Krishnakumar – volume: 30 start-page: 4365 year: 2011 ident: BFonc20163_CR66 publication-title: Oncogene doi: 10.1038/onc.2011.153 contributor: fullname: MI Rodriguez – volume: 1 start-page: 313 year: 2007 ident: BFonc20163_CR41 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2007.06.002 contributor: fullname: PC Hermann – volume: 60 start-page: 540 year: 2003 ident: BFonc20163_CR50 publication-title: Microsc Res Tech doi: 10.1002/jemt.10296 contributor: fullname: R Donato – volume: 170 start-page: 709 year: 2007 ident: BFonc20163_CR56 publication-title: Am J Pathol doi: 10.2353/ajpath.2007.060343 contributor: fullname: M Lioni – volume: 445 start-page: 106 year: 2007 ident: BFonc20163_CR45 publication-title: Nature doi: 10.1038/nature05372 contributor: fullname: CA O’Brien – volume: 103 start-page: 14825 year: 2006 ident: BFonc20163_CR54 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0606747103 contributor: fullname: M Saleem – volume: 74 start-page: 1705 year: 2014 ident: BFonc20163_CR73 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-13-1896 contributor: fullname: JH Kim – volume: 100 start-page: 3983 year: 2003 ident: BFonc20163_CR43 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0530291100 contributor: fullname: M Al-Hajj – volume: 139 start-page: 1315 year: 2009 ident: BFonc20163_CR71 publication-title: Cell doi: 10.1016/j.cell.2009.11.025 contributor: fullname: MY Kim – volume: 432 start-page: 396 year: 2004 ident: BFonc20163_CR44 publication-title: Nature doi: 10.1038/nature03128 contributor: fullname: SK Singh – volume: 11 start-page: 140 year: 2013 ident: BFonc20163_CR25 publication-title: Mol Cancer Res doi: 10.1158/1541-7786.MCR-12-0401 contributor: fullname: D Minami – volume: 127 start-page: 679 year: 2006 ident: BFonc20163_CR36 publication-title: Cell doi: 10.1016/j.cell.2006.11.001 contributor: fullname: GP Gupta – volume: 19 start-page: 194 year: 2013 ident: BFonc20163_CR26 publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-12-1139 contributor: fullname: J Botling – volume: 79 start-page: 3423 year: 1982 ident: BFonc20163_CR8 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.79.11.3423 contributor: fullname: GG Poirier – volume: 27 start-page: 2793 year: 2009 ident: BFonc20163_CR27 publication-title: J Clin Oncol doi: 10.1200/JCO.2008.19.7053 contributor: fullname: S Tomida – volume: 73 start-page: 2271 year: 2013 ident: BFonc20163_CR20 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-12-3000 contributor: fullname: J Michels – volume: 96 start-page: 844 year: 2005 ident: BFonc20163_CR49 publication-title: Cancer Sci doi: 10.1111/j.1349-7006.2005.00121.x contributor: fullname: D Matsubara – volume: 364 start-page: 947 year: 2011 ident: BFonc20163_CR60 publication-title: N Engl J Med doi: 10.1056/NEJMct0807960 contributor: fullname: VD Cataldo – volume: 11 start-page: 1487 year: 2009 ident: BFonc20163_CR42 publication-title: Nat Cell Biol doi: 10.1038/ncb1998 contributor: fullname: U Wellner – volume: 237 start-page: 2737 year: 2008 ident: BFonc20163_CR67 publication-title: Dev Dyn doi: 10.1002/dvdy.21685 contributor: fullname: TR McPhee – volume: 23 start-page: 725 year: 2013 ident: BFonc20163_CR72 publication-title: Cancer Cell doi: 10.1016/j.ccr.2013.04.009 contributor: fullname: WK Cheung – volume: 34 start-page: 739 year: 2013 ident: BFonc20163_CR19 publication-title: Carcinogenesis doi: 10.1093/carcin/bgs393 contributor: fullname: H Cheng – volume: 312 start-page: 1798 year: 2006 ident: BFonc20163_CR11 publication-title: Science doi: 10.1126/science.1127196 contributor: fullname: BG Ju – volume: 12 start-page: 877 year: 2013 ident: BFonc20163_CR24 publication-title: Cell Cycle doi: 10.4161/cc.24034 contributor: fullname: J Michels – volume: 8 start-page: e82241 year: 2013 ident: BFonc20163_CR29 publication-title: PLoS One doi: 10.1371/journal.pone.0082241 contributor: fullname: B Gyorffy – volume: 44 start-page: 1302 year: 2008 ident: BFonc20163_CR63 publication-title: Eur J Cancer doi: 10.1016/j.ejca.2008.03.019 contributor: fullname: L Tentori – volume: 9 start-page: 268 year: 1999 ident: BFonc20163_CR52 publication-title: Trends Cell Biol doi: 10.1016/S0962-8924(99)01578-0 contributor: fullname: S Tsukita – volume: 19 start-page: 1951 year: 2005 ident: BFonc20163_CR6 publication-title: Genes Dev doi: 10.1101/gad.1331805 contributor: fullname: MY Kim – volume: 488 start-page: 652 year: 2012 ident: BFonc20163_CR70 publication-title: Nature doi: 10.1038/nature11333 contributor: fullname: CA Doege – volume: 434 start-page: 913 year: 2005 ident: BFonc20163_CR13 publication-title: Nature doi: 10.1038/nature03443 contributor: fullname: HE Bryant – volume: 13 start-page: 97 year: 2013 ident: BFonc20163_CR69 publication-title: Nat Rev Cancer doi: 10.1038/nrc3447 contributor: fullname: B De Craene – volume: 9 start-page: 239 year: 2009 ident: BFonc20163_CR37 publication-title: Nat Rev Cancer doi: 10.1038/nrc2618 contributor: fullname: JA Joyce – volume: 9 start-page: e1003531 year: 2013 ident: BFonc20163_CR64 publication-title: PLoS Genet doi: 10.1371/journal.pgen.1003531 contributor: fullname: MI Rodriguez – volume: 10 start-page: 293 year: 2010 ident: BFonc20163_CR5 publication-title: Nat Rev Cancer doi: 10.1038/nrc2812 contributor: fullname: M Rouleau – volume: 447 start-page: 459 year: 2014 ident: BFonc20163_CR59 publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2014.04.025 contributor: fullname: N Chen – volume: 19 start-page: 664 year: 2011 ident: BFonc20163_CR17 publication-title: Cancer Cell doi: 10.1016/j.ccr.2011.04.010 contributor: fullname: JC Brenner – volume: 264 start-page: 8878 year: 1989 ident: BFonc20163_CR2 publication-title: J Biol Chem doi: 10.1016/S0021-9258(18)81875-0 contributor: fullname: A Huletsky – volume: 6 start-page: e22119 year: 2011 ident: BFonc20163_CR58 publication-title: PLoS One doi: 10.1371/journal.pone.0022119 contributor: fullname: N Dahiya – volume: 110 start-page: 17778 year: 2013 ident: BFonc20163_CR78 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1305823110 contributor: fullname: SR Piccolo – volume: 31 start-page: 5099 year: 2012 ident: BFonc20163_CR65 publication-title: Oncogene doi: 10.1038/onc.2012.2 contributor: fullname: MH Lee – volume: 115 start-page: 2453 year: 2015 ident: BFonc20163_CR7 publication-title: Chem Rev doi: 10.1021/cr5004248 contributor: fullname: KW Ryu – volume: 272 start-page: 177 year: 2008 ident: BFonc20163_CR39 publication-title: Cancer Lett doi: 10.1016/j.canlet.2008.05.029 contributor: fullname: CD Simpson – volume: 36 start-page: 1105 year: 2004 ident: BFonc20163_CR10 publication-title: Nat Genet doi: 10.1038/ng1426 contributor: fullname: W Yu – volume: 256 start-page: 4135 year: 1981 ident: BFonc20163_CR4 publication-title: J Biol Chem doi: 10.1016/S0021-9258(19)69404-4 contributor: fullname: N Ogata – volume: 119 start-page: 803 year: 2004 ident: BFonc20163_CR47 publication-title: Cell doi: 10.1016/j.cell.2004.11.002 contributor: fullname: MY Kim – volume: 68 start-page: 4258 year: 2008 ident: BFonc20163_CR57 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-07-5805 contributor: fullname: C Darido – volume: 33 start-page: 3205 year: 2014 ident: BFonc20163_CR74 publication-title: Oncogene doi: 10.1038/onc.2013.270 contributor: fullname: L Shan
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Snippet	The role of poly (ADP-ribose) polymerase 1 (PARP1) in cancer has been extensively studied in the context of DNA repair, leading to clinical trials of PARP1...
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SubjectTerms	13/1 13/109 13/89 14/5 38/61 45/90 631/154/53/2422 631/67/1612/1350 631/67/322 82/51 Adenocarcinoma Adenocarcinoma - genetics Adenocarcinoma - pathology Adenocarcinoma of Lung Anoikis Apoptosis Cancer Carcinogenesis Carcinogenesis - genetics Cell Biology Cell Line, Tumor Claudins - genetics Clinical trials Deoxyribonucleic acid Development and progression DNA DNA repair DNA Repair - genetics DNA-Binding Proteins - genetics Extravasation Gene expression Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Genetic aspects Health aspects Homologous Recombination Human Genetics Humans Internal Medicine Lung cancer Lung Neoplasms - genetics Lung Neoplasms - pathology Medicine Medicine & Public Health Metastases Metastasis Microenvironments Molecular modelling Neoplasm Metastasis Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Oncology original-article Patients Poly(ADP-ribose) Polymerase 1 Polymerase chain reaction Properties Ribose S100 Calcium-Binding Protein A4 - genetics S100A4 protein Transcription Transferases
Title	PARP1 enhances lung adenocarcinoma metastasis by novel mechanisms independent of DNA repair
URI	https://link.springer.com/article/10.1038/onc.2016.3 https://www.ncbi.nlm.nih.gov/pubmed/26898760 https://www.proquest.com/docview/1815730206 https://www.proquest.com/docview/2641590072 https://search.proquest.com/docview/1819145320
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